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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 100 Documents
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Search results for , issue "Volume 11 Issue 09: (2019) September 2019" : 100 Documents clear
Histomorphological Study of the Ovaries and Follicles Growth in Adult Female Albino Rats Saif M. Haibet
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
Publisher : Journal of Global Pharma Technology

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Abstract

The Ovary plays a vital role in the reproductive process and this study was carried out in order to investigate the structure of ovaries of the female mature rat Ovaries were obtained by direct incision on the abdominal cavity and were then divided into two sections and fixed in buffered formalin. The sections (5-7 μm) were cut in paraffin blocks, stained with Mayer’s haematoxylin stain, periodic acid Schiff (PAS) technique. In histological examinations it was composed of two main zones, cortex and medulla. The surfaces of the ovaries were wavy and lined by simple cuboidal or columnar epithelium. The tunica albuginea consisted of connective tissue fibres. There were connective tissue cells in the cortex, as well as interstitial cells containing. Primordial, primary, secondary, tertiary follicles, corpus luteum and atretic follicles were seen in the cortex of ovaries. Mean diameters of these follicles varied between 80 and 1600 μm. Medulla consisted of loose connective tissue which contained blood and lymph vessels of varying sizes. The diameter of ovarian follicles in the cortex was measured as primordial 36.5±1.31µm, primary single layer 60.58±2.68µm, primary multi-layer 167.84±5.59µm, secondary with C-shaped antrum 193.83 ± 75.71 µm and graafian 389.62±9.55mm.
Some of Optical Properties to Titanum Dioxide thin Films at different Calcined Temperatures Khadijh. S. Mohan
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
Publisher : Journal of Global Pharma Technology

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Abstract

The thin films of titanium dioxide were prepared by sol-gel technique and were deposited by using spin coating method. Some of the optical properties were diagnosed at different annealing temperatures.  Films prepared have been calcined at various temperatures degree for 1 hours or less for each film. The changes of optical properties with the effect of temperatures like optical absorption, optical transmittance and optical reflectivity have been diagnosed and characterized by ultra violet-visible spectrophotometer device. By the way the optical refractive index and optical energy gap were calculated from the relationship mathematical equations that will be mentioned in the results and discussion. It is worth noting that the curves were modified by using polynomial correction. Optical absorptions have been  increased with annealing temperatures, optical reflectivity and  optical refractive index with increasing of annealing temperature at the wavelengths confined between ~ 600nm to ~800nm, while the optical  transmittance showed an opposite results  of the optical  absorbance and  optical energy gaps decreasing with increasing of calcined temperatures.Keywords: Sol-gel, Calcined temperatures and optical transmittance.
Iron Status, Malondialdehyde, and Nitric oxide Levels in Iraqi Infertile Women with IgG Seropositive Toxoplasma Gondii Nada A Kadhim
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

The purpose of this study is to highlight the levels of IgG toxoplasma gondii (T. gondii) in infertile Iraqi women and its effect on iron status, malondialdehyde (MDA), and nitric oxide (NO). In order to do this, four groups were included in this study, infertile women with seropositive IgG T. gondii group (PP, n=25), infertile women with seronegative IgG T. gondii group (NP, n=25), healthy fertile women with seropositive IgG T. gondii as control group (PC, n=15) and healthy fertile women with seronegative IgG T. gondii as control group (NC, n= 15). All of the samples were tested as seronegative of IgM T. gondii. The results were as followes: Infertile women (PP) group have a significant levels of seropositive IgG T. gondii than fertile women (PC) group (P=0.008), while both (NC & NP) groups have seronegative IgG T. gondii. Serum iron and Hb concentration have been found to be with no significant differences (p>0.05), while significant increases were found in (TIBC, UIBC, transferrin and saturation of transferrin, p<0.001) in (NP vs. NC) group and (PP vs. PC) group, Also in (PP vs. NP) group and (PC vs.NC) group. The levels of malondialdehyde in serum of (NP & PP) were higher than (NC&PC) groups respectively. No remarkable changes were observed of (NC) group compared to (PC) group but a significant increase in MDA serum levels in PP group as compared to NP group, p<0.05. In addition to that levels of NO showed significant alterations in serum of infertile groups (NP & PP) as compared to that of their control groups (NC & PC) respectively (p<0.05), while no significant variation in sera of both (NP & NC) groups compared to (PP & PC) groups.Keywords: Toxoplasmosis, Infertility, Iron, Lipid peroxidation, Nitric oxide.
Nuclear Factor-kappa B Gene Polymorphism and Interleukin-8 in Iraqi Population with Severe Chronic Periodontitis Raghad Fadhil
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Background: Periodontitis is characterized by an unbalanced host response to periodontopathogens, which lead to periodontal tissues breakdown. Genetic backgrounds play a key role in susceptibility to and protection against a spectrum of periodontal diseases. Interleukin-8 is a relevant mediator of granulocyte accumulation by attracting polymorphnuclears in the inflammatory region.  Nuclear factor kappa B (NF-kB) is a key regulator during inflammatory process involving the gingiva and alveolar bone of teeth.  Aim of study: case control study used to explore the correlation between polymorphisms in NF-kB-94 gene and serum level of IL-8 and the impact of polymorphisms on the degree of susceptibility to and severity of chronic periodontitis. Materials and methods: Ninety six Iraqi subjects their age range (30-50) years were included in study divided in to two groups (patients with chronic periodontitis and healthy control), venous blood were collected from each patients for immunological analysis of IL-8 and genetic analysis forNF-kB-94. Results: The present study revealed a significant decrease in the median serum level of IL-8 (p< 0.029) among patients group (78.9pg/μl) as compared to controls group (80.4pg/μl). For genetic analysis after sequencing with sanger method two polymorphisms were detected in the promoter region of NF-κB1-94 at rs28362491 and rs569599236 as there was deletion in the sequence of ATTG for rs28362491 while there was deletion in the sequence GCA for rs569599236 with non-significant association with chronic periodontitis group although significant association was reported with serum level of IL-8 and bleeding on probing index. Conclusion: The results suggest that the ins/del ATTG polymorphisms in NF-kB1-94 is associated with increased severity of developing periodontitis, since this study have documented that polymorphisms located within genes encoding cytokines regulated by NF-κB have association with disease activity.Keywords: Chronic periodontitis, IL-8, NF-κB, gene polymorphisms.
Synthesis and Characterization of Some new 2,4-Thiazolidinedione Derivatives Zina. S. Hassan
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

The synthesized thiazolidinedione compounds were prepared from the condensation reaction between chloroacetic acid with thiourea in the presence of water. The yield of product was found to be in the range of 75-95%. The second-pot synthesized 2, 4-thiazolidinedione derivatives were prepared from the condensation reaction between thiazolidine ring with series of aldehydes aromatic (4-(Dimethylamino) benzaldehyde, 2, 3-Dimethoxybenzaldehyde, Terephathaldehyde, 2-Thiophenecarboxaldehyde, Isatin, Furfural) and confirmed by spectral data: FTIR and 1H-NMR Spectra.Keywords: 2, 4- thiazolidinedione; Characterization; Thiourea.
Association of Plasma Neutrophil Elastase and Interleukin 1 Beta Levels with Metabolic Syndrome in Obese Premenopausal Women Moushira Zaki
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Introduction: Metabolic syndrome (MS) is the state of chronic low grade inflammation. Plasma neutrophil elastase (NE) might be a critical marker associated with several choric diseases. However, relation of NE, interleukin 1 beta (IL-1β) and MS and its complications in Egyptian obese women has not been yet investigated. The aim of this study is to determine the relationship between levels of NE, IL-1β with MS and metabolic components in obese premenopausal women. Methods: This cross-sectional study was conducted on 150 obese women with MS and 150 non obese healthy women matched in age. Inflammatory markers including NE and IL-1β were measured by ELISA. Blood pressure (BP), blood glucose, lipid profile and insulin sensitivity were studied. Insulin resistance was assessed by the homeostasis assessment model (HOMAIR) and insulin sensitivity by quantitative insulin sensitivity. Body fat % was assessed by Body composition analyzer. Results: MS patients showed significant higher levels of NE, IL-1β, fasting insulin, glucose and HOMA-IR and markers of serum lipid parameters (increase of triglycerides, low density lipoprotein, total cholesterol and decrease of high density lipoprotein), elevated levels of SBP and DBP than non obese controls. In addition, significant positive correlations were observed between NE and metabolic components of MS. Partial correlations revealed significant positive relation between NE, IL-1β and HOMAIR, body fat % in obese MS cases after adjustment of BMI and age. Conclusion: NE and IL-1β and body fat % are elevated in obese women with MS, suggesting their critical role in MS complications in obese Egyptian women and emphasized that these biomarkers might be used as good indicators for severity of the disease.Keywords: Metabolic syndrome, Interleukin 1 beta, Neutrophil elastase, Insulin sensitivity.
Ultrasound Stimulate Conjugation Between Wild Type and Genetically Engineered Agrobacterium tumefaciens and Sinorhizobiummeliloti Raghad Nawaf Gergees Al-Zaidy
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Bacterial conjugations represent one of possibilities that transform bacteria. This study aimed to detect the occurrence of conjugation between two genera of bacteria includes wild strain A.tumefaciens (Atmco1), standard strain A. tumefaciens (C58Cl) and Sinorhizobiummeliloti. The results proved the conjugation through the sensitivity of those bacteria to specific antibiotics. The obtained data reported the stimulation of bacteria growth when they exposed to different ultrasound treatments. These ultrasound treatments include five period (0.0, 240, 480, 720 and 900) second for (47.6) KHZ. The treatments (240, 480) s increase colonies numbers between 25-72% when bacteria grown on the surface of the specific solid medium. The interesting results of this study are that the exposures of the conjugation mixture to the ultrasound treatment increase the Trans conjugant colonies between (23-80) % and increase the conjugation frequency twice. This may be probably as akey to enhance conjugation between those of bacteria species which are not able to conjugation.
Enhance the Terahertz Wave by Varying the Laser Beam Intensity via Relativistic Plasma Bashair A. Abdul Khudher
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

In this work, the use of 14CO2">  laser and high intensity at the wavelength 10.6 14μm">  with Gaussian beam shape. This research focuses on the derivation of the equation which represents interaction between laser and plasma parameters in to states paraxial and nonparaxial in the case of self-focusing .The interaction of the laser with longitudinal magneto plasma occurs. The relation between the laser beam width and normalized distance parameters for three types intensities (0.9, 0.8, 0.7) self-focusing were studied. Then the best result self-focusing obtained at high intensity and at the lowest intensity, the self-focusing become weak .In nonparaxial beam the self-focusing been very weak and the best state at in high intensity and then at least intensity there no self-focusing exist .The THz radiation in case of paraxial beam is appear clearly with clean peaks (high resolution) so that the best at the power full self-focusing, either case nonparaxial beam obtained on the semi-stability phenomena. These results were studied and discussion.Keywords: Relativistic nonlinearity, Magneto plasma, Non paraxial, Terahertz radiation, Laser density, Self-focusing.
Spectrophotometric Determination of Atenolol via Oxidative Coupling Reaction with 2, 4 - Dinitrophenyl Hydrazine Raed M. Hussein
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

 An correct and sensitive spectrophotometric methodology has been developed for the determination of beta-adrenergic blocker (ATN) in pure and dose forms. the strategy is predicated on the oxidization of 2,4-dinitrophenylhydrazine (2,4-DNPHz) by metallic element per iodate than coupling with beta-adrenergic blocker (ATN) in a calescent  medium  to create actable, Yellow colored  , soluble dye with a most absorption at 403 nm. The variables that have an effect on the completion of reaction are fastidiously optimized. Beer’s law is obeyed over the concentration vary of (2-30 μg.mL-1) with molar absorption factor of (3.515×104 L.mol-1.cm1).The limit of detection was (0.07575μg.mL-1) and Sandal's sensitivity price was 0.0350 μg.cm-1. The projected methodology has been applied with success to the determination of antihistamine in pharmaceutical preparation.
Influence of the Combined Oral and Injectable Contraceptives on the Level of Creatinine, Urea, and Some Electrolyte Haider Mahmooed Jasim
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

This study was conducted to investigate the effect of combined oral contraceptives and injectable contraceptives on the Urea, Creatinine, Sodium and Potassium level. The study included 40 women used hormonal contraceptives who attending the family center of planning at the feminine and children hospital in Al- Muthanna Governorate. They were divided into two groups (combined oral contraceptives group and injectable contraceptives group) and were compared with control group (20 women do not use of contraceptives). The blood samples were collected to determine of serum Urea, Creatinine, Sodium and Potassium level. The results showed no significant differences in the level of Urea, Sodium and Potassium between the three study groups, while Creatinine showed a significant increase (0.01) in combined oral contraceptives group compared with injectable contraceptives and control groups. In conclusion, combined oral contraceptives and injectable contraceptives did not affect the level of Urea, Sodium and Potassium, except Creatinine, showed significant increase in women who used Compound oral contraceptives group.Keywords: Combined oral contraceptives, Injectable contraceptives, Serum electrolytes, Urea, Creatinine.

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