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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 105 Documents
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Search results for , issue "Volume 12 Issue 01" : 105 Documents clear
The Differences Between Motor Relearning Programme and Bobath Method On Standing Balance in Stroke Patients Nisfil Mufidah
Journal of Global Pharma Technology Volume 12 Issue 01
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Introduction: Stroke is a disorder of the central nervous system that can impair vital functions of the brain such as impaired coordination, impaired posture control, sensation, motion reflexes, and balance disorders such as the balance of sitting and standing. Complementary therapies like Motor Relearning Program (MRP) and Bobath Method have been involved. The aim was to analyze the differences between MRP and Bobath Method to increase standing balance in stroke patients. Method: A quasi-experimental research design is conducted, and respondents were divided into two groups. The treatment group was given the MRP and the control group was given the Bobath Method. Total sample 24 stroke patients were included as participants and obtained by simple random sampling. The independent variables were the MRP and Bobath Method. The dependent variable was standing balance. The data obtained by the Berg Balance Scale (BBS) analyzed using paired t-test and Independent t-test with a significance value of α≤0.05.  Results: The MRP (p=0.000) and Bobath method (p = 0.010) can improve standing balance. The differences in the effectiveness between MRP and Bobath Method showed a significance value of (p=0.006). Conclusion: Bobath method cause complex interactions of the sensory system and musculoskeletal and then regulated in the brain. Thus, MRP was more effective because it causes the cognitive, associative and autonomic to increase standing balance in stroke patients.Keywords: Bobath method; Stroke; Motor relearning program; Standing stability.
Insights on the Role of Mesenchymal Stromal Cells Infusion in Enhancing the Inhibitory Network and Synaptic Plasticity in Chronic Epileptic Rats Rania S. Salah
Journal of Global Pharma Technology Volume 12 Issue 01
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Objective: Temporal lobe epilepsy (TLE) is characterized by progressive synchronization with high frequencies of drug resistance. Mesenchymal stromal cells (MSCs) could open promising avenues for epileptic therapeutic approaches. The rational of the current research was to realize the therapeutic outcome of bone marrow (BMSCs) and adipose (ADMSCs)-drived MSCs against chronic epileptogenic alterations implicated in pilocarpine-induced TLE. Methods: Adult male Wister rats were distributed into five groups: Gp1: non epileptic control group, Gp2: chronic epileptic control group, Gp3: chronic epileptic group treated with BMSCs, Gp4: chronic epileptic group treated with ADMSCs and Gp5: chronic epileptic group treated with carbamazepine (CBZ). Gama-aminobutyric acid (GABA), semaphorin4D (Sema4D) and galanin concentrations were evaluated in brain via ELISA. Gene expression level of hippocampal synapsin-I was estimated using sqRT-PCR. Histological explorations of hippocampus and cerebral cortex were carried out. Results: Significant decline in GABA, galanin and Sema4D contents as well as synapsin-I mRNA level were recorded after pilocarpine injection. BMSCs or ADMSCs transplantation or CBZ administration constructed significant upgrade in GABA, galanin and Sema4D concentrations as well as synapsin-I mRNA level. Micrograph of brain tissue sections of epileptic rats showed nucleus pyknosis and neurodegeneration while, the treated groups demonstrated almost intact histological architecture. Conclusion: Based on the forementioned results, this work established the exact mechanisms underlining epileptogenesis and offered a new hope for treatment of focal epilepsies by employment of MSCs which achieved significant neuroprotective activity through modulating epileptic neuronal circuit, secreating neurotrophic molecules and restoring synaptic plasticity. Keywords: Chronic epilepsy, mesenchymal stromal cells, neuroprotection, GABA, Sema4D, galanin, synapsin-I.
Laparoscopic Versus Conventional Surgery for Colotomy Closure; Molecular Evaluation Hameed Abed Kate
Journal of Global Pharma Technology Volume 12 Issue 01
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The goal of this study was to compare between laparoscopic and conventional surgery on the healing of colotomy closure by using cruciate mattress suture pattern. Twelve adult local breed bucks (male goat), were used, it was divided into two equal groups. In group A (Conventional group), the colotomy incision was created and closed by cruciate mattress suture pattern, while in group B (Laparoscopic group), the colotomy closure by same pattern intracorporeally using 3-0 Polygalactin-910.Molecular assessment at zero time, one and three weeks post operation by vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2) gene expression to evaluate the colotomy healing process.Molecular evaluations indicate that the highest value of vascular endothelial growth factor was noted in group A whereas the lower value in group B at one-week post operation. The highest value of fibroblast growth factor-2 was noted in group B while the lower value in group A at one-week post operation. In conclusion the study clearly demonstrated that the healing process in cruciate suture laparoscopically superior to that occur in conventional technique.Keywords:Enterotomy, Colotomy, Laparoscopy, Cruciate Mattress Suture Pattern, Molecular, VEGF, FGF-2, Quantitative PCR, Colon, Bucks. Goat.  
Clinical and Laboratory Analysis of the Efficiency of Hirudotherapy in Complex Treatment of Endodontal Diseases Andrei Sevbitov
Journal of Global Pharma Technology Volume 12 Issue 01
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To date, teeth with inflammation in the periapical tissues, including destructive ones, often give non-abating exacerbations by conservative treatment, and they are removed. The article displays the clinical and laboratory results of a study of the effectiveness of hirudotherapy in combination therapy of inflammatory diseases of the endodontic. In recent years, a number of new drugs and methods for the treatment of chronic apical periodontitis have been proposed. The arsenal of new drugs for endodontic practice is extensive, but the result of treatment is often not optimistic.  The purpose of the study was to conduct a clinical and laboratory analysis of the method of hirudotherapy to increase the effectiveness of treatment of chronic apical periodontitis. Based on clinical and laboratory data, the local course of the inflammatory process was studied, including cases when using hirudotherapy in patients with acute exacerbation of chronic apical periodontitis. Hirudotherapy allows one to stop inflammatory syndrome in earlier periods and reduce the time of treatment.  The use of hirudotherapy in the combination with conventional endo therapy of patients with chronic apical periodontitis result in pronounced anti-inflammatory, analgesic, and vasoconstrictor effect that increases the effectiveness of treatment of chronic apical periodontitis.Keywords: Inflammation, Apical periodontitis, Hirudotherapy, Cytomorphology, Protocooperation.
The Polymorphism of rs2549782 gene Endoplasmic Reticulum aminopeptidase-2, high Concentration of Free Fetal DNA, and Cystatin C as Risk Factors of Preeclampsia I Nyoman Hariyasa Sanjaya
Journal of Global Pharma Technology Volume 12 Issue 01
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Background: Recently, the mechanism of the preeclampsia (PE) occurrence has not gained widespread agreement. This is related to the variations intreatment, maternal factor, and fetal morbidities as well as mortality. However, the studies of the placenta associated with PE mechanism have derived serious attention. This study aims to determine the role of rs2549782 ERAP 2 gene polymorphism, extracellular fetal DNA content, and high-level C cystatin in maternal serum as a risk factor for PE Methods: A matched case-control study among 62 maternal over 20 weeks of gestation was conducted in the Department of Obstetrics and Gynecology, Faculty of Medicine, Sanglah General Hospital, Biomolecular Laboratory of Medical Faculty, Universitas Udayana, Bali, Indonesia andProdia Laboratory Denpasar.A 12 months-period of the study was enrolled from August 1st 2016-2017. The polymorphism examination of rs2549782 ERAP 2 gene, extracellular fetal DNA content and C cystatin respectively were evaluated among 31 maternal with PE as case and 31 maternal as control (Normal). Data were analyzed using SPSS version 16 for Windowsto determine the association of rs2549782 ERAP2 genepolymorphism, extracellular fetal DNA level, and maternal serum cystatin C level using Chi-square Test and Odds Ratio (OR). Discriminant tests with logistic regression were displayed in table and narrative form.Results: The ERAP2 gene polymorphism in the case was found 7.5 times (OR = 7.50 IK95%: 3.53-15.92; p = 0.002) higher significantly compared to the control. The cell-free fetal (cff) DNAlevel in the case was 6.67 times (OR, 6.67 IK; 95% 2.67-26.33, p; 0.001) higher significantly than the control. In addition, the level of cystatin C in the case was also 6.5 times (OR, 6.5 IK; 95% 3.04-13, 89, p; 0.007) higher significantly when compared to the control. However, there wasno significant difference in the polymorphism of rs2549782 ERAP2 gene, extracellular fetal DNA, and cystatin C between groups (P>0.05).Conclusion: In can be concluded that the polymorphism of rs2549782 ERAP2 gene, extracellular fetal DNA, and high maternal serum C cystatin increase the risk of PE.Keywords:Preeclampsia, Rs2549782 polymorphism, ERAP2, DNA, cystatin C.
Development and Evaluation of Felbamate Loaded Solid Lipid Nanoparticles Ramanuj Prasad Samal
Journal of Global Pharma Technology Volume 12 Issue 01 (2020) Jan. 2020
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Solid lipid nanoparticles (SLN’s) or lipid nano particles is typically sphere-shaped, with an average diameter of 1nm to 1000nm.  They are alternative carrier systems to tradition colloidal carriers, such as, emulsions, liposomes, and polymeric micro and nanoparticles. The main aim of the current research work is to prepare and optimize the Felbamate loaded solid lipid nanoparticles using by placket and burman design of experiments. SLN’s were prepared by microemulsion technique. Based on preliminary experiments and on literature, the influence of independent variable parameters selected were lipid (X1), surfactant (X2), and co-surfactant concentration(X3),aqueous phase volume(X4),magnetic stirrer rate (X5), probe sonication duration (X6), volume of beaker used for sonication (X7), volume of cold aqueous phase (X8) on the dependent variable such as average particle size (Y1) was studies. Other parameters, i.e., magnetic stirrer rate and probe sonication duration were not having a significant impact on particle size and their levels were kept constant for all the experiments. Magnetic stirrer rate has an impact on particle size and was included in the design. It was concluded from the study that the composition prepared with lipid concentration of 50 mg, surfactant concentration of 75 mg, Co-surfactant concentration of 0.75 ml, aqueous phase volume of 5 ml, magnetic stirring speed of 400 rpm, probe sonication duration 30 minutess, volume of beaker used for sonication 500 ml and volume of cold aqueous phase 30 ml has shown the smallest particle size of 165 nm
Study of Amino Acid Composition and Basic Technological Parameters of Viburnum Fruits Harvested in Ukraine Olga P. Khvorost
Journal of Global Pharma Technology Volume 12 Issue 01
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In present material the study some parameters of viburnum fruits harvested in Ukraine. Generally, the research is carried out in order to increase the product range of medicines. However, the quality of viburnum opulus fruit as raw material plant in Ukraine was not regulated due to a lack of the monograph in SPhU 2.0. The feature of our research is that it is only a fragment of the complex system of pharmacognostic study of viburnum opulus fruit. In which raw materials series from the area of preparation on the territory of Ukraine are used. By means of HPLC the comparative research of component content of the free and linked allocation of amino acids of pericarp and a stone of fruits of Viburnum opulus L. is carried out. The content of free amino acids of a stone is the most various-16 connections of such nature. The largest and approximately identical content is characteristic for replaceable amino acid of proline (more that 175 µmol/kg), which is found in a free allocation in a pericarp and a stone and in the linked allocation in a pericarp. Thus, pharmacological and pharmaco-technological tests of crushed fruits of the Viburnum opulus were conducted and also the basic technological parameters were recognized. The results of this experiment will be considered and used to study the composition and development of industrial technology of drugs, which based on them.Keywords: Fruits Viburnum opulus L., Amino acids study, Pharmaco-technological investigation basic technological parameters raw materials.
Change of Hepatobiliary System under the Influence of Hydrazine Derivatives Saspugayeva G.Y.
Journal of Global Pharma Technology Volume 12 Issue 01
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Hydrazine derivatives are used in different spheres, in aero-space activity, medical practice, laboratory-diagnosis practice, that is why environment is polluted with hydrazines in big areas. The question about influence of hydrazine derivatives, used as the rocket fuel, on the human organism and ways of its detoxication is very actual. In connection with appeared situations, we set the goal: to study the negative influence of hydrazine derivatives-hydrazine sulphur, nitrosodimethylamine (NDMA), phenylhydrazine, isonicotinic acid hydrazide (IAH) on several biochemical features of blood and correction of functional damages of organism with “Salsocollin” preparation.Keywords: Isonicotinic acid hydrazide (IAH), N-nitrosodimethylamine (NDMA), AlAT-alanine aminotransferase, AsAT-aspartate aminotransaminase, Salsocollin.
The Differences in the Stimulation and Personal Social Development of School-Aged Children between Children WHO Raised by their Grandparents and Parents Respectively Praba Diyan Rachmawati
Journal of Global Pharma Technology Volume 12 Issue 01
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Introduction: Indonesia is a country that has a cultural feature related to child care. Grandparents can act as a parent because of unexpected factors such as the parents dying, accidents, illness, the parents being dependent on drugs, imprisonment, studying abroad or the parents still being adolescents. The aim of this research was to determine the difference between the stimulation and personal-social development of school-aged children taken care of by their grandparents and parents respectively. Method: The sample used consisted of 20 children taken care of by their grandparents and 30 children taken care of by their parents in one of the Elementary Schools in Surabaya. The independent variable was stimulation and the dependent variable was personal-social development. The data was collected using a questionnaires that was analyzed using Chi-Square and Spearman rho’s with significance α<0.05.  Results: The results showed there to be a significant difference in stimulation between grandparents and parents (p=0.007) and the same in personal social development between the grandparents and parents (p=0.000). There was no correlation between grandparent stimulation (p = 0.209) and parental stimulation (p= 0.244) with the personal social development of the school-aged children. Discussion: The personal social development of school-age children who are cared for by their grandparents was lower than those cared for by their parents. However, there was no relationship between the stimulation carried out by the grandparents and the personal social development as well as the stimulation given by their parents on the personal social development. Further research is suggested to analyze the factors that influence the stimulation and personal-social development of school-aged children by comparing the results of the grandparents’ children and those of the parents.Keywords: Grandparents, Parents problems of early childhood, Personal social development, School-aged children, stimulation.
Evaluation of Analgesic Activity of Extracts of Jasminum sessiliflorum Ruby Philip
Journal of Global Pharma Technology Volume 12 Issue 01 (2020) Jan. 2020
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The present study was designed to investigate analgesic activity of ethyl acetate and ethanolic extracts of Jasminum sessiliflorum. The analgesic activity was assessed by using acetic acid induced writhing method and tail immersion tests in rats. The ethyl acetate and ethanolic extracts decreased the acetic acid induced abdominal contractions and also significantly increased the reaction time of tail immersion test [1]. These results showed that the plant extracts had both central and peripheral analgesic action. The  results  suggest  that the extracts  of J.sessiliflorum possesses potent analgesic properties, which support its use in traditional medicine and suggesting that the plant should be further investigated for its pharmacological active natural products [2]

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