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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Technical Factors Affecting to Production of Dried Roasted Pumpkin (Cucurbita) Seed Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
Publisher : Journal of Global Pharma Technology

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Abstract

Pumpkin seeds are covered by a white husk. Pumpkin seeds are subtly sweet and nutty with a malleable, chewy texture. The seeds of pumpkin are rich in oil and nutrients. Pumpkin seed has been considered as beneficial to health because it contains various biologically active components. It lowers cholesterol level in blood. Drying and roasting are the most important processes giving neccessary alterations to the product.  Roasting can enhance flavour through caramelization on the surface of the food. There was no any research mentioned to varify the change of antioxidant (tocopherol) during infrared drying as well as storage. So the objective of the present study was to identify the effect of temperature in infrared drying, roasting condition, packaging and storage to antioxidant (tocopherol) in the dried Pumpkin (Cucurbita) seed. Results demonstrated that drying temperature (42 oC), roasting (155 oC in 4 min), vaccum packing in polyethylen (PA) bag and keeping in 4 oC were recommended to maintain the tocopherol, total phenolic and antioxidant activity in the final products for 12 weeks. The effect of drying, roasting temperature and time were clearly demonstrated to produced dried roasted pumpkin seed.Keywords: Pumpkin, Drying, Roasting, ANTIOXIDANT, tocopherol, Vaccum.
Study of the Effect of Carbopol and Chitosan on the Gelatin Water Solvation Process with the Method of Molecular Dynamics Mayorova AV
Journal of Global Pharma Technology .
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Abstract

Background: The purpose of the paper is the analysis of scientific and technical information concerning features of using microcapsules in dermal medicinal and cosmetic products, as well as a theoretical study of the effect of carbopol and chitosan on the process of gelatin solvation in microcapsules. An analysis of published data showed urgency of developing dermal medicinal and cosmetic forms using microencapsulation, as well as the prospects for studying the relationship between the material of microcapsules and chemical composition of the drug. Carbopol 940 and chitosan succinate were used as the basic carrier for the developed dosage forms. A statistically significant increase in the solvation level of gelatin in the presence of carbopol at the human body temperature compared to solvation with pure water was established by the molecular dynamics method with the use of the Bio Evrica software. In a similar way, an insignificant effect of the ionized form of chitosan on the level of gelatin solvation was found. Methods: The molecular dynamics simulation was performed with direct account of the solvent molecules, the charges of carbopol and chitosan atoms were calculated previously by abinitio method (6-311G**).Conclusion:  The obtained results show the expediency of using carbopol and chitosan as the basic carrier of external dosage forms with gelatinous microcapsules, since increasing the gelatin solvation level promotes the release of active substance of microcapsules.Keywords: Molecular dynamics, Solvation, Gelatin, Carbopol 940, Chitosan microcapsules, Gel.
Rapid Determination of Bi (III) and Al (III) in Pharmaceutical Formulations using Organic Reagent Spectrophotometrically Jumana W. Ammar
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

A new trend describes the development and validation of a simple, sensitive and selective spectrophotometric methods for the determination of Bi (III) and Al (III) in pharmaceutical formulations have been conducted. In this paper, 4-(4 acetamidophenylazo) pyrogallol was synthesized as a new organic compound, 4-APAP, by coupling pyrogallol with diazotized p- aminoacetanilide in medium of controlled pH. 4- APAP was characterized by techniques of FT-IR, H-NMR, GC-Mass, TG and DSC thermal analysis methods. Solvatochromic behavior in solvents of various polarities was also investigated.Keywords: Pharmaceutical applications, Pyrogallol, Bi (III), Al (III).
The Effect of Using Pain Management Techniques in the Rehabilitation of Chronic Lower Back Injury in Athletes and Non-athletes Haider Jumaah Asree Ktaiman
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

In the past few days increased chronic lower back pain, where today is a disease of the era due to the high effort and continuous and disproportionate exercise of the athlete and loads of low back, and the fact that chronic lower back pain is a disease of the modern era and through the experience and work of researchers in medicine Physical therapy and physiotherapy have found that there is little or no use of pain management techniques to treat chronic low back pain and that chronic low back pain is a disease of the modern age. Therefore, researchers considered this study as the first study in Iraq in terms of Techniques in pain management to treat chronic lower back pain. The researchers used the experimental method was the sample included the 12 players injured who suffer from the bottom of the chronic back pain represented by convulsions and muscle cramps, chronic where formed the experimental group of 6 players used pain management techniques within the program consists of 16 weeks either the control group used its traditional 16 week. Search Results showed superiority of the experimental group on the control group in the test Schober to measure the degree of pain where he showed differences (0.021 (in the test side flexibility differences emerged (0.01).Keywords: Pain management techniques, Rehabilitation, Lower back injury.
Silver Nanoparticles Synthesis by Hamza's Khubdat (A.S.) (Kombucha) Tea and used in Burn Wounds Treatment Esam J. Al-Kalifawi
Journal of Global Pharma Technology .
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Abstract

In the present study, silver nanoparticles were synthesized using Hamza's Khubdat (A.S.) tea as the reducing and capping agent. The nanoparticles were characterized using UV-visible, FT-IR, XRD, and SEM methods. The surface plasmon resonance peaks in absorption spectra for silver colloidal solution showed an absorption peak at 340 nm in a UV-visible spectrum. Several peaks were observed indicating the Hamza's Khubdat (A.S.) tea is composed of various functional groups which include vibration of amine groups responsible for the silver nanoparticles formation were characterized by FT-IR. The XRD results suggested that the crystallization of the bio-organic phase occurs on the surface of the silver nanoparticles or vice versa. The broadening of peaks in the XRD patterns was attributed to particle size effects and the average particles size about 29.15 nm. The silver nanoparticles synthesized by using Hamza's Khubdat (A.S.) tea were scanned using SEM. It reveals that a silver nanoparticle seems to be spherical in morphology. In addition, antimicrobial packaging was prepared by mixing colloidal silver nanoparticles synthesized by Hamza's Khubdat (A.S.) tea with nanocellulose pellicle of Hamza's Khubdat (A.S.) and depositing this hybrid coating (NCP/Ag) as a layer. The NCP/Ag coated layer were then characterized by scanning electron microscopy (SEM), furthermore study their antimicrobial activity. SEM showed deposition of Ag nanoparticles on the surface of NCP and formation of a relatively smooth, dense coating layer on the pellicle surface. The results also demonstrated that the NCP /Ag coating exhibited good antibacterial activity against four Gram-negative and four Gram-positive bacteria which causing burn wounds inflammation.Keywords: Hamza's Khubdat (A.S.), Silver nanoparticles, Nanocellulose pellicle, Antimicrobial activity, pathogenic bacteria.
Determination of Standard Parameters of Acorn Squash Leaves Oleh S. Shpychak
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

One of the priority tasks of pharmacy is to find new sources of raw materials for the medicinal products. The purpose of this work is to determine a number of indicators of the quality of promising medicinal raw materials that are the leaves of acorn squash Cucurbita pepo (Cucurbitaceae) for the creation of regulatory and technical documentation. For our research one of the most competitive kind - "Ukrainian multi-plant" was chosen. This kind is not sensitive to climatic conditions (drought-resistant). It has been grown in many countries with moderate climate and the most parts of Ukraine (Polissya, forest-steppe, steppe) and other since 1950. In this way, for the first time, 7 series of acorn squash leaves of "Ukrainian multi-plant" were studied. The main diagnostic features of morphological structure, including morphometric indicators, the main diagnostic microscopic features of the powder of acorn squash leaves were determined. The work presents the limit values of the main figures of 7 series of raw materials: weight loss during drying (not more than 8.5 %), total ash content (not more than 3.7 %,), extractive substances content (not less than 20.0%), phenolic compounds content (not less than 2.0 %). According to the results obtained the regulatory and technical documentation “Methods of quality control of” Acorn squash leaves “has been developed. Keywords: Acorn squash, Leaf, Morphological structure, Microscopic diagnostic signs, Plant raw materials.
Effect of Atorvastatin on Cerebral Vasomotor Reactivity in Patients with Ischemic Stroke Mohammad Reza Amiri-Nikpour
Journal of Global Pharma Technology .
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Abstract

Background and Objectives: statins are effective in the prevention of atherosclerotic plaques formation. According to the observed effects of statins in improving regional blood flow and their protective role against brain stroke, it seems that some of these effects are involved in improving the cerebrovascular reactivity in patients. The objective of this study was to evaluate the effect of statins on cerebrovascular reactivity in patients with ischemic stroke. Methods: This study is a single-blinded randomized clinical trial conducted on 180 patients referred to Imam Khomeini Hospital of Urmia in Iran. The patients were hospitalized due to ischemic stroke and they were included in study based on inclusion and exclusion criteria. Then, they were randomly assigned into control and intervention groups. Intervention group patients, in addition to receiving common drug treatments, were treated with daily atorvastatin 80 mg for three consecutive months and their cerebrovascular reactivity was measured and compared on the arrival, seventh and ninetieth days by Transcranial Doppler(TCD). Finally, results were analyzed using spss20 software. Results: In this study, 180 patients with ischemic stroke were examined, which some of them were excluded from study due to lack of referring for follow-up or death after study. Finally, 75 patients were assigned to intervention group and 72 of them were included in control group. The mean of variables Breath holding index (BHI) and Apnea Mean flow velocity(MFV) in patients of intervention group increased significantly compared to the that in patients of control group (P = 0.049, P = 0.003). According to the results, the difference in increase of mentioned variables in the seventh day, and especially in the ninetieth day, after taking atorvastatin was more prominent, which it can be justified by mechanism of drug. Rest MFV patients in any of the two groups showed no significant difference, which suggests lack of the drug effect on the Rest MFV patients. Conclusion: This study found evidence of significant improved cerebrovascular reactivity of patients after taking Atorvastatin, which this process is independent from benefits caused by reduced blood fat following taking statins and it is created as result of self-regulation improvement of endothelial nitric oxide synthase enzyme.Keywords: Stroke, Atorvastatin, Cerebrovascular reactivity, BHI.
Prospects for the Use of the Herb Chamomile in the Manufacture of Dietary Supplements Аngelina V. Streljaeva
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Objective: Chamomile flowers is a widely studied pharmaceutical raw material, however, pharmaceutical herb chamomile herbal raw material practically has not been studied, but in practice is an interesting and promising item for further study. The objective of the study was carrying out of the analysis of the herb chamomile raw material (two types-fresh and dried). Method: In accordance with the Russian SP (State Pharmacopoeia) procedures, there were produced etheroleum and alcohol extract. Moisture content was determined as for dried raw material: 14.00±0.74%, for fresh raw material: 71.40±2.23%. Quantitative and qualitative composition was assessed by GLC (gas-liquid chromatography, mass detector) and HPLC (high-performance liquid chromatography) methods. Results: As of comparative analysis of etheroleum and alcoholic extract from herb chamomile, it should be pointed out that azulene derivatives were present in etheroleum and in alcoholic extract; however, chamazulene as such was identified just in etheroleum. In alcoholic extract there was no chamazulene. In alcohol extract there were identified vitamins, flavonoids (kaempferol is the important one), phenol compounds, coumarins, organic acids-ferulic acid and its derivatives, peptides and sugars. Conclusion: The herb chamomile is both a promising dietary food supplement, and a pharmaceutical preparation. There are a lot of studies concerning the determination of herbal`s bioactive components. This process is important for quality control of herbs and its products.Keywords: Herb chamomile, Chamazulene, Matricin, Kaemferol, Ferulic acid.
The Effectiveness of the M.U.R.D.E.R Strategy to Solve Problems in Learning Skills of Top and Bottom Facing Service for Student in the Volleyball Saeed Gheni Noori
Journal of Global Pharma Technology .
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Abstract

The study aimed at identifying the efficacy of the murder strategy to solve problems in learning the top-down and bottom-up service skills of volleyball, and researchers have identified the research community of fifth graders, the bio branch of the Rafidain preparatory boys' school in Baghdad governorate for the 2017-2018 school year, the number (86) students, 36 students were selected as a random search sample, divided into two female and experimental groups of 15 students per group and the rest of the students selected for the exploratory experiment, the experimental group exercised a murder strategy to solve the problems, while the officer group exercised the traditional method, the program was applied by two educational units per week for 6 weeks, and in light of the findings of the two researchers, they concluded that the murder strategy to solve the problems had a positive impact on the speed of learning the artistic performance and the accuracy of the service skills facing The top and bottom of the trial group, and the use of this strategy for this group was more influential than in the security group method of learning the performance of the top-down and bottom-facing service skills.Keywords: M.U.R.D.E.R strategy, Top and bottom facing service.
The Effect of Complex Exercises Using the Strategy of Pressure Game to Develop the Energy Expended for the Heart and the Speed of the Skilled Performance of the Football Players Nabhan Hamid Ahmed
Journal of Global Pharma Technology .
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Abstract

The aim of the research is to identify the effect of the combined exercises using the play method of the pressure to develop the energy released to the heart and the speed of the skill performance of football players. As for the sample of the research, it included the players of the club of 22 players and the Anbar Youth Club participating in the 2016 league championship Results of the study showed that there were significant differences between the results of the research in the post tests of the control group and experimental and for the benefit of the experimental group. The findings of the researchers that the exercises combined with play pressure has a positive effect on the sample research Follicular and through the conclusions were to reach the most important recommendations, including the adoption of complex exercises in the training units and in the special stage of preparation and in a high-intensity interval training and repetitive because of its role in the development of research variables.Keywords: Complex exercises, Strategy, Pressure game, Energy expended, Heart and football players.

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