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All Journal Journal of Global Pharma Technology Jurnal Praba: Jurnal Rumpun Kesehatan Umum
Ramona Dumasari Lubis
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Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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The Difference in Immunoglobulin M Anti-Phenolic Glycolipid-1 Antibody Levels in Leprosy Patient, Household Contacts, and Control Ramona Dumasari Lubis
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (308.129 KB)

Abstract

Background: Leprosy is a disease caused by M. leprae infection, may affect the peripheral nervous system, skin and other tissues. Until recently, leprosy is still a health problem in Indonesia. Phenolic Glycolipid-1 (PGL-1) is a stable and unique component of M. leprae, and an antibody examination against this antigen may play a role in assisting early detection of subclinical stage leprosy (SSL) and treatment monitoring. Objective: This study aims to define the level of IgM anti-PGL-1 antibody in leprosy patients, household contacts and controls and their serology status  Methods: The examination of IgM anti-PGL-1 antibody was carried out on 52 leprosy patients, 95 people household contacts and 95 healthy controls. The data from subjects were then analyzed and tested using Kruskal-Wallis statistical test and a p-value <0.001 was obtained. Results: It was obtained that the levels of IgM anti-PGL-1 antibody significantly differed between leprosy, household contact and control groups (p<0.05). Most of the leprosy patients had seropositive status, contrary to dominant seronegative that was found in household contacts and control groups. In subgroup analysis, the IgM titer level did not significantly differ between household contacts and control groups (p=0.122). Conclusion: the IgM anti-PGL-1 antibody differed between leprosy and household contacts and control. IgM antibody titer may also depict a person's exposure status to M. leprae bacilli.Keywords: M. leprae, Leprosy, IGM anti-PGL-1 antibody, Household contacts.
Factors Associated With The Incidence Of Scabies At Hidayatullah Islamic Boarding School, Southeast Aceh Regency Minggu Noven Simorangkir; Ramona Dumasari Lubis; Arlinda Sari Wahyuni; Muhammad Ichwan; Hendri Wijaya; Nurcholisah Fitra; Ruslan Zuhair Pulungan; Abdul Rahman Ramdzan
Jurnal Praba : Jurnal Rumpun Kesehatan Umum Vol. 4 No. 2 (2026): Juni : Praba : Jurnal Rumpun Kesehatan Umum
Publisher : STIKES Columbia Asia Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62027/praba.v4i2.914

Abstract

Scabies is a contagious skin disease caused by Sarcoptes scabiei and is primarily transmitted through direct contact or contaminated fomites. The disease is commonly associated with overcrowded living conditions and poor personal and environmental hygiene. Scabies remains a public health concern and has been classified by the World Health Organization as a neglected tropical disease. This study aimed to determine the factors associated with scabies occurrence among students at Hidayatullah Islamic Boarding School, Southeast Aceh Regency. A quantitative study with a cross-sectional design was conducted from June 2024 to June 2025 involving 120 students selected through total sampling. Data were collected using structured questionnaires and analyzed using SPSS through univariate, bivariate analysis using the chi-square test, and multivariate analysis using logistic regression. The results showed significant associations between scabies occurrence and students’ knowledge, attitudes, personal hygiene, environmental sanitation, and support from boarding school management. Among these factors, personal hygiene was identified as the most dominant factor associated with scabies occurrence. These findings highlight the importance of improving students’ knowledge and attitudes, strengthening personal hygiene practices, maintaining adequate environmental sanitation, and enhancing support from boarding school management. Collaboration between boarding schools and healthcare providers is also essential to strengthen scabies prevention and control, particularly among newly admitted students.
Co-Authors Abdul Rahman Ramdzan Arlinda Sari Wahyuni HENDRI WIJAYA Minggu Noven Simorangkir Muhammad Ichwan NURCHOLISAH FITRA Ruslan Zuhair Pulungan