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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 120 Documents
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Search results for , issue "Volume 12 Issue 02 (2020) Feb. 2020" : 120 Documents clear
Molecular Detection of Multi-drug Resistant Acinetobacter baumannii from Patients Wounds Amina N. Al-Thwani
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

150 swabs were collected from patient's wounds and hospital units, population of this study included both genders with different ages in AL-Imamein AL-Kadhimein Medical City in Baghdad. The collected swabs were cultured using appropriate media and tested biochemically in order to find out the profile of bacteria that colonize patient's wounds and hospital units. The results of culture revealed that, the most common isolated bacteria were, Staphylococcus aureus followed by Pseudomonas aeruginosa and A.baumannii. The isolates of A. baumannii was tested for antibiotic susceptibility, the results showed that, clinical and environmental isolates were (100%) resist to Ceftriaxone, Ceftazidime Ampicillin–Sulbactam, and Cefepime. Metallo Beta Lactamase (MBL) genes as bla IMP gene and bla VIM were detected by Molecular method (PCR) in 12 clinical and environmental isolates of A.baumannii. The result revealed that among all isolates (12) only bla IMP gene was detected in 4 isolates while the reminder isolates (8) of A.baumannii have no amplified bands for neither bla VIM nor bla IMP. It was concluded that, A.baumannii responsible for many nosocomial infections, and these bacteria were high resistant to different types of antibiotics.
Effect of Isolate Catechin GMB4 in Expression of GRP78 and Tunel Assay in Rat Cataract Model Nugraha Wahyu Cahyana
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

AbstractThis research is to explore glucose-regulated protein 78 (GRP78) expression and Tunel assay, signs of stress of endoplasmic reticulum (ER) and apoptosis in rat cataract model. Cataract was formed by inducing a subcutaneous injection of 19 µmol/kg sodium selenite to ten-day-old Wistar rats. The neonatal rats were divided into five groups randomly (n=5 in each group): a control group, and four cataract-induction groups, treated with either 0, 50, 100, 200 mg/kg catechin Isolate From GMB4 Clone Green Tea. We performed slit-lamp biomicroscopic analysis, immunohistochemistry for GRP78 and Tunel. Both eyes of all rats in Group 1 did not exhibit cataract formation. In Group 2, one out of five (20%) developed grade 3 cataracts and the remaining four out of five (80%) developed grade 4 cataracts. The grade of cataract formation decreased in groups 3, 4 and 5. The difference in exhibited cataract in the lens of all rats between Group 2 and any eyes of groups 3 or 4 and 5 were significant (P = 0.022, 0,001, 0,001). The mean amount of Tunel cells and GRP78 of group II rats were significantly (P < 0.01) higher than the levels in Group I, Group III, Group IV and Group V. Stress of Endoplasmic reticulum and apoptosis in the lens that increased following cataract formation in rats was suppressed by catechin Isolate From GMB4 Clone Green Tea.
A Comparative Assessment Study on Natural Coagulant and Regenerated Coagulant Alok Suman
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Surface water brings impurities in the form of suspended and colloidal solids. Coagulation and flocculation followed by filtration and disinfection process involved in the treatment of surface water. This process generates large quantity of waste generally known as water treatment sludge (WTS). A typical Water Treatment Plant (WTP) produces about 100,000 tons/year of sludge whereas, on a global scale, available literature estimates that at present the daily production of sludge exceeds 10,000 tons (Babatunde and Zhao, 2007). Increase in demand for milk and dairy products, dairy industries in most of the countries of the world, including India will lead to enhanced productivity, as a result increase in wastewater generation and environmental pollution. The objective of the present study is to determine WTS characteristics obtained from WTP and to investigate the reuse of recovered/regenerated coagulant in synthetic dairy effluent and compare with natural coagulant (Moringa Oleifera Seed Powder (MOSP)). The characterization of WTS shows the maximum amount of SiO2   at 67.75% by using Energy-Dispersive X-Ray Fluorescence (ED-XRF). The other oxides also observed by ED-XRF such as Al2O3 (16.76%), Fe2O3 (5.52%) and MgO (3.33%). For the optimum recovery of the coagulant, WTS acidified with the different normality of sulfuric acid. The RC produced similar turbidity removal efficiency (94%) at 25ml/l dose as compared to natural coagulant at 60 ml/l dose. It also has been observed that the removal of TSS, TDS, BOD and COD efficiently by RC. CPCB [3] reported that some of the WTPs are cleaned once in a year and in the lack of sludge disposal management it disposed off on nearby open lands or drain. Proper handling WTS from WTPs in an economical and environmentally friendly manner remains a very important issue. The recovery, recycling and reuse may provide a sustainable solution to the WTS management.Keywords: Water Treatment, Sludge, Recovery of coagulant, MOSP, SEM, ED-XRD, FTIR, and XRD.
Histo-Chemical Effects of Iraqi-Camel Colostrum Extracts on Some Liver Biomarkers in Albino Rats Zainab Ibrahim Mohammed
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

This study was intended to investigate the histo-chemical effects of Iraqi camel (Camelus dromedaries) colostrum on liver tissues and enzymes of albino rats, Rattus norvegicus. Colostrum was collected at 30ml at post-parturition times of 0, 6, and 12hr. The colostrum was subjected to an extraction procedure to obtain a filtered fluid that contained bioactive substances. These extracted fluids were given to 4 groups/5 rats each. Group1 (0G), Rats were given 0.1ml of 0hr-colostrum extract orally for 1 week. Group2 (6G), Rats were given 0.1ml of 6hr-colostrum extract orally for 1 week. Group3 (12G), Rats were given 0.1ml of 12hr-colostrum extract orally for 1 week. Group4 (control group, CG), Rats were given tap water only. Body and liver weights were measured every week for 4 weeks. Blood samples and liver samples were collected after 30 days to perform assays of measuring serum proteins and liver enzymes. The results indicate richness of colostrum with protein and fat. The results also revealed increases the levels of liver enzymes and changes in the tissues of the livers. These levels increased especially at 30 days of the experiment for the groups that were given camel colostrum extracts. These results indicate important effects of camel colostrum to prepare and protect body against various environmental intruders such as pathogens. Our results generate important information for future work to thoroughly study colostrum extracts on infections in humans and animals.Keywords: Camel, Colostrum, Liver enzymes, Rats. 
Synthesis and Characterization of Graphene Oxide Nanosheets by Electrochemical Exfoliation Method and its Antibiofilm Activity against Pseudomonas aeruginosa Husam N. Abbas
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

In this work, the Graphene oxide (GO) nanosheets were synthesized by a electrochemical exfoliation method. The morphological, structure and optical properties were investigated by using Field emission scanning electron microscope (FE-SEM), X-ray diffraction (XRD), Raman spectroscopy, FTIR and UV-VIS spectroscopy. FE-SEM images of GO nanosheets confirmed the presence of layered structure. The crystalline size and number of layers of GO nanosheets were estimated by XRD analysis.  The UV-VIS spectrum of GO nanosheets shows maximum and shoulder absorption peaks. The oxidation of graphene was confirmed via FTIR analysis by the appearance of functional groups of oxygen. Raman analysis showed the formation of peaks D, G and 2D. The antibiofilm activity of different concentrations of GO nansheets against Pseudomonas aeruginosa (P. aeruginosa) as a model of more antibiotics resistant Gram-negative bacteria was investigated. These results confirm that the GO nanosheets material damages the biofilm of P. aeruginosa. Therefore, It can be considered as an anti-bacterial material.Keywords: Graphene Oxide, Nanosheet, Electrochemical Exfoliation, Antibiofilm, Pseudomonas aeruginosa.
Synthesis, Antioxidant, and Preliminary Antitumor Activities of New Curcumin Analogues Yasser Fakri Mustafa
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Curcumin is a molecule gifted from nature to improve human health by its multiple biological activities. However, the application of curcumin in therapeutics is limited mainly due to its poor aqueous solubility, insignificant chemical stability, and low cellular uptake. To address some of these drawbacks, eight analogues of curcumin were synthesized starting from simple molecules. Characterization of the chemical structures of these analogues was documented by interpretation of their IR, 1H-NMR, and 13C-NMR spectra. Biological activities of the synthesized analogues were studied by comparing their activities with those of curcumin. This biological assessment included examining the antioxidant capacity via DPPH and hydroxyl radical scavenging activity tests, and screening the preliminary antitumor activity against MCF-7 and HeLa cancer cell lines by MTT test. Depending on the resulted data, it was found that these analogues have the comparable biological activities but with better stability and water solubility in comparison with curcumin. It is postulated that such analogues may be useful clues to improve the therapeutic applications of curcumin.Keywords: Curcumin, Synthesis, Analogues, Antioxidant, Antitumor.
Effect of Giving A Combination of ROM and Mirror Therapy to Increase The Muscle Strength of the Upper Limb Dedi Irawandi
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Background:One of the problems in stroke patients is a decrease in muscle strength due to hemiparesis which affects the client's self-acceptance. The study aims is to determine the effectiveness of  combination mirror therapy and ROM on upper limb muscle strength and self-acceptance stage in stroke clients with hemiparesis.Materials and Methods:Quasi experimental research with pre-post control group design was done on 36 respondents with consecutive sampling technique, for 3 months in the stroke room. Upper limb muscle strength was measured using a Medical Research Council scale, while the self-acceptance stage used a self-acceptance stage questionnaire based on the Kubler Ross adaptation stage. Data were analyzed using wilcoxon and Mann-Witney test with p value <0,05.Results: Wilcoxon test known p value <0.05 for muscle strength and self-acceptance stage both in the treatment group and in the control group. The result of analysis of muscle strength difference between treatment group and control is known p value = 0.000, while for self-acceptance stage known p value <0,05 for denial, anger, bargaining and depression, At acceptance stage known p value 0,05. This analysis shows that there is a significant difference in muscle strength and self-acceptance at the denial, anger, bargaining and depression stages after being given a combination of mirror and ROM therapy with stroke clients given ROM therapy alone.Conclusion: Combination of mirror therapy with ROM can be used as nursing intervention in the hospital, especially on ischemic stroke clients with hemiparesis to increase muscle strength and self-acceptance of client
Self Care Behavior As An Indicator Of Psychological Adaptation In Patients Undergoing Chemotherapy Awatiful Azza
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Background: Chemotherapy is one of the medical actions taken to treat cancer and kill cancer cells using cytostatic drugs. This treatment not only has positive effects but also the negative effects of sufferers. This study aims to analyze the relationship of self-care behavior with the psychological adaptability of patients undergoing chemotherapy Methode: This study used a cross-sectional design. The Sample was 120 patients in the chemotherapy treatment unit at the hospital in Jember-Indonesia district, with purposive sampling. The independent variables were self-care behavior (include self-care confidence, self-care management, Self-care maintenance). The dependent variable was a psychological adaptation. Data were obtained through a modified Self Care Heart Failure In-dex (SCHFI) instrument which has been modified for patients undergoing chemotherapy. Data were analyzed by using Chi-square with a significance level of p < 0, 05. Results: of this study indicate there was a relationship between self-care behavior with the psychological adaptability of patients with chemotherapy, the p-value was 0.00 <0.05. Conclusion: Self-care behavior is one form of nursing service that can be applied to patients undergoing chemotherapy. The ability to engage patients independently during chemotherapy can increase patient self-esteem and will help improve patient adaptation due to the side effects of chemotherapy. Further study recommends developing the intervention to improve the adaptation of patients undergoing chemotherapy.Keywords: Adaptation, Self Care Behavior, Chemotherapy.
Apoptotic Index of Amniotic Membrane Cells in Preterm Labor with Premature Rupture of Membrane (PPROM) was Higher than Preterm Labor without Premature Rupture of Membrane Giri Chandra
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Introduction: Premature rupture of the membrane in preterm pregnancy is a condition that can cause increased maternal and perinatal morbidity and mortality. The study aims to compare the apoptotic index of amniotic membrane cells in preterm labor with premature rupture of membrane (PPROM) and without premature rupture of membrane. Method: This is a cross sectional study conducted at the Department of Obstetrics and Gynecology, Sanglah Hospital Bali. The Amniotic membranes were taken from the placenta after delivery then apoptotic index was measured by TUNEL examination. Result: The study included each 20 women from both groups. There was no significant difference of maternal age, gestational age, and BMI between groups (p>0,05). Chi-square analysis showed there was an association between the apoptotic index and preterm labor with PROM (p = 0.001). Subsequent analysis resulted in prevalence ratio of 19.0 (95% CI = 2.81 - 128.6). Conclusion: This study concluded that the apoptotic index of amniotic membrane cells in PPROM was higher than preterm labor without premature rupture of membrane. Keywords: Apoptotic index, Preterm Premature Rupture of Membrane, PPROM.
Synthesis of Polymers Containing 5, 5-Dimethylhydantoin and Study of its Optical Properties Ali J. Al-Zuhairi
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

In this research work, four aromatic polymers, known as 5,5-Dimethylhydantoin  derivatives. 5, 5-dimethylimidazolidine-2,4-dione have been condensed with different dihalolkanes (1,2-dichloroethan and dichloromethane respectively) to give  two different poly hetero aromatic polymers. Also 5,5-dimethylimidazolidine-2,4-dione have been treated with chloroacetic acid and polymerized with ethylene glycol and hydroquinone respectively to give two different polyester polymers. The prepared polymers have been identified using FTIR and 1HNMR instruments. All the prepared polymers have shown a high number average molecular weight (Mn) using Gel Permission Chromatography (GPC) technique. Where absorbance was measured by using a device (UV-Spectroscope).The optical properties of the prepared polymers have been studied. The transmittance, absorption coefficient, had been measured. Transmittance values of the four prepared polymers increases with increasing wavelength due to the decrease in absorption values because the transmittance is inversely proportional with absorbance. The absorbance values of the prepared polymers have been decreased with increasing the wavelength. The absorbance spectra of the polymer solution of the concentration (0.3 g/mL %) for polymer N2 and the concentration (0.2 g/ml %) for polymer N3 within the range (200-1100 nm).The highest absorbance value (310 nm) for polymer N2 and (330 nm) for polymer N3. the absorbance spectra of the polymer solution of the concentration (0.3 g/mL %) for polymer N4 and the concentration (0.2 g/ml %) for polymer N5 within the range (200-1100 nm).The highest absorbance value (310 nm) for polymer N4 and (330 nm) for polymer N5.Keywords: Absorption coefficient 5, 5-Dimethylhydantoin, Optical properties, Polymers.

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