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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 16 Documents
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Search results for , issue "Volume 09 Issue 11" : 16 Documents clear
Method to Solve Linear Differential Equations and Three Independent Variables Russell Hassan Naser
Journal of Global Pharma Technology Volume 09 Issue 11
Publisher : Journal of Global Pharma Technology

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Abstract

In this paper, we find the solution of kinds of linear partial differential, equations of variable coefficients and which have the general form as Hence,…are variable coefficients. By using some assumptions, we will transform the previous equation into the non-linear second order, ordinary differential equationsKeywords: Linear Partial, Differential Equations; Third Order; Three Independent, Variables Academic Discipline and Sub-Disciplines Applied Mathematics, Differential Equations.
Effect of Bacterocin Produced by Enterococcus Faecium on Bacteria that Cause Diarrhea in Young Horses and a Goat Jinan Mohamed Husan Faeroozali
Journal of Global Pharma Technology Volume 09 Issue 11
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Abstract

400 samples (200 samples from feases healthy young goats and infected with diarrhea and 200 samples from feases healthy and infected horses) were collected from the veterinary hospital and veterinary health centers in Najaf city for the period from January to April 2016. All isolates were subjected to cultural, microscopic and biochemical tests using Vitek2 for identification up to the species. The results showed that (43) isolates belong to Enterococcus faecium of which (30) isolates from diarrhea cases and (13) isolates from of healthy young, (32) isolates of which (22) isolates belonged to E.coli and (10) isolates belonged to Salmonella spp. All isolates were subjected to cultural, microscopic and biochemical tests by using strip (API-20E). The sensitivity of these isolates (32) was tested for antibiotics. Results revealed that isolates showed multi resistance to antibiotics. All isolates of E.coli and Salmonella spp. resistant to some antibiotics for Gram- negative Bacteria and belonging to the group Enterobacteriaceae. And detection of the ability of E. faecium local isolates to produce Bacteriocin by testing the inhibitory activity on agar and broth in two media MRS, BHI and two methods against bacteria cause diarrhea.  And the isolates  showed clear effect on the gram -negative bacteria causing diarrhea in young goats and young horses , by inhibitor zone between (13-20) mm and was MRS liquid and solid the best media from the brain heart infusion.Keywords: Enterococcus faecium bacteria, Bactriocin, inoculation steps GPID Card, sensitivity bactria for antibiotics, biochemical test, Detection methods for bactriocin
Effect of Some Types of Doping Used by Athletes on Liver and Kidneys Functional Performance in Albino Male Rats Saher Mahmood Jwad
Journal of Global Pharma Technology Volume 09 Issue 11
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Abstract

The studies and researches at the present time interested with doping especially the anabolic androgenic steroids (AAS) due to their commonly used by the athletes  and non-athletes , as well as study the effect of these doping on body organs and its tissues such as liver and kidneys, effectiveness of hepatic enzymes, the variations in the performance of liver and kidney functions, in addition to the hepatic pathological changes like cirrhosis, congestion, necrosis, increased collagen content in the liver parenchyma and disturbance in the glomerular filtration process of kidney. Therefore, this study aimed to use Nandrolone decanoate doping (ND) that has been possessed anabolic androgenic ability and diagnosis its influences on the tissues of some organs especially liver and kidneys. The current study was performed in the animal house return to the Biology department / Faculty of Education for Girls / Kufa University, in this study (30) male rats of Sprague-Dawley strain were used and divided into two main groups, the first group was the control group comprised (15) rats were also divided into three equal subgroups, a group was injected with normal saline solution (0.9%) once a week for one month, a group was also included (5) rats injected with (0.9%) normal saline solution one time weekly for two months and the last group was  also injected with normal saline (0.9%) once weekly for three months, while the second group was contained (15) rats and divided into three equal subgroups, a group was injected with Nandrolone decanoate doping (ND) at the concentration of (1 mg/kg) once weekly for one month, a group was injected with (1 mg/kg) of (ND) doping also one time at week for two months, concerning to the last group was injected with (ND) doping at the concentration of (1 mg/kg) once a week for the period of three months, the injection process of all treatments was intramuscular (in the hind limb muscle) for each rat.  The study was contained, body weight recording as well as the relative weights of liver and kidneys, estimation of some biochemical parameters of the blood as: Aspartate amino transferase (AST), Alanine amino transferase (ALT), Alkaline phosphatase (ALP), the levels of total bilirubin, total protein, albumin, total cholesterol, triglycerides, creatinine and urea, whereas the histological study included, preparation of tissue sections for the liver and kidneys. The statistical analysis of study were revealed : a significant increase (p<0.05) in the body weight, relative weights of liver and kidneys, effectiveness of hepatic enzymes (AST, ALT, ALP), levels of total bilirubin, total protein, albumin, total cholesterol, triglycerides, creatinine an urea at the groups were treated with Nandrolone decanoate doping compared to the control groups . With regard to the microscopic examination of liver and kidneys sections for male rats that injected with Nandrolone decanoate doping were exhibited various patho-histological changes when compared with the control groups. The conclusion: the present study was conducted to, the treatment with Nandrolone decanoate doping for the periods (one, two and three months) caused observable deterioration in the functional performance of both hepatic and renal tissues.Keywords: Nandrolone decanoate doping, Hepatic and renal tissues functional performance, Patho-histological effects, Physiological and biochemical properties of the blood.
Analyzing the Ways to Improve Personnel Management in the Pharmaceutical Industry of Kazakhstan Kairat Zhakipbekov
Journal of Global Pharma Technology Volume 09 Issue 11
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Abstract

The analysis of foreign and Kazakh literature that addressed the problem of finding ways to improve personnel management in the pharmaceutical industry showed that such factors as intensifying competition on the world market, complication of the internal and external environments of the pharmaceutical industry, and discrepancies between the actual conditions and the demands of the pharmaceutical labor market necessitated the search for new ways of improving the effectiveness of modern pharmaceutical organizations, the cornerstone in which is the human factor. Modern approaches to personnel management and trends in the improvement of personnel management in the pharmaceutical industry of Kazakhstan were analyzed; the profile of an average pharmacist was built: a woman (75.3%) aged 36-55 (52.3%), with 26-30 years of work experience (32.3%) and higher education in pharmacy (77.2%). Sociological studies discovered the following problems: the need for innovations in personnel management in the pharmaceutical industry, which should be aimed at the professional and personal development of each individual in particular and the entire pharmaceutical team in general; the need for an algorithm of consistent performance appraisal of pharmacists  and an algorithm of planning and progress of the professional career of a pharmacist; personnel departments require recommendations regarding methods for improving the organization of personnel management, with a view to continuously improving the skills of pharmaceutical personnel. A textbook for the postgraduate occupational training of pharmacists titled Communication Skills was drafted and implemented in the learning process of a higher educational institution.Keywords: Appraisal, Communication skills pharmacy, Reserve, Personnel management, Social and psychological climate.
Analytical Method Development for Sacubitril and Valsartan in Combined Pharmaceutical Dosage Forms by RP-HPLC S. Aparna
Journal of Global Pharma Technology Volume 09 Issue 11
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Abstract

The Present work was to develop a simple, fast, accurate, precise, reproducible, Reverse Phase High Performance Liquid Chromatographic Method for simultaneous estimation of Valsartan and Sacubitrilin pure drug form. Chromatographic separation was done using Terrosil C18 column having dimension of (100 mm x 4.6 mm) having particle size of 5.0 µm, with mobile phase consisting of Phosphate buffer (KH2PO4 and K2HPO4) pH 3 ±0.02 pH adjusted with ortho phosphoric acid and Acetonitrile (25:75 %v/v), flow rate was adjusted to 0.8 ml/min and detection wavelength at 254nm. The retention times of Valsartan and Sacubitril was found to be 2.589 and 3.711mins.  The no. of theoretical plates is 4456, 582.and the tailing factor is 1.4, 1.3.Keywords: Valsartan, Sacubitril, RP-HPLC, Method development.
Live Healthy Be Free from Anxiety and Stress Mainul Haque
Journal of Global Pharma Technology Volume 09 Issue 11
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Abstract

Live, Healthy, Anxiety, Stress.
A Comparative Study for The Alcoholic Extract Effect of Ajwa Dates (Phoenix Dactylifera L) in Protection of the Hepatic and Renal Tissues from Toxicity Induced by Aspergillus Niger in Albino Rats Alaa Abdul Ali Al-Khafaf
Journal of Global Pharma Technology Volume 09 Issue 11
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Abstract

The plant extracts and their chemical components have a long history as antifungal agents to control the growth of isolations that released toxins and for this reason, they were used in the bio techniques as a preservative due to increased fungal resistance to the fungal antibiotics. The study aimed to evaluate the efficiency of the alcoholic and aqueous extracts for Ajwa dates in inhibiting the production of Ochratoxin A from Aspergillus Niger, and study the possible protective effect of these extracts on the tissues of vital organs such as liver and kidneys against the toxicity that induced by Ochratoxin A. The analysis results of the chromatography methods (HPLC, TLC) showed an influence of these two extracts on the production of Ochratoxin A, and the full inhibitory impact for the production of this type of fungal toxin was in the two concentrations ( 25, 20 mg / mL) by using the medium of Yeast Extract Sucrose (YES). The present study did not find any significant differences (P˃0.05) between the activity of aqueous and alcoholic extract in Ochratoxin A inhibition. The present study performed in the animal house of Biology department/Faculty of Education for Girls, twenty laboratory male rats of Sprague-Dawley strain were divided into four equal groups, the first group of animals (control) was orally administrated with normal saline solution (0,9%),the second group was orally given alcoholic extract of Ajwa dates at the concentration of (1) mg/kg, while the third group was orally treated with Ochratoxin A at the concentration of (289) μg /kg ,with regard to the last group was orally received alcoholic extract of Ajwa dates (1) mg/kg + Ochratoxin A (289) μg /kg respectively, the treatment of all animals was once daily for five days a week. During this study the body weight as well as the relative weights of liver and kidneys for rats were recorded, also the effectiveness of some hepatic enzymes (Aspartate amino transferase AST, Alanine amino transferase ALT and Alkaline phosphatase ALP) was estimated, in addition to the other biochemical parameters such as urea and creatinine levels, also the study was comprised the preparation of histological sections for liver and kidneys. The statistical analysis results of the current study were revealed ,Ochratoxin A caused a significant decrease (P˂0.05) in the body weight at the group of rats that treated with it when compared with the other experimental groups ,contrary to that, the Ochratoxin A showed a significant increase (P˂0.05) in the relative weights of liver and kidneys ,effectiveness of hepatic enzymes AST,ALT , ALP, levels of urea and creatinine at the male rats were submitted to this type of mycotoxin compared to the other groups of study. In relation with the microscopic examination of liver and kidney sections for the laboratory animals that treated with Ochratoxin A, several patho-histological changes were noted as compared with the other groups. From the results of this study can be concluded that the alcoholic extract of Ajwa dates was ameliorated the functional performance of both liver and kidneys through its preservative properties to protect the tissues of those organs from the nephrotoxicity and hepatotoxicity that induced by Ochratoxin A. Keywords: Ochratoxin A, Ajwa dates, Patho-histological effects, Biochemical properties
Formulation, Development Optimization of Miconazole Tablets for Buccal Drug Delivery System Sunil Reddy
Journal of Global Pharma Technology Volume 09 Issue 11
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Abstract

Objective the main objective of the present study was to develop sustained release formulation of Miconazole to maintain constant therapeutic levels of the drug for over 10 hrs.  Method various grades of HPMC were employed as polymers. Miconazole   dose was fixed as 100 mg. Total weight of the tablet was considered as 250 mg. Polymers were used in the concentration of 50 mg, 75mg and 100 mg concentration. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits.  Results From the dissolution studies it was evident that the formulation (F2) showed better and desired drug release pattern i.e., 98.56 % in 10 hours. Conclusion From the dissolution data it was evident that the formulations prepared with HPMC K100M as polymer were unable to retard the drug release up to desired time period i.e., 10 hours. Whereas the formulations prepared with HPMC K4M retarded the drug release in the concentration of 75 mg showed required release pattern i.e., retarded the drug release up to 10 hours and showed maximum of 98.56% in 10 hours with good retardation. It followed zero order release kinetics mechanism.Keywords:  Miconazole, HPMC, Buccal Tablets.
Synthesis of New Organic Compounds Via Three Components Reaction with Studying of (Identification ,Thermal Behavior, Bioactivity on Bacteria of Teeth) Nagham Mahmood Aljamali
Journal of Global Pharma Technology Volume 09 Issue 11
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Abstract

All  compounds  in  this  work  prepared  via  mannich   reaction   through  various  starting  materials  like  (  furan , thiophene ,  benzothiazole  derivatives  )  with   functional  groups  in   terminals  of  compounds  like ( hydroxyl  group , carboxyl  group ) ., our  method  involved  reaction  between  diamine  compounds   with  aromatic  aldehyde. then  identification  of  synthesized compounds  via  identification  techniques  ( FT.IR , H.NMR , Mass ) – spectrophotometric , studying  of  thermal   behavior   , studying  of  bioactivity  behavior  for  our  compounds  toward  types   of  bacteria  ( bacteria  of  Mouth like  ( Streptococcus  Mutans   ,   Streptococcus  Salivarius ) . Keywords: three components, bacteria, activity.
AN EFFICIENT MODEL FOR SUGARCANE YIELD PREDICTION sumathi A
Journal of Global Pharma Technology Volume 09 Issue 11
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Abstract

Sugarcane is one of India's most basic renewable business crops. Yield prediction is one of the important problems in agricultural field. Data mining techniques are better choice to solve this problem. Using different data mining techniques increase the sugarcane yield performance.

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