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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 74 Documents
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Search results for , issue "Volume 11 Issue 04." : 74 Documents clear
The Effect of Bay Leaves (Syzygium Polyanthum) Administration Towards the Final Weight and Carcass Percentage of Laserpuncture-Induced Male Hybrid Ducks Lucia Tri Suwant
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

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Abstract

The carcass weight of laserpuncture-induced male hybrid ducks is not maximum yet. Nevertheless, it can be resolved by using bay leaves (Syzygium polyanthum) as a supplementary feeding to support the optimal work of laserpuncture technology. This research aims to evaluate the impact of bay leaves (Syzygium polyanthum) towards final weight and carcass percentage of laserpuncture-induced male hybrid ducks. This research applied Completely Randomized Design (CRD) with three treatments. Each treatment consisted of six replications, and each replicate consisted of six male hybrid ducks with homogenous age and weight. The three treatments were P0 (Control), P1 (Laserpuncture), and P2 (Laserpuncture and bay leaves). The data were analyzed by using Analysis of Variance (ANOVA) and continued by Least Significant Difference (LSD). The results suggested that the bay leave administration on laserpuncture-induced male hybrid ducks (P2) provided a significant effect (P<0.05) in comparison with (P0) & (P1) on the final weight. However, an insignificant effect (P>0.05) was identified on the carcass percentage of male hybrid ducks. The bay leaves administration on laserpuncture-induced male hybrid ducks can intensify the final weight gained, but it does not affect the carcass percentage.Keywords: Hybrid Duck, Laserpuncture, Bay Leaves (Syzygium Polyanthum).
Coating of Plastic Materials with Metals Under Low Pressure Ban Khalid Mohammed
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

There the outcomes concerning the investigations regarding floor energy then chasm durability on abrasive then other enormously strong substances the usage of the approach regarding micro stress so much affords high dosage about localization on the software over an external force action, are presented. The fundamental regularities over elastic-plastic deformation or brittle defeat of the procedure on micro indentation have been determined because of every the investigated materials. Based of the studies we additionally identified the power or energy conditions about elastic-plastic deformation and slight dud of the manner on micro indentation of fairly solid or brittle materials. It was once found, to that amount within the 1st flooring on the corrosion manner the precise work of break and the power depth element are immediately proportional after the bulk on the stress concentrator, i.e. the imprint diagonal. Therefore the power depth component so is widely used of mechanics or micromechanics concerning materials can keep legitimate solely when that is described among terms over sustainable increase concerning cracks of the 2nd board regarding unsound cleft of the investigated material. According in imitation of take a look at consequences we present the important traits regarding power then crack toughness on a quantity concerning abrasive substances ancient in enterprise or lookup organizations.Keywords: Method of micro pressure; Brittle fracture; Micro volumes; Origin; Critical stress; The relative elastic deformation.
Acupuncture Prevent Progression of Cachexia in Breast Cancer in Outpatients of Dr. Saiful Anwar General Hospital Malang East Java Indonesia Laily yuliatun
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Objective: This study was aimed to assess effect of acupuncture in progression of cachexia in breast cancer patient. Indicator progression of cachexia in this study is level of BMI, FM and FFM was measured before and after eight session of acupuncture procedure.Methods:  Seven patients were diagnosed breast cancer provide eight acupuncture session before chemotherapy and radiotherapy procedure. Acupuncture procedure was done every 2 days, with duration 30 minutes for every session. Bioelectrical impedance analysis (BIA) measurements were taken at before and after eight acupuncture session to evaluate the body composition of patients. BIA is fast, inexpensive and noninvasive method for evaluating Body Mass Index (BMI), Fat Mass (FM) and Fat-Free Mass (FFM).Results and Conclusion: All patients were include in the analysis were complete the acupuncture intervention and BIA measurements. Average age was 54 years, with rang 47-58 years. Most of patients in advanced cancer, 28.5% stage 3 and 43% in stage 4. In this study acupuncture could prevent progression of breast cancer cachexia, with maintain body composition during procedure. BMI was relative constant after eight session of acupuncture (20.25±3.1; p>0.00). Similarly, from BIA measurement, FFM decrease only 0.4% (p>0.05) and FM increase 0.4% (p>0.05). The constant value of body composition mean acupuncture could maintain the metabolism rate in cachexia patients. This study indicate acupuncture could prevent progression of cachexia in breast cancer. Keywords: Acupuncture, Cachexia, Breast Cancer, Body composition.
Role of Leptin in Iraqi Male Infertility Batool A. Al-Haidary
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Background: Many etiological factors participate in initiation and development of males’ infertility. Leptin is an adipokine that play a crucial role in obesity and many other biological effects. One of these its effects are on Hypothalamus and Pituitary glands to which males’ infertility may be attributed.  Aims of Study: This study was designed to investigate the role of Leptin and its’ receptor in development of infertility among Iraqi males Materials & Methods: Seventy sub-fertile males were included in this investigation to estimate Leptin and its receptor levels in seminal plasma by ELISA techniques. All patients had been diagnosed as a sub-fertile male under the supervision of consultant physician.  Seminal fluid analysis was performed for each patient. Body mass index for each patient was calculated besides sera LH, FSH and testosterone hormones determinations and the results of the above tests were compared with those for 30 normal fertile men who matched the patients in their ages. All data has been analyzed statistically. Results: The results revealed highly significant decline in the mean of leptin levels (27.283±3.034ng/ ml) among patients in comparison with healthy fertile control group (47.975±7.152 ng/ ml) (P=0.002). Moreover, LH hormone showed an increment in its mean level (34.699±1.594) in highly significant manner in comparison with control group (14.859±1.947) (P= 0.001). This study referred to highly significant correlation between leptin receptor and BMI (P=0.0001), in addition to significant correlation with testosterone (P=0.046). Meanwhile significant correlation was observed between leptin and FSH (P=0.027). Conclusion: In view of the above results it can be concluded that there is an association between Leptin and FSH which in turn significantly correlated with sperms’ count and theirs ’motility.Keywords: Leptin, Obesity, Sex hormones, LH, FSH, Testosterone, Seminal fluid analysis.
Physical Factors in the Treatment of Chronic Venous Insufficiency of the Lower Extremities Aleksandr Derinov
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

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Abstract

Trophic ulcers are one of the most severe complications of chronic venous diseases, leading to functional insufficiency of the lower extremities and a sharp decline in the life quality. Complex of preoperative preparation and combination with various methods of surgical correction are essential in this case. Higher results can be obtained with combined application of several techniques. Topical application of combined low-intensity laser radiation and micro dispersed drug irrigation is a pathogenetically substantiated non-invasive method of conservative treatment and preoperative preparation of trophic ulcers in patients of the C6 class.Keywords: Bactericidal therapy, Pain syndrome, Varicose veins, Trophic ulcers.
Effectiveness of Edible Coating to Extend Shelf-Life of Dry Fermented Sausage N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

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Abstract

The manufacturing of rapid and shelf stable dry fermented sausages became an art and provided the market with a very diverse range of delicacies. Fermented sausages can be defined as a meat product made of a mixture of mainly pork meat pork fat, salt, curing agents, sugar, spices, and in many cases starter cultures are added. The mix, including as little oxygen as possible, is placed into steam - permeable casings and subjected to a fermentation and drying process. Fat is one of the important factors contributing to enhanced flavor, texture, juiciness, and mouth feel of dry fermented sausage. However, fat is easily rancid to create bad odor as well as lower product quality and shelf-life. Objective of the current research studied the feasibility of edible coating in extending shelf-life of dry fermented sausage. The dry fermented sausages were treated by different formulas (N0: control; N1: 2.0% wheat gluten; N2: 2.0% w/w chitosan; N3: 2.0% w/w sodium alginate; N4: 2.0% w/w collagen) and in different concentration of chitosan (2.0%, 2.5%, 3.0%, 3.5%, 4.0%). The effectiveness of edible coating was based on the physicochemical attributes such as pH, water activity (aw), TBARS value (mg/kg); biogenic amines such as tyramine (mg/kg), 2-phenylethylamine (mg/kg), tryptamine (mg/kg), cadaverine (mg/kg), putrescine (mg/kg) and histamine (mg/kg); antimicrobial capacities such as total plate count (cfu/g), Enterobacteriaceae (cfu/g), Coliform (cfu/g), E. coli (cfu/g), Staphylococus (cfu/g), Listeria (cfu/g), Salmonella (cfu/g), Vibrio (cfu/g), yeast (cfu/g), mold (cfu/g) and sensory characteristics of dry fermented sausage during storage. All treated samples were analyzed after 9 months of storage at ambient temperature under vaccum packing. Results revealed that the incorporation of 3.0% w/w chitosan could inhibit microbial spoilage and lipid oxidation and therefore maintain the sensory score of the dry fermented sausage for 9 months during storage. The study indicated that the combination treatment with edible coating could be commercially utilized to maintain the freshness and prolong the shelf‐life of the dry fermented sausage.Keywords: Dry fermented sausage, Wheat gluten, Chitosan, Sodium alginate, Collagen, Antimicrobial, biogenic amine, Sensory.
In Vitro Assessment of Total Phenolic, Total Flavonoid and Sunscreen Activities of Crude Ethanolic Extract of Belimbing wuluh (Averrhoa bilimbi) Fruits and Leaves Muhammad Ryan Radix Rahardhian
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

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Abstract

Averrhoa bilimbi, namely belimbing wuluh in Indonesia. It’s the fruits used to food in vegetable dishes. Belimbing wuluh’s leaves and fruits are traditional herb in Indonesian. This study aim to determined total phenolic content, total phenolic content and sunscreen activity from ethanolic extract of Belimbing Wuluh fruits and leaves. Total phenolic content of fruits ethanolic extract is 19.8022 ± 1.6696 mg GAE/g more than leaves ethanolic extract 6.5886±0.0590 mg GAE/g. Both have significant differences after tested t test (sig<0.05). Total flavonoid content of fruits ethanolic extract 24.7458±0.3291 mg RE/g more than leaves ethanolic extract 13.3126±0.5695 mg RE/g. Both have significant differences after tested t test (sig<0.05). Sun Protecting Factor of leaves ethanolic extract better than fruits ethanolic extract. Only one leaves ethanolic extract concentration of 300 ppm can be drawn in the total block valuation category with ultra protection. The conclusion is leaves ethanolic extract has good potential as an active sunscreen ingredient although it has a total phenolic content and a lower total of flavonoids than fruits ethanolic extract of belimbing wuluh. These data indicate that the sunscreen active ingredients found on the leaves of belimbing wuluh are suspected of phenolic compounds and other components that have a conjugated double bond that can absorb UV light in the 290-320 nm range.Keywords:  Averrhoa bilimbi, Total Phenolic Content, Total Flavonoid Content, Sunscreen Activity.
Use of Integrative Medicine Approaches for Treating Adults with Sleep Disturbances Raad Issa Taqi Al-Shammaa
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Objective: This learning recognized the occurrence then effectiveness of perceived, influencing elements or assessment about data sources as much well as like boundaries then facilitators for the usage regarding IMA between the past 12 months in accordance with treat adults together with sleep disorders. Background: There are no researches evaluating the use concerning complementary remedy strategies among adults together with couch disorders. Method: Perform a sectional scan. Adults along intentional lie issues had been elected beside a lie center in a sanatorium into Taiwan. Binary logistic regression used to be back after analyze yet examine variations into use corporations then non-use of. Results: The response rate was 94.5% (n = 515). The occurrence over the uses of complementary medication techniques was 53.4% (n = 275). The almost frequent IMA is music. However, the near fine integrative medicine techniques were acupressure, accompanied via tune and meditation. Independent explanatory variables had been academic attainment, quantity regarding persistent diseases / symptoms, or wholesome lifestyles because IMA use. The near common source concerning statistics is television / radio. Was the top facilitator and obstruction in imitation of the uses on complementary medicinal drug techniques beyond the facet results of slumbering drugs yet confined access? Conclusions: IMA is ancient through a big share over adults in conformity with deal with lie problems between Taiwan. The results concerning that lesson recognized important explanatory variables because of IMA utilizes and furnished a primary perception regarding the elements over IMA utilizes into adults along couch problems so much are of precise value to health ponderabil vendors among the work related with their patients.
Effects of coal dust particulate matter exposure on H2O2, MDA, IL-13, TGF-β3 level and bronchioles sub-epithelial fibrosis in allergic asthma mice model Fujiati .
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Objective: Pulmonary fibrosis in asthma is marked by a rapid decline in lung function. Unfortunately, the environmental factors aggravating this condition are still poorly understood. To date, the pathomechanism of exposure to coal dust affecting the subepithelial fibrosis in asthma remains unclear. Methods: Twenty-fourth female BALB/C mice were divided into four group. The first group was control, the second was mice exposed to coal dust particulate matter (PM) (days 46-75), the third was OVA sensitized mice  (Initial sensitization on day 0 and 14, re-sensitization days 21-75), and the fourth was made of OVA-sensitized mice and exposed coal dust PM. Results: The results showed coal dust PM significantly decreased levels of IL-13 BAL (p-value=0.001) but significantly elevated H2O2 BAL levels (p-value=0.001) and increased sub-epithelial bronchial fibrosis thickness (p-value= 0.000). This was based on the scale of fibrosis (0=<5 μm, 1=5-10 μm; 2=11-15 μm; 3=>15 μm; score 0-1=mild; 1-2=moderate; and 3= severe). The combination of ovalbumin sensitization and PM coal dust caused severe fibrosis (score 3).There was no significant association between IL-13, TGF-β3, H2O2, and MDA BAL with sub-epithelial fibrosis thickness. Conclusions:  PM exposure to coal dust may increase sub-epithelial fibrosis of the bronchioles by a mechanism independent of inflammation and oxidative stress.Objective:Pulmonary fibrosis in asthma is marked by a rapid decline in lung function. Unfortunately, the environmental factors aggravating this condition are still poorly understood. To date, the pathomechanism of exposure to coal dust affecting the subepithelial fibrosis in asthma remains unclear. Methods: Twenty-fourth female BALB/C micewere divided into four group. The first group was control, the second was mice exposed to coal dust particulate matter (PM) (days 46-75), the third was OVA sensitized mice (Initial sensitization on day 0 and 14, re-sensitization days 21-75), and the fourth was made of OVA-sensitized mice and exposed coal dust PM. Results: The results showed coal dust PM significantly decreased levels of IL-13 BAL (p-value=0.001) but significantly elevated H2O2 BAL levels (p-value=0.001) and increased sub-epithelial bronchial fibrosis thickness (p-value=0.000). This was based on the scale of fibrosis (0=<5μm, 1=5-10μm; 2=11-15μm; 3=>15μm; score 0-1=mild; 1-2=moderate; and 3= severe). The combination of ovalbumin sensitization and PM coal dust caused severe fibrosis (score 3).There was no significant association between IL-13, TGF-β3, H2O2, and MDA BAL with sub-epithelial fibrosis thickness.Conclusions:  PM exposure to coal dust may increase sub-epithelial fibrosis of the bronchioles by a mechanism independent of inflammation and oxidative stress.
Anti-obesity effect of Dunaliella salina: Study on the gastric inhibitory polypeptide, ROS, DNA damage and metabolic gene expression in rats Howaida Ibrahim Abd-Alla
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

This study aimed to identify the gene expression profiling of lipid related genes in animal model of obesity and the role of microalgal Dunaliella salina (alga) in modulating the expression of these genes during the initial period of obesity. The diet-induced obesity model was used using fifty male Wistar albino rats (weighing 150-160 g) that have obesity caused by being fed high-fat diet (HFD) for 12 weeks. These rats were randomly divided into 2 groups (10 rats each) and treated with D. salina extract and orlistat for 6 weeks. The anti-obesity effect of this halophilic unicellular green alga was compared to orlistat, a standard anti-obesity drug promoting weight loss as a gastric and  pancreatic lipase inhibitor. Treatment with the alga and orlistat showed significant effect in reducing gastric inhibitory polypeptide (GIP). Also, the treatment of obesity-induced rats with the alga increased significantly the mRNA expression levels of lipid catabolic genes (peroxisome proliferator-activated receptor PPAR-α and carnitine palmitoyltransferase CPT-1) and decreased significantly the expression levels of lipid anabolic gene (SCD-1) compared with obesity-induced rats. In addition, D. salina extract was able to decrease ROS generation and inhibit the rate of DNA damage in obese rats. The study was extended to evaluate the phytochemical composition of  microalgal extract. The fatty acid methyl esters were analyzed by GLC. The extract contained considerable level of omega-3 fatty acids. The presence of  palmitic (62.5%), linolenic (9%), oleic (8.6%) and linoleic (7.4%) was revealed. The percentage of saturated and unsaturated fatty acids were 67.7 and 32.1%, respectively. D. salina extract administration which is rich in omega-3 fatty acids, has anti-obesity properties. Results suggested that D. salina might be available as functional alga and bioactive diet supplement for the treatment of obesity.

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