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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Autonomic Function in Peripheral Nerve Regeneration Especially in Radial and Ulnar Nerve Injuries after Microsurgery: A Systematic Review Ria Margiana
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

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Abstract

This literature review seeks to understand the difference in autonomic function of radial and ulnar nerve injuries after microsurgery. During this surgery, additional damage to nerves is also experienced. This research focused on peer-reviewed articles from Pubmed-NCBI database. This is a medical database which features medical peer-reviewed articles on various illnesses treatments and outcomes. The eligibility criteria used were that the article must be full text, published within the past 10 years, written in English language, and featured the keywords-radial nerve injury, ulnar nerve injury and microsurgery. There was no specific characteristic for participants as all individuals with injury were considered. The search from the database yielded 121 initial articles. Of this number, 33 were excluded for being editor comments and no full texts. This had led to 88 remaining articles which were further screened to remove articles written in other languages and those which were older than 10 years. This featured a total of 43 articles. Of this remaining total, only 30 articles were used. The other 15 were excluded as a result of research reliability issues. The procedures used in the articles featured a lot of limitations which questioned the validity of their results. This paper concludes with a summary of the analysis of the difference in autonomic function of the radius and ulna after microsurgery.Keywords: Autonomic function, Radial nerve, Ulnar nerve, Microsurgery.
Purification and Characterization of Tracp from sera of Patients with Chronic Renal Failure Hathama R. Hasan
Journal of Global Pharma Technology .
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Abstract

Background and Objective Tartrate Resistant Acid Phosphatase (TRACP) also known as type 5 acid phosphatase is a glycoprotein with basic pI , and occurring as two similar isoforms 5a and 5b with different carbohydrate content. This study aims to characterize both TRACP isoforms physico-chemically and spectrophotometrically Materials and Methods: Ion exchange chromatography was applied in order to purify TRACP isoforms (5a and 5b) from sera of control and patients with End Stage Renal Disease (ESRD). Results: The results indicated different specific activities of TRACP 5a and 5b and their proportional amounts in sera of patients with ESRD were different from that of the control group, they had approximate molecular weight of (36.8-39.3 KDa) and a basic isoelectric point equal to9.6 incontrol and patients with ESRD. The optimal pH for 5b is relatively higher than for 5a, the heparin (23 KU/L) had an inhibitory effect only on the activity of TRACP 5a, the iron content of isoform 5b was found to be one mole per one mole of enzyme, and UV spectrum of TRACP 5a was found to be different from that of TRACP 5b in both control and patients with ESRD. Conclusion: We conclude that there are differences in the characterization of both isoform TRACP 5a and 5b in sera of end stage renal disease.Keywords: TRACP, Purification, Isoform, Characterization.
Isolation and Identification of Bacterial Causes of Acute Tonsillitis Frial Gemeel Abd
Journal of Global Pharma Technology .
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Abstract

Acute tonsillitis was an inflammatory process of the tonsillar tissues and was usually infectious in nature. Acute tonsillitis starts suddenly and usually goes away again within one to two weeks. This infection was often bacterial, or sometimes viral.   A hundred of blood and swabs specimens were collected from patients who were suffering from tonsillitis whose did not take any drugs for both sex with age ranging from 1-60 years in AL-Hilla-Teaching hospital and hospital Babylon for birth and children during a period from October 2017 through January 2018 . The causative agent for tonsillitis was   isolated and diagnostic of microorganism according to morphological and biochemical test  by using VITEK compact 2 .The results  appeared the number of gram positive bacteria about 100 and 23 isolate from  gram negative bacteria .The most common causative agent was Streptococcus pyogenes and Staphylococcus aureus. The sensitivity of bacterial to antibiotic was appeared most of bacterial resistance to amoxicillin, Cefotaxime and Aztreonam) but sensitive to other antibiotic such as Gentamycin, Chloramphenicol and Ciprofloxacin kit. Qualitative and semi quantitative ASO determination was done using the ASO latex agglutination kit. 24%of patient was ASO positive and 67% was ASO negative The level of ASO in patients that tested positive for the presence of ASO ranged from 1600IU/ml to 25600IU/ml. 12 sample were the highest concentration of 25600IU/ml .The conclusion of this study found that Streptococcus pyogenes was most common causative agent for tonsillitis and the bacteria resist amoxicillin.Keywords: Tonsillitis, Amoxicillin, Streptococcus, ASO.
Caring Behavior Improvement Model on Nursing Students at Poltekkes Kemenkes Pangkalpinang Nurhayati Nurhayati
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

This study aims to establish models and measures of caring behavior in nursing students at the Poltekkes Kemenkes Pangkalpinang. The research method used is a quantitative method with survey techniques in phase I, and experiments by making a book as an experimental tool with the design of the One Group Pre-test Post-test for stage II. Furthermore, the data analyzed by qualitative methods in stage III. The sample consisted of 69 students; as a combination of first-year and second-year students. This study revealed that the Compassion variable influenced the formation of Competence, whereas the Conscience and Commitment variables did not affect the formation of Competency. Meanwhile, overall, the variable Compassion, Conscience, Commitment, and Competence influence the formation of Caring Behavior. Keywords: Behavior, Caring, Nursing, Students
Influence of roller compaction parameters on properties of granules and quality characteristics of finished product Olga Oleksandrivna Yuryeva; Yuriy Victorovich Naida; Oksana Volodimirivna Tryhubchak; Svitlana Nicolaivna Gureyeva; Yuliya Anatoliivna Kondratova; Andrew Mihaylovych Goy
Journal of Global Pharma Technology .
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Abstract

Roller compaction widely used in pharmaceutical industry as alternative to wet granulation. This technology acknowledged as more cost-effective and productive, improves granules properties, which in turn will enhance tableting process.Objective. Powder mixtures for products with immediate release: Glucose monohydrate 75 g granulated powder, Sodium picosulfate 7.5 mg tablets and Amlodipine/Valsartan 5/160 mg coated tablets.Methods. In this research the analysis of influence roller compaction parameters on flowability, bulk density and particle size distribution of granules was performed. Tablets, compressed from these granules tested for analytical properties (assay, dissolution, impurities) and technological properties (disintegration, friability, hardness).Results. For Glucose monohydrate 75 g optimum compaction parameters are primed: hydraulic pressure 50 bar and 1,25 mm screen size, with roller speed 11,5 rpm and roller gap 2,0 mm. The research of Sodium picosulfate 7.5 mg allowed determining the optimum compaction parameters: 50 bar hydraulic pressure, 0,8 mm screen size, 2.5 mm roller gap, roller speed 11 rpm, mill speed 80 rpm. For Amlodipine/Valsartan 5/160 mg optimal values of properties are indicated by regression analyses.Conclusion. As the result, influence of roller compaction parameters on quality characteristics of finished product and perspective of this technology for solid dosage forms manufacturing confirmed.
Apoptotic Index of Amniotic Membrane Cells in Preterm Labor with Premature Rupture of Membrane (PPROM) was Higher than Preterm Labor without Premature Rupture of Membrane Giri Chandra
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Introduction: Premature rupture of the membrane in preterm pregnancy is a condition that can cause increased maternal and perinatal morbidity and mortality. The study aims to compare the apoptotic index of amniotic membrane cells in preterm labor with premature rupture of membrane (PPROM) and without premature rupture of membrane. Method: This is a cross sectional study conducted at the Department of Obstetrics and Gynecology, Sanglah Hospital Bali. The Amniotic membranes were taken from the placenta after delivery then apoptotic index was measured by TUNEL examination. Result: The study included each 20 women from both groups. There was no significant difference of maternal age, gestational age, and BMI between groups (p>0,05). Chi-square analysis showed there was an association between the apoptotic index and preterm labor with PROM (p = 0.001). Subsequent analysis resulted in prevalence ratio of 19.0 (95% CI = 2.81 - 128.6). Conclusion: This study concluded that the apoptotic index of amniotic membrane cells in PPROM was higher than preterm labor without premature rupture of membrane. Keywords: Apoptotic index, Preterm Premature Rupture of Membrane, PPROM.
The Correlation between the Performance of Some Basic Skills and the Level of Cognitive Achievement of handball Players Hossam Ghaleb Abdulhussein
Journal of Global Pharma Technology .
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Abstract

The importance of research in the analysis of the level of cognitive achievement and its relation to the skillful performance of handball game to improve the level of the game and thus benefit the acquisition of knowledge and theoretical information related to the game plans, which is generated through the explanation and theoretical discussions of the positions of the athlete during the application of skill or sports competition.The research aims atDesign a form for the collection of knowledge with indicators (law, Shoot, plans) for players who advance handball.Build a test for the scientific knowledge collection of players who advance handballTo identify the relationship between the achievement of knowledge of the players and the performance of some basic skills handball.The hypotheses of the research were:There are differences of statistical significance in scientific knowledge and the performance of some basic skills of handball.There is a significant relationship between the level of cognitive achievement and the performance of some basic skills of handball.The research areas were:Human Field: Al Qasim Club players in the Premier League handball.Time domain: from 12/1/2017 until 14/3/2017.Spatial space: the forum of youth of the denominator.The conclusions wereThere is a significant correlation between the cognitive achievement of the three axes and the following skills (handling, correction of jumping, defense moves, and wall of resistance).Keywords: Performance, Basic skills and cognitive achievement.
Several Parameters Influencing Wine Production from Mangrove Apple (Sonneratia ovata) Fruit Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

The ripe mangrove apple is a potential source of natural antioxidants owing to its significant antioxidant activities. Phytochemical analysis of fruit extract revealed the presence of carbohydrate, protein, flavonoid and phenolic compounds. It can enhance the capability of antioxidant human body and therefore reduce the risk of chronic diseases. It is sweet in taste and usually consumed fresh or made into juice. There is limited study mentioning to processing of this functional fruit. Therefore we explored a wine fermentation from mangrove apple (Sonneratia ovata) fruit by focusing on the effect of different variables such as sugar supplementation, innoculum size, fermentation temperature in the primary fermentation, and fermentation time and temperature in the maturation to mangrove apple (Sonneratia ovata) wine quality (%v/v alcohol; g/l titratable acidity; oBrix residual sugar; sensory score). Our results proved that the primary fermentation should be conducted with 12% sugar ratio, 0.25% Sacchromyces cerevisiae inoculum at temperature 30.0oC in 15 days. The maturation was adequate in 10.0oC for 3 weeks to get a pleasant flavor and aroma. Mangrove apple (Sonneratia ovata) wine also evaluated the antioxidant capacity and total phenolic content. Mangrove apple (Sonneratia ovata) wine could be considered as a healthy source of antioxidants and phenolics ideal for daily consumption.Keywords: Mangrove apple (Sonneratia ovata), Wine, fermentation, Sacchromyces cerevisiae, Antioxidant, Phenolic.
Investigating the Effect of Atorvastatin in Preventing Ventilator Associated Pneumonia among Patients with Cerebral Ischemia Hospitalized in ICU in Imam Khomeini Hospital in Urmia City Mohammad Reza Amiri-Nikpour
Journal of Global Pharma Technology .
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Abstract

Introduction:  ventilator associated pneumonia is one of the main reasons of death in patients under ventilator, especially those with impaired consciousness hospitalized in intensive care unit (ICU). Having anti-apoptotic, antioxidant, and immunomodulatory effects, atorvastatin can be effective in preventing pneumonia in patients with stroke who are under ventilator, while it is also prescribed to reduce cholesterol and accelerate recovery process in ischemia cases. The present study aims at investigating the preventive effects of atorvastatin on ventilator associated pneumonia among patients who suffer from stroke and are under the ventilator. Methodologies in the present study, 60 patients hospitalized in ICU unit under ventilator following an ischemic attack were divided to two groups of 30. The treatment group received a daily 40-mg dose of atorvastatin, while the control group didn’t. Then the occurrence of pneumonia was extracted for both groups during at least 14days of hospitalization, and the results were analyzed using SPSS20 software. Results the results of the study indicated that the amount of occurrence of pneumonia among patients treated by 40 mg atorvastatin was significantly lower than the patients in control group. Therefore prescribing daily 40 mg atorvastatin for the patients with ischemia in ICU unit who are incubated and are under mechanical ventilation would reduce ventilator associated pneumonia significantly. Conclusion atorvastatin has a significant reducing effect on occurrence of ventilator associated pneumonia in patients suffering from ischemic stroke in ICU unit, who are incubated and under mechanical ventilation, which will be proved clinically in the present study. Keywords: ventilator associated pneumonia, Cerebral ischemia, Atorvastatin. 
Evaluate the Effectiveness of Oral Dosage with Probiotic Bacteria Lactobacillus rhamnosus GG, Lactobacillus Planetarium and Lactobacillus reuteri on Some Immune Indicators in Rabbits Rahem E. Alziadi
Journal of Global Pharma Technology .
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Abstract

This study was designed to evaluate some immune Indicators for rabbits oral dosage with three types of probiotics bacteria culture Lactobacillus rhamnosus GG, Lactobacillus planetarium and Lactobacillus reuteri. Rabbits were divided into four treatments, each subjected as the followings: treatment A, used as a negative control. treatment B,  sub divided into four groups: group1 used as a positive control  and other three groups were oral dosage with 1.0 µl\100gm weight\day with Lactobacillus rhamnosus GG, Lactobacillus planetarium  and Lactobacillus reuteri . Treatments C and D, the dose used was 200and 300µl\100gm weight\day from same. The results showed increasing in white blood cells (WBCs), red blood cells (RBCs) and hemoglobin (HB) and other parameters like immune origins weight (liver and spline) according to type of oral dosage bacteria and amount of dose, the dosage with Lb. rhamnosus GG bacteria was the beast compared with Lactobacillus planetarium  which were better than Lactobacillus reuteri dosage  and control. The study showed that dosage with 300µl\100gm weight\day was best comparing with other treatments and control respectively.Keywords: Oral dosage, Probiotics bacteria, Probiotics dose, Immune Indicators.

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