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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 7 Documents
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Search results for , issue "Volume 09 Issue 02" : 7 Documents clear
Are Household Water Purification Devices Useful to Improve the Physical Chemical and Microbial Quality of the feed Water? Case Study: Bandar Abbas South of Iran Mojtaba Afsharnia
Journal of Global Pharma Technology Volume 09 Issue 02
Publisher : Journal of Global Pharma Technology

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Abstract

Part of the Bandar Abbas population in southern Iran, in order to access to better water quality than municipal tap water systems, use household water purification devices. The aim of this study was to determine to what extent these devices are effective in improving the quality and the efficiency are desirable for the production of water quality. This cross-sectional study that was conducted in a six-month period time in 2015 in Bandar Abbas. A total of 30 samples of water from various home water purification apparatuses were sampled and tested for hardness, alkalinity, pH, total dissolved solids (TDS) and electrical conductivity (EC), turbidity and MPN was performed on the samples. Statistical analysis was performed using SPSS version 19 and statistical tests ANOVA and Pearson correlation test. The efficiency of the apparatuses to reduce turbidity, hardness, alkalinity, Na, K and Cl, respectively were 45.9, 39, 22.3, 30.6, 34.9 and 53 percent, and in reduce of TDS and EC respectively were 37.5 and 59 percent. The devices ability to change the pH of water was low and negative; (-5.8 percent). In 26.6% of influent samples, microbial contamination was detected, which in all mentioned cases, the microbial contaminated were showed in effluent samples. In general, the use of these devices was not necessarily lead to improved water quality. After working the 12-month period significantly decreased efficiency. The number of treatment stages did not impact in device efficiency improvement.Keywords: Water treatment, Purification devices, Water quality, Chemical quality.
CYTOTOXIC ACTIVITY OF SOURSOP (Annona muricata) LEAVES EXTRACTS AND THEIR PHYTOCHEMICAL CONTENTS Lili Indrawati
Journal of Global Pharma Technology Volume 09 Issue 02
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Abstract

Objective:Annona muricata (soursop) leaves belong to Annonaceae family, has been used as traditional medicine in Indonesia. Several plant  polyphenols, such as flavonoid quercetin and flavone (2-phenyl-4H-1-benzopyran-4-one) may  have chemoprevention  property  by reducing  the incidence of many types of cancer, especially in colon epithelia. This study aims to determine cytotoxic activity of the extracts and their total flavonoid content of the leaves extract. Methods: Extract used in flavonoid level determinaion are  standardized water extract (Zirzak Orac), ethanol-soluble fraction (ESFAM) and ethanol-insoluble fraction (EIFAM). The level of flavonoid content were determined by spectrophotometer UV-Vis with quercetin  and rutin as standard. Antiproliferative effect was evaluated against colorectal cancer cell line (DLD-1 and COLO 205), and normal cell (HEK) using microculture assay based on the metabolic reduction of 3- (4, 5-dimethylthiazol- 2-yl) -2,5-diphenyltetrazolium bromide (MTT). Results: Flavonoid concentrations of  Zirzak Orac, ESFAM, EIFAM are 0.15%, 0.83% and 0.07%, respectively. EIFAM shows the lowest IC50 value against DLD 1. The value of IC50 on the normal cells HEK is expected to be as  high as possible, EIFAM has the highest. Conclusion.EIFAM showed selective cytotoxic activities in vitro, while it contains the lowest concentration of flavonoid and annonacinKeywords - Annona muticata L., cytotoxicity, flavonoid
A Comparative Analysis of the Current Performance of University Deputies and Main Functions of Management Abbasali Karimi
Journal of Global Pharma Technology Volume 09 Issue 02
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Abstract

Introduction: the organizations are established for the realization of the certain goals and the level of achieving to these goals depends on performance of organization. The Organization's performance quality depends on main performance of organization management, while managers mainly perform their main tasks (planning, organizing, leading, and controlling). Evidence suggests that the failure of any organization in achieving its mission and vision is a serious issue. Lack of attention to main functions of management among the usual programs of managers is one of the major reasons for this failure. The aim of this study was to compare the current performance of the medical science university deputies with the main functions of management. This study was a cross-sectional research, which its population included educational, health, cultural, student, support, food and medicine deputies of Yasuj medical science university in the years 2010-2011. Deputies trained on recording the current performance and main functions of management collected data required to study. In this process, a researcher-developed tool was used, which includes the type of activity, time spent on each activity and its method. The validity of this tool was determined by using the opinions of experts and its reliability was determined by Cronbach's alpha (0.84). These activities were recorded during the entire week of one year and one day per week. Then, data inserted in forms were coded by researchers and they were analyzed after entering to SPSS software. The results showed that almost 90% of activities of university deputies were consistent with their written organizational functions. However, 47 percent of all recorded activities were among the main functions of management: planning with 17%, organizing with 16%, leading with 9%, and controlling with about 5%. In other words, about 53%time of deputies at their account ability location belonged to activities apart from the basic functions of management. the prerequisite for the dynamics of the organization, and to achieve goals focus on the main management functions. According to the findings of this study, it seems firstly that designing organizational structure (including the hierarchy, description of duties and functions, conditions) needs to serious reviewing and revising so that description of functions and duties notified to them to be in line with main functions of the management and it does not include merely the usual performance. Secondly, with an inadequate focus on the core functions of management by managers, health sector that has special sensitivity in society is deprived of optimal guidance and achieving to organizational goals will be very difficult.Keywords: Management, performance, Health sector, Planning, organizing, University Deputies.
Risk Detection and Assessment in Wood and Metal Products Industries using HAZAN Method Hamed Biglari
Journal of Global Pharma Technology Volume 09 Issue 02
Publisher : Journal of Global Pharma Technology

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Abstract

Developing and advancing technology in the industries has increased the number of risks at work environment and the number of workers at risk as well. These risks and the risk factors need to be managed, assessed, and controlled using systematic methods. Therefore, the present study is aimed at assessing and detecting risks in wood and mental products industries using HAZAN method. Data gathering was done using HAZAN worksheet, observation, walking and talking method, risk detecting checklists, technical documents, and plots available. The findings represented 137 risks at workshop, out of which 2.92% were 1st rank (unacceptable), 2.92% were 2nd rank (undesirable), 85.4% were 3rd rank (acceptable if controlled), and 8.76% were 4th rank (acceptable). Most of the risks were found at MDF section (n 30), metal assembly (n 28), metal works (n 27), and MDF assembly (n 23). In addition, high risks jobs were bending, electrical welding, PVC work, and guillotine work. The results showed that 3rd rank risks were the largest group of risks and this showed that great improvement could be made in cutting the number of accidents and financial and life loss by controlling these risks. It is notable that 1st rand risks should be controlled immediately using engineering and administrative controls and 2nd rank risks shall be turned into 3rd rank risks in a reasonable time frame. With regard to 3rd rank risks, we need to make sure of availability of controls; and the 4th rank risks were acceptable. Taking measures such as safety training and permanent supervision by the safety authorities were also effective to minimize the risks.Keywords: Risk, assessment, HAZAN method, industrials products, workers risk 
Characterization of Biofilm production in antibiotic resistant Klebsiella pneumonia isolated from different clinical samples in Iraqi hospitals Rawa Abdul Redha Aziz; Sawsan Sajid Al-Jubori
Journal of Global Pharma Technology Volume 09 Issue 02
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Abstract

Objective(s): Klebsiella pneumonia is a causative agent of chronic infections leading to increase morbidity and mortality; especially when performing biofilm(1). Therefore, biofilm formation has been linked to the survival of pathogenic bacteria in the hospital environment, leading to susceptible bacterial colonization which creates an important public health problem. Therefore, to characterize biofilm production in local Iraqi K. pneumonia isolated from different clinical samples in Iraqi hospitals using phenotypic biofilm assays including scanning electron microscopy. Material and Methods local isolates were collected from different Iraqi hospitals and re-diagnosed by compact Vitek 2 and genetically by using housekeeping gene (16s rRNA and 23s rRNA 639 bp). Phenotypic detection of biofilm formation among isolates was screened by using microtiter dish assay, twitching motility assay, and scanning electron microscopy (SEM).Results: It was found that 22/24 (91.67%) of isolates could form biofilm (OD≥0.68). Twitching motility test revealed that 20/24 (80.3%) of isolates could move on the M63 medium. Scanning electron microscopy showed 83.3% of K. pneumoniae isolates made biofilm in different stages started with adhesion step and ending with a mushroom like architecture as highly magnification images showed on glass cover slips embedded statically in LB broth. It was interesting that K. pneumoniae S2 demonstrated a dense mat of cells aggregates on cover slips generating different biofilm formation step. Conclusion K. pneumonia could produce biofilm, describing the ability to resist many kinds of antibiotics and rising a concern of disseminating chronic infection among hospitalized patients in many hospitals in Baghdad.  
Influence of a New Preparation on the Microstructure of Separate Internals of Animals Secondary to Immunization RA Asrutdinova
Journal of Global Pharma Technology Volume 09 Issue 02
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Abstract

The current paper evaluates the influence of a test sample of polysaccharide-based new preparation on the microstructure of separate internals of rabbits after vaccination under the conditions of industrial rabbit breeding. Post vaccinal immunomorphological changes, particularly in liens of the test group, included formation of multiple lymph nodes, saturation in periarterial zone of T-lymphocytes in the formed nodes after the action of the vaccine and “Gemiv” polysaccharidic preparation. Lien lymphatic tissue was represented by middle and large lymphocytes. The structure of the liver was preserved even by the end of the experiment. A significant amount of binuclear hepatocytes was observed, which is indicative of reparative capability. The studied organs testified that the use of polysaccharidic preparation “Gemiv” during vaccination of rabbits against salmonellosis had no negative influence on the function and structure of the internals.Keywords: Immunostimulant, Vaccination, Young stock, Organ minute structure.
Studying the Status of Biological and Physico-Chemical Indicators of Swimming Pools of the City Kermanshah (Iran) in 2016 Mojtaba Afsharnia
Journal of Global Pharma Technology Volume 09 Issue 02
Publisher : Journal of Global Pharma Technology

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Abstract

Swimming pools are the most attractive and popular of sports centers. Swimming has constructive effects on human physical and mental health care and lack of proper sanitation and disinfection Regulations of water in swimming pools is led to health problems and infectious disease transmission among swimmers. The aim of this study was to evaluate and compare the results of swimming pools in Kermanshah with the national standards. This study was descriptive-sectional and carried out in 2016 in 24 active pools in Kermanshah city by collecting statistics. In the survey in addition of the characterization of Public Pools Through interviews, heterotrophic bacteria, fecal coliforms, Pseudomonas aeruginosa, Staphylococcus aureus and physicochemical parameters such as residual chlorine, turbidity were assessed in the sampling sites and were recorded in the relevant forms. All calculations were performed with SPSS software (version 16) and statistical significance was considered 0.05. The results showed that from 99 samples in 15.2% of Pseudomonas aeruginosa has exceeded the standard level. In addition, 17.2% Staphylococcus aureus, 15.2% and the amount of fecal coliform, 17.2% bacteria heterotroph and 17.2% of residual chlorine levels were out of the standard limit. According on the results, residua chlorine, Staphylococcus aureus, Pseudomonas aeruginosa, fecal coliform, heterotroph bacteria indicators had the minimum compliance with standard levels which indicates the need for continuous monitoring of physical, chemical and biological indicators of water as well as filtration and disinfection of water. It also recommended alternative antibiotics.Keywords: biological, physical, chemical, swimming pool, Kermanshah, Iran

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