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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 42 Documents
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Search results for , issue "Volume 11 Issue 6." : 42 Documents clear
The Effect of the Use of Semicircular Device to Learn the Performance of the Two Stages of Planting in the Box and Raise the Jump Pole for Female Students Mohammed Naji Shaker Abugneam
Journal of Global Pharma Technology Volume 11 Issue 6.
Publisher : Journal of Global Pharma Technology

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Abstract

The study included the design, manufacture and use of a semi-circular circular mechanical device. Mechanisms were used to learn the technical stages of performance by jumping the pole for female students. It was installed on the ground. And thus helped the students to perform easily as the effectiveness of bowel jump needs physical and motor abilities in addition to the correct technical performance as well as the general neuromuscular consensus according to the paths of movement, especially for students .The exercise was applied to the device from the group of experimentation Of term (6 weeks) by two units learning at a rate of 12 educational units then it was compared with the control group in reserving the technical performance of the digital level as statistical results showed experimental superiority over the control.Keywords: Design, Educational device, Jumping and learning.
Nephrotoxicity: protection of silica nanoparticles loaded sodium salicylate and ginger in experimental rats Eman Refraat Youness
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

Background: Ultrasound-assisted sol−gel method was used to prepare hollow structured porous silica nanoemulsion loaded with sodium salicylate as a model drug. Objective: This work was extended to achieve the target of the current work via investigating the protective role this nanoemulsion model as anti-inflammatory drug or ginger for its antioxidant effect against cisplatin-induced nephrotoxicity in male albino rats. Results: The results clarify that the nanoemulsion model was synthesized using ultrasonic assisted with small size and well stabilization as proved by TEM and DLS analysis.  Additionally, blood urea and serum creatinine were increased after cisplatin injection with disorders in oxidative stress and rising of homocysteine levels. Also, histopathological changes of the kidney tissue were observed.  These changes back to normal via treatment with silica nanoparticles loaded sodium salicylate (Si-Sc-NPs), ginger or both. Oil /water nanoemulsion of (Si-Sc NPs) and ginger showed a protective and promising preventive strategy against nephrotoxicity due to their antioxidant and anti-inflammatory effects.
Targeted Systems in Cancer Treatment Yuliya Tikhonova
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

The World Health Organization (WHO) estimates that in 2015 cancer was the first or second leading death cause before the age of 70 in 91 out of 172 countries, and ranked third or fourth in the other 22.  This study analyzes three main types of targeted cancer therapies: low molecular weight inhibitors; monoclonal antibodies; and immunotoxins. The low molecular weight inhibitors analyzed in the paper are Gleevec, Sprycel, VEGF targeting, Nexavar, Tykerb, Iressa, EGFR and HER2 Targeting, Torisel. The monoclonal antibodies include VEGF, EGFR and HER2, Herceptin, Avastin, CD20, Rituxan, Zevalin, Campath. The DAB389IL-2 (or Ontak - FDA Approved Medication for the Treatment of Acute T Cell Lymphoma) represents immunotoxins. It proves that depending on the location of the unregulated protein, different approaches are implemented. Monoclonal antibodies can block interactions and functions of unregulated proteins within the extracellular compartment, while low molecular weight inhibitors can reach proteins that are within the cell compartment. Currently, many of these drugs are used in combination with traditional cancer treatments to increase patient survival. As it was found, VEGF inhibitors, for example, Avastin, increased in low concentrations the survival time of patients with metastatic colorectal cancer from 13.8 to 21.5 months.Keywords:  Low molecular weight inhibitors, Gleevec, Pro-angiogenic molecules, Monoclonal antibodies.
Contribution of Equilibrium Variables with the High Spike Accuracy of the Position Diagonal Center (4) in the National Volleyball Team Players Ban Faisal Al-Azzawi
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

What is important about this study is whether there is a relationship between the ability to balance and beating overwhelming for the Iraqi national team volleyball? The study aims to identify the percentage of the equilibrium contribution and its variables with the accuracy of the skill of beating the high spike Diagonal center (4) in the players. In the national volleyball team season (2016-2017), the researchers used the descriptive approach in the style of associative relationships to suit the problem of research. The research community included all the players specialized in the high beating of the Iraqi national team applicants in the ball The researchers concluded that the equilibrium variables contributed accurately and quickly to the high landslide of the region (4), and the researchers recommended the emphasis on the stability exercises, which showed a significant contribution and impact in the accuracy And the speed of beating the Diagonal high ground, and the adoption of tests of accuracy and speed in the assessment of the level of the ballots in the national team because it gives greater realism to the level of training.Keywords: High spike, Accuracy and diagonal center.
The Usage of Paracetamol and Ibuprofen in Children with Persistent Ductus Arteriosus . Yulistiani
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

Backgrounds: Persistent Ductus Arteriosus (PDA) is the structure of the ductus arteriosus that failed to close after the birth of the baby. One of the therapies which are used to overcome the closure of PDA is pharmacological therapy using prostaglandin inhibitors. Aim: to determine usage profiles, including dosage, frequency, route, and duration of paracetamol administration and ibuprofen for DAP. In addition, it also assesses the actual outcomes and side effects of using paracetamol and ibuprofen in children with PDAs. Method: this research was a quantitative research with a retrospective method. The sampling method used random sampling. The total sample was 32 children who were hospitalized with diagnosis of PDA with or without complications. Data was collected by conducting an assessment of the patient's medical record to the documentation sheet.  Results: Based on research in 32 patients, 78% of patients received paracetamol therapy, 16% of patients received ibuprofen, and 6% of patients received replacement therapy for paracetamol to ibuprofen. From 25 patients who received paracetamol therapy, 12 patients (48%) gave the outcome of PDA closure and eliminated patient tachypnea and cyanosis. The average dose of paracetamol used for PDA is 7.5-15 mg / kg every 6 hours for 3-7 days by oral route (9%) and intravenously (63%).While the average dose of ibuprofen for PDAs is 10 mg / kg / day for the first day and 5 mg / kg / day for the second and third days by oral route (100%). Conclusion: the use of paracetamol and ibuprofen for PDAs was in accordance with existing literature relating to the dose, route, frequency, and duration of administration for PDAs. However, there were some patients with special conditions that require adjustment of the second dose of the drug. The use of paracetamol and ibuprofen for PDAs did not cause actual side effects. The use of paracetamol for PDAs needs to be further investigated regarding the effectiveness and drug related problems and the need to consider the use of ibuprofen for PDAs related to potential side effects that can be caused.Keywords: Patent ductus arteriosus, Paracetamol, Ibuprofen, Pediatrics.
The Effect of Special Exercises in the Development of Some Sense of Mobility and its Contribution to the Skillful Performance of Futsal Players Ali Falah Mohamed Hassan
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

The game of football is one of the most popular games in the world and this game enjoys great care and attention everywhere, because it is one of the most popular games in the countries of the world and the characteristics and variables of search of perceptions of sense - motor and the proportion of its contribution to the performance of the skills of football halls. The aim of the letter is to: Prepare exercises in the development of some sense of mobility for football players of the halls. The study hypotheses were: There were significant differences in the results of the Pre and Post measurements and for the two groups of research (control, experimental) and for the sake of distance measurements. There were significant differences in the results of the dimension measurements and the two groups of research (control, experimental) and for the benefit of the experimental group. The problem of research in some of the club exercises was observed. There is a lack of attention to the dimensions that directly affect the performance of the skills, including the cognitive requirements, despite their importance. So the researchers wanted to go into the study of this problem a pilot study was the development of special exercises to develop awareness (sense - motor) and then the extent of his contribution to the development of the skillful performance of the players of football halls. The research community consists of players of the fans club for the sports season (2017-2018) and one of the clubs was chosen by lottery (18 players). The most important sensory movements that contribute to the skillful performance of the Futsal Hall were identified through a questionnaire distributed to specialists and obtained special perceptions (Time and place and ball) the highest ratios and then the tests were chosen for the research and modified one of them to suit the subject and after the homogeneity and the experiment was carried out for two times and then conducted Pretests on the members of the research sample and then was given special exercises for the experimental group and adopted the group الظا The course was conducted on the trainer's curriculum and lasted for two months and varied methods of giving exercises to fit the best performance and taking into account the training bases and after the tests were carried out in the same conditions as in the Pretests, the fourth section included the presentation of the results and analyzed and discussed by the researchers put them in the tables and which are illustrative means of what came Results of the study in order to identify the validity and conformity of the objectives of the study and its mandate to analyze the reality of the differences between the Pre and Post tests of the two groups as well as the contribution ratios of perceptions sense of movement and skill performance of the post-test MJ Experimental anguish In order to achieve the objectives of the study researcher used the bag statistical (SPSS) .Thus to reached several conclusions and recommendations of the most important of which there is a positive influence in the development of dynamic perceptions _football players lounges and two sets of research (experimental, control), but to varying degrees. The experimental group, which adopted the exercise exercises, showed a clear superiority over the control group in all the post-tests. Based on these results, the researchers recommended the following: The recommended exercises should be used to develop the level of awareness of the players of the football player’s .And the need for the attention of coaches’ players, including the category of applicants to develop the level of perceptions sense - kinetic to meet the requirements of the skills, planning …Football.Keywords: Special exercises, Mobility, Contribution, Skillful performance and futsal.
Ergonomic Participatory in Halal Assurance System (HAS) Implementation to Reduce Boredom and Fatigue in Workers in the Sate Bandeng Processing Industry Wahyu Susihono
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

Every processing industry that has obtained a halal certificate from LPPOM MUI is obliged to maintain and maintain the implementation of Halal Assurance System (HAS), as well as sixteen halal certified milkfish satay processing industries from LPPOM-MUI Banten Province. However, in general the implementation of HAS-23000 has been carried out, but there are still weaknesses that need to be fixed. This weakness lies in the awareness of meeting the criteria and data updates by the company's internal halal management team. This weakness is due to the fulfillment of HAS that does not concern the human factors that carry out activities in the company. Humans are still considered as a complementary part of the company's business processes, not used as part of the main factors in the implementation of HAS-23000. Ergonomic Participatory Intervention needs to be done to improve employee performance seen from a decrease in work boredom and work fatigue. The subjects in this study were workers in 16 processing industries that were randomly selected; the sample fulfilled the inclusion criteria of the study. The design of this study was experimental research (treatment by subject design). Subjects in 16 processing industries, prior to the ergonomic participatory intervention, the initial observation (group I) was conducted, then the subject became an intervention group (application of ergonomic partitioning) referred to as group II. Result: The results showed that after an intervention in the form of ergonomic participatory implementation in the implementation of Halal Assurance System (HAS) in 16 milkfish satay processing industries, the mean of work boredom in group I was 89.44 ± 4.53 and group II was 65.69 ± 4.69 or decreased 26 , 64%, the average general fatigue in group I was 93.69 ± 10.85 and group II 83.13 ± 12.28 or a change of 11.27%, general fatigue felt by workers in 16 industries there were significant differences after an ergonomic participatory intervention (p <0.05 ), while fatigue in the aspect of activity experienced a change of 5.30%, fatigue in the aspect of motivation experienced a change of 24.38%, fatigue in the physical aspect experienced a change of 12.58%. Fatigue in the aspects of motivation and physical aspects there is a very significant change, but in the fatigue aspect of the activity changes that occur is not significant p> 0.05). Intervention with ergonomic participatory can improve employee performance in halal certified satay milkfish food processing industry, seen from the decrease in the level of boredom and work fatigue (general fatigue, activity fatigue, motivation fatigue and physical aspect fatigue). Decreased boredom also occurs (26.64%), indicating that there has been an increase in employee performance as indicated by an improvement in employee mental perceptions. Improved employee performance shows an improvement in the implementation of the criteria in the Halal Assurance System (HAS).Keywords: HAS-23000, Halal, Participatory ergonomics, Boredom, Fatigue.
Male Infertility As A Bad News: A Review Fahmi Bahar
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

Having children is a dream for every married couple. However, this process is not that easy for 15% couples worldwide who suffer infertility. Infertility is the failure to achieve a clinical pregnancy after twelve months of regular and unprotected intercourse. Half of infertility causes come from the man called male infertility. Male factors of infertility vary greatly from mild one like oligozoospermia to severe one like extreme oligozoospermia which make the natural pregnancy difficult to happen, hence a help from assisted reproductive technology is needed. In more extreme case like testicular agenesis, having children really becomes a necessity and it will bring bad news to him. Bad News (BN) refers to a condition of hopelessness, threatening life and body or anything which raises the patients’ anxiety about his future. In this case, male infertility can be categorized as BN since it causes loss of hope and anxiety. The process of Breaking Bad News (BBN) requires good communication skill. There were several BBN protocols formulated previously covering Advance preparation, Build relationships, Communicate well, Deal with the patient, Encourage emotion (ABCDE), Background, Rapport, Explore, Announce, Kindling, Summarize (BREAKS) and Settings, Perception, Invitation, Knowledge, Empathy, Strategy (SPIKES). Each protocol had been applied to other medical fields such as oncology, pediatric etc. Whilst its application on male infertility cases has never been published. Even if this protocol is able to be applied properly, it is capable to increase the patients’ knowledge, improve their psychological condition and maintain the threshold of hope for having children.Keywords: Male Infertility, Communication, Bad News, Breaking Bad News
Bladder Endometriosis that Invisible to Repeated Cystoscopies: A Case Report Ida Bagus Putra Adnyana
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

Background: Bladder endometriosis (BE) is a form of Deep Infiltrating Endometriosis (DIE) which affects approximately 1% of women with endometriosis. BE commonly presents with lower urinary tract symptoms such as frequency, dysuria, hematuria, and, less frequently, bladder pain and urgency. The diagnosis and treatment of this condition could be difficult and requires multidisciplinary care. Due to overall rare cases, BE might pose a challenge, both to diagnose and treat. This article aims to share an experience in order to increase awareness and insight about BE for practising gynaecologist and urologist. Case: A Thirty-one years old woman, nulligravida, complained of painful, bloody stained urine, which occurs during menstruation since married for the last 18 months. Previously patient had a regular menstruation cycle with moderate pain and normal menstrual volume and no history nor any specific symptoms of disease. Gynaecological examination showed no remarkable finding. Ultrasound scan (US) by gynaecologist showed a mass protruded from the posterior wall of bladder. Cystoscopic finding by a urologist showed an adenomatous reddish nodular mass, and TUR was conducted. Pathological examination showed a cystitic glandulare. After three months temporary improvement, the symptoms reoccur. The patient underwent US and CT scan, again showed a mass, and another two rounds of TUR were conducted, to remove all residual mass. After three surgeries with no significant improvement, a team of gynaecologist and urologist were set to conduct a laparoscopic partial cystectomy with cystoscopy guidance to achieve complete excision of the lesion. The modified technique, which results in symptoms-free recovery, will be described in detail. Conclusion: BE could be challenging both in diagnostic and treatment. Cystoscopy and TUR are not recommended to diagnose and manage the lesions. A multidisciplinary approach is needed, and concomitant Laparoscopy with cystoscopy for partial cystectomy might give a satisfying outcome.Keywords: Bladder Endometriosis, Deep Infiltrating Endometriosis, Cystoscopy, Laparoscopic partial cystectomy, Lower urinary tract symptoms.
Nanotechnology Applications in the Single-Cell Analysis for Cancer and Therapy Ali Hamad Abd Kelkawi
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

Understanding the molecular, cell, genetic, and functional heterogeneity of tumors at the cell level has become a major challenge to cancer research. Microfluidic technology has emerged as an important tool that offers advantages in single-cell analysis with the ability to integrate labor-intensive, labor-intensive experimental procedures, such as single-cell capture into a single small device at ease and in high productivity. Single-cell processing and analysis can be performed within a microfluidic multifunctional device for various applications in cancer research. Here, we present recent developments in microfluidic devices for single-cell analysis related to cancer biology, diagnosis, and treatment. First, we briefly present several microfluidic pads used to analyze one cell, followed by different microfluidic techniques to manipulate a single cell. Next, we highlight their various applications in cancer research, with a focus on cancer biology, diagnosis, and treatment. Current limitations and potential trends of one microfluidic cell analysis are discussed in the end.Keywords: Microfluidic lab-on-a-chip, Single cell analysis, Cancer biology, Cancer diagnosis, Cancer therapy, Cancer research.

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