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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 105 Documents
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Search results for , issue "Volume 12 Issue 01" : 105 Documents clear
Jet Lag, Stress, and Behavioural Changes of Daily Living on Umrah Pilgrims from Indonesia Eko Mulyadi
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

Introduction:Umrah is an Islamic pilgrimage to Mecca that can be undertaken at any time of the year the Umrah pilgrims who depart from Indonesia to Saudi Arabia has air travel for 10 hours, this study aims to observe the phenomena umrah pilgrim from Indonesia conducted in Indonesia and Saudi Arabia with a long time of 18 days. Method:This study involved 14 participants who perform umrah pilgrims, by using interview technique and direct observation. Research design used a qualitative study with a phenomenological approach. Results:The result of the study showed that pilgrims experience jet lag, also stressed. Disturbance sleep. and behavioral change of daily living. Although umrah (pilgrims) is a spiritual activity, but the implementation made the pilgrims stressed, long flight up to 10 hours with boarding matter, visa examination, made the pilgrims stressed. Conclusion:Umrah pilgrims who experience stress will affect their physical condition. Where physical conditions will affect other biological conditions. including its ability to worship.Keywords: Jet Lag Syndrome, Umrah pilgrims, Stress.
Ethanolic Extracts of Young Papaya Seed (Carica papaya, Linn) Decrease Spermatocytes, Leydig Cells, and Androgen Receptor of Leydig Cells of Adult Mice (Mus musculus) Christopher Ryalino
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Background: Uncontrolled population growth is one of the problems in Indonesia. Among the various types of wild plants that can be used as anti-fertility drugs are papaya plants. This study aims to determine the effect of extracts on the number of spermatozoa, Leydig cells and androgen receptor (AR) expression on Leydig cells as an anti-fertility mechanism.  Materials and Methods: This was an experimental, randomized posttest-only controlled group study. We used a total of 36 Wistar rats as the subjects of this study. The rats were classified equally into two groups by simple random sampling method. Group E rats received 0.5 mL ethanol extract of papaya seeds for 50 days (orally), and the rats in Group C (control) received 0.5 cc aquabidest for 50 days. Results: The treatment group showed a decrease in the number of spermatozoa (201.86 vs. 94.3, p <0.001), a decrease in the number of Leydig cells (7.61 vs. 3.32, p <0.001), and decreased AR expression of Leydig cells (46.19 vs. 18.48, p <0.001) compared to the control group. Conclusion: ethanol extracts of young papaya seeds significantly reduce the number of spermatocytes, Leydig cells, and the AR expression of the Leydig cells.Keywords: Young papaya seed, Male anti-fertility, Androgen receptor, Leydig cells.
Evaluation of Antioxidant Efficiency of Nanosized Quercetin: An In Vitro Study Ghassan M. Sulaiman
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

Quercetin is a bioactive compound that is widely used in botanical medicine due to its powerful antioxidant activity. This work aims at encapsulated of quercetin into PLGA nanoparticles by using the nano participation technique. Following by the valuation of their functionality as antioxidant activity. Quercetin and quercetin nanoparticles by using straight forward in vitro free radical scavenging systems including DPPH (1,1-diphenyl-2-picryl hydrazyl) free radical-scavenging assay and hydrogen peroxide radical scavenging. Quercetin nanoparticles showed strong scavenging effects against DPPH, hydrogen peroxide and this effect was more potent than pure quercetin. The scavenging activity of quercetin nanoparticles was concentrations dependent in the range of 4-12 µg mL-¹ showing maximum activity of 90% at 12 µg- mL-¹in similar way to Vit.C which was used as positive control. In conclusion, this work displayed that quercetin exhibited antioxidant activity and could be considered as a source of antioxidants from nature.Keywords: Quercetin nanoparticles, Antioxidants, DPPH, DNA damage.
Comparison Of Ethanol Emulgel Extract Activity Of Duku Fruit Peels (Lansium domesticum Corr) With Tranexamic Acid As A Skin Lightener Lusi Nurdianti
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

ABSTRACT Objective : Emulgel which has the potential for skin lightener is a medical cosmetic preparation used to inhibit the formation of melanin pigments so that it can brighten the skin. The purpose of this study was to determine the effect of concentration variations of duku (Lansium domesticum Corr.) peel waste extracts on the evaluation results of preparations, the level of irritation to rabbits, and an increase in brightness on human skin compared with emulgel containing tranexamic acid. A dermatoscopic test is used to look at the imaging of the skin surface after the use of an emulgel. Material and Method : In this study, concentration variations of ethanol extract from duku peel waste of 10%, 15% and 20% were used. Result : The test results obtained that all formulas meet the requirements of organoleptic test, pH, homogeneity, dispersibility, and centrifugation test. Irritation test with the Draize method obtained all formulas do not irritate. The results of testing the increase in skin brightness on emulgel preparations showed that F1 (16.67%), F2 (33.33%), F3 (60%), F4 (60%). Conclusion : Increasing the brightness of emulgel preparations containing 20% ethanol extract of duku peel is comparable to 4% tranexamic acid.Keywords: Tyrosinase, Lightening cream, Duku fruit Peel, Tranexamic acid.
Surveillance and Monitoring Brucellosis at Denpasar Veterinary Center Working Area in the 2016 Suharsono H
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Background: The situation of Brucellosis in the working area of the Denpasar Veterinary Center (BBVet) varies between provinces. The provinces of Bali and NTB have been declared free of Brucellosis. However, specifically in NTT, only Sumba Island was declared free of Brucellosis. The situation of Brucellosis in NTT Province, on the island of Timor, Belu Regency and TTU is a heavily infected area of brucellosis with a prevalence of > 2%, while other islands have an unknown prevalence. One Brucellosis reactor found in Ende District in 2006. Continuous surveillance was carried out as an early detection step to keep the area free. Objectives: Brucellosis and monitor the possibility of entry/emergence of new reactors in the region, and to determine the prevalence of Brucellosis in areas that are not yet free of Brucellosis. Methodology: The samples tested were samples received by the BBVet Denpasar Bacteriology laboratory during 2016. The samples were tested using the Rose Bengal Plate Test (RBPT) method if positive continued with the Complement Fixation Test (CFT) test. Results: A positive sample of CFT expressed as a Brucellosis reactor. The test results of 4,602 serum samples from Bali Province and 2,504 serum samples from NTB Province were all negative for Brucella antibodies. Whereas serum samples from NTT Province were 1,533 samples, three positive samples were CUC brucellosis; namely, two (2) positive samples from 175 serum samples came from Malacca District and one (1) positive sample from 73 serum samples came from North Central Timor District ( TTU). Whereas samples from the districts of Alor, Ende, Lembata, Manggarai, West Manggarai, East Manggarai, Nagekeo, Ngada, RotenDao, Southwest Sumba, West Sumba, East Sumba, East Timor Tengah (TTS), and Kupang City, Conclusion: all negative. Based on these data it can be concluded that the Provinces of Bali and NTB are still free of Brucellosis.Keywords: Brucellosis, BPT, CFT, Bali, NTB. NTT.
A Concise Review of Spermatogenic Cells Culture: Assessing the Apoptotic Pathway Silvia Werdhy Lestari
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

In the absence of sperm retrieved from azoospermic male, thus considered in utilizing developed spermatogenic cells including spermatogonia to spermatid in restoring male fertility. Spermatogenic cells obtained from testicular tissue culture need to be expanded prior its utilization, yet the excessive apoptosis of resulting cell culture is a challenge. This review was aimed to discuss article dealing with the factors and the underlying mechanism inducing apoptosis of spermatogenic cells culture. A computerized search of PubMed and google scholar database was conducted for general terms such as “male infertility”, “azoospermia”, “human spermatogenesis, “spermatogenic cells” and “apoptosis” and followed by screening and evaluation of collected paper accordingly. Various agents induced the apoptosis in spermatogenic cells such as high temperature, hypothermic storage, metabolite of cell culture derived and gonadotropin suppression driving to apoptosis. Thus all of the agents were paving the specific pathways of inducing apoptosis, through extrinsic and intrinsic, leading to the activation of caspase initiators followed by the activation of caspase executor in various types of spermatogenic cells.Keywords: Human spermatogenic cells, Apoptosis, Culture.
Possibility of Herbal Tea Production from Corn Silk (Zea mays) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Corn silk is usually discarded as waste. It has a great medicinal importance due to the presence of valuable bioactive phytochemical compounds. It’s believed to be nontoxic and safe for human. Among various parts of corn, the corn silk is a rich source of antioxidant components and possesses strong antioxidant potential. It could be utilized as herbal tea like a healthy beverage. Objective of this study focused on the effect of blanching temperature and time; vacuum drying temperature and pressure to anthocyanin (mg/L), flavonoid (µg RE/g) and overall acceptance (sensory score) of the dried corn silk tea. Results showed that corn silk should be blanched in hot water 95oC at 10 seconds in the present of CaCl2 1.5% and then being dried by vacuum dryer at 45oC, -0.8 bar for 4 hours to get the final moisture content 8% available for preservation. It’s considered as a suitable raw material for production of functional food.Keywords: Corn silk, Blanching, Vacuum drying, Herbal tea, Anthocyanin, Flavonoid.
Protective Activity of 1, 8-Cineole against Inflammatory and Oxidative Stress Marker from Methyl Methacrylate Exposure Sianiwati Goenharto
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Objective: This study was aimed to determine the potential of 1,8-cineole to reduce the amount of malondialdehyde (MDA), interleukins (IL)-8 and neutrophils in MMA-exposed lung alveolar cells. Methods: Thirty mice were divided into five groups: a normal control group (K0), a negative control group (K1) and a treatment group, further subdivided into P1, P2 and P3, whose members were administered 5 mg, 10 mg and 15 mg doses of 1,8-cineole. The treatment group subjects were placed in a glass cage containing 150 ppm MMA vapor that has been nebulated by 1.8-cineole vapor for 120 minutes. The mice were subsequently terminated, and tissue removed from their lungs. Observation of MDA and expression of IL-8 was conducted during immunohistochemical examination. Neutrophils was observed using Hematoxylin Eosin (HE) staining. Results: MMA exposure significantly increased MDA, IL-8 and neutrophil counts. Meanwhile, administration of 1, 8-cineole successfully reduced MDA numbers. Fifteen milligrams of 1, 8-cineole constituted the only dose which proved capable of reducing the expression of IL-8. Administration of 1, 8-cineole in all groups also decreased the number of neutrophils. Conclusion: 1, 8-cineole, especially at a dose of 15 mg, can reduce the levels of MDA, IL-8 and neutrophil in the lung tissue of mice following exposure to MMA vapor.Keywords: MMA, 1, 8-cineole, Inflammation, ROS, MDA.
Synthesis, Characterization and Antioxidant Activity of Some New Schiff base Derived from Cytosine Ali A. Mahmood
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Cytosine is used to synthesize several derivatives of Schiff base when reacted with some aldehydes which are refluxed by using ethanol as a solvent and non solvent with adomestic microwave (Compounds A1-A4). These products of the Schiff base are treated first with chloroacetyl chloride to synthesize four-membered heterocycles (Compounds B1-B4). After that, they treated with hydroxyl acetic acid to synthesize five-membered heterocyclic (Compounds C1-C4). In the third step, the products are used to react with amaleic acid anhydride to produce seven-membered heterocyclic (Compound D1-D4). The antioxidant activity of the compounds (A1-A4) and two of the compounds (B1, B3), (C1, C3) and (D1, D3) in different concentrations of (100, 200, 300, 400 and 500 mg/ml) are tested with 1, 2-Di Phenyl-2-Picryl Hydrazyl (DPPH) for scavenging a radical activity. Finally, these compounds are diagnosed by several technical devices such as IR, proton1HN.M.R and13C N.M.R. spectroscopy.Keywords: Synthesis; Cytosine; Schiff Base;
Acoustic-Assited Osmotic Dehydration of Dried Pumpkin Jam Minh Phuoc Nguyen
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Acoustic drying accelerates the mass transfer rate during dehydration. Osmotic dehydration has recently gained a significant interest. It consists of immersing the material to be dried in a hypertonic solution. Acoustic-assisted osmotic dehydration, have been implemented as an alternative pretreatment associated to drying procedures. This study focused on the synergistic effect of osmotic and acoustic dehydration in the dried pumpkin jam production. Our results revealed that pumpkin slices should be soaked in 40% sugar and then dried by convective drier for 4 hours under assistance of ultrasonic wave at frequency 37 kHz in power 500 W. From this combination, the dried pumpkin jam would be obtained with the safe moisture content and high beta-caroten retention.Keywords: Pumpkin, Acoustic, Osmotic, Drying, Jam, Beta-caroten.

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