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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 12 Documents
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Search results for , issue "Volume 10 Issue 01: (2018) Jan. 2018" : 12 Documents clear
Preparation, Spectral Investigation, Thermal Analysis, Biochemical Studying of New (Oxadiazole - Five Membered Ring)- Ligands Nagham Mahmood Aljamali
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
Publisher : Journal of Global Pharma Technology

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A series of oxadiazole- Azo ligands have been synthesized via  many  steps  sequence. Oxadiazole -azo  ligands   were prepared through   reacting  azo–oxadiazole  derivatives  with phenol  heterocyclic  derivatives  diazotized   then  coupled   via   coupling  reaction  followed  by  cyclization  reaction   to  yield   azo- heterocycles   derivatives   which  act   five  membered  ring. The structures of the newly  prepared    Ligands  were  identified   through  more  than   technique  like (1H NMR, IR and Mass spectra) ,(Thermal ,microbial  assay ) for  all  ligands.Keywords: Oxadiazole, Thiosemicarbazide, Thiadiazol, Cyclization, Azo,Imidazole, Oxazole, Thiazole.
Thiadiazole Cyclic Derivatives from Aldamine Compounds (Preparation, Characterization, Thermal Stability) Athraa Sahib Alrammahi
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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Seven  heterocyclic  derivatives  were  synthesized  by   using  Azotation  reaction  ,followed  by  coupling  reaction  with  phenol  derivative  , the  resulting   compound  cyclized   with  thiosemicarbazide   to  yield  thiadiazole  derivatives  which  reacted  with  carbonyl  compound ( benzaldehyde) with  drops  of  glacial   acetic  acid  to  produce  imine  compound   followed  by  breaking  of  imine  bond (CH=N) to  react   with  ( succinic  anhydride , chloroaceto chloride  , glycine , ortho mercapto benzoic  acid )  to  yield  cyclic  derivatives  from  Aldamine-thiadiazole  derivatives.  Thiadizole-aldamine  derivatives   were  characterized   by  chemical   techniques  such as (1H NMR , IR  and  Mass-  spectra ,  Thermal  Stability).Keywords: Therm, Technic, Stable.
Herbal cure for the leukemia- A challenging progression Kirthika Dhanraj; Anitha Joseph; Renuka Saravanan; Sivakumar Ramalingam
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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Traditional medicine system is still used by approximately 65-80% of the world’s population in developing countries because of its fewer side effects. Most of the molecules derived from plants are effective against different cancer with different targets. The review mainly deals different plants such as Alisma orientale, Annona glabra L, Tinospora cordifolia, Euphorbia formosana Hayata which are used in the treatment of leukemia. It throws light on the therapeutic efficacy of different plant molecules such as berberine, flavanoids, caffeic acid and kolavirion with the mode of action in different cells, which have already been used for the treatment of leukemia. This review will promote research towards the development of plant based drugs which could be used for the treatment for the cancer.Key words: Leukemia, Medicinal plants, Phytoconstituents and HL-60. 
Azotation and Coupling Reaction of Amino Oxadiazole Ligands with (Characterization, Chromatography, Solubility) Study Muhammed Abdel Hasan Shallal
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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This  paper  involved   reaction  between   two moles of   semicarbazide   with  mole  of  diethyl malonate which   refluxed   for ( 17 hrs ) in absolute  ethanol   then  added ( 4 ml ) of  H2SO4 to produce amino  oxadiazole  , the  resulting  compound   used     in  azotation  then  coupling   reaction with  various   coupling  derivatives   of  phenol ( p-hydroxy benzaldehyde , p-hydroxy benzoic acid , p-hydroxy  nitrobenzene , p- hydroxyl toluene , p- hydroxyl phenol )to produce novel  oxadiazole   derivatives   as  a ligands .The above  ligands  were investigated    through   their spectral  methods  (UV- Vis , FTIR  ,1HNMR  , Mass ) , Chromatography  technique   and  studying  of  solubility  in  series   solvents.Keywords: Soluble, Series, Hydroxyl.
Effect of Prebiotic Plus Xylanase Enzymes in Reduced-Energy High Wheat Midd Diets on Broilers Subjected to Bursa Vaccine and Clostridium Perfringens Challenge under Heat Stress Y. J. Jameel
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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This study was designed to evaluate the effect of chronic heat stress (CHS) and pathogen challenge on broilers fed reduced energy, high wheat Midd (WM) diets with or without a mixture of yeast cell wall (YCW) and xylanase enzyme (XE) on performance, carcass fat percentage and the evaluation of diet and meat cost. Two hundred forty (1- day old) chicks (Ross 308) were distributed within 2 Petersime battery brooder units (48 pens: 5 birds per pen). For this experiment, treatments were assigned as an incomplete randomized block design with 6 treatments arranged as a factorial 3 × 2 with 3 levels of energy (3000, 2900, and 2800) and 2 treatments with or without supplementing mixture of (YCW 250 ppm plus XE 25/mg per ton) were used. Chronic heat stress CHS was induced by setting the HVAC system at 36± 2ºC from day one until the end of the study (day 24). Birds were vaccinated with a commercial IBD vaccine via eye drop at 10 days of age, followed by Clostridium perfringens challenge on day 16 and 17 of the study by 3/mL oral gavages 106 cfu/ml. Results revealed that the body weight (BW), body weight gain (BW gain), Productivity Index (PI), and feed conversion ratio (FCR) of chicks fed low energy (2800 Kcal with YCW and XE; PVL) then (2900 Kcal with YCW and XE; PL) respectively, were improved numerically but not significantly (P˃0.05) at days 10, 16, 21, and 24 as compared with chicks fed high energy (3000 Kcal with (PC) or without (NC) YCW and XE. Also, no significant differences were found by dual energy X-ray absorptiometry (DEXA scan) among the treated groups, but % fat of birds fed low energy (2800 Kcal plus YCW and XE; PVL) were decreased (P˃0.05) as compared with chicks fed high energy (3000 Kcal with (PC) or without (NC) YCW and XE). However, average cost of the feed and meat were lower of treatment administration diet have 2800, and 2900 Kcal as compared with 3000 Kcal diets. In conclusion, reduced energy diets did not affect under HS may be low energy decrease heat increment. Chicks fed low energy with or without YCW and XE led to enhance performance and lower carcass fatpercentage. In addition, low energy diet led to lower the cost of diets and meat. Keywords: Broiler, performance, reduced energy, heat stress, xylanase, prebiotics.
Adsorption of 1- (2--Hydroxy - 4--Nitrophenyl azo)-2- Napthol Dye onto the Cement Kiln Dust (CKD) Nemah Sahib Mohammed Hussian
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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Abstract

The adsorption of 1-(2¯- Hydroxy-4¯-nitrophenyl azo) -2-naphthol dye onto the Cement Kiln Dust (CKD) was studied in the temperature range 298-328K. The sorption process was examined in terms of its equilibria and kinetics. Batch adsorption experiments were conducted to evaluate the percentage removal of 1-(2--Hydroxy -4- - nitrophenyl azo)-2-napthol onto CKD waste at operation conditions of sorbate concentration, pH, contact time, sorbent dose. Time-dependent experiments for the removal efficiency required a shortest contact time, i.e , binding to the CKD was rapid and occurred within 25 min. Adsorption isotherms equations were tested for all of Langmuir, Freundlich, Temkin,3 Dobinin-Radushvich, and Elovich. The equilibrium adsorption data were fitted to Freundlich and Temkin isotherms at 298K. Adsorption followed Intra – partical - diffusion rate kinetics.   Thermodynamic parameters ΔG*, ΔH*, ΔS* and Ea were computed, and showed that the adsorption process onto CKD was exothermic and non-spontaneous. Also adsorption studies suggest that physisorption might be the major mode of adsorption and CKD expressed as low affinity for removal of 1-(2¯- Hydroxy-4¯-nitrophenyl azo) -2-naphthol Dye onto the Cement Kiln Dust  that the high percentage removal was found ≈50%  at 298K , pH=6.Keywords: Cement Kiln Dust; Azo dyes; Adsorption isotherms; Kinetic study; Thermodynamic study.
Genotype and Phenotype Detection of E. coli Isolated from Children Suffering from Urinary Tract Infection Zahraa Hameed Oda Alquraishi
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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One hundred clinical urine samples were obtained from patients suffering from UTI during the period from 1, August, 2017 to 9, October, 2017. Methodology: The identification of the E. coli isolates was depended on colonial morphology, microscopic examination and biochemical tests as a primary identification. The final identification was performed by PCR technique with Mdh. In addition antibiotic genes were used such as (bla-CTM, blatem-1, aac (6) - Ib-crandsul-1). Result: Rendering  to  the  results  obtained  according to the morphological ,cultural and biochemical characters from 100 sample  only   80 (80%) isolate was  identify as  E. coli. According  to  the  results  obtained  by  PCR, Mdh gene  that  encode  was found in 56 (70%) isolates in  E. coli. The results of PCR revealed that the percentage of bla-CTX-M gene among tested isolates reached to 30/56(53.57%), 10/56(17.85%)   for blaTEM-1, 13/56(23.2%) for aac (6’)-Ib –cr and 33/42 (78.57%) for Sul-1gene. Conclusion: The  study  investigated  the  antibiotic resistance genes  of  E. coli which  play a major  role  in pathogen city .Keywords: E. coli, Urinary tract infection and antibiotic resistance genes.
Effect of Adding Different Concentrations of the Mint oil Mentha spicata L. to the Ration on Some Blood Traits of Broiler Chicks Ross 308 Nihad Abdul-Lateef Ali
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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This study was conducted at poultry farm of Animal Resources Dept., College of Agriculture, and University of AL-Qasim Green to investigate the effect of adding different concentrations of the Mint oil Menthaspicata L. to the ration on some blood traits of broiler chicks Ross 308. Use the 144 broiler chicks Ross 308 day-old were randomly assigned to four treatments by 3 replicates per treatment (12 chicks per replicate). The treatments were as follows: The first treatment (control) without adding mint oil to the ration. Adding mint oil at a concentration of 600 mg / kg basal feed (second treatment). While third treatment had mint oil at a concentration of 800 mg / kg feed. Adding mint oil at a concentration of 1000 mg / kg feed (fourth treatment). The study included the following characteristics: red blood cell counts, white blood cell counts, hematocrit, hemoglobin concentration and differential leucocyte count. The results indicated that the addition of mint oil at a concentration of 600 ، 800 and 1000 mg / kg feed to broiler ration led to a significant improvement in white blood cell counts of broiler chick’s ، and addition of 1000 mg Mint oil / kg of significantly improved the lymphocytes cell compared to the first treatment (control) and the second treatment. Keywords: Mint oil, Broiler chicks, Blood parameters.
Effect of Magnetized Water on Reducing the Histological and Physiological Effects of Experimental Infection with Ascaridia galli in Domestic Chicken Sukayna Jabbar Mushattat
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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The current study was carried out to determine the effect of magnetized water in reducing the damage of Ascaridia galli parasites. 45 local chickens were divided randomly in to three groups G1 control group, G2 infected group, and G3 infected and treatment with magnetized water. In all groups 15 lacal chickens. Results showed a significant improvement in the blood parameters of RBC, WBC, MDA.SOD, Ca, CL, Na in G3 treated with magnetized water compared with the rest of the groups G1 and G2, where the results showed significant decrease in RBC measurement and significant increase in measurement WBC in G2 compared with the rest of the groups and with a potential P <0.05. The histological study of the intestinal tract showed a significant improvement in the magnetized water treatment group. The histological study of the intestinal tract showed significant improvement in the treated group with magnetized water G3 Where the histological sections showed re-spawning in the vesicles and epithelial layer lining the intestines and the lack of necrosis in the intestinal wall and the lack of lymphocyte infiltration in addition to the number of larval stages of Ascaridia galli in the intestinal epithelium.Keywords: Infiltration, chicken.
Impact of Folic Acid and Cyanocobalamin on Growth, Milk Yield and its Components of Awassi Ewes and their Lambs Mozhir K.K. Almahdawi
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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The aim is to knowledge of vital role of folic acid and B12 vitamin on growth, milk production, milk components of Awassi sheep and their lambs.This experiment was carried out on 24 head of pregnant Awassi ewes with lambing of them in one of the private farms at Altagia village in southern of Hilla city. The experiment was included two phases, the first phase were dosage to Awassi ewes with two vitamins by mouth during experiment periods through estrus, gestation and parturition. The animals were randomly distributed into four treatments, the first treatment (control) without vitamins, second treatment was daily treated by 5mg/ewe of folic acid and third treatment was dosage of cyanocobalamin (B12 vitamin) with 225 μgm per ewe at twice time every week and fourth treatment were combination treated of folic acid and B12 vitamin as the same concentrations above. The second phase of the experiment, which began from birth of lambs and lasted weaning age ( 90 days).The lambs were dosage with two vitamins by mouth method after four hours of their born as the same mentioned of ewes in the first phase of experiment .The lambs were randomly distribution into four treatments, the first treatment was called control treatment without treated any vitamins and the second treatment were dosage with 1mg of folic acid to twice time per week, as well as the third treatment were treated with 125 μgm of B12 vitamin for twice time per week, As either fourth treatment the animals were mixture dosage of two vitamins (folic acid, cyanocobalmine) in the same concentrations. The results of statistical analysis of the first phase indicated the existence of significant differences (P≤0.05) on the averages of ewe’s weights at parturition and weaning, amount of daily feed intake, proportion of milk sugar, total protein and triglycerides of blood. As well as the results indicated high significant differences (P≤0.01) on the average of weights of ewes at the end of gestation, feed conversion , daily milk production , moisture, crude protein, crude fat non fats , total solids of milk and concentrations of cholesterol and albumin in blood of ewes. As for the second phase the results were shown significant differences (P≤0.05) on average amount of daily feed intake, total protein, albumin, triglycerides and cholesterol in the blood of lambs and another beside ,the results indicated high significant differences (P≤0.01) on average of live weight of lambs at birth and weaning, amount of daily feed intake and daily and total weight gains, and cholestrol concentration in the blood of Awassi lambs. We conclude that animals were dosages of folic acid with B12 vitamin were improving of health status and to improve significantly in most of traits of productive performance, growth and blood characteristics of ewes and their lambs as compared to the control treatment. Keywords: Folic acid, B12 vitamin, Milk yield, Milk components, Blood proteins.

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