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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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New Schiff Base Fluorescent Chemosensors for Metals: Synthesis Characterization and Applications May Jaleel Abed
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

The focus of preparing and applying distinctive fluorescent chemosensors and samples can be split into two remarkable meetings. The first arrangement with the Schiff base-determined fluorescent chemosensors, using metal cation detection and the subsequent collection, concerns the improvement of the new Ru (II) ppy luminescent D.N.A atomic tests. Particles that have their structure and capacity as chemosensors at the top of the priority list (based on the previous one). Only compounds fitted with adequate receptors, specifically intended for their target visitors and coupled with appropriate fluorochromes so far as synthetic sensing can be efficiently performed by conceivable photophysical processes.
Cloning and Expression of GST-HMPREF0351_11084 Gene in JM105 Cells: A New Potential Protein Vaccine for Pneumococcal Sddiq Ghani Al-Muhanna
Journal of Global Pharma Technology .
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Abstract

The HMPREF0351_11084 gene encoding pneumococcal vaccine antigen A family protein (GeneID: 12999770) was optimized and synthesized, then sub-cloned into pGH cloning vector. The amplified HMPREF0351_11084 gene was incorporated into Bam HI and Eco RI sites of pGEX-2T GST expression vector under the control of tac promoter. The recombinant pGEX-2T was transformed and expressed into JM105 cells. The protein of expressing bacteria was analyzed by SDS-PAGE and the target protein was detected by Western blot - enhanced chemiluminescence (WB-ECL) assay. The result shows predicted target fusion protein with molecular weight 51.2 kDa. The current study describes for the first time the expression of HMPREF0351_11084 gene, and so attempts to produce a new potential protein vaccine for pneumococcal. Further extensive study is required to generate more data about HMPREF0351_11084 protein and evaluate its immunization in elicits antibodies that are capable of passively protecting against pneumococcal infections.Keywords: Fusion protein, PGEX-2T, HMPREF0351_11084, ECL, Pneumococcal vaccine.
Molecular Study of Mastitis Susceptibility in Human Rawaa K. Judi
Journal of Global Pharma Technology .
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Abstract

Total of (260) clinical samples of blood and milk were collected from women, (160) sample from patients suffering from mastitis (80 samples from blood and 80 samples from milk), and (100) samples as control. Clinical samples were collected from mastitis women who visit the breast cancer consultant clinic in AL-Hilla Teaching Hospital at Babylon Provinces and Private Clinics. The period of samples collection were extended from October (2017) to January (2018). The mean of complement component 5a (C5a) levels in milk of women infected with mastitis was higher (250.9±15.8pg/ml) than the healthy ones (121.55±11.02pg/ml). The level of IL-6 and TLR2 concentrations in serum were measured in women mastitis cases as well as in the control groups by using ELISA technique. The mean of the serum levels of IL-6 in women infected with mastitis was higher (404.73±52.92 pg/ml) than the healthy ones (198.37±28.66 pg/ml). The mean of the serum levels of TLR2 in women infected with mastitis was higher (147.74±27.11pg/ml) than the control groups (83.36±8.58pg/ml). Genotyping of TLR2 polymorphisms was carried out by using Restriction fragment length polymorphism-Polymerase Chain Reaction (RFLP-PCR) technique. The polymorphisms in the single nucleotide for human TLR2 (Arg753Gln) gene polymorphism was detected in mastitis cases and the control groups, and the association between these polymorphisms with host susceptibility to mastitis was also determined. The results showed there was no differences between mastitis patients and control groups for alleles frequencies regarding Human TLR2 (Arg753Gln) polymorphism. However, that there were statistically significant difference in the frequency of TLR2 (Arg753Gln) genotype between patients with mastitis and control groups (P<0.05). Women with GA heterozygous genotype was overrepresented among the mastitis patients 22(50%) than in the controls 12(27.3%), suggesting an association with mastitis susceptibility; whereas the GG 20(45.5%) and AA 12(27.3%) genotype was more common in healthy subjects, than in mastitis patients 15 (34.1%) for GG and 7 (15.9%) for AA, suggesting a protective association with mastitis. The G and A alleles frequencies did not statistical difference as it was reported in Human TLR2 (Arg753Gln) between mastitis cases and control groups, the G allele frequency was 52(59 %) in the mastitis patients and same frequency in the control individuals, whereas A allele frequency was 36(41%) in the mastitis patients and in the control individuals.  Keywords: Mastitis, Gene polymorphism, Complement component, RFLP-PCR.
The Effectiveness of Reduction of Weight Metal Contents of Pb, and Hg in Water Electro-coagulation Method Ferry Kriswandana
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Background and Aim: Heavy metals in certain levels can reduce the quality of air, water, and soil. Furthermore, causing health problems for plants, animals and humans, when there is accumulation as a result of industrial activity. Until now, the reduction of heavy metal content in liquid waste has been carried out physically, chemically and biologically. Therefore it is deemed necessary to reduce levels of heavy metals in liquid waste by electrocoagulation. The purpose of this study is to study the performance of electrocoaglation as a reducing agent in reducing Pb and Hg levels in water, so that it can provide references and input for the electroplating industry, batik industry, and others. Method and Materials: This research is a true experimental research with a post test only control group design, which is a research design consisting of a control group and an experimental group. The research sample will be examined in the laboratory. The sample used in this study is a preparation that has been made by dissolving Pb and Hg so that it is like waste from the batik industry or electroplating waste or battery factory waste. The variations in this study were the current / voltage (16, 20, and 24) volts and the detention time (30, 40, 50, and 60) minutes. The independent variable is electrocoagulation which is equipped with cathode and anode. This variable will affect changes in the dependent variable. The dependent variable in this study is the quality of the waste after electrocoagulation by observing the parameters of Pb and Hg. Statistical Analysis: Data analysis using the One-way Anova test or One-way Anova. Results: The results of this study indicate that electrocoagulation as a reducing agent at 16 Volts, 20 Volts, and 24 Volts with a contact time of 30 minutes, 40 minutes, 50 minutes and 60 minutes has a significant effect on Pb and Hg reduction with α = 0.05. The most significant reduction in average Pb occurs in processing with a 20 volt electricity voltage and 60 minutes contact time. Meanwhile, the most significant decrease in Hg levels occurs in processing with a 24 volt electricity voltage and contact time for 30 minutes. Discussion and Conclusion: The reduction in Pb and Hg levels using the electrocoagulation method with aluminum electrodes comes from a redox reaction process where the anode (in acidic pH) will form the Al(s) → Al3+ (aq)¬ + 3e and the cathode will form 3H+ (aq) + 3e- → 1,5H2 (g)¬. After the anode and cathode react, there will be a floc formation which functions as a coagulant that will bind Pb. The conclusion of this study is that the most significant decrease in the average Pb level occurs in processing with a power supply of 20 volts and a contact time of 60 minutes. Meanwhile, the most significant decrease in Hg levels occurred in the treatment with 24 volt electricity and the contact time was 30 minutes. Keywords: Electro-coagulation, Voltage, Contact time, Heavy metals.
The Relationship between Three (Human, Perceptual, and Technical) Skills of Financial Managers and Their Effectiveness in Manufacturing Companies with the Intermediate Role of Empowering Managers Hossein Azimi
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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Abstract

The aim of this study is to investigate the effect of three (human, perceptual, and technical) skills of financial managers on their effectiveness in Gilan province's manufacturing companies with the mediating role of empowering managers. The research method was descriptive-correlational and the statistical population included managers and financial experts of 193 manufacturing companies in Rasht industrial town. Data collection tool was a researcher-made questionnaire which was distributed among 30 active companies by random sampling method. The reliability of the questionnaire was confirmed. Additionally, the content validity of questionnaire was confirmed by the opinion of the experts and its construct validity was confirmed by factor analysis. The results of the correlation test using spss16 software showed that there is a statistically significant effect between the studied variables. Moreover, structural equation modeling and path analysis technique were used to investigate the interactions of research variables. The results obtained from the seven examined hypotheses confirmed the impact of three (human, perceptual, and technical) skills of financial managers on their empowerment in manufacturing companies of Gilan province (P <0.05). Also, the results of this study indicated that the empowerment of managers affects the financial management effectiveness (planning, budgeting, control and assessment) in manufacturing companies of Gilan province (P <0.05).Keywords: Triple skills (Human, Perceptual, and Technical), Effectiveness of managers, Empowerment of managers.
Attitude and Performance of Nurses in Oral Care in Intensive Care Unit Patients Elham Niknejad
Journal of Global Pharma Technology .
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Introduction: Prevention of respiratory tract infections in intensive care units is an important aspect of patient safety and oral care as nursing intervention plays an important role in reducing the risk of infection so the present study was aimed to determine attitude and performance of nurses in oral care in intensive care unit patients. Materials and Methods A descriptive study in which105nurses working in special educational- therapeutic centers affiliated to Uremia University of Medical Sciences were selected by available sampling method. For data collection a part of rello et al. questionnaire was used. Data analysis was performed using descriptive statistics and Chi-square test. Results showed that the majority of nurses (87.5% and72.8%), respectively had moderate attitude and performance about their oral care, but based on chi-square tests there is no significant relationship between attitude and performance of the staff. The majority of nurses (85.3%) are not using protocol and the standard tool for the assessment of oral healthcare. Conclusion Education of basic concepts of health care is necessary in order to enhance employee attitude and performance and improve the patient's status in intensive care units and should be taken into consideration by the authorities’ and directors of nursing.Keywords: Attitude, Performance, Nurses, Oral Care, Intensive care unit.
Effect of Topical Phytosterol Fraction of Chenopodium murale on Induced Hypertrophic Scar in Rabbits Aya Ashraf Ahmed
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Objective: The present study aimed to evaluate the role of phytosterol fraction of Chenopodium murale in experimentally induced hypertrophic scar in rabbits. Methods: Surgical wound was performed on day 1 with an 8‑mm biopsy punch four wounds were created on the ventral surface of the rabbit ear (in vivo) down to cartilage. Triamcinolone acetonide (TAC) and phytosterol extracts of Chenopodium murale are administered topically to established scars on day 31. The outcome measures include the study of histopathology of skin section, transforming growth factor beta-1(TGF-β1) level and collagen III alpha in skin tissue. Results: The treatment groups produced high significant reduction in inflammatory scores, height, index of scar and in immunological scores of TGFβ1 and scores of collagen III in comparison with induced hypertrophic scar group (P≤0.001). Significant reduction was observed also in fibroblast count as compared with induced hypertrophic scar control group (P<0.05).Conclusion. Phytosterol extract of Chenopodium murale was effective in treatment of induced hypertrophic scar through its ability to produce reduction in inflammation, fibroblast count; height and thickness of hypertrophic scar in addition to decrease in immunological scores and the results were nearly comparable to that of topical triamcinolone acetonide.Keywords: Chenopodium murale; Rabbits; Topical phytosterol.
The Effect of Special Exercises in the Development of Some Visual Abilities and the Accuracy of Some Basic Skills of the Young in the Handball Thaerah Abdul Jabbar Saleh
Journal of Global Pharma Technology .
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The problem of research is the lack of use of some trainers for visual exercises during the training modules and do not have great importance in their training curriculum as it is for the physical, skill and planning aspects, and thus the objectives of the research are as follows:Develop special exercises to develop some visual abilities and the accuracy of some of the basic skills of beginner's handball.Knowing the impact of special exercises in developing some of the visual abilities of the emerging handball players.Knowing the effect of special exercises in developing the accuracy of some of the basic skills of beginner's handball.Either Research HypothesesThere is a significant impact of special training in developing some visual abilities of the emerging handball players. There is a significant effect of special exercises in developing the accuracy of some of the basic skills of beginner's handball.  The researchers adopted the experimental approach in the design of the two equal groups with Pre and Post testing through the research society represented by the players of the specialized center of handball at Al-Qasim Sports Club. The number of (40) player was randomized. The random number of 16 players was divided into two equal groups, And the tests used in the visual abilities and skill handball were conducted Pretests, and then applied visual exercises for the experimental group by combining them with the curriculum prepared by the trainer (3) units per week for a period of (8) weeks, and then conducted After the data were obtained from the Pre and Posttests where the researcher treated them statistically to extract the results. The results were presented, analyzed and discussed according to research objectives, the most important conclusions reached by the researchers in:There is an evolution of the experimental group in all visual and technical tests of the hand pulley except the test (Perception of the depth of vision) as well as the control group, except for the Perception of the depth of vision and the test of the accuracy of handling from the head level by the field of vision. Visual training is futile in the latest development in the Perception of the depth of vision and accuracy of the performance of the correction of the jump field of vision of the two groups.Keywords: Special exercises, Visual abilities and accuracy.
Isolation and Identification of Pathogenic Fungi from Cyprinus carpio L. (1758) in Al-Nasiriya City Ihsan Flayyih Hasan AI-Jawhari
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Thirty  samples  of  Cyprinus  carpio  were   collected  from Al-Nasiriya fish  ponds  during  the  period  from  March   until  Novmber  2017 . Seventeen  fish  samples  showed  fungal  infection .In this study eight species were identified and the most common were Aspergillus  niger, Saplolegnia sp., Achyla  prolifera, Alternaria  alternate , Penicillium funigulosum, Rhizopus  stolinifer, Aspergillus  fumigatus and  Aspergillus  flavus . Aspergillus Niger and Saplolegnia sp. were the most prevalent fungi infecting all the organs of Cyprinus carpio. Gills  and  abdomen   had  higher  infection  than  rest  of  the  organs .Keywords: Contaminnet, Disease, Environment, Fishes, Fungi, Ponds.
The Effect of Interpersonal on the Use of Traditional Medicine in Hypertension Patients with Health Promotion Model Approach Ronal Surya Aditya
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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ABSTRACT: Hypertension is a disease that requires compliance with drug consumption, but many people are affected by using traditional medicine. Interpersonal influences affect them in the choice of treatment. This study aims to determine the interpersonal influence on traditional drug use in hypertensive patients with a theoretical approach to health promotion models. The subjects of this study were 148 hypertension people in Posyandu, Jenggolo Village, Kepanjen Regency. The design of this research is Cross-Sectional with the sampling technique uses purposive sampling to get a sample of 108 people. Retrieval of data using questionnaire sheets and multiple linear regression statistical tests. The results of the study using multiple linear regression test showed that family support had a B value of 0.111 with sig = 0.036, support of health workers had a value of B 0.156 with sig = 0.028, and peer support had a value of B 0.233 with sig = 0.002. The beta coefficient value on family support is 0.203, health worker support is 0.212, and peer support is 0.297. It can be concluded that the three supporters, namely family, health workers and peers, influence the use of traditional medicine. The most dominant influence in this study was on peer support. The results of this study are expected to provide input for other researchers about providing interventions to peers in patients with hypertension.

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