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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 120 Documents
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Search results for , issue "Volume 12 Issue 02 (2020) Feb. 2020" : 120 Documents clear
Grafting onto Different Rootstocks Influences Yield, Quality, Chemical Composition, and Bioactivities of Tomato Fruits under Greenhouse Conditions Howaida I. Abd-Alla
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Objective: Grafting is a possible chemical free solution that shows several changes in plants, with the aid of vigorous rootstock. Methods: The influence of grafting on the yield and fruit quality of tomato cultivars grown under greenhouse condition was conducted during two successive seasons of 2016 and 2017. The metabolic composition of fruits of tomato Solanum lycopersicum L. Nefret hybrid (T1) grafted onto four rootstocks were identified by gas chromatography coupled to mass spectrometry (GC-MS). The levels of aspartate and alanine aminotransferases and alkaline phosphatase were analyzed for the determination of liver functions. The levels of oxidative stress markers; malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione (GSH) were determined in the rat's liver tissue. Kidney function parameters of serum urea and creatinine levels were also measured. Histologic examinations of the liver and kidney tissues were also performed. Results: The effects of grafting on the vegetative growth, yield, and fruit quality characteristics, i.e., fruit weight, length, diameter, total soluble solids content and titratable acidity of T1, grafted onto four rootstocks have showed great variability.  The vegetative growth, i.e., plant height of T2, was increased when S. lycopersicum L. var. VFN (T2) was used as a rootstock.  T2 has showed no adverse effects in all biochemical parameters under investigation compared by the other treatments. Aldehydes, ketones, esters, fatty acids, terpenoids, carotenoids, phenolics and alkaloids were the main identified components and the major compound was β-ionone (13.37%) in T2. Conclusion: The nutritional content of T2 and that it has showed no alteration in oxidative stress markers, liver and kidney function tests and their histopathological patters support its safety. While, un-grafting or grafting onto Solanum melongena L. cv. Balady (T3) may be a tool to improve the crop quality. Keywords: Greenhouse-grown tomato, Grafting, GC-MS, Carotenoids, Lycopene, Polyphenols, Liver, Kidney, Histopathology.
Evaluation of Antioxidant and Anticancer Activity of Kohautia Aspera (Heyne Ex Roth) Bremek Kavitha G; Sivakkumar T; Elessy Abraham
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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The purpose of present study was to investigate the antioxidant and anticancer activities of selected extracts of Kohautia aspera (Heyne ex Roth) Bremek. The chloroform, water and ethanolic extracts which are rich in phytoconstituents were subjected to DPPH photometric assay and standard MTT assay. The percentage of growth inhibition in antioxidant study increased with increasing concentration of extracts. The ethanolic extract showed better antioxidant activity followed by other extracts. The anticancer potential of plant was investigated by standard MTT assay against SK-MEL 28 skin cancer cells. In vitro cytotoxic activity of plant increased with increasing concentration of extracts. The results clearly indicated that the extracts of the study species has potential inhibition of free radicals and powerful anticancer activity against skin cancer cells.
Substantiation of use of Photodynamic Therapy in Experimental Research in Vitro with Strains of Periodontopathogenic Bacteria and Fungi Candida Vadim O. Samusenkov
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Photodynamic therapy is used for the treatment of inflammatory periodontal diseases. This study was aimed at determining the effectiveness of the treatment of periodontitis and gingivitis with the use of a photosensitizer that interacts with the light flux, has the ability to adsorption on the surface of the bacterial cell. To determine the sensitivity of photodynamic effects, the following priority strains of microorganisms were selected: Aggregatibacter actinomycetemcomitans, Streptococcus constellatus, Candida glabrata. For the cultivation of microorganisms in the bioreactor, two types of tubes were used: 50 ml tubes with a membrane filter (TubeSpin) and 50 ml tubes of Falcon type with a lid without a membrane. 20 ml of nutrient medium was added to each tube. A. actinomycetemcomitans (37°C; RPM: 500 min‒1; measurement freq.: 3 h-1; Rev. spin period: 1 sec.; volume: 15-16 ml; λ: 850 nm); S. constellatus (37°C; RPM: 1500 min‒1; measurement freq.: 3 h-1; Rev. spin period: 2 sec.; volume: 15-16 ml; λ: 850 nm); C. albicans (37°C; RPM: 1300min‒1; measurement freq.: 3 h-1; Rev. spin period: 3sec.; volume: 15-16 ml; λ: 850 nm). After bacterial suspension inoculations, the samples were irradiated with semiconductor laser devices with different wavelengths-630 nm and 662 nm, at a power of 100 j/cm2. The basis of experimental studies was automated cultivation of isolated strains of microorganisms with control of growth curves of microbial populations using different modes of exposure and photosensitizers.Keywords: Periodontopathogenic microorganisms, Photodynamic effects, Photosensitizers, Gingivitis, periodontitis.
Family Caregiver’s Perception and Comprehension toward Pressure Injury Prevention in Bedridden Patients after Discharge from Hospitals Martono .
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Objectives: Perception and understanding of pressure injury care is an important basis for family caregivers in preventing pressure injuries in stroke paralysis patients.The aims of this study to assess the caregiver family's perceptions and comprehension in preventing pressure injury. Methods: The design of this study was cross sectional. The survey was conducted on 357 family caregivers in nursing homes, Indonesia. Potential participants were recruited from Family Caregiver who treated stroke paralysis patients who were bedridden after being discharged from the hospital in a nursing home. Predictor variables (independent) of this study consisted of perception and comprehension and the dependent variable of this study was prevention of pressure injuries. Data were collected using a questionnaire: The analysis used linear regression with a significance level of p ≤0.05. Results: Simultaneously, 36.1% of perception and comprehension explained the prevention of pressure injury as evidenced by the value R2 = 0.361; p (F test) = 0.049. Partially, 19.4% perception of the prevention of pressure injury prevention was proven to be p (t-test) =0.016; R2=19.4% and 12.2% comprehension explained the prevention of pressure injury as evidenced by the value of p (t-test) = 0.019; R2=12.2% with a confidence interval of 95%. Conclusion: Family caregiver’s comprehension of the prevention of pressure toward pressure injury prevention in bedridden patients after discharge from hospitals was low. Perceptions and comprehension factors of family caregivers contribute to the prevention of pressure injury in stroke paralysis patients who are bedridden.Keywords: Caregivers, Perception, Comprehension, Pressure injury.
Microencapsulation in Food Science and Biotechnology in Iraq Marwah Ali Oudah
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

microcapsules can release their contents at controlled speeds under specific conditions, and can protect the encapsulated product from light and oxygen. The microencapsulation consists of microparticles formed by a porous polymeric membrane containing an active substance. The material or mixtures of materials to be encapsulated can be covered or trapped within another material or system. A microcapsule consists of a semi-permeable, spherical, thin and strong membrane around a solid / liquid center. The materials used for encapsulation can be gelatin, fats, oils, gum arabic, calcium alginate, waxes, wheat starch, corn, rice, potatoes, nylon, cyclodextrin, maltodextrin, sodium caseinate, whey protein or protein of soy. The applications of microencapsulation are directed to the industry, it is given to the textile, metallurgical, chemical, food, cosmetics, pharmaceutical and medical industries. Among the techniques used to microencapsulate are spray drying, cooling drying, freeze drying, coacervation and extrusion. The substances that are microencapsulated can be vitamins, minerals, dyes, prebiotics, probiotics, nutraceutical flavors, antioxidants, odors, oils, enzymes, bacteria, perfumes, drugs and even fertilizers.Keywords: Encapsulation techniques in food, Encapsulation theory.
Modeling and Optimization of Extraction of Gallic Acid from Chenopodium Murale using Response Surface Methodology Marwa Abdul Hussain Qassim
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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In this work, the investigation of recovery of gallic acid from chenopodium mural by leaching process was conducted. 99% of ethanol was used as a solvent.  Five parameters were investigated namely time (20 - 90) min, speed of mixing (200-1000) rpm, temperature (25˚C-70˚C), particle size (100-500) µm, solid/liquid ratio 1/50 gm/gm to 1/20 gm/gm. To design the experiments, Response Surface Methodology was used using Minitab 17 software. The model equation for optimization of the extraction process was found. The best conditions for the process were extraction temperature of 70 ˚C, the liquid-solid ratio of 0.05 gm/ml, extraction time of 90 min, agitation speed of 200 rpm and particle size of 100 microns. HPLC instrument equipped with UV detector UV-20A with wavelength Range 190-700nm was used for the analysis of samples. The aim of this study is to obtain a model equation for optimization of extraction of gallic acid from Chenopodium murale using response surface methodology. The influence of temperature, solid/liquid ratio, agitation speed, particle size and time on extraction yields will analyze.Keywords: Antioxidant, Gallic acid, Chenopodium mural, Leaching and Response Surface Methodology.
Synergistic Hurdle Effect of Physical and Chemical Treatments for Non-thermal Pasteurization of Guava (Psidium guajava) Juice Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Guava (Psidium guajava) is commonly known for its food and nutritional values throughout the world. It has high fermentable sugar composition when mature and ripe .It’s known for its sweet and tangy flavor and many uses. It is a fruit with good nutritional attributes but has short shelf-life under the ambient conditions. Dimethyl dicarbonate is a microbial control agent inhibitor widely applied in the food industry. Various current and potential applications of ultrasound in the fruit processing have been identified. Consumers prefer to safe, nutritious, high quality guava juices without thermal treatment. In our research, synergistic or hurdle effectiveness by ultrasound combined dimethyl dicarbonate was studied on guava juice. Different parameters of ultrasonic duration (10, 15, 20, 25, 30 min), dimethyl dicarbonate addition (10, 15, 20, 25, 30 µL/100mL) was examined on guava juice in respect of microbial inactivation. Log10 reductions of total plate count and coliform were evaluated to define the optimal variables. Our results revealed that microbial loads in guava juice would be decreased dramatically by ultrasonic treatment in 25 minutes at frequency 37 kHz with 20 µL/100mL supplementation of dimethyl dicarbonate to create a synergistic hurdle effect for a significant microbial reduction. It could be considered as an excellent non-thermal pasteurization for a better fruit juice quality, not only for guava but also for other tropical fruits to enhance their added value.Keywords: Guava juice, Synergistic, Hurdle, Ultrasound, Dimethyl dicarbonate, Microbial reduction.
Synthesis and Identification of Some New Derivatives of Benzoxazole Bearing Pyrazole and 1, 2, 4-Triazine Rings Ahmed S. Hamed
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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In this work, new derivatives of benzoxazole bearing two types of heterocyclic rings; pyrazole and 1,2,4-triazine have been described. This work involved preparation hydrazide derivative 5 as a key material in the synthetic route, which was obtained over five sequence steps. Reaction of 2-aminophenol with CS2 under basic conditions afforded 2-mercaptobenzoxazole 1 in 61% yield.  Michael addition of 1 to ethyl acrylate provided the desired ester 2 in a good yield (74%). Thereafter, hydrolysis of the ester group at 2 using basic conditions yielded the corresponding acid 3. The acid 3 was then converted to acid chloride 4, followed by nucleophilic addition of hydrazine hydrate was performed in a one-pot reaction and provided the desired hydrazide 5 in a 71% yield. Pyrazole derivatives 6-11 were then obtained via reaction of 5 with 1, 3-dicarbonyl compounds. Whereas, treatment of 5 with 1, 2-dicarbonyl compounds and NH4OAc in the presence of K2CO3 as a base gave the desired 1, 2, 4-triazine derivatives 12-17.        Keywords: Benzoxazole, Anticancer, 1, 2, 4-Triazine ring, Heterocyclic.
Evaluation of Blood Sugar Levels in Diabetes Mellitus Patients with Gangrene Complications in Hospital at Palu City Ingrid Faustine
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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From year to year, the amounts of gangrene patients continue to gradually increase. This is due to lack of consistent routines in checking blood sugar levels which result in blood sugar levels being uncontrolled. In gangrene patients who do not receive treatments, this will lead to amputation and can reduce the patient's quality of living. This study aims to determine the blood sugar levels in patients with diabetes mellitus with gangrene complications in hospitals in Palu City. The method used in the study is cross-sectional with prospective data collection, in which for examination of GDP is implemented using the auto check tool. The results of this study utilized the wilcoxon test to see a decrease in blood glucose levels before and after receiving antidiabetic and insulin therapy. The total research samples consisted of 30 patients within 1 month monitoring duration. From the results of research conducted for 3 months, it showed a significant decrease in fasting patients' blood glucose levels, with an average value before and after using antidiabetic therapy indicated as 285.87 mg / dl and 173.07 mg / dl. It is then concluded that there is a decrease in blood sugar levels in patients who suffer from diabetes mellitus with gangrene complications due to the use of antidiabetic therapy, namely insulin.Keywords: Blood Sugar Levels; Diabetes Mellitus; Gangrene; Insulin.
Icon as a Method of Choice for Injectable Treatment of Initial Caries in Patients with Fibrodysplasia Ossificans Progressive: a Clinical Case Svetlana Danshina
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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The method considered in this clinical case makes it possible to treat the initial stages of the carious process in patients who are contraindicated by local injection anesthesia. The purpose of this study is to identify opportunities for treating the early stages of the carious process using ICON technology, without the use of injection methods of anesthesia, in patients who were diagnosed with Fibrodysplasia ossificans progressive (FOP). Conclusions: Patients were treated with infiltration of polymer material, without the use of injection methods of anesthesia. The result of this clinical case showed the effectiveness of this technique for patients diagnosed with FOP.Keywords: Fibrodysplasia ossificans progressiva (FOP), Painless, Icon, Carious process, Genetic diseases.

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