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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 106 Documents
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Search results for , issue "Volume 12 Issue 06 (2020) June 2020" : 106 Documents clear
Mastication Profile and Alternative Healthy Mastication Model using Coconut Frond Shaving in Karo Women Ulina Karo-Karo
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Introduction: The use of tobacco in mastication activity has been widely known throughout the world. In China, the prevalence of mastication activity using betel leaves during student age is around 3.9%. Karo women in Deli Serdang are one of the population in Indonesia whose known have mastication habit since a long time ago. This study aimed to know the profile of the mastication model in Karo women as a primary aim and introduce coconut frond shavings mastication as the healthy mastication model. Method: This research was a combination of qualitative-quantitative diffusion of innovations research, with four stages, those are: diagnosis of action, plan of action, implementation of actions, and evaluation of an action. Results: Systolic blood pressure, diastole blood pressure, and blood sugar levels among coconut fronds chewers were less than tobacco chewers. This data also showed statistically different among two variables (p
Comparative Characteristics of QT Interval Measurements on ECG Performed Manually and by Automated Method in Male Patients at Rest Vadim A. Dulskiy
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

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Abstract

In the medical practice of cardiologists, cases of incorrect measurement and interpretation of QT interval length are very frequent. The consequences make an incorrect diagnosis and inadequate treatment. The aim of this work is to investigate the efficiency of measuring the QT interval length on an ECG in manual mode and automated mode at rest among male patients. The sample included 3925 ECGs performed among males aged over 15 years old. Each measurement of QT, QTc intervals was performed both in manual and automatic modes. The numerical values matched only in 4.3% of cases. Automatic interval measurements exceeded the real values in 83.8% of cases. The prolongation of QTc intervals over 440 ms in the automatic mode was detected in 20.4% of cases. Over diagnosis was noted in 17.4% of cases. As a conclusion, manual adjustment is required in most cases measurements of prolonged QT, QTc intervals measured in automatic mode. Among the prevailing errors in automatic measurement, the most common were connected with T-waves (lack of diagnosis of T-wave displacement, its low amplitude and alternation). These erroneous measurements amounted to 53.3% of all measurements in automatic mode. The uncertain wave Q (R) accounted for 35.0% of all cases. In addition, 8.3% of cases were attributed to an undetected diagnosis of differences between manual and automatic methods. Keywords: T wave, Manual ECG diagnostics, Automatic ECG diagnostics, interval lengths QT, QTc.
The Study of Structural- Mechanical and Physicochemical Properties of the Drug Antimicrobial and Anesthetic Action Viktoria Tarasenko
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Introduction: This work is devoted to study of structural-mechanical and physicochemical properties of soft drugs with antimicrobial and anesthetic action. The purpose of this study was to study the effectiveness of physicochemical properties of soft drugs. Materials and methods: In the process of performing the work, pharmaco-technological, physicochemical, structural-mechanical, biopharmaceutical and biological research methods according to the State Pharmacopoeia of Ukraine were used. Results and discussion: The sample was considered stable if no stratification was observed in the tubes after centrifugation. If at least one of the tubes was observed stratification of the sample or the selection of sediment, the analysis was repeated with new portions. The type of emulsions was determined by dilution and staining methods. The study of local anesthetic activity was performed on a model of rabbit eye anesthesia. The experiment was performed on 25 male rabbits, which were divided into 5 groups of 5 rabbits each. Conclusions: The study of structural-mechanical and physico-chemical properties of drugs in the form of a cream is the basis for improving its therapeutic efficacy, mechanical stability and consumer properties. Keywords: Soft drugs, Antimicrobial action, Anesthetic action, Colloidal stability, Thermal stability, Emulsions, Rheogram.
Complications of TVT Treatment of Stress Urinary Incontinence in Women Georgi Hubchev
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

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Abstract

The accent of the publication is the complications after the application of various TVT slings to correct stress urinary incontinence in women. The aim is to determine the type of complications and their frequency according to the method of TVT surgery. For the period 2005-2019, 436 women underwent TVT surgery, and 80 (18.3%) developed complications. In 334 women by the method of TVT-O-postoperative complications had 47 women (14.1%), in 78 operated by TVT-R, with postoperative complications were 23 patients (29.5%), and in 24 patients with TVT-Ophira-5 (20.8%) had postoperative complications. A retrospective method was used to determine the percentage of different complications depending on the type of TVT sling applied. The study concluded that intraoperative complications in 5 women (1.15%) obtained with the TVT-R method alone, and postoperative complications were observed in 75 of women (17.2%), using all three methods. Keywords: Stress urinary incontinence (SUI); TVT sling operations; Intraoperative complications; postoperative complications; Recurrence.
A Capillary Electrophoretic Method for the Analysis of Bupivacaine and Its Metabolites Roza Askarova
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

The article studies a capillary electrophoretic (CE) method for the analysis of urinary extracts of the local anesthetic, bupivacaine, and its three main metabolites, desbutylbupi vacaine, 3’-hydroxybupivacaine, and 4’-hydroxybupivacaine, in rat urine. After collection of blank urine, the rats were given a 20 mg/kg intramuscular injection of bupivacaine, and urine was collected for 12 h after dosing. CE analyses were performed using the CAPEL®-205 capillary electrophoresis systems. The data was collected using the Elforan® specialized software. The use of methanol to reduce peak tailing was investigated at different concentrations, but 20% and 30% v/v were proved to be the most optimal at the preparatory stage of the experiment. The resolution of 3’-hydroxybupivacaine and 4’-hydroxybupivacaine was 1.09, 0.98, 0.89 and 0.89 at 15, 40, 70 and 110 s, respectively. The initial resolution (Rs) of desbutylbupi vacaine was achieved with all studied injection periods as Rs = 1.09, 0.97, 0.96 and 0.96 at 15, 40, 70 and 110 s, respectively. Separation efficiencies for 3’- and 4’-hydroxybupivacaine were312×103, 257×103, 196×103 и 169×103μlat injection times of15, 40, 70 and 110 s, respectively. The results showed that the mass of bupivacaine, desbutylbupi vacaine, and 3’- and 4’-hydroxybupivacaine significantly recovered in the rat urine after the dose was administered. The recoveries as a percent of the dose were 0.04, 0.80, 0.15 and 0.05% for desbutylbupi vacaine, bupivacaine, 3’-hydroxybupivacaine, and 4’-hydroxybupivacaine, respectively. Separation of bupivacaine and its metabolites was achieved in 15 min. A particular advantage of this approach over published HPLC methods is that separation of the two hydroxy positional isomers of bupivacaine is possible. A number of unknown peaks were also observed in the electropherograms from the rats dosed with bupivacaine. These did not correspond to any peaks appearing in the blank urine samples. Characterization of these unknown peaks may prove useful for the further understanding of bupivacaine metabolism. Keywords: Bupivacaine, Capillary electrophoresis, Desbutylbupivacaine, Hydroxybupivacaine, metabolites.
Plasma Diagnostics of Low Pressure Helium Glow Discharges at Different Working Voltages Hanaa E. Jasim
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

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Abstract

In addition to measurements of, the neutral gas temperature, the electron density and electron temperature plays a vital role in a low-pressure helium plasma characterization and processes. For instance, in biological and mass spectroscopy applications .In this paper, low pressure plasma of helium gas was generated between a flat planar anode and cathode electrodes. A cylindrical probe was constructed and employed to analyze plasma parameters of a structure discharging glow in a negative glow region. Electrons and ions currents of helium plasma have been measured at different discharges voltages and currents. Langmuir probe results at working pressure of 0.5 mbar indicate the electron temperature decreases and density increases as applied voltage increases which can be traced to the fact that electrons collide more frequently with plasma species. Keywords: Plasma diagnostics; Helium gas; Glow discharge; Langmuir probe.
Neuropathy in Vitamin Deficiency Shahdevi NK
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Neuropathy is a disorder of the motor nerves, sensory disorders and also autonomic and tendon reflexes. The Neuropathy that occurs can be caused by systemic diseases (diabetes, hypothyroidism), drugs, infections and also vitamin deficiencies. Vitamins are organic components with a high level of potential. Vitamins themselves are classified into 2 which are air soluble and fat-soluble, for fat-soluble vitamins, there are vitamins A, D, E, K and for vitamin B complex including vitamins that are soluble in air. Vitamin B plays an important role as a co-factor or co-enzyme in various metabolic processes in the body. A continuous lack of vitamins will cause damage to the peripheral nervous system so that symptoms of neuropathy appear. Deficiency of vitamin E and vitamin B can cause damage to the nervous system and neuropathy occurs. Vitamin B which has several kinds, such as B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantonetate), B6 (pyridoxine), B7 (biotin), B9 (folate) and B12 (cobalamin) where this B vitamin has a neurotrophic function. Vitamin B cannot be produced by mammals, so we can get this vitamin through food and supplementation. Vitamins themselves function to maintain the body's physiological functions and also maintain optimal health. Keyword: Neuropathy, Vitamin, Thiamine, Cobalamin, Pyridoxine.
Single Nuclear Polymorphisms of VEGF, TGF-β1, MMP9 Genes in Type 2 Diabetic Foot Ulcer Patients in Indonesian Population: A Case Control Study Dedy Pratama
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: Vascular endothelial growth factor (VEGF), transforming growth factor beta 1 (TGF-β1) and matrix metalloprotein-9 (MMP9) are known to have roles in the process of diabetic foot ulcer (DFU) formation. VEGF rs2010963C>G rs1271283232T>C, TGF-β1 rs1982073C>T rs1800469C>T, and MMP9 rs3918242C>T rs367601348A>G genes polymorphism may result in differences in the quantity and quality of the proteins which influence the risk of DFU formation. This study aims to assess the difference in frequency distribution of certain VEGF, TGF-β1, and MMP9 genes polymorphism between diabetic patients with and without DFU.Methods: A case-control study was conducted among patients with type-2 DM with DFU (case) and without DFU (control) in Cipto Mangunkusumo Hospital Jakarta, with DNA analysis using Polymerase Chain Reaction Restriction Fragment Length Polymorphism (PCR-RFLP) technique. The confounding factors are also analyzed.Results: A total of 197 patients was assessed, 96 with DFU and 101 control. The genotype analysis by logistic regression found significant association of CT genotype in TGF-β1 rs1982073C>T  (OR:0.28;95%CI:0.13-0.60;p=0.001 compared with CC); TT genotype in TGF-β1 rs1800469C>T, (OR:2.37;95%CI:1.11-0.60;p=0.001 compared with CC); TC genotype in MMP9 rs3918242C>T (OR:0.19;95%CI:0.19-0.64;p=0.001 compared with CC). There are no significant association in any mutation in VEGF rs2010963C>G, rs1271283232T>C, and MMP9 rs367601348A>G.Conclusion: VEGF rs2010963C>G rs1271283232T>C, and MMP9 rs367601348A>G polymorphisms did not have significant association with DFU formation. CT in TGF-β1 rs1982073C>T and TC in MMP9 rs3918242C>T found as protective factor for DFU, and TT in TGF-β1 rs1800469C>T as risk factor for DFU.Keywords: diabetic foot ulcer, genetic polymorphism, VEGF, MMP9, TGF-β1, rs2010963C>G, rs1271283232T>C, rs1982073C>T, rs1800469C>T, rs3918242C>T rs367601348A>G
Simple, Selective and Sensitive Spectrophotometric Method for Determination of Trace Amounts of Lead (II), Cademum (II), Cobalt (II) with Organomercury Compounds Fatima K. Aziz
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

A selective and sensitive reagent of 2-{[(2-mercurychlorid, 4-methylphenylImino] methyl} phenol (K) was synthesized and studied for the spectrophotometric determination of Lead, Cademum, and cobalt, in detail. At a pH value (7), which greatly increased the selectivity; lead, cademume, cobalt, reacted with (K)to form a 1:1, 1:1, and 1:1 complexes, with absorption peaks at 394, 394, 389 nm, respectively. Under the optimal conditions, Beer’s law was obeyed over the ranges (1X10-6, 1X10-5, 1X10 -4, 1x10-3 1X10-2) mg/L respectively. The apparent molar absorptivity and Sandell’s sensitivities were (0.3, 0.1, 0.2) L·mol-1·cm-1 respectively, and0.027, 0.05, 0.013) μg·cm-2respectively the detection limits were found to be be0.052, 0.036, 0.039) mg/L respectively.
Evaluation of Aggressive Behaviour Management in PICU (Psychiatric Intensive Care Unit): A Focus Group Study Ah. Yusuf
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Background: PICU is a Psychiatric Intensive Care Unit. PICU is a service aimed at mental health clients in conditions of psychiatric crisis. PICU is a combination of psychiatric emergency services and intensive services, which can be held in psychiatric hospitals or psychiatric units in general hospitals. Purpose: This study is on evaluating aggressive problem management at PICU. Methods: This research was designed with a qualitative approach using focus group discussion. The total number of participants was 12 nurses. Data was collected using a focus group and analyzed using standard software NVIVO 12 Plus. This research was conducted from January to March 2020. Respondents consisted of Head of the room, Head of the nurses' team, Managing Nurse, and Supervisor. Results: This research was conducted to explore the experience of nurses in dealing with business class patients in commercial medical escorts. The results of this study found 3 themes, namely: rules are not systematic, injuries due to restrain are still high, nurses' competencies are not evenly distributed. Conclusion: several themes and sub-themes support nurses in treating aggressive client behavior. Besides, nurses must standardize services to improve patient and family satisfaction. Keywords: Aggressive behavior, Mental Disorder, Nurses, PICU.

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