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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 74 Documents
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Search results for , issue "Volume 11 Issue 2: 2019" : 74 Documents clear
Effect of Mineral Acids (H3PO4) on Rooting Response of Aging Mung Bean (Phaseolus aureus Roxb.) Cuttings via Indole Acetic Acid Level Ahmed Habeeb Al-Mamoori
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Phosphoric acid (H3PO4) effect on the rooting that is response of aging mung bean cuttings as a weak mineral acid calculated on level of Indole-3-Acetic Acid (IAA). significant increase in rooting response of aged cuttings is  shown in the data (for 3days in d/H2O) with (0.01, 0.001, 0.0001%,) of H3PO4 concentrations solution and with (% 0.01 and 0.001%) concentration show extremely significant  increase in rooting response of aged cuttings (for 3days in solution of H3PO4 ), while extremely significant decrease in rooting response compared to control (d/H2O) with  extremely concentration (0.5%) . a extremely significant increase of IAA content in hypocotyls of aged cuttings in optimum concentration of H3PO4verified by Quantitative estimation of IAA by spectrophotometric method as indicators for oxidative processes that occurrence during aging phenomenon.Keywords: Aging, IAA biosynthesis, Rooting response, Mineral acids, Macronutrients, Stem cuttings, Mung bean.
Sequential Injection Spectrophotometric Method for Determination Paracetamol in Pharmaceutical Formulations using N- bromosuccinimide and Methyl Orange as Oxidants Khdeeja Jabbar Ali
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Sequential injection analysis (SIA) system is proposed for the determination of Paracetamol (PCT). PCT was determined by SIA based on the reaction between N-bromosuccinimide (NBS) and Methyl orange as  reagent in found  PCT in acid medium , yielding a red colour complex with absorption maximum at 507 nm., Under the optimum experimental conditions   such as the flow rate  and loading coil length  , the reaction coil length , hydrochloric acid  concentration, KBr concentration , the methyl orange concentration  and NBS concentration with both volume of mix PCT and volume Methyl orange, the determinable ranges were 1–10 mg /L, the detection limit was equal to 0.0135 mg /L, this technique is characterized by its  system was ease and speed, It was applied to the determination of PCT in different drug samples.Keywords: Sequential injection analysis (SIA) system, Paracetamol (PCT), N-bromosuccinimide (NBS).
Synthesis of Polymerization of New Derivative of 2-Decanoic Acid Extracted from Coriander Seed Fatimah Ali Hussein
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

This work, includes  preparation of the derivative of decanoic acid  was extracted  from conriander seeds by fractional distillation for four hours, then reacted with one groups of amin of  thio urea  the2nd group  amin in thioureia was  reacted  with maleic anhydride a  different drugs was used to obtain  novel  derivatives.  The compounds  written off as  by using some spectroscopic methods, H1NMR and  FT-IR used to characterization the derivatives, control drug release was studying of some derivatives, biological activity against bacterial was studying and thermal stability of the derivatives.Keywords: Decanoic acid, Conriander seeds, FT-IR, H1NMR
Fluorimetric Determination of Mefenamic Acid using Sodium Per Sulfate as a Precipitating Agent and Low Pressure Mercury Lamp; Via the use of ISNAG Continue Flow Fluorimeter Nagam Shakir Turkie
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

A new, simple, sensitive and fast method for the determination of Mefenamic acid in pure form and drugs (tablets) by continuous flow injection analysis via measurement of diverged beam of light by ISNAG_-fluorimeter. The method based on the reaction of the Mefenamic acid with sodium persulfate to form yellow precipitate. Optimum parameters have been studied to increase the sensitivity for the developed method. The linear dynamic range for the instrument response versus Mefenamic acid concentration was 0.01-5 mmol/L while the L.O.D was 215.955 ng/sample from the step wise dilution for the minimum concentration of lowest concentration in the linear dynamic range of the calibration graph. The correlation coefficient (r) was 0.9968 while percentage linearity (R2%) was 99.35%. RSD% for the repeatability (n=8) was lower than 0.2% for the determination of Mefenamic acid, with concentration of 1, 3 mmol/L respectively. The: developed method was applied successfully for the determination of Mefenamic acid in pharmaceutical tablets. A comparison was made between the newly developed methodology and the classical method (turbidometry) of analysis using the standard addition method via the use of paired t-test. It shows that there was no significant difference between the quoted values of each individual company with calculated t-value at 95% confidence interval from developed method.Keyword: Mefenamic acid, Flow injection analysis, Diverged beam of light, Homemade instrument.
Synthesis and Characterization of Some Heterocyclic Compounds and Evaluation of their Antioxidant Activity Auhood Kadhim Zaid
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

This study is concerned with the synthesis and characterization of five derivatives of two groups of heterocyclic compounds, dihydroprimidine (DHPM) and imidazole. The DHPM derivatives were [benzyl 6-methyl-4-(naphthalen-2-yl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (1a)], [benzyl 6-methyl-4-(naphthalen-2-yl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (2a)] and [benzyl 4-(1-hydroxynaphthalen-2-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (3a)] and the imidazole compounds were [1,4-bis(4-(4-bromophenyl)-1-(3-chlorophenyl)-1H-imidazol-2-yl) benzene (1b)] and [1,4-bis(4-(4-bromophenyl)-1-phenyl-1H-imidazol-2-yl)benzene (2b)]. Biological testing revealed the prepared compounds to have antioxidant properties. Keywords: Antioxidants, Heterocyclic compounds, Dihydroprimidine, Imidazole, Biological activity.
Study the Influence of Smoking on Level of Selected Pentraxin (PTX s) and Tumor Necrosis Factor Alpha (TNF-α) in Saliva of Cigarette Smoker Patients with Chronic Periodontitis Doaa Adil Abood
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Background: Pentraxin (PTX s) is a classical mediator of inflammation and super family of a cut – phase proteins. Tumor necrosis factor-α, is one of the pro-inflammatory cytokines, released in various chronic inflammatory disease including periodontitis. Subjects and method: the study comprised 75 patients,50 with chronic periodontitis (CP) (25 smoker and 25 non smoker ) and  25 normal subjects, age ranged between (20-50 years old, This study carried out in periodontal department clinic/ collage of dentistry/ university of Babylon, Hilla city , Iraq, 5 ml of unstimulated  whole saliva was collected from all  subjects to measure Pentraxin-3(PTX-3) and tumor necrosis factor (TNF-α) by Enzyme-linked immunosorbent  assay technique (ELISA).Result: the result  show  there are non-significant differences in the levels of PTX-3 and TNF-α between the patients and controls and non significant between smoker and non smoker(p≤ 0.05) .In smoker patients there is a negative correlation between concentration PTX-3 and number of cigarette per years of  smoking. While there’s a positive correlation between level of TNF-α and and number of cigarette per years of smoking. Conclusion: Smoking in chronic periodontitis patients has no effects on levels of PTX-3 and TNF-α in saliva.Keywords: Chronic periodontitis, Smoking, Saliva, PTX-3, TNF-α.
Effect of Earthworm Coelomic Fluid on Inhibition Activity Against Some Pathogenic Bacteria Zaid Naji Hassan
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

In the present study , coelomic fluid tested for antibacterial activates. four different concentration of coelomic fluid was used (100%,75%, 50%,25%)which was determine by  the agar well diffusion method and tested against five pathogenic bacteria isolates (E. coli , K. pnemoniae, Staph. eureus, Staph. epidermis, Ps. aeruginosa). coelomic fluid show highest inhibition zone aganist E.coli at concentration (100%,75%,50%) ,while staph eureus show highest inhibition at concentration (25%).Keywords: Coelomic fluid, Earthworm, Bacteria.
Immunological Effects of Ceramic and Composite Subgingivally Extended Restoration Bilal Mohammed Obaid
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

In this study, 80 samples of gingival crevicular fluid (GCF) from patients have their teeth filled with different restoration materials , collected 20 sample of composite resin restoration material ,20 sample of crown ceramic restoration material , 20 sample of metal ceramic restoration material and 20 sample of control non-filled teeth. The purpose of this study was determine the effects composite rein , ceramic crown and metal ceramic crown restoration material on (GCF) levels of interleukin 1(IL-1 β) ,  interferon gamma (IFN- γ) , Matrix Metalloproteinase-8 (MMP8) and tumor necrosis factor (TNF- β ). Paper points (size 30) were inserted into the gingival crevice until mild resistance was felt, and kept in place for 30 seconds. Following collection of GCF the paper point placed in eppendroffs tubes contain (300 micro liter) phosphate buffer saline. GCF was eluted from paper point by centrifugation at 3000 rpm for 15 minutes after that the paper point was removed and GCF sample kept at -40 ˚C till analysis. Analysis of data for immunological parameter (IL-1β, IFN- γ, TNF- β and MMP8) that got from ELISA test. Finally, the results showed mean concentration of  IL-1β, IFN- γ, TNF- β and MMP8 in patients with restoration material ( composite resin , crown ceramic and metal ceramic) significant (P < 0.05) were higher than in control while MMP-8 in ceramic crown restoration material  high but no significant (P> 0.05 ).Keywords: Composite resin, Ceramic crown, Metal ceramic crown, Periodntitis IL-1β, IFN- γ, TNF- β, MMP8.  
Effect of using Cordia myxa Crude Extract Creams in Wounds and Burns Treatments Aliaa S. Al-Faraji
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

It was found that the use of Bumper extract cream (Cordia myxa) has a high effect on the healing of wounds and burns in the experimental mice. All rat assemblies and experiments are designed according to the standard procedures. The creams were applied on laboratory mice (Swiss albino mice), which is located in the laboratories of the Center for the Preparation of Medicines / Ministry of Industry and graduated doses (1 and 2% w / w) and apply these creams to wounds and burns induced laboratory / for 10 days of treatment daily. A group of mice was designed also wounds and burns were stimulated, but treated with  Ficidin@ and Flamazin@ ointment were used as standard (2% w/w) for treatment of wound and burn respectively. The results of the study showed the effectiveness of the bumper extract with high concentration of 1% and 2% on the healing of wounds and burns compared to control and standard groups. The results of the textile cutting showed the effectiveness of the pampers on the formation of the granular tissue for burns and wounds, which in turn leads to the rapid recovery of these wounds and burns within 10 days. Results investigated the highest effectiveness of bumper extracts on the rapid recovery of wounds and burns in rats faster than using chemical medication, and thus support its traditional use.Keywords: Ficidin- Flamazin -Cordia myxa cream-Excision Wound & Burn-Healing.
Determination of Trifluoperazine Hydrochloride in Pure form and Dosage form via Reaction with Sulphanilic Acid Diazonium Salt Sahar Rihan Fadhel
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

A simple and sensitive spectrophotometric method for determination trace amount of Trifluoperazine Hydrochloride in tablet pharmaceutical preparations were described. The method was based on the coupling reaction of drug with (0.25 mole.L-1) diazonium salt prepared from reaction of sulphanilic acid with (12.07 mole.l-1) hydrochloric acid at (0-5Cº) present sodium nitrite in basic medium of sodium hydroxide (0.1 mole.l-1) to produce orange color azo dye compound can be absorbed at 500nm, the optimum reaction conditions and other analytical parameters were evaluated. The high accurate and precise results obtained with RSD%, Recovery%, ere% and D.L were 0.8142, 100.019, 0.0574, and1.1205 µg.ml-1 respectively, the linearity of rang (5.0-140 µg.ml-1). The proposed methods were successfully applied to the determination of Trifluoperazine Hydrochloride in tablet pharmaceuticals without any effect of interference of chemical materials in tablet formulation.Keywords: Trifluoperazine Hydrochloride, sulphanilic acid, spectrophotometry, azo dye coupling.

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