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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 64 Documents
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Search results for , issue "Volume 10 Issue 07: (2018) July 2018" : 64 Documents clear
Synthesis of Novel Methoxy Substituted Benzothiazole Derivatives and Antifungal Activity against Aspergillus Niger Akhilesh Gupta
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

Background Aspergillus species mainly cause a spectrum of disease ranging from airway colonization. In case of respiratory tract, aspergilloma is the most common form of pulmonary involvement, which is usually accompanied by preexisting lung disease finally architectural abnormalities most commonly stem from tuberculosis, although other associated conditions, such as sarcoidosis, bronchiectasis, and neoplasm, have been documented. Synthesis and screening of benzothiazole derivatives have great importance in heterocyclic chemistry because of its potent and significant biological activities. Methoxy substitution at benzothiazole has already proven its bioactivities in diversified areas. Methods Methoxy substituted benzothiazole derivatives were synthesized by reaction of 3- chloro-4-methoxy-aniline with potassium thiocyanate under temperature control and presence of bromine in glacial acetic acid and ammonia. Substituted nitrobenzamides then synthesized by condensation of, 2-amino-4-chloro-5-methoxy-benzothiazole with 2(3or4)-nitrobenzoylchloride acid in presence of dry pyridine and acetone. Finally, newly synthesized derivatives (K-01 to K-09) were synthesized through replacing of chlorine of nitrobenzamide by reaction with 2-nitroaniline, 3-nitroaniline, and 4-nitroaniline in presence of DMF. Analtytical characterization was performed by TLC, melting point, IR and NMR spectroscopy. Antifungal activity was performed against Aspergillus niger by cup plate method (diffusion technique) using griseoflavin as standard. Compound K-05 and K-06 showed potent antifungal activity against Aspergillus niger while compound K-01 and K-03 showed moderate inhibitory activity at both concentrations 50µg/ml and 100µg/ml as compared to standard. Conclusion In the present work efforts have been made to synthesized methoxy substituted benzothiazole derivatives and screened for antifungal activity. Compound K-05 and K-06 found as most active against Aspergillus niger.Keywords: Methoxy-benzothiazole, Benzothiazole, Antifungal activity, 2-substituted benzothiazole, Cyclization of benzothiazole, Aspergillus niger.
Enhancing Dissolution and Bioavaibility of Purely Water Insoluble Natural Compounds by Solid Dispersion with Hot Melt Extrusion Technique Sofi Nurmay Stiani; Taofik Rusdiana; Anas Subarnas
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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The use of herbal remedies is still a trend in the world, especially Indonesia as the second largest country after Brazil is rich in medicinal plants, in addition to having many pharmacological properties also have low side effects. The most common problems with biopharmaceutically related natural substances are low drug solubility, low biopharmaceutics, stability problems and active substance absorption. Bioavailability is an important factor in achieving the effects of drug therapy. Low bioavailability may occur due to low water solubility, instability in the digestion, and difficulty passing through the membrane. To overcome the problem of bioavaibility of natural material compounds should be made efforts to improve it, one of them with solid dispersion method. The solid dispersion is the dispersion of one or more active ingredients in an inert solid carrier. Technique of Dispersion in the carrier can be by way of hot spin mixing, co-evaporation, co-precipttion, freeze-drying, spray drying and HME. Techniques that are still rarely used in Indonesia is hot melt extrusion (HME). This study aims to explore characteristics of the chemical properties of natural materials, efforts to increase the bioavailability of natural compounds, and solid dispersion techniques.Keywords: Bioavailability, Natural compounds, solid dispersion, hot melt extrusion
The Study of Human Physiological Aspect; The Implementation of Clean Production Technology Through Participatory Ergonomic Decreases Workers’ Musculoskeletal Disorders Wahyu Susihono; I Putu Gede Adiatmika
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Metal manufacturing industries in Bali are spread in Klungkung Regency, Bali. The position of the metal manufacturing industries is in buffer sector of Bali tourism development, so that the stability of sales and production in each period continues to increase. Demand for product quality assurance is carrying out by exporters, including guaranteeing environmentally friendly process. There are many high-quality products are rejected in international market due to the fact that metal manufacturing industries have not consideredhuman and environmental factors (eco-labeling) in their production activity. Companies are switched from Industrial Systems Type I to Closed Loop Industrial System. Various environmental management and industrial management approaches have been carried out, but the current literature review has not reached human physiological aspect. This research is experimental research using treatment by subject design. The result shows that the implementation of clean production technology through participatory ergonomic is able toincrease work performance, in the form of the decrease of musculoskeletal disorders as much as 34.66%.Keywords: Physiological, Musculoskeletal disorders, Metal industry.
Evaluation the Efficacy of Combined Therapy Ketoconazole and Tamsulosinvs Tamsulosin in AUR Followed BPH Iraqi Patients Ali Abdulbaqi Ali Ismael
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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The  Benin prostate hyperplasia symptom may began with 40years and the  incidence increased with  increased age to reach  30% in  men aged above70 years , this associated with   sever complication like AUR which associated with higher morbidity and mortality about 1:7 of patients suffering from AUR dies during the first year, So the study aimed to evaluated the efficacy of mixed therapy versus mono therapy  as well as prolong period ( 5 and 8- days ) in success   TWOC . This study included 100 AUR as complicated to BPA patients which divided into two groups the 1st one 50 patients treated with mixed therapy Ketoconazole and Tamsulosin for 5 Daye (25patients) and 8daye (25 patients)  , While the 2nd groups treated with immunotherapy Tamsulosin for 5 day and 8 day to 25 patient for each one , then evaluate peak flow rate , Residual urine , voided volume and prostate size to determined efficient type  of therapy that gave  successful  treatment . Results clarified  that mixed therapy recorded the best  results than mono-therapy and duration for 8 day revealed  high PFR, voided volume and low residual urine  and prostate size. In conclusion Combination therapy ( Tamsulosin and ketoconazole )augment the prospers rate of treatment without catheter in AUR person this confirmed through that patient  void more successfully after catheter removal , according to  duration  the 8 day revealed high peak flow rate , voided volume and decreased the residual urine also , combination therapy with 8doses recommended to treatment AUR complicated BPH patients Keywords: BPA, AUR, Ketoconazole, Tamsulosin, TWOC, Combined therapy.
Effect of Nutritional Supplementation and Anabolic Androgen with Testosterone on Kidney and Liver Function of Athletes in Baghdad City Firas Salih Abdulhadi
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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This research was conducted to explore the impact of hormones and protein supplementabuseon liver and kidney function and some physiological parameters of athletes. Twenty four volunteers were split equally into two groups, group A: athletes who used androgenic hormones for more than six month, group B: athletes who used proteins and group C: eight volunteers male are normal control without use of any hormones or nutritional supplementation. This research studied intake effect on serum urea, creatinine, total protein, aspartate aminotransferase (AST), alkaline aminotransferase (ALT), sodium, potassium and calcium in the three groups. Results showed a significant elevate (P<0.05) in the level of urea, creatinine, AST and ALT for group A and B compared with the control group, but total protein was lower in group A and control group compared with group B. Furthermore, sodium significantly (P<0.05) decreased in group A and group B compared with control group, on the contrary potassium level and the calcium were significantly decreased in control group compared with group A&B.Keywords: Nutritional supplementation, Anabolic Androgen with testosterone, Kidney, Liver.
Biological Activities of Red and Green Algae from Visakhapatnam Coast Satyalakshmi Siragam
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

Objective: Determination of antibacterial, antioxidant, anti-inflammatory and anti-tumor activity of green and red algae collected from Visakhapatnam sea coast.Methods: In vitro methods are used for determination of biological activities of algal extracts. Diffusion method of microbiological assay was used for estimation of antibacterial activity. Reducing power and free radical scavenging method for determination of antioxidant activity of algae. In vitro anti-inflammatory activity was determined by egg albumin and erythrocyte stabilization. HeLa (Cervical carcinoma) cell lines are used for determination of anti-tumor activity.Results: Red algae Gracilaria corticata exhibited good antibacterial activity against selected test microorganisms. In vitro free radical scavenging method is used for determination of antioxidant activity of Caulerpa taxifolia and exhibited 48.76±0.08% of inhibition at 200 µg/mL. Gracilaria corticata exhibited good anti-inflammatory activity of 58% which was determined by in vitro method of erythrocyte stabilization and 66.75% by egg albumin method. Green algae Caulerpa taxifolia exhibited (IC50 = 32±1.2) remarkable antitumor activity on HeLa cell lines than control.Conclusion: Among two organic solvents used for extraction of active principles from marine algae, methanolic extracts showed better biological activity than the chloroform extract. Green algae Caulerpa taxifolia exhibited significant antioxidant and anti tumor activity than remaining two algal species. Red algae Gracilaria corticata showing remarkable anti-inflammatory activity in both the in vivo methods. This study expands the medicinal importance of marine algae collected from coastal regions like Visakhapatnam.
Gene Sequencing of Human Toxoplasma Gondii Isolated from Inoculated Sheep Ola Kamal
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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The persistence of nucleotides in precise order within a DNA structure is named DNA sequencing. In the medical diagnosis DNA Sequencing becomes a necessity in biotechnology. The technology of DNA sequencing is considered the most accurate method to complete genomes of many types and species, including the human, animals, plants, and microbial species. Studying new genes is significant in determining and identifying the drug target potential when it accompanied with phenotypes and diseases. Also evolutionary biology DNA sequencing to know how organisms are evolved and how they are differ. The inoculation of 17 samples of aborted females were the subject of the study using T.gondii tachyzoits isolation, it underwent gene sequence work from the period of the 15th September 2015 to 10th may 2016 .Genotyping using the Surface Antigen Glycoproteins (SAG2) gene locus refers to that isolates were (12 types II, 3 types I and 2 types III). All these types were illustrated by genetic map as homologues nucleotides sequencing.Keywords: DNA sequencing, Toxoplasma gondii, Sheep, Genotyping.
Various Parameters Influencing To Ambarella (Spondias Dulcis) Jam Production Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Ambarella (Spondias dulcis) has a strong radical scavenge and can be considered as good source of natural antioxidants. Ambarella fruit has a sweet sour taste. The ambarella fruit can be eaten directly in fresh or processed into wine, syrup, nectar, etc. Our attempts to process it into jam were investigated. We focused on investigation of blanching (time, temperature); sugar soaking (time of soaking, sugar addition); evaporation (pectin ratio and time of boiling); preservation (temperature, way of packing) during ambarella jam production. Our results demonstrated that blanching ambarella fruit at 90 oC at 45 seconds was enough to inactivate enzymes; soaking ambarella fruit with 30 % sugar in 15 minutes was enough to get the optimal sensory characteristic of ambarella juice; boiling in 25 minutes with 0.15% pectin was enough to get the optimal total soluble solid (> 65 oBrix) of ambarella jam; ambarella jam should be kept in 4 oC by vaccum packing bag.Keywords: Ambarella, Jam, Blanching, Pectin, Soaking, Preservation
Preparation and Characterization of Nano Hybrid Antifungal from Amphotericin B and Evaluation its Inhibitory Efficiency against Candidaalbicans Mays Ibrahim Al-Wakeel
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Direct ion exchange method was used to prepare a nanohybrid antifungal from Amphotericin B (AmB) and layered double hydroxides (LDH).The new nanoantifungal was subjected to identification .FT-IR spectroscopy revealed the appearance of new chemical groups in the prepared antifungal which indicates the formation of new compound. The X-Ray Diffraction (XRD) spectrum revealed the appearance of new diffraction planes in the nanohybrid antifungal in compare with the spectrum of layered double Hydroxides. The two and three dimensional image of the above compound obtained from atomic force microscope confirmed the formation of new antifungal with nanodimensions. The antifungal activity of prepared compound was evaluated against Candida albicans isolated from mouth and vagina.Keywords: Amphotericin B, Nanohybrid antifungal, FTIR, XRD, Controlled release, Antifungal activity
"Synthesis and Identification of (4, 5, 6 and 7) Membered Heterocyclic Derivatives from 5-nitrovanilline” Shaimaa Adnan Behget
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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AbstractThis work included synthesis new Schiff base (1-(3-((4-hydroxy-3-methoxy-5 nitrobenzylidene) amino) phenyl) ethan-1-one)(1)by reaction 5-nitrovanilline with3-aminoacetophenone in acid medium, then (1) react with 2-amino-6-methoxybenzothazole to get derivative(2). (2) React with (chloroacetylchloride, thioglycolic acid, glycine, alanine, sodium azide, phthalic anhydride, maleic anhydride) to give (β-lactam, thiazolidine, imidazolidine, tetrazole, oxazepine) derivatives. In other side5-nitrovanilline react with acetophenone derivative in alkaline medium to get3-(4-hydroxy-3-methoxy-5-nitrophenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one which react with (hydrazine , phenyl hydrazine , 2,4-dinitro phenyl hydrazine , hydroxyl amine hydrochloride , urea , thiourea , ethyl cyanoacetate , malononitrile , guanidine hydrochloride ) to get ( pyrazol , isoxazole , oxazine , thiazine ,  pyridine , pyrimidine ) derivatives. The new synthesized compounds have been identified by their melting points, 1HNMR, 13CNMR and FT-IR spectra.Keywords: Schiff bases, Chalchone,β-lactam, Thiazolidine, imidazolidine, Tetrazole, oxazepine, Pyrazol, Isoxazole , Oxazine , Thiazine ,  Pyridine , Pyrimidine.

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