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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 120 Documents
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Search results for , issue "Volume 12 Issue 02 (2020) Feb. 2020" : 120 Documents clear
Domperidone Maleate Orodispersible Tablet Formulation Using Primojel® Superdisintegrant with the Wet Granulation Method D. Gozali
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Orodispersible tablets are a solution for people who have problems swallowing drugs because they will break down instantly in the mouth without having to be swallowed. Objective: The aim of this research was to formulate orodispersible tablets using Primojel® as a superdisintegrant and domperidone male ate as an active compound to achieve the best disintegration time in the oral cavity by a wet granulation method had been carried out. Method: The tablet of 180 mg in weight was made with variation of concentration as followed 7, 2 mg (F1); 9 mg (F2); 10,8 mg (F3); 12,6 mg (F4); 14,4 mg (F5). F1, F3, F4, and F5 were qualified based on uniformity of weighing. Results: All of the formulas (F1, F2, F3, F4, and F5) were qualified based on the disintegrating time of orodispersible tablets (below three minutes). F2 has a quickest disintegration time and F1 has the longest disintegration time. Statistical analysis at α = 0, 05 showed that the concentration variation of Primojel® affected the disintegration time of the tablet. Hedonic test with five parameters included likeness, flavor, taste after taste showed that F5 was the most favorite formula. Conclusion: All formulas met the requirements of the Indonesian Pharmacopoeia IV crush time that was no more than 3 minutes. The results of the statistical analysis stated that F5 was the most preferred formula of domperidone maleate orodispersible tablets.Keyword: Orodispersible tablets, Primojel®, Wet granulation, Domperidone maleate, Tablet formulation.
Molecular Modeling of Anti-Alopecia Compounds Found in Sauropus Androgynus Resmi Mustarichie
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

People in the village of Mak Kemas, Malaysia use the katuk leaves (Sauropus androgynus) to prevent anti-alopecia. It was thought that katuk leaves have secondary metabolites which could accelerate the growth of new hair. The objective of this study was to determine the molecular modeling of compounds contained in katuk leaves (Sauropus androgynous) providing docking and ADMET information in silico as anti-alopecia drugs. In this study, receptors were used (PDB code: 4K7A) derived from protein data banks (http://www.rscb.org/pdb) and visualized with Discovery Studio and tested 10 compounds that had the potential as ligands to prevent baldness. Molecular modeling of bioactive compounds was carried out by molecular docking computation using AutodockTools 1.5.6 and Pre-Admet to determine absorption, distribution, and toxicity. The results were an amino acid residue that showed the place-bound to the receptor, inhibitory constant (Ki), and free energy bonds (∆ G). Of the 11 compounds studied, 3 were 5-Alpha-Dihydrotestosterone; Finasteride; and Pyrene interacts well so that it could prevent baldness. From the results of docking and pre-admet that had been done, it concluded that the compounds contained in katuk leaves could be used as candidates for anti-alopecia drugs.Keywords: Anti-alopecia, ADMET, In-silico, Katuk Leaf, Sauropus androgynus.
Pulmonary Function Test among Asymptomatic Male's Smokers and Non-smokers: A Community Study in Denpasar City, Bali I Made Muliarta
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Smoking chronically affects lung function, The effect and severity changes differ between individuals. It is estimated that six million adults and ~100,000 adolescents died each year from tobacco-related health issues. Active smoking by healthy adults has been reported to cause declines in lung function. These differences between cigarette smokers and non-smokers are in direct proportion to the quantity of smoking. Study-related factor associated with pulmonary function in Indonesia, especially in Bali still limited. Aim: This study aims to examine the factor that may be associated with pulmonary function among smokers and non-smokers in Denpasar. All participants were males. Method: This is an analytical study using a case-control method conducted in Denpasar City represented by 592 male respondents. Data collection is done through interviews with structured questionnaires. Demographic data, occupation, residence, body mass index, smoking habit, spirometry examination were documented. Data were analyzed using SPSS IBM 25.0 with univariate and bivariate analysis. Results: Spirometry examination showed 0.2% respondent had obstructive lung disease, 8.3% had restrictive lung disease, and 0.3% combines. This study found the association between smoking status and impaired lung with p-value <0.0001 (3.334 (CI95% 1.898-7.204). Association between pack years above 1.9 also significant with p-value <0.05 4.020 (CI95% 2.638-8.558). Conclusion: A significant association was found between the status of smoking and lungfunction parameters. Pack years also affect towards lung function parameter, especially FEV1%. Keywords: Smoking status, Packyears, Spirometry, Pulmonary functions.
Evaluate Toxic Effect of Bisphenol A on Kidney of Male Mice and Mitigation Its Effect by Green Tea Extract Aamer. M. Ali
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Bisphenol A is a substance for the synthesis variety of plastics, primarily epoxy resins and polycarbonates. Bisphenol can have severe effects on the type and might contribute to gradual cumulative renal injury over a lifetime. This study object to estimate toxic effect of bisphenol A on type of male mice also mitigation toxic effect of bisphenol A by using extract green tea. Healthy adult male albino laboratory mice (Mus musculus) treated for two doses of bisphenol a (20 mg/kg and 40 mg/kg body weight per day) for thirty days and green tea extract was co-administration orally as antioxidant. Bio-chemical parameter of serum creatinine and blood urea was calculated as indicator of kidney function. groups treated with bisphenol A showed increased in serum creatinine and blood urea also histopathological of kidney showed significant damage in groups that treated with bisphenol A whereas groups that treated with bisphenol A and co-administration  green tea extract showed mitigation toxic effect of bisphenol  A due to role of green tea as anti-oxidant compound.Keywords:  Evaluate, Bisphenol A, Green Tea, Antioxidant compound.
An Integrated Approach to the Treatment of Severe Psoriasis: A Clinical Case Lyudmila Smirnova
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Psoriasis is a disease of autoimmune origin, affecting not only the skin, but also the internal organs of a person. Currently, many methods of treating psoriasis are in use, which vary in effectiveness. The aim of this work is to analyze the results of complex physiotherapeutic and pharmacological treatment of a patient with severe psoriasis in comparison with the initial failed treatment with traditional pharmacological methods. The therapy was carried out in 2018-2019 (observation by a rheumatologist at the place of residence), after treatment that was unsuccessfully carried out in 2016 at the Institute of Rheumatology (Federal State Budget Scientific Institution "Scientific Research Institute of Rheumatology named after VA Nasonova") with an incorrect diagnosis of rheumatoid arthritis. In the secondary complex therapy, the following treatment methods were used: a) antihistamines (Chloropyramine 1.0 IM in the evening for 22 days, Chloropyramine 1 tablet 2 times a day in the morning, 18 days for the day); b) Methotrexate 15 mg IM once a week; c) hepatoprotector (heptor 400 mg 1 tablet 1 time per day-22 days); d) Folic acid 0.1 mg 2t 2 pd -6 days; e) Desensitizing therapy (200 ml of 0.9% Sodium Chloride-20 days); f) Local therapy (Komfoderm; Salicyl-dermatol ointment-22 days); g) Physiotherapeutic methods. With complex treatment, the trunk skin showed rashes regression, up to residual hyperpigmentation. The rash regression was 50% in the form of a decrease in the brightness of erythema in the palms, a decrease in peeling and the number of papular elements. Similar processes occurred on the skin of the feet, but with the preservation of large-plate peeling. A detailed literature analysis of known methods of treatment of psoriasis, with a comparison of new and traditional methods was performed. In recent years, the treatment of psoriasis has become more focused on targeted biological drugs. New methods of treatment not only demonstrate optimistic results, but also lead to a deeper understanding of the immunopathogenetic pathways of psoriasis, identifying new potential targets for therapeutic intervention and diagnosis. Our comprehensive approach has allowed us to establish one of the ways to achieve effective treatment.Key words: Psoriasis, Pharmacology, Symmetry, Paradoxical reaction, Physiotherapy, Papules, Rashes, peeling of the skin.
Stunting Determinants Among Indonesian Children Aged 0-59 Month: Evidence From Indonesian Family Life Survey (IFLS) 2014/2015 Eka Mishbahatul Marah Has
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

This study aimed to analyze the determinants of stunting among children aged 0-59 months old in Indonesia. A cross-sectional survey by using data from the Indonesian Family Life Survey period 2014/2015 (IFLS-5) was conducted, which focused on the household with children aged 0-59 months old (n=3623). Ordinal regression test showed that determinants of stunting among children aged 0-59 months old, consist of children aged <6 and 6-23 months old; male; low birth weight; underweight mother; normal height mother; poor household; and ever had antenatal care. Integrated intervention address children, mother, and health service factors associated with stunting is needed.Keywords: Children, Indonesian family life survey, Stunting.
Preparation a New SHE-Medium Replacement of RPMI1640-Medium using Oral Rehydration Solution Ekhlass N. Ali
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

The study showed that the use of the new  culture medium which called (SHE-medium) prepared by using oral rehydration salts, led to increase  the  ratio of cell viability of PMNs and lymphocytes compare with RPMI 1640-medium on 24,48,72 h. The results shows that ratio of cell viability of PMNs in SHE-medium were 89%,91% ,93% respectively, while in RPMI 1640-medium were 80%,90%,93% respectively while the  ratio of cell viability of lymphocyte in SHE-medium were 88%,90% ,91% respectively, compare with RPMI 1640-medium which are 80%,85%,90% respectively. But when tested the effect of SHE-medium on THP-1 cell line and REF cells and comparison with RPMI 1640-medium, the results shows that the ratio of cell viability on SHE-medium were 84.33% and 74.33% respectively, while in RPMI 1640-medium were 86.67% and 80.67% respectively.Keywords: 1640-medium, SHE-medium, Oral rehydration solution.
Implementing Lifestyle Management Using Health Promotion Model Approach Khamida Khamida
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Introduction: There are problem-related to student’s health behavior in Islamic boarding schools, they do not washing their hand before they have their meals, hanging wet clothes in their room,  and they do not really care about toilet hygiene.  The aim of this research was to know the effect of peer group support to student's lifestyle management using health promotion model approach. Method: The design was quasi-experimental, pre-post-test control group the population were students who stayed in Islamic boarding school in Surabaya and Sidoarjo, and the total sample was 100 students, 50 in control group, 50 in the intervention group, the sample taken by simple random sampling.  In the intervention group, they’ve got health education and peer group support while the control only got health education by giving a student lifestyle management module. The independent variable was peer group support and the dependent variable Student's lifestyle management. The data were taken by the questionnaire and were analyzed by the Mann Whitney test. Result: The result showed that after the treatment, students in the intervention group have Mean 23.28 SD 4.83 meanwhile the control group has SD 4.27 and Mean 4.38. Conclusion: It means that peer group support could change lifestyle management based on the health promotion model. The leaders or caretakers of Islamic boarding schools are expected to continue to monitor the behavior of students in implementing the management of the student's lifestyle and activate the boarding school health center.Keywords Student, Lifestyle management, Islamic Boarding School Peer Support Group.
Effect of Adding Zirconia and Alumina Nanoparticles on the Tensile and Flexural Properties of Polymer Blend Based on Polypropylene Teeb Adnan Mohameed
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Polypropylene is an important material used in many structural applications, including automotive and aircraft parts as well as machine parts.  In this paper, the properties of polypropylene were improved by blending it with 5% ratio of poly methyl methacrylate (PMMA) and adding nanoparticles powders of zirconia (ZrO2) and alumina (Al2O3) in different ratios (0.3, 0.5 and 0.7%) to polymer blend, which consists of [PP: 5% PMMA and adding 1% of (polypropylene-grafted-malic anhydrated (PP-g-MA) as compatibilizing agent)]. Polymer blend and its nanocomposites were prepared by melt blending technique using twin screw extruder. Investigation of some mechanical properties and the morphology structure test of the nanocomposites samples was studied. The results illustrated that the mechanical properties increased when adding nanoparticle (ZrO2 and Al2O3) to polymer blend (PP: 5%PMMA: 1%(PP-g-MA)) and the highest values were obtained for tensile strength, modulus of elasticity, flexural strength and flexural modulus, at 0.3% ratio of (ZrO2 and Al2O3) nanoparticles in the blend. The fracture surface morphology showed that the addition of nanoparticles led to reduce the micro pores that exist in the morphology structure of polymer blend.Keywords: Polymer blend, Nanocomposite, PP, PMMA.
Comparison the Effect of Ewe and Goat Colostrum Extracts on the Hematological and Biochemical Profiles: Rat as a Model Afrah Sabeeh Mhyson
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

This study was generated to provide information about the hematological and biochemical changes affected by exposing female rats to colostrum extracts of ewes and goats. As a start, 30 female rats were classified randomly into 3 groups (10 rats/each). The experiment was lasted for 30 days. Until the end of the experiment, a group received ewe colostrum extract (ECE) as 0.1ml orally/daily, another group was given goat colostrum extract (GCE) at 0.1ml orally/daily, the control group (C) was provided with normal saline at 0.1ml orally/daily. After the experiment was done, sacrificing of the tested animals was performed, and blood-based samples were obtained. These blood samples were tested for changes in the blood profiles using certain features such as RBCs counting, hemoglobin (Hb) level, packed cell volume (PCV), WBC counting, glucose (Glu) level, cholesterol (Ch) level, triglycerides (TAG), alkaline phosphatase (AP), alanine transferase (ALT), basophils (B%), eosinophils (E%), monocyte (M%), lymphocyte (L%), and neutrophils (N%). The results recognized significant (p<0.05) effects of the extracts on the RBCs, Hb, PCV, Glu, Ch, and TAG when compared with those in the C group. Furthermore, no significant (p>0.05) differences were provided from such effects on the WBCs, AP, and the ALT when compared with those in the C group. There were significant (p<0.05) effects of the extracts on the L% when compared with that in the C group. However, no significant (p>0.05) differences were provided from such effects on the B%, E%, M%, and N% when compared with those in the C group. No differences were noticed from these effects between both extracts on all those parameters. The study provides very important data about the effects of ewe and goat colostrum extracts on the hematological and biochemical characteristics in female rats that could be further used as supportive information for future studies.Keywords: Blood, Biochemical, Colostrum, Ewe, Goat, Parameters, Rat.

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