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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 19 Documents
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Search results for , issue "Volume 10 Issue 01" : 19 Documents clear
Genotype and Phenotype Detection of E. coli Isolated from Children Suffering from Urinary Tract Infection Zahraa Hameed Oda Alquraishi
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
Publisher : Journal of Global Pharma Technology

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Abstract

One hundred clinical urine samples were obtained from patients suffering from UTI during the period from 1, August, 2017 to 9, October, 2017. Methodology: The identification of the E. coli isolates was depended on colonial morphology, microscopic examination and biochemical tests as a primary identification. The final identification was performed by PCR technique with Mdh. In addition antibiotic genes were used such as (bla-CTM, blatem-1, aac (6) - Ib-crandsul-1). Result: Rendering  to  the  results  obtained  according to the morphological ,cultural and biochemical characters from 100 sample  only   80 (80%) isolate was  identify as  E. coli. According  to  the  results  obtained  by  PCR, Mdh gene  that  encode  was found in 56 (70%) isolates in  E. coli. The results of PCR revealed that the percentage of bla-CTX-M gene among tested isolates reached to 30/56(53.57%), 10/56(17.85%)   for blaTEM-1, 13/56(23.2%) for aac (6’)-Ib –cr and 33/42 (78.57%) for Sul-1gene. Conclusion: The  study  investigated  the  antibiotic resistance genes  of  E. coli which  play a major  role  in pathogen city .Keywords: E. coli, Urinary tract infection and antibiotic resistance genes.
Effect of Adding Different Concentrations of the Mint oil Mentha spicata L. to the Ration on Some Blood Traits of Broiler Chicks Ross 308 Nihad Abdul-Lateef Ali
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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Abstract

This study was conducted at poultry farm of Animal Resources Dept., College of Agriculture, and University of AL-Qasim Green to investigate the effect of adding different concentrations of the Mint oil Menthaspicata L. to the ration on some blood traits of broiler chicks Ross 308. Use the 144 broiler chicks Ross 308 day-old were randomly assigned to four treatments by 3 replicates per treatment (12 chicks per replicate). The treatments were as follows: The first treatment (control) without adding mint oil to the ration. Adding mint oil at a concentration of 600 mg / kg basal feed (second treatment). While third treatment had mint oil at a concentration of 800 mg / kg feed. Adding mint oil at a concentration of 1000 mg / kg feed (fourth treatment). The study included the following characteristics: red blood cell counts, white blood cell counts, hematocrit, hemoglobin concentration and differential leucocyte count. The results indicated that the addition of mint oil at a concentration of 600 ، 800 and 1000 mg / kg feed to broiler ration led to a significant improvement in white blood cell counts of broiler chick’s ، and addition of 1000 mg Mint oil / kg of significantly improved the lymphocytes cell compared to the first treatment (control) and the second treatment. Keywords: Mint oil, Broiler chicks, Blood parameters.
Effect of Magnetized Water on Reducing the Histological and Physiological Effects of Experimental Infection with Ascaridia galli in Domestic Chicken Sukayna Jabbar Mushattat
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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Abstract

The current study was carried out to determine the effect of magnetized water in reducing the damage of Ascaridia galli parasites. 45 local chickens were divided randomly in to three groups G1 control group, G2 infected group, and G3 infected and treatment with magnetized water. In all groups 15 lacal chickens. Results showed a significant improvement in the blood parameters of RBC, WBC, MDA.SOD, Ca, CL, Na in G3 treated with magnetized water compared with the rest of the groups G1 and G2, where the results showed significant decrease in RBC measurement and significant increase in measurement WBC in G2 compared with the rest of the groups and with a potential P <0.05. The histological study of the intestinal tract showed a significant improvement in the magnetized water treatment group. The histological study of the intestinal tract showed significant improvement in the treated group with magnetized water G3 Where the histological sections showed re-spawning in the vesicles and epithelial layer lining the intestines and the lack of necrosis in the intestinal wall and the lack of lymphocyte infiltration in addition to the number of larval stages of Ascaridia galli in the intestinal epithelium.Keywords: Infiltration, chicken.
The Role of Know About Business (Kab) Entrepreneurship Training in Creating Entrepreneurship Skills in Trainees of Technical and Vocational Training Centers in Sistan & Baluchestan Abdolali Keshtegar
Journal of Global Pharma Technology Volume 10 Issue 01
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Abstract

The role of training in promotion of entrepreneurship attitudes and behaviors has widely been taken into account nowadays. Population growth in developing countries has ended in a reduction in resources and facilities along with appearance of new social and economic requirements in these countries, and all of such needs have attracted the attention of institutions and authorities for periodical solutions. The purpose of this study was to explain the role of KAB in creating entrepreneurial skills of trainees in Technical and Vocational Training Centers in Sistan & Baluchestan. The study was applied according to the purpose. Furthermore, as the present study dealt with the feasibility of training entrepreneurship skills, the method was descriptive-survey. The population was all 290 students of Technical and Vocational Training Centers in Sistan & Baluchestan. Using Morgan table to determine the sample size, we selected 165 people as the sample. The sampling method used was simple random method, as each trainee had the chance to be selected as the sample. Studying the related documents and a researcher-made questionnaire were used to collect data in this study, whose validity has been confirmed by professors, experts, and reliability by Cronbach's alpha. Descriptive and inferential statistics were used for data analysis. Descriptive statistics were used for collection and classification of demographic data; the inferential statistics were used for rejection or confirmation of the hypotheses; and statistical tests such as univariate t-test and Friedman test were used. SPSS20 was used for data analysis. The results showed that entrepreneurship training based on KAB model had a positive effect on entrepreneurial skills (technical, personal and managerial).Keywords: Entrepreneurship training, KAB model, Entrepreneurial skills, Trainee, Technical and vocational.
Impact of Folic Acid and Cyanocobalamin on Growth, Milk Yield and its Components of Awassi Ewes and their Lambs Mozhir K.K. Almahdawi
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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Abstract

The aim is to knowledge of vital role of folic acid and B12 vitamin on growth, milk production, milk components of Awassi sheep and their lambs.This experiment was carried out on 24 head of pregnant Awassi ewes with lambing of them in one of the private farms at Altagia village in southern of Hilla city. The experiment was included two phases, the first phase were dosage to Awassi ewes with two vitamins by mouth during experiment periods through estrus, gestation and parturition. The animals were randomly distributed into four treatments, the first treatment (control) without vitamins, second treatment was daily treated by 5mg/ewe of folic acid and third treatment was dosage of cyanocobalamin (B12 vitamin) with 225 μgm per ewe at twice time every week and fourth treatment were combination treated of folic acid and B12 vitamin as the same concentrations above. The second phase of the experiment, which began from birth of lambs and lasted weaning age ( 90 days).The lambs were dosage with two vitamins by mouth method after four hours of their born as the same mentioned of ewes in the first phase of experiment .The lambs were randomly distribution into four treatments, the first treatment was called control treatment without treated any vitamins and the second treatment were dosage with 1mg of folic acid to twice time per week, as well as the third treatment were treated with 125 μgm of B12 vitamin for twice time per week, As either fourth treatment the animals were mixture dosage of two vitamins (folic acid, cyanocobalmine) in the same concentrations. The results of statistical analysis of the first phase indicated the existence of significant differences (P≤0.05) on the averages of ewe’s weights at parturition and weaning, amount of daily feed intake, proportion of milk sugar, total protein and triglycerides of blood. As well as the results indicated high significant differences (P≤0.01) on the average of weights of ewes at the end of gestation, feed conversion , daily milk production , moisture, crude protein, crude fat non fats , total solids of milk and concentrations of cholesterol and albumin in blood of ewes. As for the second phase the results were shown significant differences (P≤0.05) on average amount of daily feed intake, total protein, albumin, triglycerides and cholesterol in the blood of lambs and another beside ,the results indicated high significant differences (P≤0.01) on average of live weight of lambs at birth and weaning, amount of daily feed intake and daily and total weight gains, and cholestrol concentration in the blood of Awassi lambs. We conclude that animals were dosages of folic acid with B12 vitamin were improving of health status and to improve significantly in most of traits of productive performance, growth and blood characteristics of ewes and their lambs as compared to the control treatment. Keywords: Folic acid, B12 vitamin, Milk yield, Milk components, Blood proteins.
A Study of Efficient Factors on Consumers Purchase Motivation of Foreign Brand in Contrast with Local Brand among Consumers of Chain Stores in Kerman City Abdolali Keshtegar
Journal of Global Pharma Technology Volume 10 Issue 01
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Abstract

The purpose of this research is investigated on effective factors on motivation of consumer purchase of foreign brand than domestic brand in Iran market. Today, consumers in developing countries like Iran and China rising by choosing between global and local brands are facing. In the competitive environment of global brands and local retailers that consumers need to know why and how these markets your brand to choose. The assumptions in this research are based on previous experience buying and preferences of the respondents, related to foreign and local Brand were evaluated. Data from a sample of customer’s convenience store chain was collected in Kerman who was selected by simple random sampling. A total of 420 customers participated in the study. This study used a questionnaire that its reliability is Cronbach's alpha equal to 0.845. The results of this study showed that using structural equation modeling. As well as consumer attitudes to global brand on perceived quality and emotional value of foreign brands have a positive effect, while the effect on Iran is different brand. Emotional value for the foreign brand is an important factor affecting purchase intention was to evaluate the effect on the Iranian brand was also approved. Concepts and applications of the study of both Iranian and foreign brands are presented in the following article.Keywords: Brand, Motivation of purchase, Brand trust, Emotional value, Perceived quality.
Analytical Method Development for Simultaneous Estimation of Cobicistat and Darunavir by RP-HPLC Method A. Sindhuja
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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Abstract

A new method was established for simultaneous estimation of Cobicistat and Darunavir by RP-HPLC method.  The chromatographic conditions were successfully developed for the separation of Cobicistat and Darunavir by using Xterra C18 5µm (4.6*250mm) column, flow rate was 1ml/min, mobile phase ratio was Phosphate buffer (0.05M) pH 4.6: ACN   (30:70%v/v)   (pH was adjusted with orthophosphoric acid), detection wave length was 255nm. Five trails have been done with various composition of mobile phase. Among them the mobile phase composition Acetonitrile and phosphate buffer in the ratio of 70:30 (trail no 5), using C18 column as stationary phase and detection at 255nm has produced a well resoluted peak. The no of theoretical plates was 5105, 3788 with a tailing factor of 1.3, 1.4. The peak retention time was 2.399, 3.907 with a peak area of 946124, 11541. The results shown that developed method is rapid, specific for the simultaneous estimation of cobicistat and darunavir in combined dosage form.Keywords: Cobicistat,Darunavir, RP-HPLC, Phosphate buffer, ACN
Determination of Neutron Flux of Isfahan ZPR in Different Level of Energy by MCNP COD for Investigate of BNCT Eghbali Borujeni Akram
Journal of Global Pharma Technology Volume 10 Issue 01
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Relating to deaths caused by cancers, we have tried to investigate the type of the cancers, and common method used for their treatments. Then we have evaluated the advantage and disadvantage of different methods, in regarding with the type of cancers, aiming to proof, that BNCT method can be the most appropriate methods for treatment of cancer in comparison with the other methods available. Now of days, advanced method of BNCT use a thermal (E n < 0.5 eV), or epithermal (0.5 eV < E n < 10 keV), neutron beam in conjunction with tumor- targeting boron compound for irradiation of glioblastoma and metastatic melanomas. In conjunction with, a systematic Mont carlo N-particle (MCNP) investigation of the different level of energy for neutron in ZPR (Zero Power Reactor) has been performed.  We did calculated with MCNP code, on neutron flux in ZPR, for different level of energies, and to complete the work, we compared the results with neutron flux requirements in BNCT cancer treatments. We believe that in future, BNCT can pursue its way as one of the safest and fastest method of brain cancers treatment, and we hope that in the near future, an appropriate (bed) will be established, for research and development of this method in our country, so that this method can become Vastly available to those patients, who are hopelessly seeking, a safer methods of brain cancer treatment.  Keywords: BNCT, Cancer therapy, Neutron source, Neutron flux, MCNP, ZPR.
Evaluation of In-Vitro Anticancer Activity of Hibiscus Rosa Sinensis against HeLa cell Line P. Sampath Kumar
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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Abstract

            The antifungal activity of Hibiscus rosa sinensis was evaluated against the following pathogenic fungi such as Candida albicans, Aspergillus niger, Trichoderma viride and  Rhizopus microsporus. The acetone extract of Hibiscus rosa sinensis flower showed little antifungal activity.  The acetone extract of Hibiscus rosa sinensis flower showed higher activity against HeLa cell line using MTT assay. The results obtained from the study revealed that Hibiscus rosa sinensis flower  Possess anticancer  activity against HeLa cell line using MTT assay.  

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