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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Evaluation of the Effect of Preoperative Oral Tizanid in on the Rate of Anesthetic Consumption & Hemodynamic Changes in Tiva (Total Intravenous Anesthesia) Shahryar Sane
Journal of Global Pharma Technology .
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Abstract

Objective: Materials and Methods: A double-blind clinical trial has been performed on 50 candidates for elective laparoscopic colecystectomy undergoing general anesthesia in Educational Hospital of Imam Khomeiny uromieh, Iran. 25 randomly selected patients (the case group) were given 4 mg of oral Tizanidine 90 minutes before the induction of anesthesia whereas the remaining subjects (the control group) were given placebo. Bispectral index “BIS” level before induction and after Tizanid in premedication, Induction time(Time of bispectral index “BIS” to reach 60), Mean arterial pressure and heart rate before and after induction of anesthesia, and after intubation and 10 min after peritoneal gas insufflations and   in intraoperative period and after extubation, ,and the needed Propofol & Remifentanyl  dosage were measured and recorded. Data analysis was done with T-test and Chi-squared test, using SPSS software version 19.Results: BIS level before induction and after tizanidin premedication was 91.04±1.13 & 94.56±1.82 in control and case group respectively (p valu<0.01). Induction time was 56.9±5.35 and 80.2±2.9 seconds in control and case group respectively (p valu<0.009). Average propofol & remifentanyl needed dose for anesthesia maintenance in case group was 28.95% & 33.3% less than the needed amount in the control group respectively. There is no difference in mean arterial pressure and heart rate before and after induction of anesthesia between the two groups. Variations of mean arterial pressure and heart rate after intubation and 10 min after peritoneal gas insufflations and   in intraoperative period and after extubation, were less in Tizanidine group generally. Conclusions: Using oral Tizanidine as a premedication decreased BIS level & diminished induction time of anesthesia decreased required Propofol and remifentanyl & yielded stability in mean arterial pressure and heart rate during surgery. Considering its short duration of action, Tizanidine use as a premedication is recommended for sedation and stabilization of hemodynamic responses during the operations.Keywords: Tizanidine, Hemodynamic, Propofol, Remifentanyl, BIS,  Premedication.
Analysis of Magnetic Resonance Image Segmentation Using Spatial Fuzzy Clustering Algorithm E. Udayakumar
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

The paper presents the MRI brain diagnosis support system for structure segmentation and its analysis using spatial fuzzy clustering algorithm. The method is proposed to segment normal tissues such as White Matter, Gray Matter, Cerebrospinal Fluid and abnormal tissue like tumor part from MR images automatically. The most of MR image are corrupted by artifacts which lead to affect the image processing for analysis of brain images. Due to this type of artifacts and noises, sometimes one type of normal tissue in MRI may be misclassified as other type of normal tissue and it leads to error during diagnosis.The proposed method consists of pre-processing using wrapping based curvelet transform to remove noise and modified spatial fuzzy C Means segments normal tissues by considering spatial information because neighboring pixels are highly correlated and also construct initial membership matrix randomly. The system also uses to segment the tumor cells along with this morphological filtering will be used to remove background noises for smoothening of region. The paper results will be presented as segmented tissues with parameter evaluation to show algorithm efficiency.   Keywords: SFCM, NN, GLCM, DWT, MRI, CT.
Role of Chloride on Corrosion of Carbon Steel Reinforcing Bar in Simulate Concrete Electrolyte Abdulkareem M.A. Al-Sammarraie
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

It is well known that chloride ion plays an important role in the destruction of various kinds of concrete structures such as bridges of buildings and reservoirs because of the corrosion of carbon steel reinforcement bar, causing huge human and material damages. In this study, the effect of saline conditions on carbon steel reinforcement was investigated artificial concrete solution in a range of sodium chloride concentrations from 0.5 to 4.5% and at temperatures of 20°C to 50°C. Three electrodes potentiostat was used to measure the corrosion rate and the probability of pitting corrosion through Tafel and cyclic polarization plots respectively. The measurements were supported using other techniques; atomic force microscopy and optical light microscopy. The results showed an increase in corrosion rates of the carbon steel reinforcing bar at all chloride ion concentrations, and increased with increasing the concentration and the temperature, all chloride concentrations showed susceptibility to pitting corrosion and highly depend on NaCl continents.Keyword: Reinforcing bar, Pitting, Artificial concrete solution.
Antibacterial Effect of Diode Laser and Silver Nanoparticles against Biofilm Bacteria Thamer Mutlag Jasim
Journal of Global Pharma Technology .
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Abstract

The present study has been undertaken to illustrate the antibacterial effect of diode laser and nanoparticle on isolated resistant biofilm bacteria. From the patient with urinary tract infection (UTI).Atotal of 90(56%) urine samples from patients with urinary tract infection (UTI) from Al Yarmuk hospital in Baghdad showed growth on culture. Proteus mirabilis was the most common pathogen accounting for 21(37.5), Staph aureus 20 (35.7), Klebsiella pneumonia 15(26.78). The biofilm bacteria exposed to diode laser after   focal with alens of (15) cm after focal point for different time 0.5, 1, 1.5, 2, 2.5, 3 min. The synthesized nanoparticle was characterized by UV-spectroscopy. The antibacterial activity of synthesized silver nanoparticle was compared by agar well diffusion method. The effect of minimum inhibitory concentration (MIC) and sub (MIC) concentration of Ag NPs were determined by microtiter plate assay. The antibacterial effect of Ag NPs and diode laser has already been studied, Ag NPs, Laser group within our results, we found that that Ag NPs with lasers present low values in comparison With Ag NPs alone. The MIC value were higher these difference could due to divergence found in the cellular wall of each kind of bacteria. The synthesized silver nanoparticle and diode laser have shown good antibacterial efficacy as compared to laser alone and may prove to be better antibacterial agent against biofilm bacteria. The result showed the biofilm bacteria completely killed after exposure to diode laser for 3min with nanoparticles. In this study, synthesized Ag NPs have the efficient antibacterial activity against biofilm bacteria.  Ag NPs have an important function in the field of nanotechnology. The results of this work revealed the potential of the synthesized Ag NPs as safer bactericidal agent against biofilm bacteria. The laser light enhances the antibacterial activity of silver nanoparticles by at least one fold. It conclude that the Ag Nps combined with laser exposure be used as local effective antibacterial approach   inhibit the bacteria isolated from Urinary tract infection. The result stated that Ag NPs synthesized were nontoxic and good antibacterial agent against biofilm bacteria. These result that Ag NPS could be used as an adjuvant for the treatment of UTI infection disease.Keywords: Biofilm, Diode laser, Nanoparticle, antibacterial.
Evaluation of Some Purine Metabolism Enzymes in Iraqi type 1 Diabetic Patients Wisam M. Mohammed
Journal of Global Pharma Technology .
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Abstract

Type 1 diabetes mellitus (T1DM) is the result of the destruction of the insulin-secreting β-cells of the pancreas by a process in which T-cells play a central role. This study was conducted on 60 T1DM patients from both sexes that were randomly selected from those attending the National Diabetes Center for Treatment and Research at Al-Mustansiriya University/Baghdad between August 2016 to December 2016. For comparison, 24 apparently healthy controls were selected for the control group. Moreover, the study was conducted to evaluate serum adenosine deaminase (ADA) and 5-nucleutidase (5-NT); furthermore, xanthine oxidase (XO) enzymes were quantitatively determined manually in T1DM patients and the control group. Fasting serum glucose (FSG), serum uric acid, urea, and total protein were determined, as well as other anthropometric measurements, such as body mass index (BMI);waist to hip ratio (W/H) and thoracic to hip ratio (T/H).The diabetic patients had significantly higher levels of ADA and 5-NT enzymes (p<0.000) compared with those of control group. No significant difference (p<0.463) was observed in the serum XO enzyme between the patients and the healthy control group. Further, the level of UA was significantly lower (p<0.000) in the patients compared with that of the healthy control group. This study suggests a significant role for ADA and 5-NT enzymes and a non-significant role for XO enzyme, which, therefore, cannot be used for predicting the progression of T1DM in the early stages.Keywords: Diabetes mellitus, Type 1 diabetes mellitus, Adenosinedeaminase enzyme, 5-Nucleutidase enzyme, Xanthineoxidase enzyme.
The Degree of Agreement between Manual and Digital Histological Evaluation of Immunohistochemical Expression of Estrogen and Progesterone Receptors in Breast Carcinoma Hameda Abd-Al Mahdi Ghazi Ghazi
Journal of Global Pharma Technology .
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Abstract

Background Malignant neoplasm involving the breast is by far one of the most frequent cancers that affect mankind. Globally, it is estimated that breast cancer accounts for about 25% of all cancers affecting women. Carcinoma of the breast is heterogeneous; however, they all share the common origin from the terminal duct lobular unit. They are generally classified into ducal and lobular. The three gold standard immunohistochemical makers, nowadays, are progesterone and estrogen receptors (PR and ER) and her2neu. Other markers like p53 and bcle2 expression are also important. The study of PR and ER receptors permits the decision of adding and adjunct mode of treatment, hormonal treatment. Aim of the study the objective of this study was to assess automated digital study of immunohistochemical markers as a substitute for the original manual method. Materials and methods: The present study included 35paraffin embedded, formalin fixed histological blocks of breast carcinoma. The duration of the study extended from January 2017 to June 2017 and was conducted in the teaching laboratories of College of Medicine, Al-Qadissiyah Univerist, Al-Diwaniayah province, Iraq. The paraffin blocks were retrieved from the teaching laboratories of Al-Diwaniyah teaching hospital, Al-Diwaniayah province, Iraq. Results: Following conversion into positive and negative cases, matching was assessed using kappa agreement statistic and the results were as following: number of positive ER cases were 14 and 16 according to manual and digital scoring, respectively; whereas the number of positive PR cases were 15 and 17 according to manual and digital scoring, respectively, as shown in table 3 and 4. The degree of agreement between manual and digital scoring was 0.87, considered good, in both ER and PR expression status. Conclusion Digital scoring appears to be faster than and as accurate as manual scoring; however it needs to be correlated with clinical prognosis of breast carcinoma.
Nutritional Status in Breast and Cervical Cancer Survivors: Differences in Each Stage of Survivorship Ni Putu Wulan Purnama Sari
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Objective: Nutrition is one important physical aspect supporting the achievement of optimum quality of life (QOL) in cancer survivors. This study aimed to 1) compare and analyze the differences in nutritional status between breast and cervical cancer survivors (BCS and CCS) generally, and between stages of survivorship specifically in both cases, and 2) determine the best predictor of nutritional status in both cases.  Method: This cross-sectional study involved 58 BCS and 47 CCS (n=105). The questionnaire of PG-SGA was used in data collection. Various statistical tests were used in data analysis (α<0.05). Result: Nutritional status was not significantly different between BCS and CCS (p=0.116), but significant differences found in activities and function between cases (p=0.040). In BCS, nutritional status was not significantly different between survivorship stages (p=0.068), which indicates that this aspect is stable/stagnant across the survival life span in this case. While in CCS, nutritional status was also not significantly different between survivorship stages (p=0.382), but the intake and physical exam were significantly different in this case (p=0.040 and p=0.008, respectively) which indicate that these two aspects change over time along with the survivorship stages in CCS. Body Mass Index (BMI) is the best predictor of nutritional status in BCS, which were accounted for 15.9% variance of nutritional status (R2=0.159); while weight loss is the best predictor of nutritional status in CCS, which were accounted for 49.6% variance of nutritional status (R2=0.496). Discussion: More significant predictors of nutritional status were found in CCS compared to BCS.Keywords: Breast cancer, Cancer survivors, Cervical cancer, Nutrition, Nutritional status.
Ecosystem Modeling with External Data Spatial Temporal in Iraqi Marshland Estabraq Mohammed Ati
Journal of Global Pharma Technology .
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The impacts of human activities and climate change on Iraqi marshes ecosystems that are challenged limitations of present-day ecosystem models, this research presented a part of a larger study to develop a new approach to ability interaction six main stations of the Missan governorate (Al- Auda Marsh, Al- Battat Marsh) between metals (Cu, Fe, Pb) by geographic information systems (GIS) technology into a flexible and modular software approach to illustrate capabilities of the new framework. Have been predictive abilities of the concentration elements between plants and soil model and applied this framework showed changes at the plants level due to changes in production species. The results in all stations under study showed low concentrations and varied mostly similarly limiting factors with natural boundaries, A little increase come from of some pollutants that are discharged from waste populated. The correlation showed significantly between these variables in the aquatic environment, It would be transmitted an ecological balance between plants and soil. This considered as a very important database for environmental risks and health in aquatic ecosystem of marsh which can be updated through a unified future other periodic data.Keywords: Iraqi Marshland, Environmental risk assessment, Model comparison.
In-Silico Screening of Ranggap Bananas (Musa troglodytarum L) Compound Components against Dipeptidyl Peptidase 4 Receptors as Therapeutic Targets for Type 2 Diabetes Anredera cordifolia Leaves Sub-fraction as Anti-Hyperlipidemia Resmi Mustarichie
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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This study aimed to evaluate the anti-hyperlipidemic properties of the sub-fraction of the Binahong (Madeira vine, Anredera cordifolia) extract in male Wistar rats. The rats were given high-fat food every day for 3 months and pure cholesterol on weeks 0, 3, 7, and 11. Furthermore, Ethyl acetate sub-fraction of binahong leaves with 0, 12 mg/kg BW, and 0, 24 mg/kg BW doses were given orally for 3 weeks and observed for lipid profile on day 21. The result showed that sub-fractions of Madeira vine leaves decreased in triglyceride, cholesterol, and low-density lipoprotein (LDL) levels and did not influence the high-density lipoprotein level (HDL). Meanwhile, statin decreased total triglyceride, cholesterol, and the LDL level, and increased the HDL level. It concluded that Madeira vine sub-fraction with 0, 24 mg/kg BW dose presented improved results in the lipoprotein profile. Keywords: Binahong, Madeira vine, Anredera cordifolia, Hyperlipidemia, Ethyl acetate fraction.
The Effect of Seed Priming with Salicylic Acid and Ascorbic Acid on Viability of Local Okra (Abelmoschus Esculentus L.) Seeds Stored for Three Years Hussein J. Hussein
Journal of Global Pharma Technology .
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The present study was conducted to knowledge the effect of seed priming techniques on seeds viability characteristics of okra seeds, an experiment were conducted at the seeds obtained directly from the okra field of Babil governorate during the season of (2012) and stored until 2015. Seeds were treated for 6 hours at 30 Cº with priming media (50mg/L of ascorbic acid, 100mg/L of salicylic acid, hydro-priming and untreated seeds as control).Maximum seed germination percentage, germination index (GI), seedling vigour index (SVI), root length, shoot length, seedling length, seedling fresh and dry weights were observed when the seeds treated with (100 mg/L of salicylic acid and 50 mg/L of ascorbic acid) compared with control.Keywords: Seed priming, Ascorbic Acid, Salicylic acid, Okra seeds.

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