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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Anti-Dermatophytes Activity of Macroalgal Extracts (Chara vulgaris) Isolated from Baghdad City-Iraq Ahmed S. Dwaish
Journal of Global Pharma Technology .
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Abstract

In the present study, the metabolic andethanolic extracts of specie (Division: Chlorophyta)  Chara vulgaris was tested  for antifungal (Dermatophytes) activity for in vitro at concentration (100,50 and 25 mg/ml) against two clinical isolates of Dermatophytes fungi (Trichophyton rubrum and Trichophyton mentagrophytes) by measuring  percentage of inhibition growth. The results indicated that the hot ethanol extract of Chara vulgaris was more efficient(89.8 %) inhibition growth at concentration 100 mg/ml and the lowest effect was (20.4%) at concentration 25 mg/ml  against the tested pathogenic fungi.  Chemical analyses showed that the active chemical compounds for hot ethanolic and methanolic alga (Chara vulgaris )extracts  were contains alkaloids, phenols ,Terpenes , Steroids, Flavones, Resins ,Saponines and tannins. Finally the result of GC mass analysis for Chara vulgaris extracts proved the presence of many antimicrobial activity compounds.Keyword: Fresh water algae, Anti-Dermatophytes activity, Hot ethanolic and methanolic extracts, Baghdad City-Iraq.
Review on Cyclic Adenosine Monophosphate signaling pathway (cAMP), DLK Signaling Pathway, RAS/RAF Signaling, Retinoic Acid Signaling, Phosphatidylinositol 3-kinase (PI3K) as the Signaling Pathways Involved in Peripheral Neuronal Generation Ria Margiana
Journal of Global Pharma Technology Volume 11 Issue 01.
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Neuronal regeneration is the physiological process wear, after neuronal injury, the body stimulates mechanisms of self-healing. Thus, through coordinated different processes and signaling that involves diverse molecules in the body, the nerves are able to regain, to some extent, their initial capability to transduce and convey signals. After, neuronal injury, there is a defect in the normal signal transduction. This presents with different symptoms depending on the system in which the nerve belongs. This may be mortar or sensory. Injury to mortar neurons means the supply of the muscle innervated is cut off. This, therefore, implies that the muscle will not have enough power or will become spastic. It is in response to this injury, that the nerve, through some intricate intrinsic signaling pathways, is able to regenerate in order to return the normal physiologic functioning of the body. Methode of this paper is summed up with systemic reviews of articles in the same topic under study. The articles were searched using the Pubmed search engine and were all in English. None of the articles was translated. The inclusion and exclusion criteria was guided by PRISMA guide, as a predetermined outline. The result of this article is out of forty-three, eight articles were selected as eligible, this is because they met the PRISMA criteria and had adequate relevant and supporting experiments to back the signaling pathway under study.  These articles had a clear and elaborate outline of the whole signaling pathway, the associated molecules, the interconnections between the pathways, supporting experiments and even recommended research in the same field or topic. The comparison of the strengths of facts backing the individual pathways was used to determine the pathway that is most involved, or that can be presumes the “mother” signaling pathway in the process of neuronal regeneration.Keywords: Neuronal regeneration, Neuronal injury, Signaling pathway.
Synthesis, Characterization and Antifungal Activity of Some Indolo [2-3-b] Quinoxaline Derivatives Khitam Abdul Kareem Ismail
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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In this research the focus was to synthesis new series of indolo [2-3-b] quinoxaline through the reaction of Isatin with 4-methyl-o-phenylenediamine in the presence of water to obtain 2-methyl-6H-indolo [2-3-b] quinoxaline (A1). Compound (A2) was prepared by refluxing  of compound (A1)  with chloroacetyl chloride in the presence of triethylamine, compound (A2)  was treated with hydrazine hydrate to give 2-hydrazino-1-(2-methyl-indolo[2,3-b]quinoxalin-6-yl)-ethanone (A3), While the Schiffe bases (A4- A8) were synthesized by the condensation of compounds (A3)  with aromatic aldehydes. The prepared compounds identified by spectral methods [FTIR, 1H-NMR] and measurement some of its physical properties. Furthermore we were studied the effects of the preparing compounds on some strains of Antifungal activity.Keywords: Isatin, Indolo [2-3-b] quinoxaline, Antifungal Activity, Schiffe base. 
Assessment of Learning Efficiency in Iraqi Nursing Education Ahmed Sh. Alzuheri
Journal of Global Pharma Technology .
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Many nurses make up the health system. Therefore, their education has a significant impact on the health of society. One way to ensure their abilities is to provide effective education. Nursing is professional discipline. A professional is an individual who possesses the knowledge and skill of experts in a particular field acquired through formal education in higher education institutions and through experience, which uses that knowledge and skill on behalf of the community through specific customer service 11. Objective: To assess the nursing education colleges regarding nursing education process. Design: Descriptive design (cross-sectional) survey study design has conducted throughout the period of 1 September 2016, to July 20th 2017 in order to Assessment of learning efficiency in Iraqi nursing education. After getting the approval of the University of Babylon / College of Nursing Council for the study, the researcher has submitted a detailed description including the problem statement, questionnaire and objectives of the study to the Ministry of Planning (Central Statistical Organization), which was accepted the study instrument. Later, the permission is presented at all nursing colleges in Iraq. Results: The finding of the study indicate that there is a clear shortage in the number of faculty members of all academic rank, in relation to the number of existing colleges, and also this shortage exists in the number of faculty members for students, in most colleges.Keyword:  Learning efficiency, Nursing education, Iraqi.
Metformin Attenuates Cognitive Deficits in Experimentally Induced Alzheimer’s Disease Laxmianarayana Bairy Kurady
Journal of Global Pharma Technology .
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A study was undertaken to evaluate the effect of metformin on learning memory inexperimentally induced Alzheimer’s disease in Wistar rats. A total of 30 Wistar rats were divided in tofive groups of six rats each. Group 1 served as control. In Group 2,3 and 4 Alzheimer’s disease wasinduced by administering aluminum chloride (17 mg/kg) orally to the animals for a period of 4 weeksonce daily. Group 1and 2 received distilled water, group 3 received rivastigmine (0.3mg/kg) and group 4and five received metformin 100mg/kg. All the rats were subjected to passive avoidance test. At the endof the experiment the rats were sacrificed and brain acetylcholinesterase level was estimated.Administration of aluminium chloride resulted in poor learning and memory and this was significantlyreversed by rivastigmine and metformin. In conclusion, the memory impairment induced by aluminumchloride was revered significantly by both rivastigmine and metformin.Keywords: Alzheimer’s disease, Metformin, Rivastigmine, Passive avoidance test, Acetylcholinesterase.
Immunological Study and Molecular Detection of Listeriosis of Aborted Women in Al Muthanna Province Sarah Zegheer Hussein
Journal of Global Pharma Technology .
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Abstract

Abortion is considered as one of the important clinical problems that may affect pregnant women causing dangers to the mother and her fetus This study designated for immunological and molecular detection of Listeriosis in Al Muthanna province during pregnancy should be considered a significant risk factor for adverse pregnancy outcomes in human. This study was carried out in Children and delivery's Hospital at Al Muthanna Province during 26/11/ 2017  to 25/ 4/ 2018, 100 women who had single or repeated abortion were selected for this study, and they were referred with a physician report for TORCH tests to determine the final diagnosis of pregnancy loss. The 50 controls were healthy pregnant women with a history of a normal pregnancy. Blood, serum, swab, and placenta were collected for tests NBT, MTT, ELISA and RT-PCR). The test is done to estimate the phagocytic activity in abortive women, the results of (NBT) test showed a significant difference (P<0.001) in phagocytic activity (39.6%) in the blood abortive women compared with healthy individuals as controls. The MTT assay used for evaluating the lymphocyte transformation index of peripheral blood leukocytes in abortive women The results of MTT assay showed a significant difference (p<0.0001) in the lymphocyte transformation index (34%) in the lymphocytes of abortive women compared with controls. Indirect ELISA assay was IgG done to diagnosis human listeriosis as the causative agent of abortion. The results of an Indirect ELISA IgG was 10(10%) for L. monocytogenes. Real-Time Polymerase chain reaction results showed 7(7%) was positive L.monocytogenes that is done by using SYBR Green I dye and the diagnostic gene was hlyA L. monocytogenes.Keywords: Abortion, Listeriosis, ELISA, RT-PCR, and Al Muthanna province.
Design and Development of Losartan Potassium Press Coated Tablets for Pulsatile Drug Delivery S Ramkanth; Ashok Kumar Janakiraman; Saminathan Kayarohanam; Vetriselvan Subramaniyan; Sinouvassane Djearamane
Journal of Global Pharma Technology Volume 13 Issue 01 (2021) Jan. 2021
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Abstract

The objective of the present study was to design and evaluate time-dependent pulsatile delivery systems (PDDS) of losartan potassium pulsatile press coated tablets. Losartan potassium (LP) is angiotensin II (AG II) receptor antagonists to treat hypertension. LP pulsatile systems are time-controlled drug delivery systems which are designed to mimic the circadian rhythm of the body and deliver the drug at a specific time. LP core tablets were prepared by direct compression method using a single punch machine. The prepared tablets were shielded with a combination of different grades of Hydrosy propyl methyl cellulose (HPMC) and Ethyl cellulose (EC) as coated materials. Prepared core and pulsatile tablets were optimized and evaluated for various properties like diameter and thickness, uniformity of weight, hardness, friability, disintegration time, drug content and in vitro dissolution studies. The drug release profile LP pulsatile tablet batch of LH-3 designated as the optimized batch that shows the lag time 8 hrs with complete drug release of 99%. LP pulsatile tablets will be taken at bedtime, releasing the drug in the morning hrs when the symptoms are more prevalent can prove to be a revolution in the treatment of hypertension.
The Effectiveness of Cognitive-Behavioral Therapy (CBT) Based on Kesh's Eight-Step Model on Body Image and Self-Esteem among Married Women in Birjand Zahra Khayati
Journal of Global Pharma Technology .
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Background and objective: In recent decades, body image problems have been considered by clinical practitioners and some therapeutic methods have been designed for them. At present, a widespread attention is paid to cognitive-behavioral therapy, because this type of treatment provides clear and complete methods for intervention and measurements. The present study was done to investigate the effectiveness of cognitive-behavioral therapy based on Kesh's eight-step model on the body image and sexual self-esteem among married women in Birjand. Method: This was a semi-experimental study which was carried out on 30 married women referred to Omid Counseling Clinic in Birjand. The subjects were selected through convenience and voluntary sampling method and randomly assigned to experimental group (n=15) and control group (n=15). The experimental group received eight 90-minute sessions of training techniques of cognitive-behavioral therapy based on Kesh's eight-step model. The instruments to collect data were Multidimensional Body Self-Relations Questionnaire (MBSRQ) and Zeanah and Schwarz   Sexual Self-Esteem Inventory for Women (SSEI-W). To analyze data, multivariate analysis of covariance in the environment of SPSS software (ver. 21) was used. Findings: The results of covariance analysis showed that there was a significant difference between the mean scores of body image in experimental and control groups based on group membership in the post-test with 99% confidence (P<0.01), and the intervention effect was 0.49. Also, there was a significant difference between the mean scores of sexual self-esteem in experimental and control groups based on group membership in the post-test with 99% confidence (P<0.01), and the intervention effect was 0.38.ConclusionOverall, it can be said that the cognitive-behavioral therapy based on Kesh's model can be used as an appropriate intervention method to treat problems related to body image and sexual self-esteem.Keywords: Cognitive therapy based on Kesh's eight-step model, Body image, Sexual self-esteem.
Synthesis and Biological Evaluation of Oxazolone Derivatives G Mariappan; Dipankar Sarkar; Rashmi Karki; Lipika Pandey; Deepak Kumar
Journal of Global Pharma Technology Volume 02 Issue 10: (2010) Oct.2010
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A new series of oxazolone derivatives (OXZ1 to OXZ5) were synthesized. The structures of the synthesized compounds were assigned on the basis of UV, IR, 1 H NMR and Mass spectral data. The synthesized compounds were screened for analgesic and anti-inflammatory activities. Among the entire test compounds OXZ1, OXZ2 and OXZ4 showed promising analgesic activity as compared to std. pentazocine. In case of anti-inflammatory activity, all the compounds are active. But OXZ2 was found to be more active as compared to std. aspirin. From both activities, the compound OXZ2 shows significantly more analgesic and anti-inflammatory activity. All the experimental results were statistically significant at p<0.01 level.
The Effect of Special Exercises to Develop Some of the Variables and Basic Skills of the Young Basketball Hasan Saleh Mahdi Al-Okbi
Journal of Global Pharma Technology .
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The importance of research is reflected in the fact that it helps to detect the effect of aerobics and to know its efficacy with antioxidants that work to get rid of the free radicals causing fatigue to young basketball players. Researchers used the experimental approach to fit the nature of the problem on the players of the Sports Solidarity Club youth basketball season (2017-2018) (13), the comprehensive survey method was adopted in the selection of the sample and three players were identified for the purpose of conducting the exploratory experiment, reaching The final number of members of the main sample is (10) players. Through a gathering of data, most importantly, the exercises used, which were specialized exercises in the type of skill and complex exercises and skilled exercises for the speed of performance contributed to the development of some of the basic skills of basketball, for both the jump and high pituitary and chest handling and defensive movement, there was a direct impact of the effort in the proportions of salts in the body due to exposure to effort bodily led to fluid loss.Keywords: Physiological variables, Basic skills and basketball.

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