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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 19 Documents
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Search results for , issue "Volume 10 Issue 01" : 19 Documents clear
Thermodynamic Study of Reaction of Formation of Cd2 + Cation Complex and 18-Crown-6 Ligand in Two-Component Mixtures of Methanol / Ethyl Acetate, Acetonitrile / Ethyl Acetate, Tetrahydrofuran / Acetonitrile, Methanol / Dimethyl Formamide, Acetonitrile / Methanol And Dimethyl Sulfoxide / Acetonitrile Using Conductometry Method Ali Mohebi
Journal of Global Pharma Technology Volume 10 Issue 01
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Abstract

The reaction of formation of complex between Cd2 + cation and large ring ligand of 18-crown-6 in solvent systems of methanol / ethyl acetate, methanol / dimethyl formamide, methanol / acetonitrile, acetonitrile / ethyl acetate, acetonitrile / tetrahydrofuran, and acetonitrile / dimethyl sulfoxide was studied at different temperatures by conductometry method. The obtained results indicate that the formed complexes have a stoichiometry of 1: 1 [ML]. The values of the complex stability constants, determined by using conductometry data, show that the formed complex stability is affected by the nature and composition of the solvent. In all two-component mixtures of solvents, a nonlinear relationship is observed for variations in stability constant of the complex, formed by the composition of the solvent. This type of behavior is attributed to solvent-solvent interactions in solvent binary mixtures. The values of the thermodynamic parameters (ΔH ° c, ΔS ° c, ΔG ° c) for the complex have been obtained from temperature dependency of the stability constants. These results showed that the reaction thermodynamics of the formation of the complex is affected by the nature and composition of the mixture of solvents. In the studied solvent systems, entropy or enthalpy, and in some cases, both factors were favorable for complex formation.Keywords: Thermodynamics, 18-Crown-6, CD2 + Cation, Non- Aqueous Two-Component Mixture Solvent, Conductometry.
Preparation, Spectral Investigation, Thermal Analysis, Biochemical Studying of New (Oxadiazole - Five Membered Ring)- Ligands Nagham Mahmood Aljamali
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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Abstract

A series of oxadiazole- Azo ligands have been synthesized via  many  steps  sequence. Oxadiazole -azo  ligands   were prepared through   reacting  azo–oxadiazole  derivatives  with phenol  heterocyclic  derivatives  diazotized   then  coupled   via   coupling  reaction  followed  by  cyclization  reaction   to  yield   azo- heterocycles   derivatives   which  act   five  membered  ring. The structures of the newly  prepared    Ligands  were  identified   through  more  than   technique  like (1H NMR, IR and Mass spectra) ,(Thermal ,microbial  assay ) for  all  ligands.Keywords: Oxadiazole, Thiosemicarbazide, Thiadiazol, Cyclization, Azo,Imidazole, Oxazole, Thiazole.
Thiadiazole Cyclic Derivatives from Aldamine Compounds (Preparation, Characterization, Thermal Stability) Athraa Sahib Alrammahi
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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Abstract

Seven  heterocyclic  derivatives  were  synthesized  by   using  Azotation  reaction  ,followed  by  coupling  reaction  with  phenol  derivative  , the  resulting   compound  cyclized   with  thiosemicarbazide   to  yield  thiadiazole  derivatives  which  reacted  with  carbonyl  compound ( benzaldehyde) with  drops  of  glacial   acetic  acid  to  produce  imine  compound   followed  by  breaking  of  imine  bond (CH=N) to  react   with  ( succinic  anhydride , chloroaceto chloride  , glycine , ortho mercapto benzoic  acid )  to  yield  cyclic  derivatives  from  Aldamine-thiadiazole  derivatives.  Thiadizole-aldamine  derivatives   were  characterized   by  chemical   techniques  such as (1H NMR , IR  and  Mass-  spectra ,  Thermal  Stability).Keywords: Therm, Technic, Stable.
Herbal cure for the leukemia- A challenging progression Kirthika Dhanraj; Anitha Joseph; Renuka Saravanan; Sivakumar Ramalingam
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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Abstract

Traditional medicine system is still used by approximately 65-80% of the world’s population in developing countries because of its fewer side effects. Most of the molecules derived from plants are effective against different cancer with different targets. The review mainly deals different plants such as Alisma orientale, Annona glabra L, Tinospora cordifolia, Euphorbia formosana Hayata which are used in the treatment of leukemia. It throws light on the therapeutic efficacy of different plant molecules such as berberine, flavanoids, caffeic acid and kolavirion with the mode of action in different cells, which have already been used for the treatment of leukemia. This review will promote research towards the development of plant based drugs which could be used for the treatment for the cancer.Key words: Leukemia, Medicinal plants, Phytoconstituents and HL-60. 
Preparing, Identifying, and Electrochemical Studying of Cobalt Complexes with Aspartate and Benzoate Ligands and Comparing Their Consumption Rates in Food Industry Ali Bakhshi
Journal of Global Pharma Technology Volume 10 Issue 01
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Abstract

Aspartame is a synthetic sweetener and sodium benzoate is the second most consumable preservative substance, used widely nowadays in processing and packaging foods. Excessive consumption of these additives is harmful for health, and uncontrolled consumption of these additives is associated with side effects. In this research, the interaction between cobalt metal and aspartate and benzoate ligands was examined to evaluate their reactivity and the obtained product was identified by FT-IR and UV-VIS methods and examined electrochemically by cyclic voltammeters. The FT-IR spectrum of the resulting complex showed the frequencies of 2956, 3133 and 3321 for groups C = O and C = N, and the transfer electron spectrum related to ligand at 700,1738 and 3207 nm range, and the d-d metal transfers in the 380 and 630 nm range.Keywords: Aspartame, Sodium Benzoate, Electrochemical, Cobalt (II) Nitrate
Azotation and Coupling Reaction of Amino Oxadiazole Ligands with (Characterization, Chromatography, Solubility) Study Muhammed Abdel Hasan Shallal
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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This  paper  involved   reaction  between   two moles of   semicarbazide   with  mole  of  diethyl malonate which   refluxed   for ( 17 hrs ) in absolute  ethanol   then  added ( 4 ml ) of  H2SO4 to produce amino  oxadiazole  , the  resulting  compound   used     in  azotation  then  coupling   reaction with  various   coupling  derivatives   of  phenol ( p-hydroxy benzaldehyde , p-hydroxy benzoic acid , p-hydroxy  nitrobenzene , p- hydroxyl toluene , p- hydroxyl phenol )to produce novel  oxadiazole   derivatives   as  a ligands .The above  ligands  were investigated    through   their spectral  methods  (UV- Vis , FTIR  ,1HNMR  , Mass ) , Chromatography  technique   and  studying  of  solubility  in  series   solvents.Keywords: Soluble, Series, Hydroxyl.
Effect of Prebiotic Plus Xylanase Enzymes in Reduced-Energy High Wheat Midd Diets on Broilers Subjected to Bursa Vaccine and Clostridium Perfringens Challenge under Heat Stress Y. J. Jameel
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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Abstract

This study was designed to evaluate the effect of chronic heat stress (CHS) and pathogen challenge on broilers fed reduced energy, high wheat Midd (WM) diets with or without a mixture of yeast cell wall (YCW) and xylanase enzyme (XE) on performance, carcass fat percentage and the evaluation of diet and meat cost. Two hundred forty (1- day old) chicks (Ross 308) were distributed within 2 Petersime battery brooder units (48 pens: 5 birds per pen). For this experiment, treatments were assigned as an incomplete randomized block design with 6 treatments arranged as a factorial 3 × 2 with 3 levels of energy (3000, 2900, and 2800) and 2 treatments with or without supplementing mixture of (YCW 250 ppm plus XE 25/mg per ton) were used. Chronic heat stress CHS was induced by setting the HVAC system at 36± 2ºC from day one until the end of the study (day 24). Birds were vaccinated with a commercial IBD vaccine via eye drop at 10 days of age, followed by Clostridium perfringens challenge on day 16 and 17 of the study by 3/mL oral gavages 106 cfu/ml. Results revealed that the body weight (BW), body weight gain (BW gain), Productivity Index (PI), and feed conversion ratio (FCR) of chicks fed low energy (2800 Kcal with YCW and XE; PVL) then (2900 Kcal with YCW and XE; PL) respectively, were improved numerically but not significantly (P˃0.05) at days 10, 16, 21, and 24 as compared with chicks fed high energy (3000 Kcal with (PC) or without (NC) YCW and XE. Also, no significant differences were found by dual energy X-ray absorptiometry (DEXA scan) among the treated groups, but % fat of birds fed low energy (2800 Kcal plus YCW and XE; PVL) were decreased (P˃0.05) as compared with chicks fed high energy (3000 Kcal with (PC) or without (NC) YCW and XE). However, average cost of the feed and meat were lower of treatment administration diet have 2800, and 2900 Kcal as compared with 3000 Kcal diets. In conclusion, reduced energy diets did not affect under HS may be low energy decrease heat increment. Chicks fed low energy with or without YCW and XE led to enhance performance and lower carcass fatpercentage. In addition, low energy diet led to lower the cost of diets and meat. Keywords: Broiler, performance, reduced energy, heat stress, xylanase, prebiotics.
Adsorption of 1- (2--Hydroxy - 4--Nitrophenyl azo)-2- Napthol Dye onto the Cement Kiln Dust (CKD) Nemah Sahib Mohammed Hussian
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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Abstract

The adsorption of 1-(2¯- Hydroxy-4¯-nitrophenyl azo) -2-naphthol dye onto the Cement Kiln Dust (CKD) was studied in the temperature range 298-328K. The sorption process was examined in terms of its equilibria and kinetics. Batch adsorption experiments were conducted to evaluate the percentage removal of 1-(2--Hydroxy -4- - nitrophenyl azo)-2-napthol onto CKD waste at operation conditions of sorbate concentration, pH, contact time, sorbent dose. Time-dependent experiments for the removal efficiency required a shortest contact time, i.e , binding to the CKD was rapid and occurred within 25 min. Adsorption isotherms equations were tested for all of Langmuir, Freundlich, Temkin,3 Dobinin-Radushvich, and Elovich. The equilibrium adsorption data were fitted to Freundlich and Temkin isotherms at 298K. Adsorption followed Intra – partical - diffusion rate kinetics.   Thermodynamic parameters ΔG*, ΔH*, ΔS* and Ea were computed, and showed that the adsorption process onto CKD was exothermic and non-spontaneous. Also adsorption studies suggest that physisorption might be the major mode of adsorption and CKD expressed as low affinity for removal of 1-(2¯- Hydroxy-4¯-nitrophenyl azo) -2-naphthol Dye onto the Cement Kiln Dust  that the high percentage removal was found ≈50%  at 298K , pH=6.Keywords: Cement Kiln Dust; Azo dyes; Adsorption isotherms; Kinetic study; Thermodynamic study.
Studying Aura in Hafiz’ Poetry Based on New Criticism School Mohammad Reza Roozbeh
Journal of Global Pharma Technology Volume 10 Issue 01
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Abstract

The aura is one of the desired principles of new criticism school. It can be known as a quality that the art works should have. According to a special place that Hafez’ poetry has found in the mind and language of world, it is considered as one of the outstanding examples for studying the aura element. Since it is essential for Mission of the school of new criticism not to understand the quiddity of aura but how to be created it in a work of art, in this literary investigation we have studied the features that create the aura in Hafiz’ poetry; we examined the factors that cause these features and introduce each of these factors with some examples. The other achievement of this article is to explain the linguistic structures and intellectual factors that generate the aura of Hafez’ poetry.Keywords: New criticism, Luminosity, Linguistic constituents, Intellectual themes.
Criminological Analysis of Sexual Slavery Mehdi Zakavi
Journal of Global Pharma Technology Volume 10 Issue 01
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Sexual slavery as an organized crime in the 21st century has become a proplem for human societies and is expanding and due to the lack of strong implementation guarantee and comprehensive and restricted rules in order to give an answer to these uncontrolling conditions and disrespects to the extent of value and dignity of human, this phenomenon of the century is rising day by day. This study is aimed to investigate the reasons and factors of prevalence of sexual slavery in the present century which has been studied and analyzed by library and internet studies and news sites. According to obtained results several reasons have caused this global scourge to be occurred such as problems and poverty, unwariness, changing position and lack of prosecution due to the fear of prestige and such factors from the side of victims themselves, low cost, high profit of this dirty business, not getting caught the perpetrators of these crimes and their enjoyment of broad support. This dilemma, which is hated by all international societies, is sharply growing and is considered as a very important source of income. There is a need for a strong determination at national and international levels by concluding protocol and law and implementation guarantee and informing and training individuals through mass media as well as to support the victims of these crimes in order to serious fight agaist this problem.Keywords: Sexual slavery, Organizing, Crime against humanity, Human trafficking.

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