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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 105 Documents
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Search results for , issue "Volume 12 Issue 01" : 105 Documents clear
Lactoferrin as a Marker of Chronic Telogen Effluvium in Premenopausal Women Alaa F Hasseeb
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

Aim: Evaluation of serum Lactoferrin, Hb and ferritin levels in females with chronic telogen effluvium (CTE) or acute telogen effluvium (ATE), in order to validate their role in these common hair loss diseases. Methods: Fifty three females (aged range 18 - 45 years) with hair loss, in the form of TE (ATE=27 as G2, group aged range18-35), (CTE=26 as G3 group aged range 18-45), and 26 age-matched females with no hair loss (as G1 group), were included in the study. Diagnosis was based upon clinical examination as well as dermoscopy. Serum Lactoferrin and ferritin levels were determined for each participant. Results: Serum lactoferrin levels showed highly significant differences (p= 0.00) in the comparison of chronic TE (G3) and Acute TE (G2) (7.68±2.13 ng/ml vs.  4.65±2.18 ng/ml), Also between (G1) and (G3) (5.21±1.03 ng/ml vs. 7.68±2.13 ng/ml), but there is no significant difference between (G1) and (G2) (5.21±1.03 ng/ml vs.4.65±2.18 ng/ml).Plasma ferritin level showed highly significant decrease (p=0.001) in comparison  (G1) group and (G2) group(50.72±11.17 µg/dl vs. 36.49 ±15.04µg/dl ) respectively ,Also showed highly significant decrease (p=0.00) between (G1) group and (G3)( 50.72±11.17 µg/dl vs.31.98± 15.98 µg/dl) but there is no significant difference(P=0.47)  between (G2) and (G3) (36.49 ±15.04 µg/dl vs. 31.98± 15.98 µg/dl).Hemoglobin level showed highly significant decrease (p=0.028) in (G1) and (G2) (12.89±0.70 mg/dl vs. 12.15±1.19 mg/dl) respectively, Also showed highly significant decrease (p=0.00) between (G1) and (G3) (12.89±0.70 mg/dl vs. 11.60±1.09 mg/dl ), but there is no significant difference(P=0.12) between (G2) and (G3) (12.15±1.19 mg/dl vs. 11.60±1.09 mg/dl). Conclusion: High serum Lactoferrin is associated with hair loss in females with CTE, while low levels of ferritin are associated in ATE and CTE. Screening to establish ferritin levels in cases of hair loss and supplementing with them when they are deficient may be beneficial in the treatment of disease.Keywords:  Lactoferrin, Telogen effluvium, Ferritin, Transferrin
Effectiveness of Peroxyacetic Acid as Disinfectant to Physico-chemical, Microbial and Organoleptic Characteristics of Fresh Pangasius Fillet during Chilling Storage Minh Phuoc Nguyen
Journal of Global Pharma Technology Volume 12 Issue 01
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Pangasius fillet is a good source of amino acids, low residue levels of heavy metals and polychlorinated biphenyls, high amounts of saturated fatty acids, low amounts of polyunsaturated fatty acids, low cholesterol levels. However, it is highly perishable.  During the processing of Pangasius fillets, washing could reduce the microbial loads on the fish fillets as much as possible.  Objective of this study focused on the efficacy of different concentrations of peroxyacetic acid (PAA) to the firmness (N), peroxide value (meq/kg), total plate count (cfu/g), sensory score of fresh Pangasius fillet during 20 days of preservation at cooling temperature. Our results showed that 75ppm PAA was appropriate to maintain physico-chemical, microbial and sensory characteristics of fresh Pangasius fillet during storage.Keywords: Pangasius fillet, Peroxyacetic, Firmness, Peroxide value, Total plate count, Sensory score.
The Effect of Nimodipine on Nuclear Factor Erythroid-2-Related Factor 2 (Nrf2) Activation in Neuron Cell Line SH-SY5Y Culture Exposed By Chronic Hyperglycemia Shahdevi NK
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Introduction: Diabetes is a dysregulation of glucose metabolism due to defects in insulin secretion, decreased insulin sensitivity, or a combination of both that causes hyperglycemia. Diabetic neuropathy is induced by oxidative stress that results from excessive ROS production. When oxidative stress increases, it triggers a transcriptional response of antioxidant genes mediated by Nrf2. Based on the above mechanism, the researchers tried to use nimodipine as a calcium channel blocker which is neuroprotective to reduce Nrf2 activation. Objectives: This study aims to look at the effect of nimodipine on decreasing Nrf2 activation. Methods: This research was conducted in vitro using SH-SY5Y neuron cell culture induced hyperglycemia for 6 days with glucose concentrations of 5 mM, 25 mM, and 50 mM. Then the cell is harvested and given nimodipine for 30 minutes at a dose of 10 nM and 100 nM. Nrf2 expression was observed under a confocal microscope. Results: The results of nimodipine at doses of 10 nM and 100 nM were able to reduce the activation of Nrf2 in neuron cell culture that had been significantly induced by chronic hyperglycemia (p <0.05) at 50 mM glucose concentration. Conclusion: It can be concluded that the administration of nimodipine doses of 10 nM and 100 nM can reduce Nrf2 activation in neuron cell cultures exposed to chronic hyperglycemia with glucose concentrations of 50 Mm.Keyword: Hyperglycemia, SH-SY5Y Cell, Nimodipine, Nrf2.
Cervical Caries: Modern Methods of Diagnosis and Treatment Alexei Yumashev
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Objective: The purpose of this study is to study the effectiveness of the cervical caries treatment when filling with different materials in the short and long term.  Methods: To study the elemental composition, electron probe microanalysis method was used. The quality of fillings from NC, GC, CM was evaluated in the following terms: a week after restoration, six months, a year, two years.  Results: Features of the anatomical structure of the cervical region indicate an increased risk of caries here. Areas with increased tissue hardness, as well as hardness, stability and mineralization may form in the dental tissue. These foci are able to withstand the demineralization of the tooth for some time. Conclusions: When filling NC and CM in the intermediate layer between dentin and material, the structure is homogeneous. The hard tissues of the tooth are enriched due to the contained fluorides. Scanning microscopy data confirmed the opening of the dentinal tubules. The first group of patients (low resistance to caries) improved 1.4 times the performance of the marginal fit of the fillings, provided that ozonation was present (p≤0.05). For the second group, the safety of fillings was established for 2 years in 95% of cases, but subject to the presence of ozonation.Keywords: Cervical caries, Ozonation, Nanocomposites, Glass ion cements, Nanoglassionomer, compomer.
Investigation Structural Properties of Cu2ZnSnS4Thin Films Prepared by Pulse Laser Deposition Ali J. Khalaf
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

The prepared samples of thin-film by laser ablation method were achieved. Powders of (CZTS) copper (Cu), zinc (Zn), tin (Sn) and Sulfur (S) of and   then compressing by approximately 3 tons in Pellets form.  The samples were ablated by using Neodymium-YAG laser with different laser energies (400mJ, 500mJ, 600mJ, 700mJ, 800mJ) and number of pulses (300) pulse, frequency (6Hz) and wavelength (1064) nm obtained the plasma plume at 10-5mbar pressure. Results indicate by using XRD, AFM , SEM and EDX devices.by x-ray diffraction study of Cu2ZnSnS4 compound films prepared are proven to be  polycrystalline tetragonal as noted when the laser energy is increased when the process of ablation of the target CZTS  The grain size increases while the strain, the dislocation density  and the lattice constants (ao, co) decrease. Through the images of the atomic force microscope (AFM) it was observed that the grain size decreases from (CZTS400mJ-CZTS700mJ) and then increases. There is also an increase in the surface roughness rate and the square root rate (CZTS600mJ - CZTS800mJ) by increasing the laser energy when the process of ablation of the target CZTS with constant other laser parameters. Through scanning electron microscopy (SEM) images, the spherical shape of the nanoparticles is observed by increasing the laser energy when the process of ablation of the target CZTS with constant other laser parameters with irregular forms. The EDX test showed that the films contained Cu, Zn, Sn, S elements as expected, indicating the formation of high-purity CZTS films.Keywords: Structural, Thin film, Nanoparticle, CZTS, Composite, XRD, AFM, SEM, EDX, laser ablation.
Effect of Storage Conditions on the Chemical Composition of Vietnamese Clove (Syzygium aromaticum) Essential Oil Mai Huynh Cang
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

In this study, changes in the composition of the oil from clove buds (Syzygium aromaticum) and their blends were investigated by mass gas chromatographic analysis during different storage under light and temperature conditions for a period of four months. Samples that were taken periodically were used to assess the chemical composition. Under these conditions, clove essential oil retains its main ingredients, including Eugenol, β-Caryophyllene and Acetyleugenol for four months. However, the oxidation rate of the essential oil under direct light and 45 ° C is rapid, contrasted by that essential oils stored in the dark and 4 ° C. The total Eugenol content in essential oils increased further at the end of the storage period under storage conditions. Changes in these compounds during storage can serve as an indicator of quality for clove essential oil.Keywords: Syzygium aromaticum, Essential oïl, Storage, Temperature, Light, Oxidation.
Synthesis, Characterization, and Antimicrobial Activity of New Schiff’s and Mannich Bases of Isatin and Isatin Derivatives May Mohammed Jawad Al-Mudhafar
Journal of Global Pharma Technology Volume 12 Issue 01
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Objective: Schiff’s and Mannich bases of isatins are an important group of heterocyclic compounds which are of great importance in medicinal chemistry as antimicrobial agents. In the vision of these facts, new bis-Schiff bases and Mannich bases of isatins were synthesized. Methods: Three different bis-Schiff bases (3a-c) have been synthesized by reacting isatin, 5-fluoroisatin and 5-methoxy isatin with thiophene-2-carboxaldehyde using hydrazine hydrate to link between the carbonyl compounds, and then these bis- Schiff bases were condensed with two different secondary amines (piperidine and morpholine) separately, and formaldehyde to form the Mannich bases (4a-c and 5a-f), respectively. Results: The structures of the newly synthesized compounds were confirmed using (Fourier- transform infrared) FTIR, 1H-nuclear magnetic resonance spectroscopy (¹H-NMR) and CHNS elementary analysis. All the synthesized bis-Schiff bases and Mannich bases were screened for their antimicrobial activities. Conclusion: The target compounds showed convincing antibacterial activity, whereas their antifungal activity was more potent, and the most active ones were Mannich bases of 5-methoxy isatin derivatives (4c and 5c) against Candida albicans.Keywords: Antimicrobial activity, Bis-Schiff bases, Isatin derivatives, Mannich bases, Thiophene-2-carboxaldehyde.
Nursing Supervision Model toward Patient Safety Goals On The Ward Nursalam .
Journal of Global Pharma Technology Volume 12 Issue 01
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Clinical supervision of interactive reflective model is a guideline for the implementation of patient safety goals at the hospital.  This supervision supports the one who is supervised to improve self-awareness and professional development in the implementation of patient safety goals. The purpose of this research was to find out the influence of reflective interactive supervision model toward  the implementation of patient safety goals. The method used is quasi-experimental with pretest-posttest with control group design.  There were 24 subjects in interventions and 24 subjects in control  group. Data were taken using a proportional stratified random sample. The data were analyzed by using chi-square, independent sample t-test, paired sample t-test, Pearson correlation, and general linear model repeated measure was used for multivariate analysis. The result shows that there are significant differences after the implementation of interactive reflective supervision (p < 0.000). The average achievement score of the implementation of patient safety goals between groups shows a significant difference. In the intervention group, the achievement score began to show an improvement starting from the second measurement and the maximum score was seen in the fifth measurement. Clinical supervision interactive reflective model is potentially required by the head nurse as a guideline for supervising the implementation of the patient's safety goals in the hospital.Keywords: Supervision, Interactive reflective, Patient safety goal, Hospital.
Hallux Valgus Deviation: Causes and Methods of Treatment Iuliia Khamitova
Journal of Global Pharma Technology Volume 12 Issue 01
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The purpose of this study is to test the minimally invasive method of surgical intervention with hallux valgus of the first toe in the elderly. The total number of operated and examined feet is 192 (182 in patients with bilateral valgus deviation and 10 with unilateral). The average age is 64.3±2.1 years.  Overload on the first finger and the second and third metatarsal bones is completely absent after the operation, as well as overload on the first metatarsal bone (p≤0.001). The number of cases of overloads between the first finger and the first metatarsal bone in the postoperative period was halved (p≤0.05). In the proposed scheme of surgery, there is a significant improvement in the general condition of patients, in particular, biomechanical indicators of overload between different parts of the foot. After the operation, there was an increase in the longitudinal and a decrease in the transverse projection of the foot. Examination of the walking features of patients with bilateral hallux valgus showed the absence of pain after surgery, as well as a significant increase in the coefficient reflecting the rhythm of walking. This scheme of operation is simple in execution and methodology, and, at the same time, gives a positive result both in the short and long term. In addition, this operation is simple and cheap for patients compared to other methods of operations. The scheme of surgical intervention used on the head of the first metatarsal bone that we used allowed us to significantly improve the anatomical and biomechanical properties of the foot. The valgus deviation disappeared, gait parameters improved, and the load on both feet became more even. The consequence of the operation in the long term is a return to a normal lifestyle, wearing ordinary shoes, and an increase in physical activity. This type of surgery is most suitable for the elderly, as it is cheap and easy to perform, combined with a quick recovery.Key words: Hallux valgus, First toe, Metatarsal bones, Rhythmic walking, Biomechanical properties of the foot.
Inability of Polysaccharides of Spirulina Platensis to Protect Hepatocyte Cells Line on Toxoplasma Gondii Infection In Vitro Lucia Tri Suwanti
Journal of Global Pharma Technology Volume 12 Issue 01
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Toxoplasmosis is one zoonotic disease which caused by an obligate intracellular protrozoan parasite,  Toxoplasma gondii. The parasite infects humans and warm-blooded animals (mammals and birds). The drug of choice against toxoplasmosis is combination between pyrimethamin with sulfadiazine, but both can induce side effects and toxic to host cell, so alternative therapeutic compounds are needed.  Many reseachers have explored microalgae for food and medicine. One of the main components of  Spirulina platensis that plays a role in enhanching immunity is polysaccharides. The present study investigated effect of Spirulina polysaccharides on Toxoplasma gondii infection in Vitro. Polysaccharides of S. platensis were extracted with hot water and alkhaline method. Extraction Rate (ER), sugar and protein levels were compared between the two methods. The Hepatocyte Cells Line (HCL) were infected with T. gondii and treated with polysaccharides of S. platensis. The parameters were Parasite burden and Viability Host Cell. The result shows that Extraction Rate, carbohydrate and protein levels were affected by extraction method. Carbohydrate level in polysaccharides with hot water extraction was higher than alkhaline extraction, on the contrary, ER and protein level were lower. Polysaccharides of S. platensis did not protect HCL infected with T. gondii. More than 5 mg/mL polysaccharides of S. platensis was toxic to host HCL.  Keywords: Alkaline extraction, Hot water extraction, Polysaccharides, Spirulina platensis, Toxoplasma gondii.

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