Article Per Year (5 Year)
p-Index From 2020 - 2025
1.116
P-Index
This Author published in this journals
All Journal ISM (Intisari Sains Medis) : Jurnal Kedokteran Journal of Global Pharma Technology JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
I Putu Yuda Prabawa
Departemen Patologi Klinik, Fakultas Kedokteran, Universitas Udayana, RSUP Sanglah, Bali, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

Published : 7 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 7 Documents
Search

 1 
Analisis korelasi kadar serum prokalsitonin dengan jumlah leukosit pada penderita dengan kecurigaan sepsis di RSUP Sanglah, Bali, Indonesia Bagus Dwiki Arya Dharma; Ni Kadek Mulyantari; I Putu Yuda Prabawa
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (340.223 KB) | DOI: 10.15562/ism.v11i1.525

Abstract

Background: Sepsis is a systemic inflammatory response to infection, where the pathogen or toxin is released into the blood circulation, causing activation of the inflammatory process. Laboratory tests are used to detect inflammatory processes, one of which is procalcitonin. This study aims to determine the correlation between procalcitonin (PCT) serum levels by the leukocytes counts on suspected sepsis patients at Sanglah Hospital in Denpasar.Methods: An analytic observational study with the cross-sectional design was conducted among 21 samples by consecutive sampling technique. The population in this study were sepsis patients who were treated at Sanglah Hospital Denpasar during February-June 2016 period. Data were analyzed using SPSS version 17 for Windows. Results:  Most of respondents were >35 years old (85.7%), Body Mass Index (BMI) > 20 kg/m2 (76.2%), leucocyte counts < 10.000/μL (42.9%), and PCT levels ≤ 0.5 ng/mL (61.9%). There is no significant correlation between white blood cells (WBC) and PCT by Spearman Correlation test (p=0.061; r=0,641).Conclusion: The recent findings suggest that there was no significant correlation between PCT serum levels with the leucocytes counts among patients with sepsis. Latar Belakang: Sepsis merupakan suatu respon inflamasi sistemik terhadap infeksi, dimana patogen atau toksin dilepaskan ke dalam sirkulasi darah sehingga terjadi aktivasi proses inflamasi. Tes laboratorium yang digunakan untuk mengetahui adanya proses inflamasi salah satunya adalah prokalsitonin (PCT). Penelitian ini bertujuan untuk mengetahui korelasi antara kadar serum prokalsitonin dengan jumlah leukosit pada penderita dengan kecurigaan sepsis di RSUP Sanglah Denpasar.Metode: Penelitian observasional analitik dengan desain tong lintang dilakukan terhadap 21 sampel dengan teknik konsekutif. Populasi dalam penelitian ini adalah pasien sepsis yang dirawat di Rumah Sakit Sanglah Denpasar selama periode Februari-Juni 2016. Data dianalisis menggunakan SPSS versi 17 untuk Windows.Hasil: Sebagian besar responden berusia> 35 tahun (85,7%), Indeks Massa Tubuh (IMT)>20 kg / m2 (76,2%), jumlah leukosit <10.000 / μL (42,9%), dan tingkat PCT ≤ 0,5 ng / mL (61,9%). Tidak terdapat korelasi yang bermakna antara sel darah putih (WBC) dan PCT dengan uji Korelasi Spearman (p = 0,061; r = 0,641).Kesimpulan: Hasil penelitian saat ini menunjukkan bahwa tidak terdapat korelasi yang bermakna antara kadar serum PCT dengan jumlah leukosit pada pasien dengan sepsis.
Risk factors and novel prognostic score for predicting the 14-day mortality of severe traumatic brain injury patients Nyoman Golden; Putu Eka Mardhika; Wayan Niryana; I Made Sukarya; I Putu Yuda Prabawa
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (484.992 KB) | DOI: 10.15562/ism.v11i3.831

Abstract

Introduction: The mortality of severe traumatic brain injury (TBI) is contributed by the severity of the head injury, associated trauma, and complication during treatment. This study aimed to develop a prognostic scoring system of risk factors that contribute to the 14-day mortality of severe TBI.Methods: This was a prospective cohort study including 105 severe TBI patients recruited consecutively from March to October 2016. Multivariate analysis with logistic regression was performed to determine the most contributing risk factors. The validation of prognostic factor was performed with ROC, sensitivity and specificity analysis.Result: There were five significant risk factors of 14-day mortality, which were age > 60 years old (RR: 15.6, 95% CI: 1.88 – 129.95), hypoxia (RR: 17.78, 95% CI: 2.05 – 154.11), GCS 3 – 5 (RR: 34.71, 95% CI: 6.85 – 175.98), effacement of basal cistern (RR: 12.71, 95% CI: 2.61 – 61.95), and traumatic subarachnoid hemorrhage (tSAH) (RR:7.57, 95% CI: 1.19 – 48.36). The prognostic score ranged from 0 to 6 with the best cut-off point of 1. The best predictive AUC with ROC analysis was 0.817, 81.2% of sensitivity, and 75.0% of specificity.Conclusion: The proposed prognostic score has shown good predictive ability.
Aberrant expression of CD5 in a B-lineage Acute Lymphoblastic Leukemia (ALL): a case report Ni Ketut Puspa Sari; Ni Nyoman Mahartini; Ni Kadek Mulyantari; Anak Agung Ayu Lydia Prawita; Ni Komang Krisnawati; I Putu Yuda Prabawa; Sianny Herawati; Made Minarti Witarini Dewi; Ekarini Katharina Yunarti Nabu
Intisari Sains Medis Vol. 12 No. 2 (2021): (Available Online: 1 August 2021)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (522.872 KB) | DOI: 10.15562/ism.v12i2.1011

Abstract

Background: CD5 is expressed in several B-lymphocyte malignancies, including Chronic Lymphocytic Leukemia (CLL), Mantle Cell Lymphoma (MCL), but CD5 positive B-cell lineage Acute Lymphoblastic Leukemia (ALL) is extremely rare. Aberrant T-cell antigen expression is associated with poor prognosis and is a useful marker to identify patients at increased risk. This case report aims to elaborate on the aberrant expression of CD5 in B-lineage ALL.Case Presentation: A 16-years-old male presented with a history of gum bleeding and abdominal pain of 7 days with associated fever, weakness and bone pain of 2-month duration. The bone marrow aspiration showed lymphoblast 30 % with the positive vacuole. In addition, the immunophenotyping test indicates for leukemia B-lineage with expression CD19, CD10, HLA-DR, CD 34, and there is the aberrant expression of CD5.Conclusion: Aberrant expression CD5 in cases of ALL B lineage is very rare. This can be associated with a poor prognosis.
Perbandingan kadar Thyroid Stimulating Hormone (TSH) dan kadar Free T4 (FT4) antara metode Fluorescence Immunoassay (FIA) dan metode Electrochemiluminescence Immunoassay (ECLIA) di RSUP Sanglah, Bali, Indonesia Ekarini Katharina Yunarti Nabu; Sianny Herawati; Ni Kadek Mulyantari; Anak Agung Wiradewi Lestari; I Putu Yuda Prabawa
Intisari Sains Medis Vol. 12 No. 2 (2021): (Available Online: 1 August 2021)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (286.92 KB) | DOI: 10.15562/ism.v12i2.1062

Abstract

Background: Diagnostic and therapeutic cases of hyperthyroidism can be identified by examining the levels of Thyroid Stimulating Hormone (TSH) and Free T4 (FT4). There are several examination methods, namely the Fluorescence Immunoassay (FIA) and the Electro-Chemiluminescence Immunoassay (ECLIA) method. This study aims to evaluate the difference in TSH and FT4 level in the FIA method and ECLIA method.Method: This study used observational analytic methods cross sectional design, with 45 samples serum patient with hyperthyroid in January-March 2019. Examine level TSH and FT4 levels with FIA methods (NANO ENTEK FRENDTM) and ECLIA method (Cobas e601 ROCHE). Data were analyzed using SPSS version 17 for Windows.Results: Most of the respondents were aged 25-34 years (28.8%) and female (86.7%). There was no significant difference in the mean TSH level on examination using the ECLIA method (0.60±0.79 mIU/L) and the FIA method (0.63±0.76 mIU/L) (p=0.639). In addition, there was no significant difference in FT4 both in the examination using the ECLIA method (1.67±1.05 ng/dl) and the FIA method (1.69±1.72 ng/dl) (p=0.745).Conclusions: There was no significant difference between TSH and FT4 in both ECLIA and FIA methods. Latar Belakang: Diagnosis maupun pemantauan terapi kasus hipertiroid dapat diketahui dengan pemeriksaan kadar hormon Thyroid Stimulating Hormone (TSH) dan Free T4 (FT4). Terdapat beberapa metode pemeriksaan yaitu metode Fluorescence Immunoassay (FIA) dan metode Electro-Chemiluminescence Immunoassay (ECLIA). Penelitian ini bertujuan untuk mengevaluasi perbedaan kadar TSH dan FT4 metode FIA dan metode ECLIA.Metode: Penelitian ini menggunakan metode observasional analitik dengan desain potong lintang pada 45 sampel serum penderita hipertiroid selama periode Januari-Maret 2019. Dilakukan pemeriksaan kadar TSH dan FT4 dengan metode FIA (NANO ENTEK FRENDTM) dan metode ECLIA (Cobas e601 Roche). Data dianalisis dengan SPSS versi 17 untuk Windows.Hasil: Sebagian besar responden berusia 25-34 tahun (28,8%) dan berjenis kelamin perempuan (86,7%). Tidak terdapat perbedaan bermakna rerata kadar TSH pada pemeriksaan menggunakan metode ECLIA (0,60±0,79 mIU/L) maupun metode FIA (0,63±0,76 mIU/L) (p=0,639). Disamping itu, tidak juga terdapat perbedaan bermakna rerata kadar FT4 baik pada pemeriksaan menggunakan metode ECLIA (1,67±1,05 ng/dl) maupun metode FIA (1,69±1,72 ng/dl) (p=0,745).Kesimpulan: Tidak ada perbedaan yang bermakna antara kadar TSH dan FT4 pada metode ECLIA dan FIA.
Potensi terapi kombinasi Liver Growth Factor (LGF) dan Adrenomedullin (ADM) sebagai harapan baru penatalaksanaan Azoospermia Non-Obstruktif (ANO): tinjauan pustaka Ni Made Dian Hartaningsih; I Putu Yuda Prabawa; Benediktus Bosman Ariesta Gusti Putu; Dwijo Anargha Sindhughosa; Ida Bagus Amertha Putra Manuaba; I Gusti Ngurah Pramesemara
Intisari Sains Medis Vol. 13 No. 1 (2022): (Available Online : 1 April 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/ism.v13i1.1363

Abstract

Non-Obstructive Azoospermia (NOA) is caused by the failure of spermatogenesis process. This case becomes the highest prevalence, 95% of the total azoospermia. Therapeutic modalities in use today such as invasive techniques, hormonal therapy, and gene therapy are less effective in the treatment of azoospermia. In addition, the overall therapeutic modalities also have serious side effects such as infection, testicular atrophy, nerve damage and other side effects. Referring to the problems above, non-obstructive azoospermia is an urgent health issue and requires effective and efficient management with minimal side effects, as the combination of Liver Growth Factor (LGF) and Adrenomedullin (ADM). LGF is able to regenerate spermatogenesis after spermatogonia testicular stem cell damage. LGF also works specifically by stimulating germinal cells without changes in somatic cells. The motility of reactivation could be improved by combining the ADM into therapy, which bind to specific receptors, and the result of increasing the cAMP / PKA and NO that are important in the regulation of cilia’s movement. Combination LGF and ADM are potential to create new therapeutic candidates in the management of non-obstructive azoospermia, which can be immediately implemented as effective and efficient therapy. Azoospermia Non-Obstruktif (ANO) adalah azoospermia yang disebabkan kegagalan proses spermatogenesis dan merupakan kasus dengan prevalensi tertinggi (95% dari total azoospermia). Modalitas terapi yang digunakan sampai saat ini seperti teknik invasif, terapi hormonal, dan terapi gen terbukti belum efektif dalam tatalaksana azoospermia. Selain itu, keseluruhan modalitas terapi ini juga memiliki efek samping serius yang perlu diwaspadai seperti infeksi, testis atropi, kerusakan saraf, serta efek samping lainnya. Merujuk pada permasalahan diatas, azoospermia non-obstruktif merupakan masalah kesehatan yang mendesak dan membutuhkan tatalaksana yang efektif dan efisien dengan efek samping yang minimal seperti dengan kombinasi terapi LGF dan ADM. LGF mampu meregenerasi testis dan mereaktivasi spermatogenesis setelah kerusakan sel punca spermatogonia. LGF juga bekerja secara spesifik dengan menstimulasi sel-sel germinal tanpa menyebabkan perubahan pada sel-sel somatis. Motilitas sperma hasil reaktivasi spermatogenesis kemudian ditingkatkan dengan mengkombinasikan ADM kedalam terapi dimana berikatan pada reseptor-reseptor spesifik sehingga berefek pada peningkatan cAMP/PKA dan NO yang penting dalam pengaturan kibasan flagella. Perpaduan antara terapi LGF dan ADM ini sangat berpotensi menciptakan kandidat terapi baru dalam penatalaksanaan NOA yang efektif dan efisien. 
Post-exercise hypotension phenomenon in elderly after aerobic exercise Agha Bhargah; Made Muliarta; I Putu Yuda Prabawa; Ida Bagus Amertha Putra Manuaba; Varennia Bhargah
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Post-exercise hypotension (PEH) which means the occurrence of changes in blood pressure after a physical exercise to a lower blood pressure level after the start of physical exercise. The incidence of PEH can be concluded as a benefit when viewed regarding people who experience a state of hypertension, but if in people with normal blood pressure circumstances can cause the risk of a state of hypotension. The purpose of this study was to determine the magnitude of the decrease in post-exercise hypotension in elderly. Study model using a quasi-experimental model with pre-test and post-test group design involving 28 elderly as a research subject. Aerobic exercise in this study was performed through a healthy heart gymnastics exercise with a duration of 45 minutes. Blood pressure measurements were performed before exercise (baseline value), immediately after exercise, 15 minutes, 30 minutes, 45 minutes, and 60 minutes after exercise was done. Statistical analysis using normality and homogeneity test, ANOVA test, and paired sample t-test to compare differences in blood pressure parameter between period of measurement. There are differences in systolic, diastolic, and Mean Arterial Pressure (MAP) blood pressure between time measurements (p<0.001). The systolic blood pressure was significantly lower at 60 minutes post exercise (121.96±1.43 mmHg) compared with baseline (141.35 ± 8.76) (p<0.001). Diastolic blood pressure was significantly lower at 60 minutes post exercise (121.96 ±1.43 mmHg) compared with baseline (91.75 ± 1.48) (p<0.001). MAP was significantly lower at 60 minutes post exercise (93.89 ± 1.15 mmHg) compared with baseline (108.39±1.34) (p<0.001). Aerobic exercise through a healthy heart gymnastics session on elderly provides a post-exercise hypotension phenomenon. The lowest reduction of blood pressure was found at 60 minutes after aerobic exercise.Keywords: Systolic, Blood Pressure, Hypotension, Diastolic.
HUBUNGAN ANTARA SIKAP DAN TINGKAT PENGETAHUAN SEPUTAR KLINIK WISATA PADA WISATAWAN DOMESTIK MAUPUN MANCANEGARA TERHADAP PEMANFAATAN KLINIK WISATA DI KAWASAN WISATA PANTAI KUTA, BALI I Putu Yuda Prabawa
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 2 No 2 (2014): JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pendahuluan: Penelitian ini bertujuan untuk mengetahui hubungan antara sikap dan tingkat pengetahuan seputar klinik wisata pada wisatawan domestic maupun mancanegara terhadap pemanfaatan klinik wisata yang terdapat di kawasan wisata pantai Kuta, Bali. Penelitian ini bersifat deskriptif-analitik dengan desain Cross-sectional. Metode: Pengambilan sampel menggunakan metode Consecutive sampling di kawasan wisata Pantai Kuta. Variabel yang dinilai meliputi data deskriptif dan analitik dengan Chi-square dan Pearson correlation. Hasil: Hasil penelitian diperoleh bahwa wisatawan Jakarta (24%) dan Australia (22%) terbanyak. Usia 26-45 tahun serta tujuan berlibur dominan pada domestik (40%;62%) maupun mancanegara (46%;80%). Pembahasan: Informasi diperoleh dari teman/keluarga, mengunjungi Pantai Kuta lebih dari sekali, tidak mengetahui dan tidak pernah mengunjungi klinik wisata dominan pada domestik (30%, 76%, 76%, 94%) dan mancanegara (56%, 68%, 62%, 94%). Keindahan pantainya alasan utama pada domestik (48%) dan berselancar pada mancanegara (28%). Sebagian besar wisatawan memiliki kemauan memanfaatkan klinik wisata serta mempunyai sikap dan tingkat pengetahuan yang baik: domestik (64%, 58%, 64%) dan mancanegara (66%, 62%, 62%). Kesimpulan: Terdapat hubungan serta korelasi positif kuat antara sikap dan tingkat pengetahuan (P=0,000) seputar klinik wisata terhadap pemanfaatan klinik wisata pada domestik (r=0,570; r=0,557) dan mancanegara (r=0,589; r=0,662) yang terdapat di kawasan Pantai Kuta, Bali.
Co-Authors Agha Bhargah Anak Agung Ayu Lydia Prawita Anak Agung Wiradewi Lestari Bagus Dwiki Arya Dharma Benediktus Bosman Ariesta Gusti Putu Dwijo Anargha Sindhughosa Ekarini Katharina Yunarti Nabu Ekarini Katharina Yunarti Nabu I Gusti Ngurah Pramesemara I Made Sukarya I Wayan Niryana Ida Bagus Amertha Putra Manuaba Made Minarti Witarini Dewi Made Muliarta Ni Kadek Mulyantari Ni Ketut Puspa Sari Ni Komang Krisnawati Ni Made Dian Hartaningsih Ni Nyoman Mahartini Nyoman Golden Putu Eka Mardhika Sianny Herawati Varennia Bhargah