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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 74 Documents
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Search results for , issue "Volume 11 Issue 04." : 74 Documents clear
Morus alba and Morus rubra alleviate hepatic disorder, oxidative DNA damage and gene expression profile change in obese rats Howaida Ibrahim Abd-Alla
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: To examine the impact of Morus rubra and Morus alba extracts on physiological and metabolic functions of obese male rats induced by high fat diet. Methods: Orlistat was used as standard drug. Seventy Wistar male rats (weighing 150-160 g) were fed for 12 weeks with high fat diet to induce obesity. The obese rats were randomly assigned to three groups (10 rats each) and treated with Morus rubra and Morus alba extracts or orlistat for 6 consecutive weeks. The level of visfatin was measured by enzyme-linked-immunosorbent. The suppression impact of extracts against DNA adducts 8-hydroxy-2′-deoxyguanosine (8-OHdG) and 2-deoxyguanosine (2-dG) generation was measured by high-performance liquid chromatography. Expression of genes including ATP- citrate-lyase, peroxisome-proliferator-activated receptor-γ and HMG CoA reductase in liver tissues were also measured by quantitative real time-polymerase chain reaction. Results: Treatment with the Morus rubra and Morus alba extracts and orlistat significantly decreased visfatin level. Morus rubra and Morus alba extracts significantly decreased the levels of mRNA expression of ATP-citrate-lyase, HMG CoA reductase genes, and peroxisome-proliferator-activated receptor-γ compared with high fat diet rats. In addition, Morus rubra and Morus alba extracts decreased the level of 8-OHdG/2-dG ratio. Conclusions: The ameliorating effect of Morus rubra and Morus alba extracts on visfatin levels  reducing fat may be attributed to the rich content of polyphenolic which suppresses lipid synthesis in liver tissues. Moreover, anti-DNA damage effect of Morus rubra and Morus alba extracts suggests their role as natural antioxidants against diseases such as obesity associated with genetic damage.
Bentonite as an Adsorption Surface for Bromothymol Blue Dye from Aqueous Solution Kawther Ahmed Sadiq
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Accomplishment of Adsorption of dye from aqueous solution on the surface of bentonite was done under the following optimized conditions: temperature, initial concentration, contact time and weight surface. Via utilizing the technique of UV-Vis spectophotometry at (λmax= 432 nm) the quantitative estimation of the dye adsorption has been performed. this study has demonstrated that the more increasing of  adsorption with the more increasing of temperature from 25 ˚C to 45 ˚C also increasing of clay weight (0.1-1.1 g).calculating thermodynamic parameters like change in the free energy (∆G), the enthalpy (∆H), the entropy (∆S). Results of adsorption isotherms obtained in this study were inconsitence with fitted with Freund lich adsorption isotherm.Keywords: Adsorption, Bentonite, Bromothymol blue.
Effectiveness of Edible Coating, Preservation Temperature and Packaging to the Rancidity and Proteolytic Activity in Dried Mudskipper (Pseudapocryptes Elongatus) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Mudskipper (Pseudapocryptes elongatus) has become a high value species in the markets of Mekong Delta, Viet Nam. Mudskipper aquaculture has potential for coastal aquaculture development and is an alternative to shrimp farming in the Mekong Delta. In terms of nutritional quality of fish, sometimes dry fish have higher quality standards compared to fresh fish. P. elongatus aquaculture has developed rapidly to supply the high demand of domestic consumers. Consumption of dried mudskippers fishes has increased during recent years as consumers have become more aware of its nutritional benefits and of the health concerns associated with other meat products. However the dry-salted mudskippers are not stable at normal preservation by rancidity and proteolytic activity because they have too much oil as well as protease enzyme in their abdomen. Edible coating provide a replacement and fortification of the natural layers at the product surfaces to prevent moisture losses, gas aromas and solute movements out of the food, while selectively allowing for controlled exchange of important gases. Biodegradability, barrier properties, biocompatibility, and edibility as well as being nontoxic and non-polluting are a few advantages of edible films and coatings over plastic packages. Preservation temperature and packaging method also influenced to rancidity and proteolytic activity in the dried mudskippers (Pseudapocryptes elongatus). Objective of the current research studied the feasibility of sodium alginate coating in preservation of dried mudskipper (Pseudapocryptes elongatus). The dried mudskippers were treated by different concentration of sodium alginate (1.0%, 1.5%, 2.0%, 2.5%, 3. 0%). The effectiveness of sodium alginate coating was based on quality changes of dried mudskippers such as lipid oxidation: Peroxide value (mEqO2/ kg), Thiobarbituric acid (mg maloaldehyde/ kg); proteolytic changes: total volatile base (TVB-N, mg N/100 g) nitrogen content and trimethylamine (TMA, mg N/100 g). All treated samples were monitored during 12 months of storage at ambient temperature in 3 months of interval sampling. Results revealed that the coating of 2.5% w/w sodium alginate, 4oC in vaccum bag could control microbial spoilage and lipid oxidation of the dried mudskippers. By this approach, the dried mudskippers (Pseudapocryptes elongatus) are stable at normal environment for 12 months. The study indicated that the edible coating could be commercially utilized to prolong the shelf‐life of this oil fish. The improvement in the quality of the seafood products is achieved through inhibition of proteolytic reaction, reduction of lipid oxidation reduction and enhancement of sensorial attributes. Keywords: Pseudapocryptes elongatus, Sodium alginate, Proteolytic reaction, Lipid oxidation, Shelf-Life.
Molecular Analysis of Type 1 Fimbriae Operon in E. coli Isolated from UTI Duaa Al-Musawi
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

One hundred E.coli isolates wascollected from urinary tract infections. Patients aged between 2 and 73 years, 66 females, 34 males. E. coli's commitment to urinary epithelial cells appears to be 100% in local isolates and the ability of bacteria to form biofilm was detected by using conjured-plate method and result showed that 96% of these isolated capable to form biofilm and only 4 isolates non-producer. Types1 fimbrial adhesions are encode by a fimgene clusters, include nine gene essential for the biosynthesis. ( FimB, Fim E, fim A , FimI, Fim C, FimD, FimF, FimG, FimH )  according to this study all the above mentioned genes were  detection using PCR technique but there percentage were differ with (93% , 85% , 98%, 98% , 100% , 100% , 100% ,100% ,98%) respectively . the results indicated that isolates were negative for fim H gene may be negative for biofim formation this indicated the importance of type 1 fimbriae in biofilm formation.Keywords: Uropathogenic Escherichiacoli (UPEC); Bioflim, (PCR); Type1fimbriae.
Potential of Astaxanthin from Asian Tiger Shrimp (Penaeus Monodon) Shell Extract as an Antibacterial and Ant Inflamatory Sukmawati .
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Asian tiger shrimp (Penaeus monodon) shell is an industrial waste which becomes one of the sources of carotenoids in the form of astaxanthin (3.3’-dihydroxy-β, β′-carotene-4.4′-dione) which has a very potential biological activity because it can work on target molecules. Astaxanthin in Asian tiger shrimp shell is well known to be lipophilic, being insoluble in water but soluble in organic solvents, one of which acetonitrile. The characteristics of astaxanthin were obtained through qualitative and quantitative analyses using FTIR (Fourier Transform Infra-Red) and HPLC (High Performance Liquid Chromatography). Furthermore, antibacterial and anti-inflammatory activities had been tested. Based on the research results done on the inhibition of Asian tiger shrimp (Penaeus monodon ) shell extract on the 5th growth of the test bacteria, the tiger shrimp shell extract had antibacterial activity on Eschericia coli., Streptococcus mutans, Pseudomans auriginosa, Salmonella typhi, Staphylococcus aureus which was characterized by the presence of clear zone / inhibition zone / Oligodynamic zone which showed the effect of tiger shrimp shell extract in killing and inhibiting the growth of test bacteria. Besides, An anti-inflammatory testing through extracting chemical components with acetonitrile solvent with several concentrations showed that the anti-inflammatory activity with a concentration of 1000 ppm with % stability on erythrocyte membrane obtained 60.516%, indicating that the higher the concentration used, the better was the anti-inflammatory effect.Keywords: Astaxanthin, Asian tiger shrimp, Antibacterial, Anti-inflammatory.
Antibacterial Effect of Freshwater Crab Powder against Pathogenic Bacteria Nebrass F. Chachain
Journal of Global Pharma Technology Volume 11 Issue 04.
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The objective of this study was to examine the antibacterial effect of crab powder on Klebsiella pneumonia, Pseudomonas fluorescens and Escherichia coli. Four concentration (250,300,400 and 500) mg /ml was used ,all bacteria giving the inhibition zone in all concentrations .Powder of freshwater Crab were  show the highest inhibition zone (18mm) in bacteria in  P. fluorescens at concentration 500 mg/ml and lowest inhibition zone  to same species of bacteria was  (11mm) at 250 mg/ml concentration .Keywords: Pathogenic Bacteria; Freshwater Crab Powder; Antibacterial Effect.
The Association between Plasma Soluble ICAM-1 and Adiponectin with Over Nutrition in Pediatric Patients with Dengue Infection Ni Kadek Elmy Saniathi
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Introduction: Dengue Hemorrhagic Fever (DHF) is one of the urgent health problems in tropical countries, including Indonesia. On the other hand, the prevalence of overweight is also increasing among children even in developing countries. Recent studies proved that adiponectin has significant influence toward immune system. Therefore, this study aimed to provide a preliminary data about the relationship between overweight and DHF with sICAM-1 as the biomarker. Method: An analytic observational study with nested case control study design was conducted using 78 subjects. The DHF status was established using 1997 WHO criteria while the sICAM-1 and Adiponectin were assessed using ELISA technique. All of the data were statistically analyzed. Result: The baseline characteristics of the subjects between the groups were considered homogenous. The Odds ratio of overweight toward the risk of dengue shock syndrome (DSS) was found to be quite high at 2.89 (95% CI: 0.81 – 12.25) while the adiponectin level was also significantly different between overweight and normal subjects in DHF group. However, no significant difference was found in sICAM-1 level between the groups. Conclusion: It can be concluded that sICAM-1 and adiponectin level was differ between patient with over-nutrition than normal counterparts with over-nutritional patients tended to have higher sICAM-1 and lower adiponectin level. But the difference was not statistically significant.Keywords: Dengue hemorrhagic fever, Overweight, sICAM-1, Dengue shock syndrome.
Production of Lemongrass (Cymbopogon Citratus) Powder Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Lemongrass (Cymbopogon citratus) is a perennial grass belonging to genus Cymbopogon. The lemongrass has a very wide demand in nutritional, medicinal and flavoring industry. Cymbopogon citratus contains various phytoconstituents such as flavonoids and phenolic compounds, terpenoids and essential oils, which may be responsible for the different biological activities. The demand for lemongrass (Cymbopogon citratus) is for its high citral content. But it is not stored as fresh for long time at ambient condition because it turns brown and rotten quickly. Even processing or preservation, its volatility and susceptibility to degradation are the major drawbacks for the use of Cymbopogon citratus oil. This research studied the feasibility of lemongrass dried powder production by treatment of vapor steaming (140oC in 10s; 130oC in 15s, 120oC in 20s, 110oC in 25s), drying temperature (40oC, 45oC, 50oC, 55oC) in 6 hours to 6.5% moisture content, grinding and coating materials (β-cyclodextrin, sodium alginate, carrageenan, cacboxymethyl cellulose) in different concentration (1.0%, 1.5%, 2.0%, 2.5%). The total chlorophyll content (mg/100g), citral content (%) were estimated. Results revealed that vapor steaming at 130oC in 15s, drying at 50oC in 6 hours to 6.5% moisture content, grinding and coating with 2.0% of β-cyclodextrin were appropriated for lemongrass dried powder production.Keywords: Lemongrass, Dried powder, Chlorophyll, Citral, β‐cyclodextrin, Sodium alginate, Carrageenan, Cacboxymethyl cellulose
Potential Of Biological Activities From Chemical Compounds Of Nigella Sativa As Anti-Osteoporosis, An Insilico Study Mohammad Kuntadi Syamsul Hidayat
Journal of Global Pharma Technology Volume 11 Issue 04.
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Objective: The objective of the study was to investigate the potential of biological activities from chemical compounds of Nigella sativa (NS) as anti-osteoporosis using the computational chemistry insilico study. Methods: Database search from KnapSack was conducted to find out NS active compounds. Next, explore using the PASS Server database to find out compounds that have anti-osteoporosis potential. Exploration with STITCH to analyze the interaction of NS active compounds with cell proteins related to anti-osteoporosis, then docking using PyRx to determine the bond affinity that occurs between NS active compounds and cell proteins. Result: There were 36 active NS compounds, 28 of which had anti-osteoporosis potential. One active compound that has a probability to be active value (Pa)> 0.7 and 21 active compounds that have Pa: 0.3 - 0.7. Found 6 active compounds that have interactions and play a major role in the anti-osteoporosis process. With the docking process, binding affinity longifolene is obtained with estrogen receptors: -8.2 kcal / mol, compared to Bazedoxifene -9.6 kcal / mol Conclusion: From the study of insilico, Nigella sativa has the potential as an anti-osteoporosis Keywords : Osteoporosis, Nigella sativa, insilico, anti-osteoporosis
Effect of MnCl2 Additive on Optical and Dispersion Parameters of Poly methyl Methacrylate Films Nadir Fadhil Habubi
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

PMMA films with various content of MnCl2 additive (1, 3%) are prepared by casting method. Amorphous films of PMMA-Mn are examined using X-ray diffraction (XRD). UV-Visible spectrophotometer is used to record the transmittance spectra, which decreased with the increasing of MnCl2. Energy gap value decreased from 3.91 eV for PMMA to 3.39 eV for film with 3% additive of MnCl2, while the Urbach energy are increased from 555 meV to 741 meV for the same additives. Dispersion parameters are determined using Wemple and DiDomenico model. The Ed, Eo, and So increased with the increasing of MnCl2 additive, while n (0), λo, and M-1, M-3 are decreased.Keywords: PMMA, Dispersion parameters, Composite, Optical properties.

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