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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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The Effects of Using a Geometric Shaped Sponge on the Physiological Motion and Kinematics Variables to Perform the Front-Hand Somersault Skill Mohammed Jasim Mohammed Al-Khalidi
Journal of Global Pharma Technology .
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Abstract

The study included a number of axes that concentrated on using the sponges in the learning process as supportive means towards learning this particular skill which is considered rather difficult. A certain type of sponges where used to learn each stage of this skill. These types were different in shape and size, considering the height and potential of the individual sample, in order to help the learners master this skill in the best way possible. The learning group was given a 4-weeks course to learn the front-hand somersault using these supportive techniques, two credits a week. After 4 weeks, the result of each group was collected and compared (The original and the experimental group). The statistical results showed that the experimental surpassed the original one.Keywords: Sponge Pieces, Physiological Motion, Kinematics Variables, Performance Learning.
Association between Hypothyroidism and Herpes Simplex Virus with Interleukin-23 Sahar H. Al-Hindawi
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Background: Hashimoto’s thyroiditis and Hypothyroidism play a distinct role in the suppression and reactivation of herpes viruses. Herpes simplex virus infections have been assumed as one of the factors that may trigger autoimmune thyroid diseases; however, IL-23 has an important role in the pathogenesis of several inflammatory and autoimmune conditions. Objective: This study aimed to investigate the association between thyroid hormones in hypothyroid state and the Herpes simplex virus status in such patients; besides detecting the role of IL-23 in these cases. Materials and Methods: The present study included 65 Iraqi female hypothyroid patients with age ranged between 26-54 years and 25 healthy controls with age ranged between 25-50 years. Serum samples were collected from the study groups. Levels of thyroid hormones (TSH, T4, and T3) were determined by using automated Chemiluminescence Immunoassay (CLIA) analysis system. The detection of herpes simplex virus IgG and IL-23 levels in the serum samples were determined by an enzyme linked immunosorbent assay (ELISA) kits. Results: The current study results revealed that serum IL-23 and HSV levels are increased significantly (P<0.001) in the hypothyroid patients group as compared with control. There was a significant positive correlation between TSH and (IL-23, HSV); also between IL-23 and HSV (P<0.01). Moreover, there was a significant negative correlations (P<0.01) between IL-23 with (T4, T3) and between HSV with (T4, T3).  Conclusion: The present study pointed to the association between thyroid hormones deficiency in Hashimoto thyroiditis cases and IL-23 levels through disruption of the patient’s immune system; and with Herpes simplex viruse-1by their role in the replication.Keywords: Hashimoto Thyroiditis, Hypothyroidism, Herpes Simplex Virus, IL-23.
Herbal Drugs, Diet and Lifestyle Changes for Liver Diseases- A Review S. Sivakrishnan
Journal of Global Pharma Technology Volume 11 Issue 03 (2019) March. 2019
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Abstract

The liver is an important part of human digestive system. The organ’s function include food metabolism, energy storage, waste removal, detoxicification, immune system support and production of chemicals. There are several things damage the liver such as toxic substances, viruses, medications, genetic diseases and alcohol. Some of the herbal drugs and its extracts showed a good potentials for use in liver diseases.  Therefore, the present work constitutes a review of the literature on plant extracts and chemically defined molecules of natural origin with hepatoprotective activity. In addition diet and lifestyle changes can help to improve the conditions of hepatotoxicity. 
Mesoporous Silica and Zno@Sio2 as Adsorbents for Crystal Violet Dye Removal from Aqueous Solutions Sameer H. Kareem
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Sol-gel method was used to prepare two samples of mesoporous Silica (mSiO2) and zinc oxide- mesoporous silica (ZnO@mSiO2) in the presence of HydroxycetylHydroxy ethyl Diamonium Chloride (dehyquart) surfactant as template. The two adsorbents prepared were characterized by nitrogen adsorption-desorption, XRD and AFM techniques. The results show that the mSiO2 sample has a mesopores in the range 2- 8 nm with a high degree of ordering of the porous structure, while Zn@SiO2 sample has pore distribution in the range 2-50 nm. The adsorption ability of the two adsorbents to removal of Crystal Violet (CV) dye from aqueous systems has been studied using a batch experiments method to measure the adsorption as a function of contact time and adsorbent dose at the temperature 293 K. Adsorption isotherms were fitted with the Langmuir, Freundlich, Temkin, and Dubinin-Radushkevich models and the results show a best fitted for the two adsorbents, and the adsorption processes were physical adsorption type. The kinetic data were analyzed and found to match well with pseudo-second order kinetic model.Keywords: Mesoporous silica, Crystal Violet, Zn@SiO2, Adsorption isotherm.
Laboratory Evaluation of Supernemic Insecticide (Neem Oil) and its Effect on Larvae of Big Headed myiasis Blow Fly Chrysomya Megacephala (Fibricius, 1794) (Diptera: Calliphoridae) Nawal Sadiq Mehdi
Journal of Global Pharma Technology .
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Abstract

This study was carried out to evaluate the efficiency of Supernemic in the control of larvae of big headed myiasis fly Chrysomya megacephala by direct spraying and food treatment, the results of direct spraying of the second instar larvae with concentrations 0.3, 0.6 and 1ml.l-1 led to cumulative mortality reached 25, 37 and 59% respectively, with a decrease in the emergence number of adults insects to 75, 36 and 41%, respectively, as well as 76% of the adults which produced from larvae were treated with 1 ml.l-l of supernemic died after 24 hours, some of malformation in the dead larvae was noted such as blackening the whole body of the larva or appearance of black spots on it. The treatment of larval food with same concentrations showed a cumulative mortality reached 27, 64 and 65%, respectively, and the adults emergence percentage were 67, 36 and 35 respectively, we conclude that the larvae of this fly were sensitive to the insecticide, as well as food treatment was more efficient in controlling of this fly compared to the direct spraying treatment.Keywords: Neem oil, Myiasis, Chrysomya megacephala.
Synthesis, Characterization and Biological Activity of New Derivatives of Hetrocyclic Compound Athraa B. Mohamad
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

This study included the preparation and characterization of a series of new derivatives of  pyrazoline, isoxazoline by two steps the first step involved the preparation of chalcones by reaction between aldehyde and acetophenone the second step involved the react of chalcones two stepe react chalcones with hydrazine to form pyrazoline also chalcones was reacted with hydroxylamine hydrochloride in present a basic medium for the preparation of the derivative isoxazoline The derivatives has shown moderate to good activity against gram-positive bacteria (Staphylococcus aureus), gram-negative bacteria (Escherichia coli)  when compared with standard antibiotic gentamycin .all prepared compounds were diagnosed by spectra of H1-NMR, mass.Keywords: Isoxazolin, Pyrazoline, Chalcones, Synthesis, Biological activities. ­­­­­­
Histological Description of Hedgehog (Hemiechinus auritus) Abdomen Skin Al-Zubaidi KA
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

The present study was conducted on six healthy male’s hedgehog, to distinguish the normal histology of the abdomen skin. The hedgehogs were anesthetized by ketamine (15 mg/kg. body weight) injected intramuscular after scarfing of hedgehogs, the skinning of the ventral surface of the abdomen was carried out, then the skin specimens fixed in the formalin (10%). Routein histological processes were done. The histological structure of the hedgehog abdomen skin was revealed many invaginations of the skin folds projected from superficial surface; these folds had many bifurcation were divided by grooves, and the folds appeared as the ridges. The abdomen skins of hedgehog covered by keratinized squamous epithelium, the keratin layer consider as protective layer foe the superficial skin which represented the epidermis. Under lining the epithelium there was loose connective tissue that supported the superficial skin; and consisted of collagenous and elastic fibers as well as cellular elements such as fibroblasts, lymphocytes, myoid cells were distributed among collagen and elastic fibers which extended into the cores of the abdomen skin folds. Beneath the loose connective tissue, the dermal spines follicles were found and surrounded via a layer of smooth muscle fibers. Clusters of sweat glands were distributed deeply under the dermal spines follicles. Striated muscle fibers below the sweat glands. The striated muscle fibers were arranged; circular, longitudinal and oblique in the orientation, these muscle fibers which support the upper layer of the skin. The dermal papillae was absent in the hedgehog skin. Keywords: (hedgehog, Histology, Abdomen skin).  
Synthesis and Characterization of Novel Nematic Liquid Crystal Compound Mohammed Obaid Hasan
Journal of Global Pharma Technology .
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Abstract

A series of  N1-(4'-((4-(alkyloxy)benzylidene)amino)-[1,1'-biphenyl]-4-yl)-N4-(4'-((Z)-(4-(alkyloxy)benzylidene)amino)-[1,1'-biphenyl]-4-yl)terephthalamides were synthesized by thermal condensation reaction of N1,N4-bis(4'-amino-[1,1'-biphenyl]-4-yl) terephthalamide with 4-(alkoxy) benzaldehydes in absolute ethanol at reflux condition. The structure of the synthesized compounds were elucidated by FT-IR spectral data and determining the M.Ps, and element content (C.H.N %). Their liquid crystal properties were studied by measuring the values of the phase transition temperatures by differential scanning calorimetry (DSC) and the texture of mesophases by using optical polarizing microscopy (POM).The target compounds showed significant liquid crystal properties.Keywords: Nematic liquid Crystal, benzylidenaminoterephthalamides.
Dental Caries and the Early Diagnosis using Low Level Laser Mahdi Ali Sukkar Al-Farawn
Journal of Global Pharma Technology .
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Abstract

The current comparative investigational work was performed to identify the reliability of the occlusal-caries-based (OC) detection using the laser fluorescence device (DD) and the traditional methods of visual-based inspection, probing-dependent detection, and periapical dental radiographs. Moreover, fissure sealant (FS) and fluoride-based topical application (FTA) was evaluated using the DD technique. Here, 60 patient molar teeth were selected for the current work from a school primary oral care center, Al-Najaf City during the years of 2016-2017. Those teeth were randomly divided based on the diagnostic tool used into VI, probing, dental x-ray, and DD (VPXD group, 40 teeth (females (n)= males (n) 6-7 years old) diagnosed as a positive sing or a negative sing for intact caries or an intact tooth respectively), FS application followed up with DD (FSD group, 10 teeth diagnosed before and after the application), and FTA followed up with DD (FTAD group, 10 teeth diagnosed before and after the application). The teeth were polished and then assigned to their diagnostic methods. The current work results identified that the DD was more reliable in detecting caries and evaluating FS and FTA than those in dental probe, VI, X-Ray. In conclusion, DD ensures a viable method for detecting protection of FS and fluoride application methods against caries.Keywords: DIAGNO dent, Fissure sealant, Fluoride, laser.
Synthesis, Characterization of 2-azido-4-(azido (2-azido-2-( azido carbonyl)-1,3-dioxoian-4-yl)methyl)– 5-((R-azido (hydroxyl) methyl-1,3-dioxole-2-carbonyl azide. ethanol. hydrate (L-AZD) with Some Metal Complexes Ala H. Hassn
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

The reaction of (L- AsCl2) : Bis [O,O – 2,3, O,O – 5,6 – (chloro(carboxylic)methylidene] – L-ascorbic acid with sodium azide in ethanol with drops of distilled water has been given a new product (L-AZD), was isolated and characterized by elemental analysis (C,H,N) , 1H-NMR, mass spectra and Fourier transform (Ft-IR). The reaction of the (L-AZD) with: [VO(II), Cr(III), Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II)], has been investigated and was isolated as tri nuclear cluster and characterized by: Ft-IR, U. v-Visible, electrical conductivity, magnetic susceptibilities at 25 Co, atomic absorption and molar ratio. Spectroscopic evidence showed that the binding of metal ions were through azide and carbonyl moieties resulting in a six- coordinating metal ions in [Cr (III), Mn (II), Co (II) and Ni (II)]. The Vo (II), Cu (II), Zn (II), Cd (II) and Hg (II) were coordinated through azide group only forming square pyramidal for VO (II), square planar geometry for Cu (II) and tetrahedral for Zn (II), Cd (II) and Hg (II), - for Ni (II), Cr (III) complexes were calculated, the ratio of (L-AZD) to metal ions was (3:1) confirmed by metal ratio and atomic absorption spectrophotometer, magnetic moment values at (298 K) of VO (II), Cr (III), Mn (II), Co (II), Ni (II) and Cu (II) are lower than the total spin-only indicate a dominate of anti-ferromagnetic coupling between them. Keywords: Synthesis, Tri nuclear cluster, Azide.

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