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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 120 Documents
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Search results for , issue "Volume 12 Issue 02 (2020) Feb. 2020" : 120 Documents clear
Effectiveness of Pitaya Pulp Incorporated to Wheat Flour in Bread Making Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

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 AbstractThere has a trend towards the consumption of functional foods beneficial for human health.  Bread is one of the most important staple foods in the world.  Pitaya pulp is a rich source of nutrition like carbohydrate, pectin, crude fibre, vitamin and minerals. It also contains a great amount of phytochemical constituents like phenolics, flavonoids. It would be of functional benefit if wheat flour could be substituted by pitaya pulp to utilize anthocyanin pigment in adherent as natural valuable colorant in bread-making. We have attempted in the application of composite flour through the incorporation of pitaya pulp into wheat flour to improve nutritional quality of bread. In this study, pitaya pulp was utilized to substitute refined wheat flour in bread-making doughs at 3.5%, 5.0%, 6.5%, 8.0%, 9.5% substitution levels. Various variables of texture firmness (g), specific loaf volume (cm3/g), water activity (aw), rancidity (meq O2/kg fat), total phenolic (mg GAE/ 100g), total flavonoid (mg GE/ 100g) and sensory characteristics of bread were carefully observed. The substituted bread-making with 8.0% pitaya pulp had the improved firmness, rich in total phenolics and flavonoids but low in rancidity. During 7 days of storage in OPP/LLDPE pouch at ambient temperature, the physico-chemical, microbial and sensory characteristics of bread still satisfied to acceptable level.Keywords: Bread, Pitaya, Firmness, Specific loaf volume, Water activity, Phenolic, Flavonoid, Rancidity.
Effect of Ozone on Antagonistic Activity of Lactobacilli Anzor A. Ismailov
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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This article describes study results that confirm the effect of ozone on the antagonistic effect of Lactobacillus plantarum 8P-A3 against Bacillus subtilis, Escherichia coli and Candida albicans test cultures. A stable (within 48 hours) dose-dependent effect on lactobacilli antagonistic activity was proven; it was maintained in all used ozone concentrations (from ˂0.29 mg/L, 0.29 mg/L, 0.38 mg/L). It was found that the intensity of lactic acid formation which is the most important criterion for lactobacilli antagonistic activity is significantly higher at the ozone concentration of ˂0.29 mg/L than in control samples; herewith the bacterium retains the properties of a strong antagonist. Level of lactic acid at the doses of 0.29 mg/L and 0.38 mg/L is reduced in comparison to control samples, and lactobacilli can be characterized as weak antagonists.Keywords: Antagonistic activity of lactobacilli, Antagonistic factors, Ozone, Effect of ozone on microorganisms, Lactic acid.
The Effects of Socio-Demographical Factors and Perceived Seriousness Upon Motherly Skill of Managing Eating Disorder on Children with Avoidant Restrictive Food Intake Disorder (ARFID) Yoyok Bekti Prasetyo
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Objective: Perceived seriousness is considered to mothers in making decisions for the sake of protective attempts upon children suffering from avoidant restrictive food intake disorder (ARFID). This study aimed to identifyy the predictor factors of motherly skill in managing eating disorder on children with ARFID. Method: A cross-sectional descriptive survey was held to 245 mothers taking care of children with ARFID. This research was conducted in 3 subdistricts and three community public health centres in Malang.  Data were collected by questionnaires of perceived seriousness and a managing eating disorder. Data were processed descriptively, using Pearson correlation and multiple linear regression (level of significant 0.05). Results: Factors in respect of motherly skill of managing eating disorder included the feeling of fear of children’s condition (p= 0.006), feeling of failure to contribute when children suffered from malnutrition (p= 0.010), serious condition (p= 0.017), and the whole-life changes (p= 0.002). The multiple-linear regression revealed that factors influenced motherly skill of managing eating disorder covered education (β = 1.089, p = 0.022), the number of children (β = -1.582, p = 0.025), and perceived seriousness (β = 0.097, p = 0.020). Conclusion: This current research had indicated that perceived seriousness was a significant factor to influencing mothers in making decisions for the sake of protection upon their children. Thus, we recommend that motherly belief is fostered in the event of health promotion.Keywords: Perceived seriousness, The skill of managing an eating disorder, ARFID.
The Implementation of Ergo-Learning 2.0 Strategy in Reducing Fatigue and Improving Speed, Thoroughness and Constancy of Vocational School Students in Semarapura City, Bali I Wayan Sudiarsa
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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The ergo-learning strategy 2.0 is a combination between e-learning 2.0 and the principles of ergonomics, so that a humanistic learning process can be generated. This learning strategy was implemented in the form of improving the redesign of the classroom, lighting arrangements, learning media, active break, and stretching using Systemic-Holistic-Interdisciplinary-Participatory (SHIP Approach). This study was an experimental study, conducted using a Randomized Pre- and Post-test Control Group Design. Each group (control and treatment) consisted of 12 people. General fatigue data were collected using a 30 items of rating scale questionnaire with a Likert scale, while speed, thoroughness and constancy data were collected using the Bourdon Wiersma test. The results showed that the ergo-learning strategy 2.0 could reduce fatigue as seen from a decrease in general fatigue by 28.09%, an increase in student speed by 65.91%, an increase in student thoroughness by 50.88% and an increase in student constancy by 48.11%. It is recommended to teachers to implement the ergo-learning 2.0 strategy in learning and to policy makers in schools to consider applying the principles of ergonomics in the management of Education.Keywords: Ergo-Learning 2.0, fatigue, Speed, Thoroughness, Constancy, Ergonomics.
Scalp Nerve Block in Combination to General Anesthesia Lower the Increase of Inflammatory Markers Compared to General Anesthesia alone in Craniotomy Surgeries Tjokorda Gde Agung Senapathi
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Background: Regional anesthesia reduces the inflammatory response and surgery-related immunosuppressive response. The scalp nerve block technique is a relatively simple and safe technique. The goal of this study was to compare the inflammatory response between a combination of general anesthesia and scalp nerve block compared with general anesthesia in craniotomy surgery. Methods: This was a double-blind, randomized controlled trial with pre and post-test study in 50 subjects carried out at Sanglah General Hospital (Bali, Indonesia). Group A treated with scalp nerve block using 0.25% levobupivacaine solution, and group B treated with scalp nerve block using 0.9% NaCl solution. Blood tests were carried out before and after the surgery to measure platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and C-reactive protein (CRP) as inflammatory markers. Results: The mean difference of PLR, NLR, and CRP between the two groups were significantly different (p <0.001) at 72 hours after the surgery. The tests found no significant difference at before and right after the surgery (p >0.05). Conclusion: The application of scalp nerve block in combination to general anesthesia lower the increase of PLR, NLR, and CRP compared to general anesthesia alone in craniotomy surgeries.Keywords: PLR, NLR, CRP, Inflammation, Regional anesthesia.
Nurses’ Perception of The Implementation of Patient Safety in the Inpatient Ward of a Teaching Hospital Setiawan Setiawan
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Patient safety is a complex system to prevent injuries caused by mistakes and it allows the nurse to consider taking action or not to deal with the problem of patient safety. The purpose of this study was to explore the nurses’ perceptions of the implementation of patient safety in the inpatient ward of a teaching hospital. A qualitative study was used. The sample consisted of 20 nurses who were involved in a focus group discussion for 70 minutes. The data was analyzed using content analysis as guided by Collaizi. This research found 5 themes that included events almost causing harm to the patients during shifts, obstacles related to reporting events, information about events that should be reported, primary concerns regarding patient safety and habits done to reduce the risk of making mistakes. The implementation of patient safety still needs to be improved due to the lack of perception among the nurses. Patient safety occupies an important position in the health services provided and it plays an important role in the perception of the nurse.Keywords: Inpatient ward, Nurse perception, Patient safety.
Structural, Spectral and Thermal Studies of Novel Tridentate Schiff Base Ligand Type (NOO) as Donor Atoms Derived from Nalidixic Acid and 4-Aminoantipyrine and Metal Complexes and Evaluation of their Biological Activity Hawraa K. Salloom
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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In this study, a novel Schiff base (E)-4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylimino)-1-ethyl-7-methyl-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid [HL] was synthesized from nalidixic acid 4-Aminoantipyrine and its metal complexes for metal ions M=VO, Mn, Co, Ni, Cu, Zn, Pd and Pt in ethanol and acetic acid  with mole ratio (M:L) (1:2). All complexes have general composition [VO (L)(SO4)] H2O, [Mn(L)2], [Co(L)2] H2O, [Ni(L)2] H2O, [Cu(L)2] H2O, [Zn(L)2].H2O, [Pd(KL)2] and [Pt(KL)Cl2] Cl2 where L- =C23H22N5O3. The ligand and all complexes were characterized by modern spectroscopic (FT-IR, UV Vis, 1HNMR, Mass spectroscopy, atomic absorption), along with elemental microanalysis, magnetic susceptibility measurements, thermal analyses, chloride content and molar conductance. In addition to evaluated their biological activity against one type of bacterial and one type fungus. Based on date for all techniques we suggested that all the prepared complexes have octahedral geometry accept [[VO (L)(SO4)] H2O] square pyramidel geometry and [Pd (KL) 2] Square planer geometry. The value of antibacterial activity of this prepared complexes showed higher inhibition activity compared to the free ligand and starting material.Keywords: Nalidixic Acid, 4-Aminoantipyrine, Metal complexes, Biological activity.Introduction
Antidepressant Effects of Cleistocalyx nervosum Extract Consumption in a Rat Model of Post Stroke Depression Wathita Phachonpai
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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The aim of this study was designed to evaluate whether Cleistocalyx nervosum (C. nervosum) extract improved depression-like behaviors induced by middle cerebral artery occlusion (MCAO) in post-stroke-depression (PSD) rats. Right MCAO procedure was performed on day 1 in male Wistar rats. C. nervosum was thereafter administered (250, 500 and 750 mg/kg), daily for 28 days. Neurological functions after ischemia were determined by the forelimb grip force and the hot plate tests. Tail suspension (TST) and forced swimming (FST) tests were used to assess depression-like symptoms. Plasma corticosterone (CORT) level, and brain oxidative status, and scavenging enzymes were also investigated. Our results showed that three doses of C. nervosum treatment were able to diminish neurological impairments and exert antidepressant effects in PSD rats. This was accompanied by the decrease in stress hormone level and brain oxidation indices, and increase in antioxidant enzymes activities. It suggested that C. nervosum could improve the depression-like emotional status and promote recovery of motor and sensory functions in PSD, and can be applied as a complementary agent for treatment of PSD.
Synthesis and Preliminary Antibacterial Activities of New 2, 3-Disubstituted-1, 3-Oxazepane-4, 7-Diones of Benzothiazole Zeid Hassan Abood
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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2-aminobenzothiazole 1 was converted to analogues diazonium salt which reacted with alkaline solution of 2-hydroxybenzaldehyde to yield azo-benzothiazole derivative 2 bearing aldehyde group. The resulting aldehyde 2 was then condensed with some aromatic amines including (4-nitroaniline, 3-nitroaniline, 4-aminophenol, 4-methoxyaniline, 4-bromoaniline, 4-chloroaniline and 2, 4-dichloroaniline) using microwave irradiation technique in absolute ethanol to produce seven imine derivatives of benzothiazole 3a-g, respectively. Treatment of the resulting imines 3a-g with succinic anhydride using microwave irradiation in dry benzene afforded seven new 1, 3-oxazepane-4, 7-diones 4a-g bearing the benzothiazole moiety, respectively. Preliminary in vitro antibacterial activity of the target compounds were investigated using two types of bacteria, Staphylococcus aurous (Gram-positive) and Escherichia coli (Gram-negative). The results indicated that all oxazepane compounds exhibited better activity to gentamycin against Gram-positive bacteria. On the other hand, the oxazepane compounds (4a, 4e and 4g) showed greater activity against Gram-negative bacteria when compared with that of the control drug.Keywords: Benzothiazoles; Oxazepanes; Imines; Azo; Antibacterial activity.
Seasonal Variation, Antibiotic Resistance of Some Sewage Bacteria from Hamdan Waste Water Treatment Plant in Basrah City-Iraq Maytham A. Al-Hamdani
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Seasonal variation and antibiotic resistance pattern of some sewage bacteria have been studied during the period of at Hamdan wastewater treatment plant in basrah city-Iraq. The results obtained revealed that there is a seasonal variation in the number of bacteria studied. The bacterial taxa in the present study found to resist several antibiotics. The isolated bacteria are multidrug resistant bacteria.  Higher percentage of antibiotic resistance was recorded for bacteria from raw sewage that decreased during the subsequent treatments. Sewage bacteria showed different antibiotic resistance patterns. The effluents to Shatt al-Basrah still contain multidrug resistant bacteria that cause a big health problem through dissemination of multidrug resistant bacteria to the area around.

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