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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 63 Documents
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Search results for , issue "Volume 09 Issue 12" : 63 Documents clear
Cystatin C as Marker for Detection of Renal Function Change in Obstructive Uropathy Due to Ureteric Stone Mufeed J. Ewadh
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Objective: To Detection of Ureteric Stone Using Cystatin C "marker in Compare with serum Creatinine. Methods: Between September 2016 to February 2017 at Al-Hilla Teaching Hospital, Urology Department. The study group consisted of 25 healthy subjects as control with age between (20-66)year and 25 patients of Ureteric Stone with age from (20-62)year, the biochemical measurement including human CST3 (Cystatin C), ELISA kit used in the present study and serum Creatinine test used as biochemical diagnostic assessment. Results: Statistical analysis show significant difference (P<0.005) in the mean age (40.64±11.47), 21-30 years was the most influential of these disease compared with the other age groups. The percentages of males and females in patients group 16(64%) and 9(36%) respectively, while in the control group female were 14(56%), and male 11(44%) respectively. In total twenty five  patients  60% from the total  number  were unilateral and 40%  bilateral ureteric stone, study reveals that there was a significant increase (P. value<0.001) in the Cystatin C marker between study groups the mean value was (2.56 ±0.81) compared to  control group (0.82 ±0.17) with (P. value<0.001). Creatinine level revealed no significant association (p>0.05) between the level in the control and patients. In order to confirm the results of cystatin C levels using ELISA , the characteristic of the teqnique :Sensitivity (92%) , Specificity (96%).The characteristic of colorimetric methods test as compare to clinical diagnosis  in detection of Creatinine :Sensitivity (40%) , Specificity (88%). Conclusion: Cystatin C found to be a more accurate than Creatinine in detection the obstruction due to ureteric stone.Keywords: Creatinine, Stone, Cystatin C, Biochemical study, Urinary Tract.
Immunological Impact of Laser and Activated Carbon Nanoparticles on the Vaccination Efficiency with DTP Vaccine Kaiser N. Madlum
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Objective(s): This work aimed to investigate the possibility of using laser vaccine adjuvant (LVA) to enhance deeply injected intramuscular vaccination. The second aim was to detect the effect of super activated carbon nanoparticles (SACNP) on the immune response.  Materials and Methods: (DTP) vaccine was used in this study to vaccinate male rats intramuscularly (i.m.), after irradiation with either red (λ=635 nm) or green (λ=532 nm) laser lights. Blood samples were collected 14 days later.  Results: LVA caused dynamic alteration of rat immune response. It caused a significant elevation in the pro-inflammatory cytokines (IL-1β & IL-6) and anti-inflammatory cytokine (IL-4) levels. SACNP showed an attractive effect on immune response especially in the presence of laser light. Conclusion: This paper demonstrates the applicability of LVA for intramuscular vaccination. Red laser and SACNP, which is a new form of nanoparticles, show an attractive effect on immune response.Keywords: DTP, Laser adjuvant, Vaccination, Cytokines, Immune response, Bio stimulation.
The Adsorptive Removal of Sulfadiazine Drug from Aqueous Solution Using Poly (Acryl Amide-co-Crotonic Acid) Hydro Gels Layth Sameer Jasim
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

The adsorption of Sulfadiazine drug from aqueous solution has been investigated using acryl amide-co-crotonic acid croos-linked as the adsorbents. Batch kinetics and thermodynamics studies were carried out to evaluate the effect of contact time, ionic strength, pH and temperature. The calculated data were in accordance with Freundlich equation and the adsorption isotherms are of S-curve type according to Giles classification. The results obtained show greater adsorption uptake of the Sulfadiazine than Sulfathiazole on the hydro gels. The adsorption phenomenon was examined as a function of temperature (15, 25, 30 and 35oC). The extents of adsorption of durg on the hydro gels were found to decrease with increasing temperature (exothermic process). The basic thermodynamic functions have also been calculated. Adsorption on hydro gels surfaces was examined as a function of ph. The adsorbed amount of drug on surface was increased as the pH decreased. The adsorption process is affected by the electrolyte concentration. The results indicated an increase adsorption of drug in the presence of sodium hydrochloride.Keywords: Adsorption, Hydro gels, Sulfadiazine, Isotherms, Thermodynamic.
Oxidative Stress and Some Related Trace Elements in Women with Unexplained Infertility Khansaa A. Hussien
Journal of Global Pharma Technology Volume 09 Issue 12
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AbstractThis study aims to evaluate the oxidative stress and related trace elements (iron and copper) in women with unexplained infertility (UI). 60 women with unexplained infertility as well as (40) women with polycystic ovarian syndrome (PCOS) aged (20-35) year were included in this study. The women were divided according the type of infertility into primary and secondary groups (1ºUI, 2ºUI, 1ºPCO and2ºPCO) respectively. 50 healthy fertile women with the same age were included in this study as a control group. The results showed a significant increase in serum malondialdehyde (MDA) levels in all infertility groups compared to control group. Whereas serum levels of the antioxidants glutathione (GSH), superoxide dismutase (SOD) and ceruloplasmin (Cp) were significantly decreased in all infertility groups in comparison with control group. Serum levels of iron and copper significantly increase in unexplained infertility groups in comparison with explained infertility and control groups. No significant differences in iron levels between explained infertility groups and control. Whereas serum levels of the copper were significantly increased in explained infertility groups in comparison with control group. This study concluded that is a disturbance in serum oxidant- antioxidant balance in women with UI and PCOS infertility.Keywords: Unexplained infertility, Lipid per oxidation, Ceruloplasmin, Superoxide dismutase Iron, Copper.
Adsorption of Nitrate from Water by Zn-Al Layered Double Hydroxide Hamieda Eadan Salman
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Zinc-aluminum Layered double hydroxide was synthesized by copercipitation method in molar ratio Zn/Al 4:1.The prepared layered double hydroxide were characterized by Fourer-transform infrared spectra (FTIR),X-ray diffraction (XRD)and Atomic force microscope (AFM).The synthesized layered double hydroxides were used to study the adsorption of nitrate anion (NO3-) from water. The influence of some parameters on nitrate adsorption, including PH, temperature and adsorption of kinetics the results showed that the adsorption of nitrate anion (NO3-) on the surface of the layers (Zn/Al-LDH) increases by increasing the temperature but decreases by increasing the PH and the adsorption of isotherm is following the frindlch equation .The adsorption of kinetics were subjected to modified first grad false the lagergren equation. The thermodynamic parameters, such as (∆H, ∆G, ∆ S) clarified that the adsorption on the Zn/Al-LDH is endothermic and spontaneous.Keywords: Layered double hydroxide, Adsorption, Nitrate.
Synthesis of a New Three-Dimensional Network Co-polymer and Studying the Ability of Drug Delivery System Zahraa Mushtaq Abd Al-Aama
Journal of Global Pharma Technology Volume 09 Issue 12
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In this work, a new co- polymer was synthesized from the reaction of pentarythritol with fumaric acid to form the linear co- polymer. Three different moles of acrylic acid monomer (0.5, 1.0 and 1.5 mole), were added to obtain three new co- polymers. Swelling of the polymer samples were measured in the buffer solution in the basic and acidic medium. The albumin protein was loaded onto the co- polymer samples and then the release of the albumin protein was measured in the acid and basic medium. The results obtained showed that the protein loading and release process in the basic medium were higher than in the acidic medium, indicating that the combined co-polymer is selective in the medium.Keywords: Hydro gel; Polymer; Condensation polymerization; Three-dimensional network; Selectivity; Swelling; Buffer solution;  Drag delivery system.
Incidence of EBV and HTLV-1 Infection Associated With Leukemia Patients Ali Hussein Al-Marzoqi
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Multidrug insurance (MDR) in hurt cells is a phenotype whereby cells show decreased affectability to anticancer arrangements, in setting of a blend of instruments, joining a development in persevering efflux, the diminishment of pharmaceutical take-up, the incitation of cell change and survival hailing, the advance of DNA repair, and the impediment of apoptosis hailing. Widened verbalization of the plasma layer quiet efflux pumps, the ATP-confining tape (ABC) transporters, is associated with MDR. P-Glycoprotein/ABCB1 is a man from the ABC transporter family, and animates the efflux of various anticancer meds, including anthracyclines, vinca alkaloids, epipodophyllotoxins, taxanes, and kinase inhibitors, from cells. Infections by herpesviruses are enduring considers in patients being supervised for wearisome leukemia and those encountering bone marrow transplantation. Reactivation of endogenous sit without moving sullying caused by the immunosuppressive and cytotoxic effects of cytoreductive pharmaceuticals is a normal instrument of infection. With HTLV-1 securing of exogenous contamination by transfusion of blood things containing sickness and from the bone marrow join by restraint of bone marrow transplantation can happen.Keywords: Human T-lymphotropic Virus; Herpesvirus; ABC; MDR.
Isolation and Identification of Some Pathogenic Bacteria from Otitis Media in Babylon Governorate Hawraa Jawad Kadhim
Journal of Global Pharma Technology Volume 09 Issue 12
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This study was conducted for the period from February to November 2016 in Babylon Teaching Hospital , during this period, 200 swab ear of people with otitis media in the city of Babylon were collected . 120 sample was diagnosed with bacterial isolates depending on morphology on the different culture media and some biochemical tests. The highest rate of infection in the age group (21-40)years , and the least in the age group (41-60)years as it was(46 %,15%)respectively. In this study were isolate five types of a bacteria (Pseudomonas aeruginosa,  Staphylococcus aureus , Escherichia coli, Streptococcus pneumonia and Klebsiella pneumonia) and the highest rate of infection has reached (35 %, Pseudomonas aeruginosa), ( 26%,Staphylococcus aureus). As for the results of examination of the sensitivity of the bacterial isolates to antibiotics was the highest rate of antibiotic resistance was (94%Tetracyclin, 92%Ampicilin and 91% Chloramphenicol), while the resistance decreased in the case of antibiotics (42%Amikacin, 42%Gentamicin and 31%Tobramycin). Streptococcus pneumonia were detected by PCR , 16 cases were PCR positive for Streptococcus pneumonia , there was no samples displayed culture positive and PCR negative for Streptococcus pneumonia .Keywords: Pathogenic bacteria, Otitis media, Sensitivity test, PCR.
Synthesis, Characterization, Antimicrobial of Studies New 2, 2'-[(1Z, 2Z)-ethane-1, 2 Diylidenedi (2Z) Hydrazin-1-yl-2-ylidene] bis (5-phenyl-1, 3, 4-Oxadiazole) and their Transition Metal Complexes Ibrahim A. Flifel
Journal of Global Pharma Technology Volume 09 Issue 12
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A new ligand 2,2'-[(1Z,2Z)-ethane-1,2-diylidenedi(2Z)hydrazin-1-yl-2-ylidene]bis(5-phenyl-1,3,4-oxadiazole) and its Cr (III) , Co (lll) and Ni (ll) complexes were synthesized . The new ligand and its complexes have been characterization on the basis their spectra of1HNMR, mass, Fourier transform infrared (FTIR), as well as magnetic susceptibility, elemental analysis[C, H, N] and conductance measurements. The program of hyper hem 7.51 has been used up for theoretical accounts using PM3 method [1] to study the electrostatic potential that provided good information about the complexity site. Of the results obtained we can suggest octahedral geometrics for Cr (III) and Co (III) complexes, while tetrahedral geometry for Ni (II) complex. A ligand and its complexes were screened for their antibacterial activity against two kinds of strains Escherichia coli (gram negative bacterial strains) and staphylococcus aureus (gram positive bacteria strains), this research showed excellent results in comparison with Ciprofloxacin as standard drug.Keywords: Ligand, Complexes, Characterization, Hyper Chem, Electrostatic potential, Antibacterial.
The Prevalence of the Gram Positive and Gram Negative Bacteria in Open Fractures and their Resistance Profiles to Antimicrobial Agents Aamal Ghazi Mahdi Al-Saadi
Journal of Global Pharma Technology Volume 09 Issue 12
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Objectives:  We aimed to evaluate the bacteriology of open fractures and to determine the susceptibility patterns of the identified bacterial species to some antimicrobial agents. Methods:  150 superficial swabs were collected from open fracture wounds of patients visited private fractures clinics in Al- Diwaniya city/ Iraq in a period from January to December 2016. Bacterial species recovered from the collected samples were identified by cultural, morphological and biochemical characteristics, then confirmed using Vitek2 compact system. Susceptibility to antimicrobial agents was determined using disc diffusion method. Results: A total of 119 bacterial isolates were obtained from culture positive fracture wounds. The most frequent identified bacterial species was Staphylococcus aureus (23.52%)  followed  by Acinetobacter spp ( 19.32%) ,then E.coli (14.28%), Pseudomonas spp (11.76%), Enterobacter spp ( 9.24%), Klebsiellaspp (6.72%), Coagulase Negative Staphylococci (5.04%), Citrobacterspp (4.20%), Proteus spp (2.52%), Diphtheroids (0.84),Streptococcus pyogenes (0.84%), Viridans streptococci(0.84%),  Micrococcus spp (0.84%).Most of isolates ( 64.70%) were obtained from upper extremities compared with the lower extremities (35.29%). The average resistance rate of  Staphylococcus aureus in the current study was (38.31%), the Coagulase Negative Staphylococci( 26.7%), Diphtheroids (70%), Streptococcus pyogenes (40%), Viridans streptococci( 20%), and Micrococcus spp(10%)., Acinetobacter spp (58.36%), E.coli (43.58%), Pseudomonas spp(62.19%), Enterobacter spp (48.21%), Klebsiella spp (40%), Citrobacter spp (32.5%), Proteus spp (35%).  Inhibitory effects of citric acid and vinegar on all isolated bacterial species growth were recorded. Conclusion: S. aureus and Acinetobacter spp were the predominant bacterial species isolated from open fractures patients with extensive antibiotic resistance patterns for most of isolated bacterial species underscoring the need to monitor the antibacterial resistance pattern routinely in order to select the right prophylaxis and treatment to open fracture wounds infections. The use of citric acid and vinegar is recommended to effectively eliminate multiple antibiotic resistant bacteria in open fractures.Keywords: Open fractures, Gram positive bacteria, Gram negative bacteria, Antimicrobial agents.

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