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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 81 Documents
Search results for , issue "Volume 11 Issue 03" : 81 Documents clear
Palynological Study of the Genus Arabis l. (Brassicaceae) in Iraq Khazal Dh. Wadi Al-Jibouri
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Pollen morphology of 4 species (A. aucheri , A. auriculata, A. caucasica, A. nova) belonging to the genus Arabis L. in Iraq was examined by light microscope and scanning electron microscope to determine the significance of pollen features as a taxonomic characters. The results showed pollen grains of the species were monades, homopolar, tricolpate, and with medium size, but the species varied in shapes (polar and equatorial view), colpus length and width, exine thickness and exine ornamentation. Pollen colors were brown convert to brownish yellow.Keywords: Arabis, Cruciferae, Palynology, Pollen grain.
Prevalence of Tuberculosis in Nasiriyah City from 2010-2015 Kadhim Mohan Manhil
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Tuberculosis deployed in Nasiriyah City this study aimed to prevalence of Tuberculosis in Nasiriyah City, It is during visit to the health centers in the first and second Nasiriyah sector and updating us on the data found where the number of total infections in Nasiriyah from a year 2010 and 2015 to 2821 cases distributed among different age groups where the infection rate among children 5% and women 25% and men 70% and through study and observation of the database and the number of cases. low that number infection case in 2015 than it was in 2010 where the number of people with tuberculosis in 2010 in 628 infection case in 2015 was 260 cases and this shows a lower incidence gradually The study was conducted in Nasiriyah City, said the number of infected men more than women and children, and this goes back several reasons in men and through the study also found Variation in infection to the health center. Some centers recorded the highest cases of infection from tuberculosis during this year’s, some did not score in three years, an infection in Nasiriyah, the second sector is generally more than the infection in the first sector.It is during our visit to the health centers in the Nasiriyah to first and second Nasiriyah sector and updating us on the data found Also, the percentage fixed in Nasiriyah, from 2010 to 2015 among children, women and men, but the disparity in number by every year.Keywords: Tuberculosis, Nasiriyah city, Iraq.
Potential Role of Titanium Dioxide (TiO2) Nanoparticles against the Toxicity of Leishmania Tropica in Adult Albino Male Rats Ahmed Hamad Saleh
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

The present study was designed to show the role of green Tio2 nanoparticles against toxicity of Leishmania tropica. The present study used 15 adult albino male rats that divided randomly to following groups (each group consist 5 rats); control group received ad libidium, second group infected with Leishmania tropic, third group treated with 50ug/kg green Tio2 nanoparticles. Oxidative stress and antioxidant parameters in positive group injected show significant increased (P < 0.05) in levels of MDA (malonedialdehyied) and significant decreased (P < 0.05) in levels of glutathione (GSH) and catalase compared with control group. While, after used green Tio2 nanoparticles, the results showed non-significant changes (P < 0.05) in MDA, GSH and catalase levels showed non-significant changes (P < 0.05) compared with control group. Histological study of skin in positive group show severs lymphocytes infiltration between collagen fibers in dermis layer with oedema. On other hand, skin in treated group show  epidermis layers normal with dermis appear normal with normal distributed of collagen fibers and hair follicles. It was concluded that green Tio2 nanoparticles has been potential role against toxicity of Leishmania tropica in male rats.Keywords: Tio2 nanoparticles; Leishmania tropica; Oxidative stress; Antioxidant factors.
Gliomatosis Cerebri (GC), Presentation, Management & Prognostic Overview Raad Ahmed Hussein
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Gliomatosis cerebri (GC) is a rare, infiltrating glioma of brain & spinal cord. It is affects children, adult & elder age groups. Objective: To have an overview on the clinical presentation, management, prognosis & survival period of patients with GC. Material & methods: We retrospectively studied the clinical presentation & management and prognosis in 14 patients of gliomatosis cerebri between 2013 and 2016. The presentation is that of raised ICP, focal neurodeficit & epilepsy.  Results: All patients treated with radiotherapy, followed in few cases by chemotherapy. The survival time was not more than 2 years in all cases. The diagnosis is based on radiological MRI studies & histopathology.  Treatment: Surgical treatment is not usual option due to wide spread neuraxis involvement. Radiation therapy & chemotherapy may give some survival benefit. The outcome of the disease & the prognosis is poor & the survival period not exceeds 24 months with the best combined chemotherapy & radiotherapy.Keywords: Multiple malignant glioma. Gliomatosis  cerebri.
The Effects of Local Alendronate with Biphasic Calcium Phosphate on Augmented Rabbit Sinus Zainab M. Hameed
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Background: Biphasic calcium phosphate   considered a good synthetic bone graft substitutes, and its effective role in sinus floor lifting. Alendronate (ALN) is a common formula of bisphosphonates that have potential effects to decrease the osteoclast differentiation. Aim of  study is -to evaluate histologic and histomorphometric effect of  local alendronate with  BCP  with  ratio( 30: 70)when used with  a  rabbit sinus. Materials and Methods:--8 male adult (New Zeeland) rabbits were selected. Sixsteen sinus floor, elevation procedures, were prepared, 2 on each animal and were distributed into two groups (n=4): the BCP group, where the sinus was grafted with, B CP with HA ׃β ̵ TCP (30 ׃70).And BCP/ALN group, where the sinus grafted with (OSTEON II), mixed with Alendronate solution, the solution was prepared by dissolving of 20 mg of ALN with 1 ml of distal water. The rabbits killed at 7, 14, 30 and 60 days after surgery and the histological   analysis were achieved. The histologic evaluation was performed using a light microscope. The new bone area represents the proportion of dark red area to the total augmented area, while the (FCT) represents the proportion of light red area to the total augmented area. Results: Although there  were significant differences  of  new  bone formation between two study groups after 7,14 and 30 days  periods ,but there's  non-significant differences occurred after 60 days . In addition, the FCT area was decreased in these two groups with the progressing healing periods, at the same time the FCT area was less in BCP/AL group; and there were   statistically nonsignificant differences between two groups after 60 days periods. Conclusions: - Local application of ALN with BCP with the (HA: β ̵ TCP (30:70)) ratio, did not have beneficial effects when augmented sinus rabbit model to increase bone formation. Keywords: Biphasic calcium phosphate; Alendronate; Rabbit maxillary sinus.
Quantitative Estimation of Gallic Acid in Triphala Churna by HPTLC Gouri Kumar Dash
Journal of Global Pharma Technology Volume 11 Issue 03 (2019) March. 2019
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Abstract

A simple, reliable and rapid HPTLC method was developed for qquantitative estimation of gallic acid in the methanol extract of Triphala churna. The method was validated as per ICH guidelines for linearity, accuracy, precision, and specificity. Silica gel 60 F254 pre-coated aluminium plates were used as the stationary phase. Toluene: Ethyl acetate: Formic acid: Methanol (12: 9: 4: 0.5) constituted the mobile phase.  Percentage of gallic acid was estimated through densitometry scanning using a TLC Scanner III (Camag, Switzerland) with winCATS software. The amount of gallic acid present in the sample was found to be 0.41 ± 0.08 % w/w with respect to dried plant material. Thus, the developed method can be applied in quantifying the amounts of gallic acid in Triphala churna and results of this work will support in the standardization process of Triphala churna using gallic acid as the biomarker.Keywords: Triphala churna, Methanol extract, HPTLC, Gallic acid.
Determination of Parents Burnout for Child with Type 1 Diabetes Mellitus in Endocrine and Diabetes Center at Al-Nasiriyah City Amer Muhasin Naser
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Objectives: To assess level of parents’ burnout   for child with type 1 diabetes mellitus (T1DM). Also to find out the association between parents burnout, and demographic characteristics (child age at diagnosis, gender of parents’, parents' level of education).Methodology: A descriptive cross-sectional study design was conducted in Endocrine and Diabetes Center at AL-Nasiriyah city to assess level of parents' burnout for child with T1DM and find out the association between parents burnout, and demographic characteristics (child  age at diagnosis ,gender of parents' , parents' level of education). The study was conducted on 200 parents' who have child with type T1DM. The data were collected using the interview and the questionnaire form, which was designed to contain (44) items containing the form of personal and demographic characteristics and parents'' burnout, as followed by Maslach burnout interview after modification (Maslach, 2001). This part involves (34) distributed into three sub-domains, which are (Emotional exhaustion, Personal accomplishment and Depersonalization). The data were analyzed using descriptive statistics method (frequency, percentages, Chi Square). Results: The study shows that the parents' are moderately burned out and there is no statistically significance between parents' bournut and parents' demographic characteristics. Recommendations: Study recommended establishing educational program should be done for parents' to decreases burnout level. Instructional class or folder given for parent's for increase their knowledge toward effects of burnout on their daily physical and emotional functionsKeywords: Parents', Burnout, T1DM.
Identification and Association Polymorphisms of TGF-β and IFN-y Genes with Schizophrenia Risk in Iraqi Patients Anwar Abed Nasser Dhabaan
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Genetics study for IFN-γ (Interleukin-γ) T/A +874 and TGF-β1(Transforming growth factor-beta) +869*C/T genes polymorphisms for schizophrenia patients with mean age 49.95±1.6 was studied by using ARMS-PCR (Amplification refractory mutation system technique). The results revealed the presence of two alleles A and T with three genotypes (TT, TA and AA) for IFN-γ (+874 T/A) gene, and two alleles C and T with three genotypes (CC, TT and CT) for TGF-β1 (+869*C/T). The result show that high frequency for allele A of IFN-γ +874 T/A as compare with T allele in schizophrenia patients samples (n=38) and associated with etiological fraction (EF) of schizophrenia, dependent on values of odds ratio (OR) and confidence intervals (CI), while T allele associated with preventive fraction (PF) of schizophrenia. The ARMS-PCR analysis results present AA and TT homozygotes genotypes of IFN-γ T/A +874 gene was more than in schizophrenia patients as compared with control and showed that AA and TT genotypes associated with EF in schizophrenia risk, while TA heterozygote genotype present in high frequency in control as compared with schizophrenia patients and associated with (PF). The T allele for TGF-β1 (+869*C/T) gene exist in high frequency for schizophrenia patients and associated with (EF) schizophrenia, while C allele associated with (PF) schizophrenia. The TT homozygote genotype frequency of TGF-β1 (+869*C/T) gene was more than in schizophrenia patients and associated with (EF) of schizophrenia, while CC homozygote and CT heterozygotes genotypes present more than in control as compared with schizophrenia patients and associated with (PF).Keywords: Polymorphism, Schizophrenia, IFN-γ T/A +874 and TGF-β1 (+869*C/T) genes.
Inhibitory Activity Evaluation of Two Medicinal Plant Extracts (Rosmarinus officinalis & Alhagi maurorum) against Adult of Tribolium Castaneum Meison Abdulbary
Journal of Global Pharma Technology Volume 11 Issue 03
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Medicinal plants (Rosmarinus officinalis and Alhagi maurorum) alcoholic extracts inhibitory effect against Tribolium castaneum adults were examined with concentrations 50, 75 and 100 mg/ml through 24, 48 and 72 hours respectively. The total results indicate that the two plants can be used as insecticides for T. castaneum.  However ,The results indicated a significant difference between the two plants in the adult mortality rate, where were adults mortality rate of treatment with plant extract Alhagi maurorum (2.37) in contrast to the plant Rosmarinus officinalis which amounted to (1.19) after 72 hours of treatment. The results showed non-significant differences between concentrations of the plant extract Rosmarinus officinalis  in the adult mortality  Tribolium castaneum in 24 and 48 hours , while there was a significant difference between concentrations in 72 hours where was the adult mortality rate 5.67 with concentration 100 mg/ml and 1 with concentration 50 and 75 mg/ml  respectively. In addition, there were significant differences with extract of Alhagi maurorum between the concentrations in the adult mortality rate at 24 and 48 hours, but the results showed significant differences between the concentrations of the extract in 72 hours reaching 1.33, 4.33 and 5.67 respectively with the concentrations 50, 75 and 100 mg/ml respectively.                                                                                                              Keywords: Rosmarinus officinalis, Alhagi maurorum, Tribolium castaneum.
Isolation and Molecular Characterization of Lactobacillus Genus from Patients Wear in Fixed Orthodontic Appliance Anphal Ihsan Jasim
Journal of Global Pharma Technology Volume 11 Issue 03
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Background: The fixed appliances might prevent effective oral hygiene and cause high cariogenic challenge. Objective: This study was examining the presence of lactobacillus Spp by traditional culture and PCR methods. Material and Method: A total 74 patients with age range from 15 to 35with mean age (19.67) that enrolled in this study. The samples were collected from patients admitted to orthodontic department in collage of dentistry during the period from November 2017 to March 2018. The result:  The result were shown 59 of 74 was positive result, Thirty eight of 59was positive in PCR technique while 21of 59 positive in culture ,The methods of PCR and growth detected this bacteria was only 35.6%positive in culture ,while PCR methods were 64.4%%. Conclusion: the higher level of bacteria detected by PCR than routine culture method  confirm that  the PCR method is very sensitive, specific and time consume technique for detecting of oral bacteria.Keywords: Orthodontic Appliances, Lactobacillus, Polymerase Chain Reaction, Biofilm formation, Culture.

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