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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 118 Documents
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Search results for , issue "Volume 11 Issue 07" : 118 Documents clear
Determination of Cefotaxime Sodium in Drugs via the use of Six Source of White LEDs Coupled with One Solar Cell as a Detector using CFI Analyser Marwah A. Kadhim Al-Banaa
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

A direct method is described for the determination of cefotaxime sodium in drugs and pure formulations using six LEDs for turbidimtric measurements and one solar cell as a detector. The method is based on formation of a red-brown precipitate produce via the reaction between cefotaxime sodium with Ce(IV) sulfate at acidic medium. Under the optimum established conditions, the linear range of 0.001-0.3mmol/L along with r of 0.9975, limit of detection (LOD) 35.81ng/sample and precision expressed as relative standard deviation for eight replication measurements at 0.07 and 0.25mmol/L less than 1% were obtained for cefotaxime sodium. The method was successfully applied for the estimation of cefotaxime sodium in three drugs. The newly method using the standard additions procedure and the results have shown that no significant difference between the two methods using ANOVA one way test.Keywords: Cefotaxime sodium, Flow injection analysis, Turbidity.
Production, Purification and Characterization of Laccase from Pleurotus ostreatus Ghassan M. Sulaiman
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Laccases are a model for multi copper oxidases and contribute in several applications such as biopulping textile, bioremediation, food industries and pharmaceutical compounds. In this work, factorial parameter was used to study the optimization of production conditions yielded an enzyme .The fungal laccase which produced by Pleurotus ostreatus using barley bran under optimization condition by solid state fermentation was purified by DEAE-Cellulose (IEXC) and this purified laccase enzyme was effected to pH and temperatures to determine the pH optimum and temperatures for laccase activity using syringaldazine as substrate. Results showed that the optimal conditions for enzyme production were incubation temperature: 35 oC, inoculum size: 3mm discs moisture ratio: 1: 10 W\V, Incubation period: 22 days. Whereas the optimal enzyme activity was at temperature 45°c and the enzyme remain stable at the same temperature.  Further the optimal pH for enzyme activity at 5.6 and more stable in pH 6.6.Keywords: Laccase, Pleurotus ostreatus, Optimization, Laccase production.
The Evaluation of IL-4, IL-6 and Histopathology Study in Mice Infected with Entamoeba histolytica and Treated with Proteins Extracted from Shrimp Mariam Shareef Abdul Hussein
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Approximately 60% of the world’s population is infected with intestinal parasites. Entamoeba histolytica constitutes one of the commonest protozoal infections in world, and it is estimated to infect 50 million cases of invasive amebiasis, and about 100,000 deaths and probably represent the third leading parasitic cause of death, behind only malaria and schistosomiasis. Oral inoculation of mice with (1*103 cell/0.1ml) cysts of E. histolytica isolated from the feces of 170 patients with amoebasis in Ibn Al-balady hospital, AL-Kindi Teaching hospital and Fatima Al-Zahraa hospital in Iraq resulted in an infection between (2-3) days after inoculation with the parasite .Among all the infected mice as shown by the presence of trophozoites in the large intestine and colon. Many histological abnormalities in the large intestine and the liver were detected in experimentally infected mice with Entamoeba histolytica. These abnormalities as necrosis, severe hemorrhage, increased in numbers of goblet cells, congested blood vessels. High level of IL-6 and IL-4 in the positive group compare with the negative group and the groups that treated with flagel and the group that treat with shrimp extracted proteins.Keywords: Entamoeba histolytica, Shrimp extracted proteins, IL-4, IL-6, Histopathology study.
Optimum Condition for Peroxidase Activity in Crude Extract of Loranthus europaeus Shaema Saadon Fadel
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

In this study peroxidase was extracted from fruit part of Loranthus europaeus then peroxidase activity was detected and optimized. Optimum conditions for the activity of crude peroxidase were studied. Results showed maximum activity of peroxidase was achieved 0.5125U/ml when the enzyme was incubated with 1mM of 4-aminoantipyrine at 40 oC  for 10 minutes in the presence of 0.2M of potassium phosphate buffer solution at PH7.Keywords: Loranthus europaeus, Peroxidase, enzyme activity.
Oil Active Fractions of Nigella Sativa and Their Activity Against Brest Cancer Cell Line MCF-7 Taif H. Al-Ameedy
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Objective: Seeds of Nigella sativa have been used as spice and food preservative, also these seeds have been used to promote health and fight disease especially in the Middle East. The aime of this study is to evaluate the effect of partially purified oil fractions extracted from Nigella sativa purified oil fractions against breast cancer cell line. Methods: The oil of black seed was extracted with 96% ethanol and partially purified by adsorption chromatographically using silica gel column with different solvents depending on the polarity of N.sativa compositions. Subsequently the resulted fractions (hexne, chloroform, ethyl acetate, acetone, ethanol, methanol and water fractions) were tested as anticancer against breast cancer cell line Michigan cancer foundation-7 (MCF-7)  and compare with the human hepatic cell lineWRL 68 as a normal cell line. Results: The most effective oil fraction for killing MCF-7 cell  was hexane with IC5087.52µg/ml, followed ethyl acetate and ethanol fraction the cytotoxicity against WRL68 were  significantly (P≤ 0.0001) less than for MCF7 and it was 203.1µg/ml and 218.3µg/ml respectively. Whereas the rest fractions including chloroform, acetone, methanol and water fractions had slightly anticancer activity. Conclusion: The black seed oil contain effective compounds act as antitumor agents and their were had no activity against normal cell, so we can use a chemotherapy drugs after perform another detailed research for other activities and study the chamical structure to modify for increase their anticancer activity. Keywords: Nigella sativa, Oil seeds, Anticancer activity, Medicinal plants.
Assessment OF Ki-67 and Bcl-2 Immunohistochemical Markers in Gingival Pyogenic Granuloma: A Comparison with Peripheral Giant Cell Granuloma Ameera Kamal Khleel
Journal of Global Pharma Technology Volume 11 Issue 07
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Background and objectives: Pyogenic granuloma (PG) and peripheral giant cell granuloma (PGCG) are common focal reactive hyperplastic lesions affecting the gingiva.  The aim of the present research was to study the clinical and the immunohistochemical expressions of Ki-67 and Bcl-2 for gingival pyogenic granuloma in comparison with peripheral giant cell granuloma. Materials and Methods: Formalin fixed, paraffin-embedded biopsy specimens of (48) gingival pyogenic granuloma and (39) peripheral giant cell granuloma were used in the study.  Clinical and immunohistochemical analysis for Ki-67 and Bcl-2 were studied in pyogenic granuloma and peripheral giant cell granuloma. Results: The female to male ratio of pyogenic granuloma and peripheral giant cell granuloma was (1.18:1 and 1.43:1) respectively. The mean age was (32.47±19.575 and 35.03±18.22) year respectively. The pyogenic granulomas were mostly affecting the maxillary gingiva, while peripheral giant cell granulomas were mostly affecting the mandibular gingiva. Reactivity percentages for Ki-67 and Bcl-2 markers were significantly higher in peripheral giant cell granuloma compared to pyogenic granuloma (21.71±8.596% vs. 12.68±6.117 %, and 38.77±20.396% vs. 3.547±1.59%) respectively. Conclusion: PGCG showed more proliferative and anti apoptotic activity compared with PG.  This can add insight to the clinical behavior and might reflect the differences in pathogenesis of these lesions.Keywords: Pyogenic granuloma, Peripheral giant cell granuloma, Ki-67, Bcl-2.
Influence of Iron Nano Co-polymer Catalysts on the Liquid Hydrocarbons Production in the Synthesis Fischer Tropsch Abdulqadier Hussien Al-Khazraji
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

In this paper the synthesized composites were used in the Fischer - Tropsch reaction(FT) which compared the catalytic activity of catalysts based on Co-polymer (COP)such Styrene Butadiene Rubber (SBR)) and Polyethylene terephthalate (PET)) with catalysts. The COPS were supported within polypropylene (PP) in the system nano Fe-Paraffin-polymer. The behavior of Co-polymers gave significant effects in the creation of nano catalysts by stabilizing the nanoparticles, and producing new active sites for synthesized hydrocarbons from CO and H2as sources of energy. Catalytic materials shows sensitivity and selectivity in the Fischer-Tropsch process with three phase slurry reactors. The greatest conversion of CO was obtained in 66%, which forming hydrocarbons liquid reach to 60g/m3for catalysts copolymer(SBR) , whilst using catalyst with PP reduce the conversion of CO to 50% which also forming 38g/m3ofhydrocarbons.  The iron nano particles were characterized by AFM technique and XRD in the polymer-paraffin matrix.Keywords: Fischer-Tropsch (FT), Three phase slurry reactor, Polymers.
Histopathological and Hematological Effect of Silver Nanoparticles against acute Escherichia coli Infection in Male Rats Ghusoon A.A Alneamah
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

The potential treatments of silver have known long time ago. Recently many researchers have used silver nanoparticles in the area of medication because their antimicrobial, bio affinities and their easy ways to synthesis. In the present study we have estimated the antimicrobial and hematological effect of silver nanoparticles (AgNps) against acute E.coli infection in male rats. firstly the Ag Nps was synthetic and characterization by SEM which reviled size in about 25 nm in diameter, UV-vis have shown peak absorption in 410 nm. (40) Male rats use in the experiment was divided equally into (4) groups as following (n=10): Group I: Rats served as control and gavage   0.4 ml/ rat from distilled waters   for three days. Group II: Rats served as experimental and gavage 0.4 ml/rats  from AgNps for three days .Group III: Rats  infected with E. coli  ( 0.2)ml/rat single dose  (I/P).Group IV: Rats  infected with1×10 9CFU of E.coli (0.2)ml/rat   single dose  (I/P ) +  gavage 0.4 ml/rats from AgNps  for three days. After three days the animals were sacrificed, the blood collected directly from the heart for hematological analysis, and the specimens from liver, and intestine were dissected out for histopathological examination. The hematological results showed significant decrease in RBCs, Hb compared with control group and increase in WBCs in infected group compared with infected group .While this value improved in group (II, IV). Regarding the histopathological results the infected group showed inflammatory cells infiltration, necrosis, and hemorrhage in both organs and micro thrombi in liver. After treatment with AgNps showed improvement in the both hematological and histological parameters.Keywords: Silver nanoparticles (AgNps), Escherichia coli, Histopathology, Rats.
Synthesis and Characterization of Some New Derivatives of Thiourea and Study of Their Biological Activity Miad Hassan Jebur
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Some new derivatives of Suberyl Chloride  synthesized by reacting with ammonium  thiocyanate then the product is reacting with some amino acids to prepare thioureio-amino acid,  as well as react with two amino hetrocyclic compounds are 2-aminobenzo[d]thiozole-6-carboxylic acid and thiophen-2-amine to prepare thiourea derivatives. This reaction was checked by thin‐layer chromatography (TLC) method. All new compounds were characterized by melting points, elemental analysis, FT‐IR and 1H&13C-NMR. The antibacterial action of these derivatives was also determined as well as study three of these derivatives as anti-breast cancer. Keywords: Suberyl Chloride, thioureio-amino acid, antibacterial, thiourea derivatives, anti-breast cancer.
Evaluation of Enzymes Liver and Kidney Function in Serum People the Exposures at Risk of Chemicals Volatile in the Lab Pharmaceutical Samarra Methaq N. Mahmood
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Included the present examination procedure of making sense of the value, sum, or nature of something  of certain numbers that change identified with the synthetic substances in living things in the squandering almost no while working or delivering something of the functions of the liver represented by the enzymes ALT and AST and organ that creates urine represented by the creatinine and the Uric acidin blood of people workers in the public company for medicine Samarra from exposure at risk of materials chemical dangerous and unstable used in the making of medicine compared of people non-workers as a group control in the city of Samarra, a total of 60samples 30samples from workers in the public company for medicine Samarra from exposure at risk of materials chemical dangerous and unstable 30 control non-workers group their ages ranged from 30 to 45 years, and after the separation of serum managed and did/done tests (related to the chemicals in living things) own research. Results showed big increased(P˂0.05) at levels of the enzymes ALT and AST in the group exposure at risk of materials chemical dangerous and unstable as compared with the control group, As showedresults increased (a lot)( P˂0.05) at levels of the creatinine in the group exposure at risk of materials chemical dangerous and unstable as compared with the control group, Whereas the Uric acid had a big drop in group exposure at risk of materials chemical dangerous and unstable as compared with the control group.Keywords: Exposed volatile chemical, ALT, AST, Creatinine, Uric acid

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