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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 73 Documents
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Search results for , issue "Volume 10 Issue 06: (2018) June 2018" : 73 Documents clear
Biodegradation of Crude Oil Contaminated Soil in Kirkuk/ Iraq by using Pseudomonas Aeruginosa and Klebsiella Pneumoniae Aqeel Mohammed Majeed Al-Ezee
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

The aim of present study was to show crude oil biodegradation by Pseudomonas aeruginosa, K. pneumoniae. The samples of oil were obtain from tanks of crude oil belonging to Kirkuk city/Iraq. The present research was study crude oil biodegradation at a different condition (temperature and pH). The results show the, typical conditions of biodegradation, of crude oil were, temperature 37,0C and. Under typical condition, consumption level reported, P. aeruginosa and K.pneumoniae, at fourth day, (pH 7: 39.7; 37.5 and, temperature 37 0C: 43.1; 30.1 respectively). Also, cell numbers reported, P. aeruginosa and K. pneumoniae, at fourth, day (pH 7: 11.9; 11.3 X log 10 and, temperature 37 0C: 11.8; 10.4, respectively). It was, included from this study that ideal conditions of P. aeruginosa and K. pneumoniae to oil biodegradation were temperature 37 and pH 7.Keywords: Crude oil, Bio-degradation; P. aeruginosa; K. pneumoniae.
The Effect of Using Teaching with Motor Tasks According to Total and Partial Training in Developing Attention Focus and Learning Some Types of Shooting in Basketball Emad Toma Radi
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Variability and overlap in teaching and learning methods achieve high percentages of development in characteristics, skills and other aspects of teaching strategies and methods. Teaching is one of these methods using motor tasks which currently play an effective role in modern teaching through which a part of the teacher’s authorities is transferred to students.  The problem of the study lies in that teachers did not use modern teaching methods, training schedule and organization and they kept the concept of generality in teaching and learning these skills. They also did not consider effective factors and conditions, so the researcher conducted this study to solve this problem. However, the researchers used the empirical method. The sample was represented in students of the first grade at the Sport Education Department in the college of Basic Education, AL-Mustansiriyah University (40 students). The sample was  divided into a first experimental group (20 students) using the method of teaching with motor tasks due to total training and second experimental group (20 students) using the method of teaching with motor tasks due to partial training. The researchers conducted sample homogeneity, applied tests of attention focus and skill tests. Pre-tests were applied on the sample of the study with the use of teaching method of motor tasks in the class units. Researchers concluded that:There are differences between pre and post tests for both experimental groups which refer that teaching using motor tasks due to pre and post training was more affective. Results showed that the second experimental group excelled in attention focus using teaching with motor tasks due to partial training. Results showed that the second experimental group excelled in learning some types of scoring from the free throw line and peaceful scoring using teaching with motor tasksKeywords: Effect teaching, Motor Learning & Basketball skills.
Reticulocyte Hemoglobin Equivalent (RET-HE) As A Predictor and Early Marker for Oral Iron Response in Iron Deficiency Anemia Patients Ketut Suega; I Made Bakta
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

This study was aimed to determine whether Ret-He has a role for early detection and as a predictor factor for treatment response in iron deficiency anemia patient after oral iron therapy in 4 weeks. Iron deficiency anemia (IDA) patient were diagnosed based on hypochromic microcytic anemia with ferritin level < 20 ng/ml. All patients were taking oral iron pill for 4 weeks. Hemoglobin serum, absolute reticulocyte count (ARC), Ret-He, MCV, MCH, MCHC, and hematocrit were measured. Responders are defined as patients who reach total changes of their hemoglobin level > 2 g/dl in 4 weeks. Data analysis was done by SPSS. There were 26 IDA patients consisted of 15 (57.7%) female and 11 (42.3%) male patients with mean of age was 47.31. Before treatment, level of Ret-He, absolute reticulocyte count, HB, HCT and MCV were 18.16 pg (SD 4.43), 0.67 (SD 3.02), 7.94 g/dl (0.74), 26.5 % (SD 2.48), 64.9 fl (SD 0.51) respectively. There was 18 (69.2%) patient considered as responders and 8 (30.8%) patients considered as non-responders. The evaluation showed all markers were increased except for absolute reticulocyte level. On adjusted multiple logistic regression, the only variable that found statistically significant was Ret-He at week 1 with p= 0.031; 95% CI 0.349-0.950. It is suggested that reticulocyte hemoglobin equivalent (Ret-He) proved to be an early and sensitive predictor for oral iron therapy response in patients with iron deficiency anemia. Keywords: Ret-He, Treatment response, Iron deficiency anemia.
Investigation of Star Fruit (Averrhoa Carambola) Juice Production Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Star fruit (Averrhoa carambola) is widely grown in Vietnam. It is a good source of natural antioxidants especially proanthocyanidins, epicatechin and vitamin C. It is quite a popular fruit usually consumed fresh or made into fruit juice or juice beverage. In order to utilize this good source as a healthy food drink, we attempted to produce star fruit juice. We focused on investigation of dilution ratio of star fruit juice with water, soluble dry matter, and pasteurization to product quality. Our results showed that dilution ratio 40:60 (juice: water), 20 oBrix, pasteurization at 90 oC in 5 minutes gave the best star fruit juice.Keywords: Star fruit, Averrhoa carambola, Juice, Pasteurization, Soluble dry matter, dilution ratio.
Parasitological and Immunological study of the Effect of Chitosan and Chitosan Nanoparticles Loaded with Spiramycin on Toxoplasmosis Hanaa Kamil Hamad
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

This study was carried out to evaluate parasitological and   immunological of the effect of chitosan and chitosannanoparticles loaded with spiramycin on toxoplasmosis infected mice. After injection intra peritoneal with 103viable tachyzoites for acute infection, treatments given for seven days. Peritoneal fluid examination revealed a significant decrease in the number of Toxoplasmagondiitachyzoites in all treated infected mice compared with infected non-treated. The combined therapy gave better results than single. The best effect was observed in group of mice treated with spiramycin combined with chitosan nanoparticles. Also immunoglobulin Ig Manti body and gamma Interferon (INFγ), Tumor Necrosis Factor alpha (TNF-α) cytokines responses against T. gondii antigens were assessed by enzyme linked immunosorbent assays (ELISA) kits after treatment. In this study the findings indicated improvement of immune status after treatment.Keywords: Toxoplasma gondii, Nanochitosan, Spiramycin, Cytokines, ELISA.
Effect of Candesartan, Atenolol and Amlodipine on Oxidative Stress in Kerbala Patients with Hypertension Mohammed Talat Abbas
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Hypertension is a heterozygous disorder in which patients can be stable according to pathophysiological characteristics that have a direct effect on the effectiveness of specifically targeted antihypertensive drugs on detecting recoverable forms of hypertension and the risks of cardiovascular complications. This study was performed to compare the effect of anti-hypertension drug with etenolol, amlodipine and candesartan on oxidative stress in kerbala patients with primary hypertension. A total of 60 hypertensive patients (20 patients with etenolol, 20 patients on amlodipine and 20 candersarten) and 20 health components in the study. In conclusions Treatment with etenolol, amlodipine and candesartan reduces SBP, DBP, and MDA and improves the antioxidant system (SOD, CAT).Keywords: Hypertension, Etenolol, Amlodipine, candesartan, Oxidative stress.
A Review on Manufacturing Operations of Solid Dosage Forms: Design and Implementation on GMP Systems in the Manufacturing Facility Alex Joseph
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Manufacturing of solid dosage forms which should be performed accordance with the Good Manufacturing Guidelines as per the local regulatory requirements, Product quality cannot be adequately ensured only by inspecting and testing a finished product because finished-product testing cannot detect all defects, quality must be built into a product with processes that are well-controlled during design and manufacturing. Manufacturers need to establish and implement the quality design that controls each step in manufacturing process to ensure that the product meets predetermined specification. This study is anticipated to provide guidance which includes all the operations starting with procedure for obtaining the manufacturing license, procurement of raw materials and packing materials, handling in warehouse, production planning, dispensing, line clearance, in-process quality control tests, storage, sampling, analysis, approval and batch release.Keywords: Good manufacturing practice, Manufacturing license, IPQC.
Educational Obstacles Facing Primary School Teachers in Iraq from their Point of View Diaa Saleh Mahdi Al-Attar
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

The aim of this study is to identify the real obstacles related to primary school teachers in Iraq, which impede the development of the educational process, especially with regard to the student, curriculum, school administration and school buildings. To achieve this, a questionnaire was designed as a main tool in this study, the study sample consisted of (120) teachers and teachers in the schools of Karbala governorate. To collect the data from the members of this sample, a questionnaire was used consisting of five main fields. The validity and consistency of this questionnaire were verified. The results of the study showed that the teachers' awareness of the importance of the teacher and overcoming the obstacles to the performance of the tasks of his profession. The results of the study also revealed the impact of these axes on the role of the teacher is uneven, and the study presented a number of suggestions and recommendations.Keywords: Educational obstacles, Facing primary and school teachers.
Spermatogonial Stem Cells: A Review of Essential Factor for Self-Renewal and Differentiation Silvia W Lestari
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Introduction: Spermatogonial stem cells (SSCs) are considered as promising management for azoospermic patients who couldn’t obtain sperms from the epididymis or directly from testis on assisted reproductive technologies (ART) procedure. The newt highlights of the current research are the emphasis on the utilization of several substances in SSCs culture system which could maintain pluripotency or induce differentiation of SSCs. The objective of this work was to systematically review and discuss articles dealing with the subject of essential factors for self-renewal and differentiation of SSCs. Methods: To this purpose, a computerized search of PubMed database was performed on the general term such as in vitro culture, spermatogonial stem cells, growth factor, hormone and antioxidant. Results: The addition of growth factor, hormone, and antioxidant each play a distinct role in proliferation and differentiation of SSCs. The supplementation of a growth factor activates the cascade of signal transduction toward self-renewal regulation. The addition of hormones such as FSH and testosterone or an antioxidant such as retinoic acid stimulates the differentiation of SSCs in vitro in a certain concentration. Conclusion: The mechanism of these substances in maintaining the pluripotency or inducing cell differentiation varies. Successful development of the SSCs culture system will encourage utilization of SSCs through in vitro proliferation and artificial sperm formation followed by auto-transplantation even though proper investigation is still required prior clinical application.Keywords: Spermatogonial Stem Cell, Growth Factor, Hormone, Antioxidant
Synthesis, Structural Study and Biological Activity Evaluation of Cr (III), Mn (II), Zn (II), Cd (II) and Hg (II) Complexes with New Schiff Base Ligand Derived from Isatin Wurood Ali Jaafar
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

The New Schiff base [3E-3-((1,5-dimethyl-3-((4-nitrophenyl)imino)-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino)indolin-2-one][L] was prepared by two steps, 4-aminoantipyrine was reacted with isatin in the first step to produce the precursor [A], then [A] was reacted with p-nitroaniline to give a new tridentate ligand [L]. this ligand[L] was reacted with some metal ions in Cr (III), Mn(II), Zn(II), Cd(II) and Hg(II)to give a series of new metal compexes of the general molecular formula [M(L)2]Cln , where: M=Cr(III), n=3; M=Mn(II),Zn(II),Cd(II) and Hg(II), n=2. All compounds were have been characterized by spectroscopic methods [ IR, UV-Vis, atomic absorption],elemental microanalysis, chloride content, magnetic susceptibility, conductivity measurements along with 1H,13C-NMR and mass spectroscopy for ligand [L] only. According to the results of the above techniques, the suggested geometrical structures for all prepared complexes were octahedral formula.Keywords: Schiff base, Isatin, 4- amino antipyrine.

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