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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 100 Documents
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Search results for , issue "Volume 11 Issue 09: (2019) September 2019" : 100 Documents clear
Effect of Trimetazidine on Myocardial Disorders in Rats Hadeel Jabar Neama Almuoswi
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Cardiac muscle anemia affects the functions of mitochondria that results in ion disparity. The condition called cardiac arrhythmia. The research aims to study the effect of antianginal medication of trimetazidine on myocardial disorders in rats. The study was conducted on the rats. They were fed with 10 mg trimetazidine per Kg weight of mice each day for seven days. Tests were done for the effect of the moderator on mitochondrial metabolism in severe cardiac muscle anemia affected rats. Acute cardiac muscle anemia results in an injury to mitochondrial functions. So, when anemia cluster without trimetazidine treatment was observed, a major reduction within the infarction range was ascertained in trimetazidine-treated anemia cluster (31±3% vs. 52.8±4.89%). Trimetazidine maintained the mitochondrial organization. And, thus, better the metabolic process management, magnitude relation, and sophisticated activity. Moreover, the mitochondrial biosynthesis and division or fusion of the cells improved. The indubitable Promote the activated receptor gamma peroxisome proliferators (PPARγ), the Joint Co-1α (PGC-1α), mitofusins one (Mfn1), dynamin-related super molecule one (Drp1), Optic nerve atrophy one (OPA1) emerge in rats with acute cardiac muscle anemia. Therefore, the incontestable heart defending effects of trimetazidine was shown to preserve mitochondrial metabolic process, increased biogenesis, and split/union of cells. And, thus, this rat model of cardiac muscle anemia may be effectively used along with other cardio protective agents.Keywords: Trimetazidine, Myocardial disorders, Rats.
Efficacy of Old and New Generation Antibiotics in MDR Staphylococcus Aureus Isolated From UTI Weam Saad Al-Hamadany
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

The medical problem of acquired antibiotic resistance for clinical Staphylococcus aureus is a global concern. Scientist's efforts are to focus light on the alternative antibiotics for treatment of the isolates that exhibited resistance against classical antibiotics. Recurrent UTI is the commonest nosocomial infection caused by MDR S. aureus and the antibiotic treatment becomes an important issue. Methods and Materials: a total of (14) S. aureus isolates were tested in vivo for antibiotic resistance using disc diffusion method, antibiotics used were Methicillin (Me), Cefamandole (MA), Carbencillin (Py), Vancomycin (Van) and Lomofloxacin (Lom). Results: showed that both of the antibiotics Van and Lom had the highest records of sensitive isolates 13 (92.8%), while the antibiotic me recorded the highest number of resistant isolates 8 (57.2%) from the total 14 isolates. Both MA and Py recorded 9 (64.3%) as sensitive isolates. Conclusion: Antibiotics resistance exhibited by S. aureus is an obvious problem mainly for critical cases that need an urgent management with no time to loss, antibiotic sensitivity test should be an obligatory procedure before giving antibiotics to avoid acquired resistance. Old generation antibiotics Methicillin, Cefamandole and Carbencillin need to be tested for efficacy on S. aureus isolates before use on, new generation antibiotics Vancomycin and Lomofloxacin are very effective in treatment of vigorous S. aureus clinical isolates of recurrent UTI.Keywords: Multidrug resistance, Staphylococcus aureus, Antibiotic, Antibiotic sensitivity test and recurrent UTI.
In Vivo Assessment the Anti-obesity Potentials of Enteric Lactobacillus spp Al-Wendawi S.A
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Consumption of probiotics impacted gut microbiota and have potential effects on chronic diseases, such as obesity. This study investigated the anti-obesity potentials of two putative probiotics, Lactobacillus fermentum L1 (Ll) and Lactobacillus paracasei L2 (L2), individually and in combination (L1+L2) against diet-induced obese rats model. The Lactobacillus suspensions were orally administered, to experimental rats, at a daily level, with two consecutives of approximately 1×108 CFU/rat for up to ten weeks. Feeding rats with a combination of L1+L2 was more effective in improvement some of obesity related biomarkers. Rats supplementation with a combination of L1+L2 attenuated the body weight gain in rats that shifted Lee index towered normal value (0.294±0.05).The L1+L2 combinations exhibited hypoglycemic activity, represented by amelioration of glycemic parameters significantly (P<0.05), where, they reduced the levels of; fasting blood glucose (80.43±2.46mg/dl), fasting serum insulin (0.29±0.03ng/dl), and improved insulin resistant disorder (1.05±0.04) comparison with positive control group rats. Concurrently, lactobacilli combinations (L1+L2) pronounced anti- dyslipidemia and improved serum lipid profile of experimental rats, hat the level of blood lipids were significantly (p<0.05) dropped; total cholesterol (TC) to 80.0±2.56 mg/dl, triglycerides (TG) to 79.2±2.07 mg/dl, and low-density lipoproteins cholesterol (LDL-C) to 52.71±2.56 mg/dl. The satiety-related hormones (leptin and adiponectin) levels in rat sera also were altered by supplementation of rats with L1+L2, leptin level was reduced to 1.12±0.05 ng/ml, while adiponectin level was rose to 2.35±0.04 ng/ml.Keywords:  Probiotics, Lactobacillus fermentum, Lactobacillus paracasei, Anti-obesity potentials, Dyslipidemias, Glycemic parameters, Leptin and adiponectin.
Synthesis and Characterization of New Imines-Imides Functionalized Compounds Derived from Trimethoprim moiety Supplemented with Aminothiazole Mohammad F. Mesher Al-Dulaymmi
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Imides, Imines, five- and six- membered heterocyclic rings are among the compounds that have attracted a considerable attention of work due to their versatile biological activities. Therefore including these functional in the same compound perhaps enhancing the whole activity of the synthesized compounds. Trimethoprim moiety which is antibacterial drug possessing a pyrimidine ring and diamine groups, was selected as a starting material for this purpose. Mono imides (B1-B5) were prepared by treatment of the corresponding amic acids (A1-A5) (obtained by the reaction of equimolar amount of selected anhydrides and trimethoprim), with a suitable dehydrating agents. The remaining amino group was converted to the aminothiazole via the ring closure of the corresponding acetyl chloride amides (C1-C5) with thiourea in refluxing DMF. The target new imines (D1-D5) were synthesized by reaction of certain aldehydes and ketones with the new thiazoleamines. The structures of all the synthesized compounds were elucidated by considering the data of the FTIR, 1H-NMR, and other physical properties.Keywords: Trimethoprim, Imines, Imides, Cyclic anhydrides.
Synergistic Effect of Pectinolytic and Proteolytic Enzymatic Clarification on Cantalopue Juice Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Cantaloupe is consumed worldwide thanks to its sweetness, juicy taste, pleasing flavor, and nutritional value. It’s highly perishable under ambient condition if fresh consumption cannot move quickly. It’s urgent to process this therapeutic fruit in industrial scale. In fact, it can be processed into different products including functional juice. Clarity in fruit juices is desirable to make it useful in international standard. Objective of this study focused on the effectiveness of various processing variables affecting to cantaloupe juice turbidity and clarity. In our research, a mixture of pectinase and protease in different concentration (0.03%:0.07%, 0.04%: 0.06%, 0.05%:0.05%, 0.06%:0.04%, 0.07%:0.03%), holding temperature (26, 28, 30, 32, 34oC), holding time (45, 60, 75, 90, 105 min), pH (4.3, 4.5, 4.7, 4.9, 5.1), agitation (250, 500, 750, 1000, 1250 rpm) were examined. Carotenoid (µg/g), flavonoid (g/L), turbidity (NTU) and viscosity (cP) were key indicators to determine the optimal treatment. Our results showed cantaloupe fruit juice would have the best carotenoid, flavonoid, clarity as well as viscosity  by treatment of pectinase: protease ratio concentration 0.06%: 0.04%, temperature 20oC in 75 min at pH 4.7 with agitation 1000 rpm. Synergistic effect of the combined usage of pectinase and protease enzymes was clearly demonstrated. From this finding, the added value of cantaloupe juice would be improved in storage as well as commercial distribution without any worry about haze cloud.Keywords: Cantaloupe, Juice, Pectinase, Protease, Carotenoid, Flavonoid, Turbidity, Viscosity.
Long Term Survival of Pseudomonas aeruginosa in Distilled Water and in Normal Saline Mohammed F. Al- Marjani
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Pseudomonas aeruginosa is an important opportunistic pathogen primarily causing nosocomial infections in immunocompromised patients and is responsible for high mortality rates in burn centers, it can be isolated from hospitals, from the water in intensive care units, as well as sinks, basins, drains, showers, toilets and bathtubs, leading to transmission of P. aeruginosa infections. To determine the physiological adaptations which allow P.aeruginosa to survive in aqueous environments, we performed this experiment by transfer the bacterial cultures from Luria broth to distilled water and normal saline and incubate for 6 months and 12 months respectively. P. aeruginosa was able to survive in distilled water for at least 180 days( 6 months) and in normal saline for more than 360 days(12 months). We also examined the ability of this cells to pyocyanin production and antibiotic resistance, and the results showed that P. aeruginosa  cells were able to produce pyocyanin and resist to  cefotaxime , augmentin , ceftazidime cefepime and sensitive to imipenem , norfloxacin and gentamicin. The results of this study revealed that  P. aeruginosa bacteria can be preserved in distilled water or normal saline for several months, and able to pyocyanin production as well as antibiotic resistance. It is important to understand how this bacteria survives in water. Understanding the mechanisms of survival in water may contribute to novel solutions for the prevention of P. aeruginosa infection and transmission.Keywords: Persistance, Preservation, Saline, Water.
Synthesis, Characterization and Preliminary Cytotoxic Study of Sinapic Acid and its Analogues Yasser Fakri Mustafa
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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The use of natural products to treat human diseases especially cancer is an interesting trend in pharmaceutical research. Sinapic acid, being a member of hydroxycinnamic acid family and having well-established pharmacological properties, could have a potential antitumor activity that has not been investigated sufficiently. This work aimed to test the preliminary cytotoxic effect of sinapic acid and nine of its synthesized analogues utilizing MTT assay on four cancer cell lines; which are: HeLa, AMN3, SKG, and MCF-7. The chemical structures of the intermediates and of the synthesized products were approving by analyzing their IR, 1H-NMR, 13C-NMR, and MS-ESI spectra. Results of the cytotoxicity study indicated that sinapic acid analogues 3a, 3c, 3d, 3e and 3h have lower IC50 values  than that of positive control on the tested cancer cell lines, while sinapic acid itself and the other synthesized analogues did not have such cytotoxic effect.Keywords: Sinapic acid, Analogues, Gastrodigenin, MTT, Cytotoxicity.
Reduce Graphene Decorated with Iron Oxide/ Polymer Composite for Photo-Fenton Pollutants Dye Degradation Sara Abdul Karim Dawai
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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The treatment processes for industrial wastewater contains organic pollutants and removal of heavy metal ions remain challenging. In this work,   photo Fenton reaction activity was used to degrade the organic pollutants by functional composite hydrogel. The hydrogel is made up of Fe3O4 particles, reduced graphene oxide (RGO) and polyacrylamide (PAM). It is prepared from rGO/Fe3O4 and by precipitation method, GO has been prepared from graphite by Hummers method. And exhibits the outstanding mechanical strength, Photo-Fenton activity by different decomposition data that were affected differently; pH, H2O2 concentration, dye concentration, temperature, irradiation time. The morphology of the composite and the average diameter was studied by Atomic Force Microscopy (AFM). The degradation of M.B dye by Fe3O4/rGO/PAM hydrogel composite was reached to 100% after 60 min under UV irradiation. Meanwhile, COD (Chemical Oxygen Demand) decreased to 21 mg/l after one hour's visible irradiation and became low (under range) after 2 hours. This study provides a new pathway to process the industrial wastewater of high consistence and difficult decomposition.Keywords: Photo- Fenton reaction, RGO/Fe3O4/PAM composite, Methylene Blue, COD.
Synthesis and Characterization of New Schiff Bases Ligands and Studies It’s Complexes with Some Elemintes Mohmmed Hamid Said
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Preparation a new Schiff base ligand derived from reaction of terephthaldehyde with 2- aminobenzothiozol at (1:1) molar ratio and characterized by Uv-Vis, FT-IR, proton NMR and mass spectrometer and elemental analysis. The ligand mixed with Co (II), Ni (II), Cu (II), and Zn (II) chloride solutions at (2:1) molar ratio to form complexes. These complexes are characterized by elemental analysis, FT-IR, Uv-Vis, molar conductivity and magnetic sensitivity. This study concluded, the ligand acted as bidentate ligand, and all complexes have octahedral structuresKeywords: Terephthaldehyde, 2- aminobenzothiozol, Schiff base, Bidentate Ligand.
Application of Some Effects on the Degradation of the Aqueous Solution of Fuchsine Dye by Photolysis Luma Majeed Ahmed
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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This manuscript was focused on to how can utilize from UV-A light in order to decolorize the basic fuchsine dye from the aqueous solution at pH 6.4. The produced results from this study were indicated that the acidic medium is favor to decolorize this dye at pH equal to 4.6 and the efficiency of photoreaction increases from 73.75 % to 89.63 % at 70 min. The effect of temperature was done in ranged from (288.15 -333.15) K and occurred that the photoreaction of basic fuchsine dye increases with the increasing the temperature. The activation energy was calculated by depending on Arrihnes equation and found to be 10.286 kJ mol-1. Moreover, the thermodynamics parameters such as ΔH#, ΔS#and ΔG# were measured and given values equal to 7.714 kJ mol-1, -0.00362 kJ mol-1 and 8.923 kJ mol-1 respectively. The positive value of ΔH# enhances the photoreaction of photo-decolorization of this dye. A statistic study was performed by using t-test and F-test, and noticed that there was no significant difference between these methods.Keywords: Basic Fuchsine dye, Photolysis, Rosaniline hydrochloride dye,  PDE and Decolonization.

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