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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 93 Documents
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Search results for , issue "Volume 11 Issue 05." : 93 Documents clear
Prevalence of Toxoplasmosis among Aborted Women and Immunohistochemical Evaluation of their Placenta Kawther A. M. Al-Mussawi
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Toxoplasmosis is one of the zoonotic diseases caused by the obligate intracellular protozoan Toxoplasma gondii, which is associated with spontaneous abortion in infected pregnant women. In the present study, the sera of 228 first-trimester aborted women were screened for anti-Toxoplasma IgG and IgM antibodies, and the infection was further assessed in the blood and placenta of positive and negative cases by molecular methods. The results revealed that 47.4% of aborted women were sero-positive for toxoplasmosis (AT) by the latex agglutination test, while 52.6% were negative (NT). It was also found that 74.1% of AT cases were positive for IgG, while 25.9% were positive for IgM. In addition, the examined AT cases showed the amplified DNA fragment of the parasite, while it was not observed in NT samples. The placenta of molecularly diagnosed AT and NT cases were subjected for immunohistochemical expression evaluation for T-bet, GATA-3, FOXP3, IL-17, CD8, CD68 and perforin. A significant increased expression of T-bet, IL-17, CD8, CD68 and perforin was observed in AT cases compared to NT cases. In contrast, FOXP3 showed a significant decreased expression in AT cases, while no significant difference was observed for GATA-3. In conclusion, toxoplasmosis is an important risk factor for spontaneous abortion, which was associated with abnormal expression of some immunological markers in placenta.Keywords: Toxoplasmosis, Abortion, Prevalence, Immunohistochemical expression.  
Compare between Two Methods for Green Synthesis of Silver Nanoparticles Neeran Obied Jasim
Journal of Global Pharma Technology Volume 11 Issue 05.
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In this study, compared  between two biological  methods were used for synthesize  Ag nanoparticles , the first used the extract of the conocarpus and the second used Aspergillus niger .Characterized of these nanoparticles was study by UV–vis spectrum(UV), X-Ray diffraction (XRD), scanning electron microscopy (SEM )analysis .Also antimicrobial activity of synthesis nanoparticles were investigation .Results show, used of plant extract  can be considered as the best formulation for the preparation of silver nanoparticles Because of its small particle size, good stability and purity.Keywords: Ag nanoparticles, Green synthesis, Conocarpus extract, A. Niger.
Evaluation of Crestal Bone Resorption around Dental Implants In Flapped and Flapless Surgical Techniques Depending on Cone Beam CT Scan (Comparative Study) Mustafa Abdul Hussein Al Najjar
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

around the implants. Some initial loss of bone around dental implants is generally expected. There is reason to believe that reflecting a mucoperiosteal flap promotes crestal bone loss in the initial phase after an implant has been inserted. The surgical placement of a dental implant fixture is constantly changing and in recent years, there has been some interest in developing techniques that minimize the invasive nature of the procedure, with flapless implant surgery being advocated. The purpose of this study was to compare the radiographic level of the peri- implant bone after implant placement between traditional flapped surgery and flapless approach depending on CBCT during 24 weeks healing period.  Materials and Methods: A total of 25 Iraqi patients with 46 implants aged 20-60 years .Were randomized into two groups: control group which involved 27 implants inserted by conventional flapped surgical approach and study group which involved 19 implants inserted by flapless surgical approach. The bone level was measured by CBCT for each implant at buccal and palata/ lingual sides at two times, immediately after implant placement (base line data), and after 24 weeks healing period. Results: There was no significant difference between study (flapless) and control (flapped) groups in the mean of total crestal bone resorption for buccal and palatal sides. Conclusions: Bone resoption around dental implants placed with conventional flap surgery compared to flapless surgery does not seem to be influenced during the healing period before implant loading.
Phytochemical Analysis and In Vitro Cytotoxicity of n-Hexane Extract of Kaempferia pandurata and its Nanoparticle to Breast Cancer MCF-7 Cells Fadilah Fadilah
Journal of Global Pharma Technology Volume 11 Issue 05.
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Background: Finger root (Kaempferia pandurata) is a medicinal herb which has shown anticancer activity as potential targeted-therapy towards estrogen receptor positive breast cancer. Objective: This research was conducted to analyze the phytochemical contents of n-hexane extract of Kaempferia pandurata and its nanoparticle to the growth of estrogen positive breast cancer MCF-7 cells. Methods: Kaempferia pandurata rhizome was extracted in n-hexane, and its phytochemical contents was analyzed by simple phytochemical test and thin layer chromatography. Nanoparticle was then synthesized from n-hexane extract of Kaempferia pandurata. Finally, the n-hexane extract of Kaempferia pandurata and its nanoparticle were then tested using MTT Assay to MCF-7 cells in order to determine their inhibition rate and IC50. Results:. The extraction of Kaempferia pandurata rhizome in n-hexane extract was conducted successfully. Through simple phytochemical testing, n-hexane extract of Kaempferia pandurata contained flavonoids, triterpenoids, and tannins. Thin layer chromatography using non-polar eluent (n-hexane : ethyl acetate = 5 :1) showed eight spots with Rf values of 0,12; 0,18; 0,23; 0,29; 0,41; 0,55; 0,62; 0,80. MTT assay resulted in IC50 value of 94.387 ± 11.667 μg/mL and 31,298 ± 0,242 μg/mL for n-hexane extract of Kaempferia pandurata and its nanoparticle respectively. Discussion: The phytochemical contents of n-hexane extract of Kaempferia pandurata (flavonoid, triterpenoid, tannin) was shown to have anticancer activities on breast cancer cells n-hexane extract of Kaempferia pandurata and its nanoparticle has moderately active anticancer activities towards estrogen positive breast cancer MCF-7 cells. Nanoparticle enhances n-hexane extract of Kaempferia pandurata’s entry to cancer cells. Conclusion: N-hexane extract of Kaempferia pandurata and its nanoparticle can be a potenial anticancer agent towards estrogen positive breast cancer.
Identification of Some New Tetrazole and Thiazolidine Derivatives Synthesized From 4-Chlorobenzoic Acid and Evaluation Their Antibacterial Effect Maysoon Tariq Tawfiq
Journal of Global Pharma Technology Volume 11 Issue 05.
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The research  includes  the synthesis of some new derivatives of  tetrazole and thiazolidine  rings from the reactions of  2- (4-chlorophenyl)-5-hydrazinyl- 1,3,4-oxadiazole [4] with various substituted aromatic aldehydes  in absolute ethyl alcohol as  a  solvent and presence of glacial acetic acid as a catalyst to form Schiff's  bases [5-10]. The prepared new Schiff's bases [5 -10] reacted with sodium azide , and mercaptoacetic acid in THF to yield five membered rings  (tetrazole ring) [11-15], and (thiazolidine ring) [16-20]  in good products. The  spectral  methods  of  the   prepared  compounds  were  characterized  by FT.IR, and 1HNMR for compounds [9,13,14,and 19] , besides melting points were recorded , and the purity was checked through T.L.C. technique. Antibacterial activities for some of the synthesized compounds were examined.Keywords: Heterocyclic compounds, 4-Chlorobenzoic acid, Acid hydrazide, Oxadiazole, Schiff’s bases, Tetrazole, Thiazolidine, Biological activity.
Effects of Hydrochlorothiazide on Tenofovir Disoproxil Fumarate-Induced Nephrotoxicity in Rats Iman Ghanim Al-Rakhat
Journal of Global Pharma Technology Volume 11 Issue 05.
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Background: Tenofovir disoproxil fumarate (TDF), a nucleotide reverse transcriptase inhibitor used for the treatment of hepatitis B virus (HBV) and human immunodeficiency virus (HIV) infections, is now one of the most widely used antiretroviral drug. This is largely due to its high antiretroviral activity, relatively good metabolic profile and more importantly good compliance as it has a once-daily dosing. However, tenofovir disoproxil fumarate can induce renal toxicity which can be attributed to the accumulation of such drug in the proximal renal tubular cells, leading to mitochondrial toxicity, and subsequent renal tubular acidosis leading to acute kidney injury. Objective: This study was designed to investigate whether hydrochlorthiazide has renoprotective effects on tenofovir disoproxil fumarate -induced nephrotoxicity in rats. Methods: Twenty eight healthy adult male albino rats weighing 180-200g were utilized in this study. Rats were randomly divided into four groups (7animals each). Group I: Negative control (given distilled water) orally by gavage tube for 5 weeks; Group II: Rats orally received 600 mg/kg/day tenofovir disoproxil fumarate by gavage tube for 5 weeks; Group III: Rats administered hydrochlorothiazide alone at a dose (10 mg/kg/day) by gavage tube for 5 weeks and Group IV: Rats administered hydrochlorothiazide at a dose (10 mg/kg/day) plus tenofovir disoproxil fumarate 600 mg/kg/day by gavage tube for 5 weeks. Results: Administration of hydrochlorothiazide plus tenofovir disoproxil fumarate to rats for 5 weeks produced significant elevation (P<0.05) of MDA content and a significant reduction (P<0.05) in the total antioxidant level in renal homogenate compared to the corresponding levels of negative control animals. Conclusion: treatment with hydrochlorothiazide plus tenofovir disoproxil fumarate in an attempt to prevent the renal toxicity-induced by tenofovir disoproxil fumarate is not effective for inhibiting oxidative stress process.
Determain Kind and Concentration of Allium sativum L.Plant Ingredients and its Effect on Isolated Bacteria Causing Urinary Tract Infections Ayyub J. Abdl-Rahmaan Al-Baytay
Journal of Global Pharma Technology Volume 11 Issue 05.
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Atotal of  (190)  samples urinary were collected patients with Urinary Tract Infections(UTIs) from the period 2017/11/18 to 2018/2/17 ,for determain kind and concentration of Allium sativum L.ingredients and its effect on growth of the Gram-negative bacteria isolated from urinary tract infections in Al-Alam city/Tikrit Governoratr/Iraq,The study was carried out in the laboratories of Al-Alam Hospital and the laboratories of the College of Education for Women , Department of life Science,chemical analysis by HPLC apparatua showed the plant contain severel active ingrdients: S-ally cysteine,Y-glutomycysteine, Vinyl-{4H}1,2dithlin(agoene),di-allyldisulfide and Diallytrisulfide with concentrate,5.72% 9.75%, 53.09%,9.72%,12..85% and 10.60% respectively,also appeared many bacteria genus on In the samples taken from patients patients: E.coli, Klebsiella, Pseudomonus,Proteus,Serratia and Chromobacterium with isolates concentration reached for each genus reached, 44.2%, 23.5%, 17.6%, 5.5%, 5.8% and 2.9% respectively,and the current study for aquoues and alcoholic for  extracts appeared a clear contrast on inhibition of studied bacteria kinds, as it was alcoholic extract of Allium sativum more inhibiton than aquoues extract on the concentration 100% throught observation inhibition diameter on the concentration 25,50 and 100%.Keywords: Allium sativum+plant extract+bacteria.
Estimation of Alpha-L-Fucose and Vitamin D3 Levels in Beta Thalassemia Patients in Al-Najaf Province Mohammed Abdulrazzaq Assi
Journal of Global Pharma Technology Volume 11 Issue 05.
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The present study deals with the prominent inherited disease that is thalassemia. Β-thalassemia is an extreme hereditary blood disorder resulted after a change in the gene encoding for the hemoglobin β chains. Hemoglobin is made up of a genetic defect in the synthesis of a globin chain, or more, which results in a reduced rate of these chains. The creation of atypical hemoglobin molecules is a result of the reduction in the synthesis of one chain of the globin, and thus, leads to the most specific symptom of the thalassemia; anemia. This study was conducted with 40 subjects, whose age ranges from 4-20 years, divided among (males 30 and females10), who has visited the Thalassemia Center at Al-Zahraa Teaching Hospital in Najaf province, Iraq, for managing the disease, and 40 voluntary healthy as a control group. The study has been done between September and February 2019. This study was performed to evaluate the levels of serum of Vitamin D3 and L-Fucose in major and intermediate beta-thalassemia patients. It also estimates protein-bound fucose (PBF), hemoglobin (Hb), hematocrit (HCT), liver function tests, calcium, TIBC and Ferritin. The results showed a significant increase in the levels of alpha -L- fucose and protein-bound fucose in thalassemia patients as compared with control. The results showed a very important reduction (P<0.001) in Vitamin D3,Hb, HCT, TIBC and calcium in thalassemia patients in both males and females in comparison with the healthy control, except ferritin, AST,and ALT which is increased significantly(p<0.001) in those patients in comparison with control. Keywords: Thalassemia, Vitamin D, L-Fucose.
The Effect of Type II Diabetes Mellitus on Some Prostate Markers in Iraqi Men Khalid Maseer Rmaidh
Journal of Global Pharma Technology Volume 11 Issue 05.
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Aim: Diabetes mellitus is a spread disease in the whole world and this study was conducted on Iraqi diabetic men to know the relation between type II diabetic and some prostate related markers including (prostate size, total prostate antigen, random blood sugar and zinc). Material and methods: This study included one hundred men their age ranges between (40-60 year), fifty males were suffering from type II diabetes mellitus, and other fifty men were non-diabetics. Some parameters such as (Prostate size, total prostate specific antigen (tPSA), random blood sugar (RBS) and Zinc (Zn+2) were studied. Results: The results have showed significant increase in prostate size 50.5000 ± 3.748 and random blood sugar 203.55 ± 13.629 mg/dl compared with non-diabetic group 39.650 ± 2.484 and 125.750 ± 5.396 mg/dl, respectively but there is non-significant difference in total prostate specific antigen 1.543 ± 0.087 ng/ml and zinc 9.725 ± 0.344 µmol/l in diabetic group compared with non-diabetic group 1.612 ± 0.152 ng/ml and 11.025 ± 0.582 µmol/l respectively at P≤0.05.Conclusions: Patients with type II diabetes mellitus are more liable to suffer from increase in prostate size and increase in RBS levels in Iraqi men under study.Keywords: Diabetic patient, Prostate size, RBS, Zinc and tPSA.
Synthesis and Characterization of Some New Di-amines Derived from Di-amines Supplemented with Di-heterocyclic Five Membered Rings and Some Aromatic Aldehydes Noor S. Noori
Journal of Global Pharma Technology Volume 11 Issue 05.
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It has been documented that imines and heterocyclic compounds with five membered rings and their derivatives, have enormous biological activity in various area as medicinal and pharmaceutical. Therefore, supplementing the di imines with five -membered heterocyclic rings, perhaps enhance the biological activity characters of the resulting products. Consequently, the target of present work involve the developing of new imines derived from selected di amines after connecting a five membered heterocyclic rings of the type di thiazole and di oxazole to the parent molecules via the reaction of the previous di amines with chloroacetyl chloride yield the corresponding amides [A1-A3] , then subsequent reaction of the later  with of thiourea and urea give substantially new di thiazol [th1-th3] and di oxazole [Ox1-Ox3] respectively .Reaction of these new developed di amines with selected aromatic aldehydes result a pavantly in the formation of the desired bis imines [Sc1-Sc10]. On the other hand the structures of all the synthesized compounds were confirmed by their physical properties, such as colors and melting points and spectroscopic measurements FT-IR, 1H-NMR and 13C-NMR for selected compounds.Keywords: Di imines, Chloroacetyl chloride, Thiazole-2, 4-diamines, oxazole-2, 4-diamines.

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