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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 73 Documents
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Search results for , issue "Volume 10 Issue 06: (2018) June 2018" : 73 Documents clear
Instruction Ability of Wild F. Solani Related by Mutant Straining for Production Au NPs Intesar Ali Mezeal
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
Publisher : Journal of Global Pharma Technology

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Present determination studies creation of Au NPs by gentle F.solani besides influenced modified straining toward divider by everyone .Cell filtrate of F.solani castoff on behalf of reduction gold nitrate to Au NPs.  Values obtainable attainment uninhabited and the modified straining tilted (Fusarium solani B1), (Fusarium solani B2),( Fusarium solani B3), ( Fusarium solani B4) , That stayed intellectual toward manufacture   Au NPs. Values obtainable consultation stayed absorption afterward four hrs. by modified    ( Fusarium solani B3)  make sure extreme absorption band  (0.739) observed via  ( Fusarium solani B1) (0.723) afterward four hrs., followed via ( Fusarium solani B2)   (0.701)  afterward five hrs., followed via ( Fusarium solani B4)   (0.663 ) afterward five hrs., however trendy  in uninhabited  straining  stayed (0.578) afterward six hrs. numbers obtained by micrograph pictures via   (TEM) pledge dispersed figure , size of Au NPs below observation of images, conferences stayed create to stay assortments of Au NPs in size diversity (50–60) nm shaped   (Fusarium solani B3)  , nevertheless  in   ( Fusarium solani B1) size variety (40-50), while they were between   (30-40) in ( Fusarium solani B2) and  between (20-30) by  (Fusarium solani B4)  , whereas in uninhabited straining were between (15-20). Occupied data discuss that noticeably unprotected the information to AuNPs consumed unimportant effect on seed growth as connected to controller management. Typical produced atoms not behavior several toxicological properties in seeds concluded growth therefore development percentage stayed not pretentious.                                                                                          Keywords: Modified, Bio control, TEM, Au NPs, Fusarium solani, growth. 
Synthesis and Identification of Biaryi of Cholic Acid Derivatives via Suzuki-Miyaura Cross-coupling Reaction and Study of Their Biological Activity Abbas Sami Abd
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Cholic acid derivatives(2-6) and (10-15)were Synthesized by treatment of cholic acid 1 with 4-aminoaniline  in the presence of N, N'- Dicyclohexylcarbodiimide (DCC) as coupling reagent and 4-dimethylaminopyridine (DMAP) as catalyst in CH2Cl2-DMF gave compound (2) that reacted with approperate cyanophenyl, 2,3-diflurophenyl, 3,4-dimethoxy phenyl)boronic acid using palladium (0) tetraks - triphenyl phosphine (Pd(0)Ph3P)4) and Na2CO3 as a catalysts in 2ml from DMF and H2O by using microwave Technique afford (10-12)  . The carbohydrazide derivative (5, 6) was prepared from methyl cholate 3 and hydrazine hydrate. The prepared hydrazone was introduced by reaction of the cholic acid with the carbonyl compounds (4-formyl phenyl boronic acid and 4-bromo ace to phenone) in refluxing acidic Et OH. The synthesis of compounds (14-15)  was accomplished from (6) with appropriately functionalized boronic acid derivatives by using Susuki - Miyaura criss-coupling reaction while the compounds(13) synthesized from reaction of (5) with (6) under Susuki - Miyaura criss-coupling reaction too (.some of these compounds show moderate to good  activity against Staphylococcus aureus bacteria and Candida albicans fungal. The reaction was monitored by (TLC) technique. All new Cholic acid derivatives were characterized by melting points, elemental analysis, FT‐ Invra red radiation, 1H, 13C spectroscopy. Antimicrobial activity of these derivatives was also determined.Keywords: Cholic acid, Cholic acid hydrazones ,Bile acids, Susuki -Miyaura cross -coupling reaction, Antimicrobial activity.
Post-exercise hypotension phenomenon in elderly after aerobic exercise Agha Bhargah; Made Muliarta; I Putu Yuda Prabawa; Ida Bagus Amertha Putra Manuaba; Varennia Bhargah
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Post-exercise hypotension (PEH) which means the occurrence of changes in blood pressure after a physical exercise to a lower blood pressure level after the start of physical exercise. The incidence of PEH can be concluded as a benefit when viewed regarding people who experience a state of hypertension, but if in people with normal blood pressure circumstances can cause the risk of a state of hypotension. The purpose of this study was to determine the magnitude of the decrease in post-exercise hypotension in elderly. Study model using a quasi-experimental model with pre-test and post-test group design involving 28 elderly as a research subject. Aerobic exercise in this study was performed through a healthy heart gymnastics exercise with a duration of 45 minutes. Blood pressure measurements were performed before exercise (baseline value), immediately after exercise, 15 minutes, 30 minutes, 45 minutes, and 60 minutes after exercise was done. Statistical analysis using normality and homogeneity test, ANOVA test, and paired sample t-test to compare differences in blood pressure parameter between period of measurement. There are differences in systolic, diastolic, and Mean Arterial Pressure (MAP) blood pressure between time measurements (p<0.001). The systolic blood pressure was significantly lower at 60 minutes post exercise (121.96±1.43 mmHg) compared with baseline (141.35 ± 8.76) (p<0.001). Diastolic blood pressure was significantly lower at 60 minutes post exercise (121.96 ±1.43 mmHg) compared with baseline (91.75 ± 1.48) (p<0.001). MAP was significantly lower at 60 minutes post exercise (93.89 ± 1.15 mmHg) compared with baseline (108.39±1.34) (p<0.001). Aerobic exercise through a healthy heart gymnastics session on elderly provides a post-exercise hypotension phenomenon. The lowest reduction of blood pressure was found at 60 minutes after aerobic exercise.Keywords: Systolic, Blood Pressure, Hypotension, Diastolic.
Synthesis, Diagnosis and Microbiological Studies of Mn+2, Co+2, Ni+2, Cu+2 and Hg+2 Chelates of Two Schiff Bases Derived from O-Phathaldehyde L.K. Abdul Karem
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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A new Schiff base derivative ligands [H4L1] and [H2L2] have been produced by condensed o-phathaldehyde with ethylene diamine and [N1, N1’E, N1, N1’E)-N1, N1’-(1, 2-phenylenebis (methan-1-yl-1ylidene)) diethane-1, 2-diamine] with 2-benzoyl benzoic acid. Schiff base ligands have been separated and categorized by 1H, 13 C-NMR, (CHN) elemental analysis, UV-visible, mass spectroscopy and FTIR methods. Ten new coordination complexes were prepared and structurally diagnosed: [M(L1)Cl2] and [M2(L2)Cl2] where M(II) = Mn (II), Co(II), Ni(II),Cu(II) and Hg(II). The complexes have been typified by FTIR, UV-visble atomic absorption, molar conductance elemental analysis, and magnetic susceptibility. The details of the ligand (H4L1) compounds are getting an octahedral geometry while the complexes of ligand (H2L2) that are get square planar and tetrahedral geometries. Antimicrobial examinations show good results in the sharing complexes.Keywords: Schiff base, Antimicrobial, Diagnosis, O-phathaldehyde. Zz.
Assessment of Knowledge and Attitudes among Pregnant Women’s Towards Folic Acid in Take during Pregnancy in Al-Diwanyia Governorate Fadia H. Ali
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Folic acid or folate is a B9 vitamin; it is affect the formation of cells in the fetus.  Objective: Assess the pregnant mothers' knowledge and attitudes towards folic acid during pregnancy and to determine the relationship between their demographic data and (knowledge and attitude).  Methodology: A descriptive design was carried out to assess knowledge and attitudes among pregnant women's towards a folic acid intake during pregnancy in Al-Diwanyia Governorate. A non- probability, purposive sample of (103) pregnant women at Al- Diwanyia Governorate was selected from the mothers who attending for follow up in the antenatal care unit of the gynecology and pediatric teaching hospital. A questionnaire was constructed for the purpose of the study, it was composed of three Likert scale was developed in order to collect the study data that include data related to socio-demographic data, questions related to mothers' knowledge and attitudes. Results: The present study indicate that (72.81 %) of mothers aged between 20-35 years. About half of them had university education(45.63%) and majority of them(85.43 %)  are housewives lived in urban areas (75.72 %) and ( 79.6 %) of them had fair ( insufficient ) knowledge about folic acid as usage, important, dose, and sources and More than half of the studied subjects (71.8 %) were had positive attitudes toward folic acid uses during pregnancy  and there is no statistical significance between mothers' knowledge and any of socio-demographic data except level of education and monthly income are significant at p. value less than 0.05.Conclusion: The pregnant women have fair of knowledge regarding folic acid and its importance during pregnancy and the majority of them had positive attitudes toward  uses of folic acid during pregnancy .Recommendation, developing of educational program for pregnant women to raise their knowledge about folic acid and its important during pregnancy, emerging sessions to explain the important of follow up in pregnancy given to the recent wife.Key words: Assessment, knowledge, attitudes, folic acid.
Comparative Analysis of Types of Liability and Punishments for the Falcification of Mediсines in Countries of European Union Tulegenova Аigerim
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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The article presents the results of an analysis of modern approaches in determining the types of responsibilities and penalties for falsification of medicines in the EU countries. It is determined that, process of recognition and implementation of norms and requirements of The Medicrime Convention in the states that are members to the Council of Europe continues and dynamically develops. The changes, which were adopted after the signature by the EU countries of The Medicrime Convention in 2011, are analyzed. Determined, that out of all liabilities which exist in jurisprudence in regards to the issue of falsification of medicines, the criminal, administrative and civil liabilities are applied. Current practice exists in all 28 EU states. It was found that in most of the EU countries (10 countries) relatively soft criminal sanctions (from 1 to 3 years of imprisonment) dominate for the falsification of medicines. In addition, there is no consolidated position as to what kinds of offenses for falsification in the pharmaceutical market criminal sanctions should be applied. It is found that the maximum values of penalties for falsification of medicines in the EU countries varies in a wide range of indicators (from 4,3 thousand euro to 1 million euros). Relatively soft criminal sanctions in most EU countries and a wide range of fines for drug fraud contribute to the migration of organized crime in the pharmaceutical business. However, it should be noted that the positive experience of struggling against counterfeiting in the EU has great practical significance for countries with low income and health systems, which are in the stage of reforming.Keywords: Falsification of medicines, Punishment for falsification of medicines, Types of liability for falsification of medicines, The Medicrime Convention.
Drill of the Absolute Torque and their Effect on Some Biochemical Variables for Some Stages of 60-Meter Hurdle-Runners Mazin Anhair Lami
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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The need to apply special resistance exercises to athletics has become particularly strong and the indices are falling apart at every international tradition pattern of power workouts, according to the parts. Different which moves rotational movements especially running hurdles, so this search came to muscle totals operating for a 60-meter hurdles in accordance with the movements specify within the axis of the rotation of these parts, the angular kinetic work of these joints in order to achieve the condition of the runner’s power in such an efficiency to increase his muscle efficiency. The search applied to a group of runners who ran 60 roadblocks in Iraq and researchers prepared skill-based exercises with weight-added resistors to body parts according to the percentages of these parts, to develop kinetic variables. For some stages, 60 meters of hurdles were run and the exercises were applied for eight weeks, three training modules per week. The results have shown the evolution of these variables of force and speed and angles during the run, between the hurdles and the hurdle step for group research.Keywords: Absolute torque, Relative momentum and unbalanced Power.
Response of Freesia Hybrida Plant to Spraying with Roselle Calyx Extract (Hibiscus Sabbdariffa L.) and Vitamin B1 Extract in Growth Characteristics Arshad Naji Alhasnawi
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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An experiment was conducted at the nursery of Agriculture Faculty during growing season 2014 – 2015 to study the effect of spraying Roselle extract and vitamin B1 on growth and flowering characteristics of freesia plant. Experiment was adopted a Randomized Complete Block Design (R.C.B.D) with three replicates in two factors, First three concentration of spraying Roselle calyx extract i.e. (0, 5 and 10) g.L-1. Second three concentration of vitamin B1 i.e. (0, 20 and 40) mg. L-1. Means were compared by using Least Significant Difference (L.S.D) test at a probability of 0.05.   Results showed that spraying Roselle calyx extract at a concentration 10g.L-1 and vitamin B1 at concentration 20mg. L-1 increased the number of leaves per plant significantly to 8.67, shoot dry weight to 4.66g, content of chlorophyll A,B and Total in leaves to 56.01,25.00 and 68.09mg. 100g-1 fresh weight, inflorescence stalk length to 26.67cm, diameter of floret to 4.67cm, number of floret to 11.67floret, inflorescence -1, and number of corm to 3.67corm. plant-1, diameters of corm to1.63cm and decreased number of day to flowering time to 125.00 day, compared to the control which gave the lowest values( 3.87life. plant-1, 1.26g, 42,44, 12.51 and 53.0409mg. 100g-1 fresh weight, 14.40cm, 2.67mm,4.67 floret. inflorescence -1, 2.00corm. plant-1 and 1.03cm) and increased number of days  to flowering time to 140 days.                                                                                                                                  Keywords: Freesia Hybrida, Vitamin B1 (Thiamin), Roselle Plant (Hibiscus Sabbdariffa L.) Extract.             
Investigation of SOD2 Gene Polymorphism in the Patients with Type Two Diabetes Disease in Babylon Province Zahraa Kamil Kadhim Lawi
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Diabetes is a defect with body of human that causes blood glucose (sugar) levels to increase higher than normal. This is also named hyperglycemia. The free radical theory of many illness that reactive oxygen species (ROS) participate a key function in accumulation of cellular damage, The results of PCR-SSCP for SOD2  gene illustrated that two different haplotypes according to the numbers of bands in the SOD2gene including 5 and 6 bands. While, these haplotype was detected between two groups; in diabetes patient groups and control, the results indicate that was association between 3 and 4 bands in patients as compared with a control group. the patients groups, had greater levels of SOD in contrast with control groups result at significant differences (P≤ 0.05). Conclusion PCR-SSCP Is a good screening method to detection SOD2 snps gene in patient with diabetes type 2 diseaseKeywords: Antioxidant, SOD2, Diabetes, Oxidative, SSCP, PCR.
Role of Oxytocin and Cortisol Simultaneous with the Cellular Oxidative Stress in Preventing Pregnancy in Females with Un Known Infertile Cause Who Undergone to Artificial Fertilization Rasha Hasan Jasim
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Eighty two women were enrolled in the present study, they are classified into two groups, and the first included 42 females aged 23 – 42 years who had never a normal pregnancy. They had to undergo IVF with a regular 6 month menstrual cycle before applying for an IVF at the Infertility Treatment Center in Sadder City Medical in Najaf, Iraq. The second group included 40 females with age rang 22 – 40, were selected as control, results of the present work were summarized in the below table. Oxytocin and cortisol levels were evaluated in the present work in addition to several oxidants and antioxidant parameters. Results of the study showed significant elevation in the BMI (Mean ± S.D.) at females suffered unknown infertile cause comparison to healthy females and this elevation was directly correlated to pregnancy prevention. Outcomes recorded statistically significant decrease in the oxytocin and SOD Activity (U/dl) in the sera of females who submitted for artificial insemination, while all of cortisol, MDA, NO, and Cp concentration seemed to be higher in the sera of patient’s women than their corresponding in the control group. Results of the study illustrated highly significant correlation between oxytocin and cortisol (r = - 0.735 at p = 0.001), as well as oxytocin and NO (r = - 0.779 at p = 0.001, and between MDA and NO (r = 0.882 at p = 0.001). More than; the study showed there are significant correlation (r = 0.832) between Cortisol with NO, and MDA with SOD Activity (r = -859) at p = 0.005. The study concludes that oxytocin could directly affect in the preventing of normal pregnancy moreover in decrease of the success of the artificial insemination process.    Key words: Oxytocin, Cortisol, Artificial Insemination, Female Infertility, Oxidative Stress, SOD activity, NO, MDA.

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