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All Journal Media Veteriner Global Medical and Health Communication Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Indonesian Andrology and Biomedical Journal Indonesian Health Journal Journal of Global Pharma Technology Folia Medica Indonesiana
Ria Margiana
Department Of Anatomy, Faculty Of Medicine, Universitas Indonesia, Jakarta, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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AH-01 Is There Macroscopic Different Appearance in Using Formalin with Low and High Concentration in Technic of Cadaver Embalming? Ria Margiana
Media Veteriner Proceedings of The 5th Congress of Asian Association of Veterinary Anatomists (Asian AVA) 2015
Publisher : Media Veteriner

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Abstract

Is There Macroscopic Different Appearance in Using Formalin with Low and High Concentration in Technic of Cadaver Embalming?
ANATOMY VISUAL LEARNING: A NEW MODALITY TO ENHANCE NEUROANATOMY LEARNING IN FIRST-YEAR MEDICAL STUDENTS Sasanthy Kusumaningtyas; Mochamad Iskandarsyah Agung Ramadhan; Ria Margiana; Elvan Wiyarta; Reynardi Sutanto; Isabella Kurnia Liem
Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Vol 10, No 1 (2021): Maret
Publisher : Asosiasi Institusi Pendidikan Kedokteran Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpki.53276

Abstract

Background: In gaining knowledge and comprehension of neuroanatomy, medical students require not only memorizing the anatomical structures but also understanding the spatial relationships. Along with the cadaver prosection usage, we proposed an anatomy visualization learning (AVL) as possible modality to fulfill this need, yet this has to be proven. This study aimed to know whether AVL can improve student knowledge in neuroanatomy and give a positive perception to the student. Methods: A quantitative and qualitative studies were performed to the first-year medical students (n=46) of Faculty of Medicine Universitas Indonesia who were randomly divided into two groups, an interventional (n=23) and a control (n=23) group. Both groups enrolled in the neuroanatomy learning module, with additional two sessions (two hours/session) of AVL using 3D anatomy visualization table for the intervention group. Quantitative study to know the knowledge improvement was done by comparing the pre-test, post-test and gain scores between groups. Student’s perception of the learning method was done using a questionnaire on a Likert scale. Qualitative study was done using open questions. Results: The median value of the pre-test score (8 [0-30] vs. 4 [0-42]; p=0.869) and the post-test scores (44 [30-82] vs. 40 [8-84]; p=0.068) between the interventional vs control group were not different. Nevertheless, the interventional group gained higher scores than the control group (41.6±18.06 vs. 29.8±20.47; CI 95%; p<0.05). Participants (the interventional group) had a positive perception about the AVL usage for neuroanatomy learning. Conclusion: AVL can be considered as a new approach modality for neuroanatomy learning.
Autonomic Function in Peripheral Nerve Regeneration Especially in Radial and Ulnar Nerve Injuries after Microsurgery: A Systematic Review Ria Margiana
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

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Abstract

This literature review seeks to understand the difference in autonomic function of radial and ulnar nerve injuries after microsurgery. During this surgery, additional damage to nerves is also experienced. This research focused on peer-reviewed articles from Pubmed-NCBI database. This is a medical database which features medical peer-reviewed articles on various illnesses treatments and outcomes. The eligibility criteria used were that the article must be full text, published within the past 10 years, written in English language, and featured the keywords-radial nerve injury, ulnar nerve injury and microsurgery. There was no specific characteristic for participants as all individuals with injury were considered. The search from the database yielded 121 initial articles. Of this number, 33 were excluded for being editor comments and no full texts. This had led to 88 remaining articles which were further screened to remove articles written in other languages and those which were older than 10 years. This featured a total of 43 articles. Of this remaining total, only 30 articles were used. The other 15 were excluded as a result of research reliability issues. The procedures used in the articles featured a lot of limitations which questioned the validity of their results. This paper concludes with a summary of the analysis of the difference in autonomic function of the radius and ulna after microsurgery.Keywords: Autonomic function, Radial nerve, Ulnar nerve, Microsurgery.
Prospect of umbilical cord mesenchymal stem cell culture waste in regenerative medicine Jeanne Adiwinata Pawitan; Melisa Leviana; Dewi Sukmawati; Isabella Kurnia Liem; Ria Margiana; Twidy Tarcisia
Journal of Global Pharma Technology Volume 9 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract: Objective:to analyzevarious growth factor (GF) content in umbilical cord derived mesenchymal stem cell (UC-MSC) culture waste at harvest.Methods: We cultured UC- MSCs in complete medium, and collected the medium waste at harvests.  We noted the time of harvests, and measured the concentrations of EGF, VEGF, NGF and Pl GF in the various medium wastes using ELISA method. We grouped GF concentrations according to various culture lengthsat harvest, and calculated themean values and standard deviations of the various GF. We compareddescriptively the GF concentrations at various culture lengths at harvests to conclude which condition yielded the overall highest GF concentration.Results: EGF, VEGF and PlGF concentrations were highest at harvest day-3, whileNGF concentration was the highest at harvest-day-5, respectively. Therefore, overall highest concentration of most GF was at harvest day 3.Conclusion:UC-MSC culture waste at harvest day-3 containedEGF, VEGF, NGF and PlGF, which might be used in regenerative medicine.
Walking Analysis Using the Angles around the Midpoint between Print Length and Toe Spread by Four Different Color Footprints and SFI in Sciatic Nerve-Injured Rat Model Treated With Curcumin Ria Margiana
Journal of Global Pharma Technology Volume 12 Issue 08
Publisher : Journal of Global Pharma Technology

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Abstract

SFI, the sciatic function index, has been applied as an evaluation method in walking analysis over a long period. It is a method that addresses the functionality of nerves using footprints during walking analysis. Other techniques developed previously make use of one-color ink. The method has difficulties in interpretation due to footprints mingled among the mice specimen's four legs. There exists a possibility of the rats not walking straight, and this leads to overlapping, and the result is complicated measurements. SFI, as a method, entails the application of a mathematical formula that is special. Researchers have questioned this method since it is affected by muscles' contraction, automatic mutilation, and rat motion speed. During this study, the idea is to use four different colors, allowing easier and faster interpretation of the footprints results. Moreover, the study will also modify tools based on the already existing available tools in pre-existing literature. The modified tool gives a measurement of print leg denoted as PL, toe spread TS, and inter- toe spread IT’S, all belonging to the SFI component. The tool's validity and reliability are essential when applied in the measurement of components used in the functional analysis of nerves. Confirmation from the study is that results from SFI and TOA (toe out of angle) all describe footprint. Toe out of angle is an essential measurement in the walking analysis as it has an impact on the alteration of abduction-adduction as well as the internal-external navigation of the hind legs. The study will help develop a method that assesses nerves' functional analysis using the sciatic functional analysis and total out of angle spread. The angle at the intersection point of the print length and the toe spread. Keywords: SFI, TOA and ITS.
The Role of Growth-Associated Protein-43 (GAP-43) and Superior Cervical Ganglion-10 (SCG-10) mRNA and Protein Levels in Dorsal Root Ganglion Neurons of Lumbar Spinal Cord Segments (L4-L5) Associated with Sciatic Injured Nerve Ria Margiana
Journal of Global Pharma Technology Volume 12 Issue 08
Publisher : Journal of Global Pharma Technology

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The analysis focuses on the role of growth-associated protein-43 (GAP-43) and superior cervical ganglion-10 (SCG-10) mRNA and protein levels not only in DRG neurons of lumbar spinal cord segments (L4-L5) associated with sciatic injured nerve. The objective of the research study is to unearth the role of growth-associated protein-43 (GAP-43) and superior cervical ganglion-10 (SCG-10) mRNA and protein level not only in DRG neurons of lumbar spinal cord segments (L4-L5) associated with sciatic injured nerve. The sources were past scientific papers that were published and obtained from google scholar and other sites with open source access. The research review is an original work. The analysis will be centered on a review article that focused on analysis on advantages and disadvantages GAP 43 as neuroregeneration marker examination in rat sciatic nerve injury. The study eligibility criteria was articles that are not older than fifteen years, are written in English and are published. Key words: Sciatic nerve injury, GAP-43, SCG-10 and DRG neurons of L4-L5.
Immunohistochemistry Detection Method of Rejection Reaction of Human Umbilical Cord Derived Mesenchymal Stem Cell on Rat Sciatic Nerve Tissue Ria Margiana; Ahmad Aulia Jusuf; Silvia Werdhy Lestari
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
Publisher : Journal of Global Pharma Technology

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Abstract:Human umbilical cord derived mesenchymal stromal cells (UC-MSCs) that are accessible from cell banks can be actuated to separate into different cell sorts, accordingly making them handy potential hotspots for cell-based treatments. In injured peripheral nerves, Schwann cells (SCs) add to useful recuperation by supporting axonal recovery and myelin remaking. Here, we first exhibit a framework to induce UC-MSCs to separate into cells with SC properties (UC-SCs) by treatment with β-mercaptoethanol took after by retinoic corrosive and an arrangement of particular cytokines. The UC-SCs are morphologically like SCs and express SC markers, including P0, as evaluated by immunocytochemistry and converse interpretation polymerase chain response. Transplantation of UC-SCs into transected sciatic nerves in grown-up rats improved nerve recovery. The viability of UC-SCs for axonal recovery was tantamount to that of legitimate human SCs taking into account histological criteria and useful recuperation. Immunohistochemistry and immunoelectron microscopy additionally showed myelination of recovered axons by UC-SCs. These discoveries demonstrate that cells with SC properties and with the capacity to bolster axonal recovery and reproduce myelin can be effectively actuated from UC-MSCs to advance practical recuperation after peripheral nerve injury. This framework might be pertinent for the advancement of cell-based treatments.
Comparison of The Role of VEGF-B, C and D in Angiogenesis and Peripheral Nerve Sprouting After Nerve Repair Post Neurotmesis Injury Ria Margiana
Journal of Global Pharma Technology Volume 9 Issue 11
Publisher : Journal of Global Pharma Technology

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Introduction: Vascular endothelial growth factors B, C and D play various roles in angiogenesis and nerve cell sprouting.  The purpose of this study was to explore the individual roles of these growth factors in angiogenesis and peripheral nerve sprouting after nerve repair. Method: A systematic literature review of various databases was conducted for relevant data on the role of VEGF-B, C and D in angiogenesis and peripheral nerve sprouting after nerve repair (neurotmesis). The review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines Results: Fifty-four studies that met the inclusion criteria were analysed systematically, and grouped into three categories of vascular endothelial growth factors (VEGF-B, VEGF-C, and VEGF-D). The findings highlight the diverse functions of VEGF-B, VEGF-C, and VEGF-D in angiogenesis as well as peripheral nerve sprouting through the VEGF-B/ VEGFR-1, VEGF-C/ VEGFR-3, and VEGF-D/ VEGFR-3 pathways. Conclusion: VEGF-B, VEGF-C, and VEGF-D each play a unique role in angiogenesis and peripheral nerve sprouting. VEGF-B plays a major role in controlling nerve sprouting and VEGF-C influences this process, while VEGF-D is not implicated in the regulation of primary sprouts Keywords - VEGF-B, VEGF-C, VEGF-D, angiogenesis, peripheral nerve sprouting
Review on Cyclic Adenosine Monophosphate signaling pathway (cAMP), DLK Signaling Pathway, RAS/RAF Signaling, Retinoic Acid Signaling, Phosphatidylinositol 3-kinase (PI3K) as the Signaling Pathways Involved in Peripheral Neuronal Generation Ria Margiana
Journal of Global Pharma Technology Volume 11 Issue 01.
Publisher : Journal of Global Pharma Technology

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Abstract

Neuronal regeneration is the physiological process wear, after neuronal injury, the body stimulates mechanisms of self-healing. Thus, through coordinated different processes and signaling that involves diverse molecules in the body, the nerves are able to regain, to some extent, their initial capability to transduce and convey signals. After, neuronal injury, there is a defect in the normal signal transduction. This presents with different symptoms depending on the system in which the nerve belongs. This may be mortar or sensory. Injury to mortar neurons means the supply of the muscle innervated is cut off. This, therefore, implies that the muscle will not have enough power or will become spastic. It is in response to this injury, that the nerve, through some intricate intrinsic signaling pathways, is able to regenerate in order to return the normal physiologic functioning of the body. Methode of this paper is summed up with systemic reviews of articles in the same topic under study. The articles were searched using the Pubmed search engine and were all in English. None of the articles was translated. The inclusion and exclusion criteria was guided by PRISMA guide, as a predetermined outline. The result of this article is out of forty-three, eight articles were selected as eligible, this is because they met the PRISMA criteria and had adequate relevant and supporting experiments to back the signaling pathway under study.  These articles had a clear and elaborate outline of the whole signaling pathway, the associated molecules, the interconnections between the pathways, supporting experiments and even recommended research in the same field or topic. The comparison of the strengths of facts backing the individual pathways was used to determine the pathway that is most involved, or that can be presumes the “mother” signaling pathway in the process of neuronal regeneration.Keywords: Neuronal regeneration, Neuronal injury, Signaling pathway.
Analysis on Advantages and Disadvantages GAP 43 as Neuroregenaration Marker Examination in Rat Sciatic Nerve Injury Ria Margiana
Journal of Global Pharma Technology Volume 11 Issue 01.
Publisher : Journal of Global Pharma Technology

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Abstract

Analysis focuses on the advantages as well as the disadvantages of using Growth Associated Protein 43 (GAP-43) as a neuroregeneration marker examination tool in a rat sciatic nerve injury examination. The sources of this research were attained from past scientific publications that had been published on the NCBI website. The research is unique because no past researches have ever been performed to ascertain the advantages and disadvantages of GAP-43 as a neuroregeneration marker examination tool in a rat sciatic nerve injury examination. The analysis will focus mostly on a research that was published on September 10, 2016. It focused on the GAP-43, a growth associated protein used in the treatment of a sciatic nerve injury in a Norway rat. The keywords used to attain the access the publication included GAP-43, neuroregeneration marker and sciatic nerve injury. The results of the search yielded a total of twenty-six full journal articles from PubMed Central and one scientific and medical abstract citation from PubMed. These are all publications that contain information pertaining GAP-43 and its applications. The materials for inclusion in the research were all journals summarizing the effects of GAP-43 on a sciatic rat. The participants of this review were program professor and myself. The materials for exclusion in the research included all publications with the exception of peer-reviewed scientific journals and publications from the PubMed or NCBI website. The conclusion of the study revealed that although GAP-43 has a few disadvantages, it is an effective neurogenerational marker in a rat sciatic nerve injury examination.Keywords: GAP 43, Neuroregenaration marker, Sciatic nerve injury
Co-Authors Agustinus Agustinus Ahmad Aulia Jusuf Andri Rezano Atmaja, M Hidayat Surya Atmaja, Muhammad Hidayat Surya Azlansyah Azlansyah Cennikon Pakpahan Christian Christopher Sunnu Darsini, Ninik Dewi Sukmawati Elvan Wiyarta Eni Maria Sisca Fatkhurrohmah Leo Amalia Feranita Kumalasari I Made Rayo Putra Indrawan I'tishom, Reny Indrawan, I Made Rayo Putra I’tishom, Reny Jeanne Adiwinata Pawitan Jefry Albari Tribowo Joice Marlina Budiharto Khoirul Ima Kumalasari, Feranita Kusumaningrum, Selvina Cindy Kusumaningtyas, Sasanthy Liem, Isabella Kurnia Maitra Djiang Wen Maitra Djiang Wen Melisa Leviana Mochamad Iskandarsyah Agung Ramadhan Moh. Ayodhia Soebadi Nathania Nathania Nathania Nathania, Nathania Paulus Rahardjo, Paulus Pety Narulita Pratama, Andi Ahmad Thoriq Reynardi Sutanto Selvina Cindy Kusumaningrum Silvia werdhy lestari Supardi Supardi Supardi Supardi Supardi Supardi Supardi, Petrus Tiara Kirana Twidy Tarcisia Wibowo, Kristophorus Jonathan Widya Juwita William