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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 120 Documents
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Search results for , issue "Volume 12 Issue 02 (2020) Feb. 2020" : 120 Documents clear
Obestatin (OB), Calprotectin (FCP) and (SIgA) in Patients Infected with Entamoeba Histolytica in Al-Najaf Governorate, Iraq Raja Jawad Mohamed Al-Saeedi
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

The study included the identification of changes in biomarkers to determine the effect of E. histolytica on the level of calabrotectin, obstobestatin and SIgA in patients parasites, 250 patients were collected from AL-Hakeem Hospital in Najaf from (May 2018) to (October 2018), The number of  patients with amoeba was 115(46%), 65(26%) males and 50 (20%). females and compared with a control group of 50 healthy subjects The results showed sig significant increase(p≤ 0.05) in the level of obestatin, calprotectin, SIgA control groub.
Latent Membrane Protein 1 Gene of Epstein - Barr virus: 30-Base-Pair Deletion in Indonesian Nasopharyngeal Carcinoma Patients Yurnadi Hanafi Midoen
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Introduction: Epstein Barr Virus (EBV), a member of the Herpesviridae family, is a dsDNA virus. Nasopharyngeal carcinoma (NPC) patients express EBV latent genes EBERs, EBNA1, LMP1, LMP2A, and LMP2B. The LMP1 gene, in particular, plays important roles in epithelial oncogenesis and B-lymphocyte transformation. Several epidemiological studies found a specific variant of LMP gene detectable as a 30-bpdeletion in NPC patients and it is still unclear whether this deletion is associated with NPC pathogenesis in Indonesian population. The aim of this research is to understand the existence of the deletion of the 30-bp LMP1 gene in Indonesian NPC patients and to determine the frequency of 30-bp deletion of LMP1 gene and its association with the pathological status. Methods: The 30-bp deletion in LMP1 gene was identified by nested PCR and subsequent electrophoresis in 2% agarose gel. The results were determined as 162-bp DNA band of the LMP1 gene (without 30-bp deletion) and 132-bp DNA band of the LMP1 gene (with 30-bp deletion). Results: Among 100 identified samples from Jakarta, 8 samples were found to have the 30-bp deletion, 71 samples did not have 30-bp deletion and 21 samples carried coexistence variants. Conclusion: In Indonesia, especially in Jakarta, EBV variant of 30-bp deletion of LMP1 gene was found at low frequency (8%) in comparison with variant without deletion (71%). There is a variant of LMP1 gene mixtures (21% coexistence with and without deletion). Analysis of data using Fisher's exact test shows that there is no significant relationship between 30-bp deletion of LMP1 gene and NPC pathological status (p> 0.05).Key words: 30-bp deletion, NPC, EBV, LMP1, Coexistence
Immunomodulator Activity and Antirheumatoid Arthritis Extract of Ethyl Acetate Ginseng Bugis Talinum Paniculatum (jacq.) Gaertn) Andi Emelda
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

The Immunomodulator is one of the compounds that can improve immune system. Chemical compounds work through the immune system to prevent and treat disease. Rheumatoid arthritis is an autoimmune disease that is chronic-systemic inflammation. The purpose of this study was to determine the effects of imonomodulator and antirheumatoid arthritis of ethyl acetate extracts of ginseng bugis leaves (Talinum Paniculatum (Jacq.) Gaertn). This study was divided into 2 groups, namely the immunomodulatory testing using sheep red blood cells and CFA-induced antirhematoid. This study used wistar rats which divided into 6 groups for immunomodulatory activity and 5 groups for antirematoid arthritis. The dose of ethyl acetate extract used was 0.05 g/KgBW; 0.1 g/KgBW, and 0.15 g/KgBW. Statistical test results for immunomodulatory activity showed significantly different results between the extract group doses of 0.05 g/KgBW; 0.1 g/KgBW, and 0.15 g/KgBW (p <0.05) with a negative control group. Rheumatoid arthritis testing showed (p <0.05) to the foot volume and arthritis index. The results showed that ethyl acetate extract of ginseng bugis leaves have immunomodulatory and antirheumatoid arthritis activity.Keywords: Immunomodulator, Anti Rheumatoid arthritis, Ethyl acetate, Talinum Paniculatum (Jacq.) Gaertn.
Effect of Ethanol Extracts of Mustard Green (Brassica rapa L.) on Streptozotocin Induced Rats Sri Wahjuni
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Objective: This experimental study was conducted to evaluate the effect of the mustard green extract on blood glucose and the pancreas histopathological feature. Methods: Five groups of rats divided into the control group that received standard food (P0) and streptozotocin-induced group (P1, P2, P4, and P4). P1 (positive control group) was given glibenclamide; P2, P3, and P4 (treatment group) were given mustard green ethanol extract at a dose of 0.5; 2.0; and 5.0 mg/kg body weight/day respectively. The separation of ethanol extract of mustard green was carried out by  LC-MS/MS. One way ANOVA and Post hoc test was conducted to evaluate the mean difference of the blood glucose. Results: Post hoc test showed significant result for P0 vs P3 (p<0.001), P0 vs P4 (p=0.001), P1 vs P2 (p=0.048), P2 vs P3 (p=0.001). Comparison between P1 and treatment group was found a similar effect on blood glucose between P1 vs P3 (p=0.048) and P1 vs P4 (p=0.830). Histological studies showed the administration of ethanol extract of mustard green showed a restorative effect. Conclusion: Administration of ethanol extract of mustard green decrease the level of blood glucose and might be a usable treatment for hyperglycemia.Keywords: Mustard green (Brassica rapa L.), Streptozotocin, Hyperglycemic effects.
Copper Tetra-Tert-Butyl Phthalocyanine Thin Films for Ammonia Gas Detection Ameer A. Alhusseiny
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Thin films of copper tetra-tert- butyl Phthalocyanine (CuPc) have been prepared from their solution in chloroform using spin coating technique. Films then heated to (100, 200 and 300) oC to study the effect of annealing temperature on the characteristics of the prepared films. UV-visible spectrophotometer was used to investigate the absorption properties of the materials as well as the optical energy gaps. The morphology characteristics have been carried out utilizing atomic force microscopy (AFM). To demonstrate the sensing properties of CuPc films, I-V measurements were carried out using Keithly 2400 instrument to calculate the resistance before and after exposure to ammonia odorant. The prepared samples show a decrease in the resistance values after exposure to the contaminated air. Time dependency was also carried out to investigate the response and recovery time of the prepared device.Keywords: Copper phthalocyanine, Thin films, Gas sensor, Ammonia detection.
Implementation Development Of Work Climate To Better Worker Productivity Employee In Stikes Hang Tuah Surabaya Dedi Irawandi
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Productive nurses are produced from qualified educational institutions. To achieve optimal work productivity growth required several supporting factors, one of them is the harmonious working climate.  This work purports to obtain a photo of the workplace climate and its relationship to employee productivity. The dimensions of the employment climate in search are (1) the concept of the psychological dimension of employees; (2) the structural proportions of employees; (3) social dimensions of employees; (4) employee bureaucratic dimension.  This research uses a quantitative and qualitative approach. The Result of research (1) Worker productivity at Stikes Hang Tuah Surabaya shows good work productivity (58%), unfavorable (42%), (2) Psychological dimension related to work productivity; (3) Structural dimension is not related to work productivity; (4) Social dimension related to work productivity; (5) The bureaucratic dimension is not related to work productivity. Recommendations for the management, need to be developed further standard performance of a team sharing development and application of a fair reward system for the achievers and penalties for the violators
Anorexia in Childhood Ekaterina Zenia
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Over the past three decades, there has been a tendency to shift anorexia nervosa towards a younger age. It is necessary to identify a possible relationship between mental illness and the presence of anorexia. The purpose of the study is to comparatively examine the clinical, gastroenterological and psychopathological features of the development of anorexia nervosa in children with diagnosed mental disorders (autism, childhood schizophrenia). In 2008-2018, at the base of the Moscow Scientific Center for Mental Health and the Children's Psychiatric Clinic No. 6 (Russian Federation), 167 patients were selected, divided into two groups according to the diagnosis. The first included 90 children with a diagnosis of autism, the second - 77 children with a diagnosis of childhood schizophrenia. Children were observed from 3 months of age until they reach 10 years of age. At 8 years old, the children underwent gastroenterological examination. The frequency of occurrence of deviations in eating behavior was recorded. Used abdominal ultrasound, as well as esophagogastroduodenoscopy. In the group of children with autism aged 8-10 years, the total number of eating disorders is gradually decreasing, 2-2.5 times less than 1-3 years (p = 0.001). The incidence rate of anorexia was 70%. Also recorded a decrease in the frequency of occurrence of violations. At 1-3 years on average, the frequency of occurrence of eating disorders was at the level of one third of cases. At the age of 8-10 years, this indicator decreased by 6-15 times (p = 0.001). In the second group, children with schizophrenia, the manifestation of eating disorders occurs later, at 4-6 months of life. By 1-3 years, the frequency of occurrence of deceleration of chewing and swallowing increases 2 times (p = 0.05). At 8-10 years, these eating disorders develop into persistent phobias. Anorexia is recorded in 90% of cases. At 1-3 years of age, eating behavior changes: bulimia and vomitomania appear. The consequence of this is a decrease in body weight. Despite the fact that at the age of 8-10 years in the second group, many disorders are 2-4 times less likely (p = 0.001) than at 1-3 years, some (bulimia) can remain with the same frequency. Esophagitis and reflux in the esophagus are 3–7 times more likely to occur compared to cardia and erosion (p = 0.05 and p = 0.001). Gastroduodenitis and reflux were most often diagnosed in the stomach, 2 times more often than gastritis (p = 0.05), 6 times more often than erosion (p = 0.001), 10 times more than mucosal proliferation. Damage was found to occur to the gastrointestinal tract in children with anorexia nervosa in almost all of its departments. A group of patients with autism has a high percentage of anorexia (70%), with a predominance of eating disorders such as active or passive refusal to eat. In the group of patients with schizophrenia, anorexia is more common (90%), but eating disorders, edible substances, vomitomania, bulimia dominated among eating disorders. Gastroenterological examination revealed a number of diseases of the gastrointestinal tract, among which esophagitis (37%), gastroduodenitis (41%) and reflux (47%) predominated. The revealed age-related features of the development of eating disorders will allow establishing the disease in time and taking measures to cure it.Keywords: Anorexia nervosa, Autism, Schizophrenia, Bulimia, Womitomania, Eating disorders.
Synthesis, Characterization of Some Novel 1, 4- Benzoxazine- 3- One Derivatives Starting From O-Amino Phenol and Study Their Biological Activity Helen Abd Al Hassan Mahmood
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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In this work: Benzoxazinone derivatives were used as a precursor to synthesize of many heterocyclic systems. The aim of current study was to use the easily available o-amino phenol for the synthesize of 1, 4-benzoxazine-3-one. The benzoxazinone compound of interest was  synthesized by reacting the  o-amino phenol with chloroacetyl chloride, The treatment of  o-chloro acetamidophenol (FH)  and anhydrous potassium carbonate in refluxing DMF afforded the corresponding 1,4-benzoxazine -3-one (1) in excellent yield. The treatment of ethyl chloroacetate with compound (1) gave compound (2), while compound (3) was produced by reacting of hydrazine hydrate with compound (2). Compound (3) was used as precursor to synthesize  (5a-d),(ST),(6),(7a,7b),(8,9)  by its reaction with different chemical reagents,  while on treatment of the compound (1) with 4-nitrobenzaldehyde in acetic anhydride: triethylamine (2:1) as a solvent gave chalcone (10). The structures the synthesized compounds have been confirmed by FT-IR, 1H-NMR, and Mass spectroscopy. The synthesized derivatives have been screened in vitro for antimicrobial properties. The results of this investigation revealed that the newly synthesized compounds are potent antimicrobial agents.Keywords:  2-Aminophenol, Benzoxazinone, Schiff’s base, 1, 2, 4-triazole, Antimicrobial.
Spectrophotometric Method for Determination Folic Acid via Diazotization and Coupling with 4-Aminoantipyrine Resala A. Saleh
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Uncommon coupling reagent is used for the simple and sensitive spectrophotometric determination of folic acid in pure form and in its pharmaceutical preparations. The method is based on the diazotization of the p-aminobenzoyl glutamic acid formed after reductive cleavage of folic acid, followed by coupling 4-amino antipyrine to give an orange product with λmax of 469nm. The results follow ‘Beer’s law in the concentration range of 2-100 µg.mL-1 with molar absorptive of 3266.36 L.mol-1.cm-1. The limit of detection was found to be 0.1482 µg.mL-1 and the Sandell’s sensitivity value was 0.1351 µg.cm-2. Common excipients used as additives in pharmaceutical preparations do not interfere in the proposed methods. The proposed method was successfully applied to the determination of folic acid in pharmaceutical preparations.Keywords: Folic Acid; Spectrophotometry; 4-Aminoantipyrine
Development of Instruments to Measure Disaster Preparedness Hery Sumasto
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Objective: Indonesia is called a disaster supermarket due to any disaster exists. The community preparedness in Indonesia is still low. The university academic community needs to be prepared so that it has enough capacity during disasters. The purpose of this study was to develop an instrument to measure disaster preparedness at a university in Indonesia. Method: Research and Development method was used in this study. The participants were directorate officers, lecturers/staff, and students. The development of the instrument was carried out by literature study, Focus Group Discussions (FGD), and expert consultation. The instrument development steps were instrument assessment, formulating strategic problems, instrument trials, and analysis. Results: The instruments produced in this study had five parameters, including knowledge, attitude, and practice (KAP); the university policy; resource mobilization capacity; early warning system; and emergency response planning. The result of an instrument trial showed that the University had high disaster preparedness (97%). Discussion: The instruments produced in this study can be used to measure disaster preparedness in the University.Keywords: Research and development, Disaster preparedness, Disaster instruments

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