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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 106 Documents
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Search results for , issue "Volume 12 Issue 06 (2020) June 2020" : 106 Documents clear
Modified Atmosphere Packaging on Physico-Chemical Characteristics of Star Apple (Chrysophyllum cainito) Fruit during Post-harvest Storage Minh Phuoc Nguyen
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Star apple (Chrysophyllum cainito) is popularly cultivated in Mekong region. Its pulp has strong sweet taste with antioxidant constituents contributing to various phytochemical and functional advantages. However this fruit has a short shelf life due to its perishable nature. It’s necessary to have appropriate way to extend its commercial distribution. Modified atmosphere packaging can be considered as a proper alternative to store this perishable fruit. Purpose of this research focused on the application of modified atmosphere packaging (MAP) to prolong shelf-life of star apple fruit. Weight loss (%), firmness (N), total soluble solid (oBrix), and vitamin C (mg/100g) were the main variables applied to observe this valuable fruit during 21 days of storage. Under MAP (30% CO2, 15% O2, 55% N2), star apple fruit could be extended to 18 days regarding to the weight loss, firmness, total soluble solid, and vitamin C values. Our finding contributed a basic foundation for more further studies on other tropical fruits and vegetables. Keywords: Chrysophyllum cainito, Modified atmosphere packaging, Weight loss, Firmness, Soluble solid, Vitamin C.
Physical Stability of Commonly Used Medication Administered by Parenteral Nutrition Admixtures in Hospital: A Systematic Review Erza Genatrika
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Background: Inpatients requiring parenteral nutrition (PN) often need to receive intravenous medication, but physical instability can occur between medications and PN. This review aimed to bring together the available literature on the physical stability of medication with PN used in hospitals. Methods: We conducted a systematic electronic literature search of PubMed, Science Direct, and SpringerLink during the period 2009-2019 for all English language research publications evaluating the physical stability of commonly used medication administered by PN in hospital. Results: Out of 88 studies, 7 studies selected for this review. From all studies conducted in this review found 14 combinations of drugs that are not compatible with PN admixtures, including levetiracetam, albumin, amoxicillin, cefepime, esomeprazole, fluorouracil, pantoprazole, tropics, trace elements, vitamins, and vancomycin. For adding medications directly to the PN solution, specific criteria should be considered, such as physicochemical properties of the ingredients and drug concentration. Conclusion: The stability of IV medications and PN is an important concern in delivering safe and effective medication and nutritional therapy. The role of healthcare professionals is needed to avoid this incident so that patient safety can be guaranteed. Keywords: Parenteral nutrition, Drug, Medication, Stability, Physical.
Synthesis, Characterization and Biological Study of the Ligand 2-methyl-5-[(2E)-2-(4-Nitrobenzylidene) Hydrazinyl]- 1, 3, 4-Oxadiazole with some of its Transition Metal Complexes Zainab M. Kareem
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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A new series of transition metal ions (Cr (III), Co (III), Cu (II) and Ni (II) complexes with the ligand 2-methyl-5-[(2E)-2-(4-nitrobenzylidene) hydrazinyl]-1, 3, 4-oxadiazole were synthesized. A ligand was synthesized by reaction hydrazine hydrate with ethyl acetate in ethanol as solvent , the product reaction with potassium hydroxide and carbon disulphide to give 5-methyl-1,3,4-oxadiazole-2-thaiol, the product was reacted with hydrazine hydrate again to produce 2-hydrazinyl-5-methyl-1,3,4-oxadiazol. The resultant was mixed with parnitro-benzldehyde to produce the ligand (L2). The newly synthesized compounds were characterized by Fourier transform infrared (FTIR) Spectroscopy, Nuclear Magnetic Resonance Spectroscopy (1H NMR), elemental analyses (C, H, N), Mass Spectra data. The program Hyperchem 7.51 have been used for theoretical calculation using PM3 method to study the electrostatic potential, electron density, heat of complexation. It has been shown through all the above diagnostic measures that ligand is formed with the (Cu, Co and Ni) ions tetrahedral complexes and with the Cr formed octahedral complex. The biological study of ligand and its complexes showed that all prepared compounds have antibacterial against three types of bacteria and there was high percentage of hemolysis. Keyword: 1, 3, 4-Oxadiazole derivative, Antibacterial, Hyperchem, Hemolysis.
Identification of Microrna in Pediatric Latent Tuberculosis: A Preliminary Study in Indonesia Ayling Sanjaya
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Background: Pediatric tuberculosis (TB) is a major health problem in the world and Indonesia. Latent tuberculosis infection (LTBI) in children can be developed in to active state. It is difficult to prevent LTBI due to the lack of specific and diagnostic biomarkers. Research of microRNA (miRNA) conducted to identify profile of miRNA expression among pediatric LTBI specifically in Indonesia. This suggests that miRNA can be one of the tools to diagnose LTBI in children that needs to be developed. Aims: To identify specific miRNA expression in Indonesian pediatric latent tuberculosis infection. Methods: This research was an observational analytic study using a cross-sectional study design. The study used whole blood of healthy control children who had never received BCG immunization and children diagnosed LTBI. Profiling and identified miRNA expression with microarray analysis. Results: Four LTBI and two healthy control children were included in this study. Extraction of RNA with whole blood were done and profiled with gene chip microarray. Fold change >2 or
Study of Anti-Herpetic Activity of a Soft Dosage form With Acyclovir and Miramistin Kienko LS
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

The aim of the present work is to study the anti-herpetic action of the soft dosage form with acyclovir and miramistin on the model of herpes simplex virus. Using in vitro methods were studied cytotoxic concentration of substances, effective concentration, index of selectivity of substances and disinfectant action. Non-germinal guinea pigs were divided into three groups. Group I was infected with herpes virus, group II was infected with herpes virus and treated with the soft dosage form with acyclovir (5 g / 100 g) and miramistin (0.5 g / 100 g) and group III was infected with herpes virus and treated with 5 % Zovirax cream. It has been proven that the soft dosage form with acyclovir and miramistin is an active inhibitor of the reproduction of herpes virus type 2. Keywords: Acyclovir, Miramistin, Herpes viral diseases, Soft dosage form.
The Development of Nursing Diagnosis Based on Indonesian Nursing Diagnosis Standard of Patient with Schizophrenia in Hospital Rizki Fitryasari
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract Objective: Schizophrenia is the common diagnosis for the patient in the hospital who care for mental illness and need several weeks for hospitalization. An accurate nursing diagnosis must be a part of the clinical pathway for patients in a hospital setting to deliver the effective intervention of nursing care. This study aimed to develop a nursing diagnosis based on an Indonesian nursing diagnosis Standart on patients with a diagnosis of schizophrenia in the Surabaya Menur Mental Hospital. Methods: A research and development (R&D) design was employed in this study with a descriptive approach. The sample was 98 medical records documents obtained by purposive sampling. The respondents were selected by inclusion criteria: patients with schizophrenia who had been hospitalized and had experienced a recurrence. The instrument used an observational sheet. The data were analyzed using univariate analysis. Result: The results showed that six nursing diagnoses were formulated during the implementation of nursing care. They were violent behavior (41.8%), hallucinations (36.7%), social isolation (11.2%), self-care deficits (7%), delusions (2%), and risk of suicide (1%). Conclusion: The nursing diagnoses developed based on Indonesian Nursing Diagnosis Standart which were classified as a psychological, behavioral, relational, and environmental category. The nursing diagnoses can be developed in the clinical pathway as a result of evidence-based so they can improve the quality of nursing care. Keywords: schizophrenia nursing diagnosis, clinical pathway, Indonesian Standard of Nursing Diagnosis
Effect the Magnetic Water on Physiological Traits of Callus the Fenugreek (Trigonella foenum graecum L.) Basheer Abdulhamza Alalwani
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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The experiment was conducted in the tissue culture lab. Biology Dept., Babylon University. Callus induction was achieved by culturing the seeds of (Fenugreek) Trigonella foenum-graecum (L.) on MS medium supplemented with 1.0 mg/lˉ¹ 2, 4-D and BA which combination with all study treatments'. The magnetic water effected by improving the growth of callus, physiological and biochemical characteristics of callus. This study aimed to investigate the effects of magnetic water on some characteristics of growth and chemical constituent in Fenugreek. To this end callus formation was allowed to take place for 45 days in the dark at 25±2 °C from Fenugreek seeds were grown as two experimental groups. A group of seeds were irrigated with distilled water and in parallel the other group with magnetic water at three gausses 1000, 2000 and 3000 gauss. Results revealed that in comparison to control plants, irrigating with magnetic water increases the growth parameters. The treatments 1000 and 2000 gauss showed significant increase in fresh and dry weight, but decline was at 3000 gauss overcome of all treatments including control (Distilled water). From the results obtained it can be said that Physiological Traits outperformed on control by gave the highest values of CAT and SOD by using of magnetic water. Keywords: Fenugreek (Trigonella), Tissue cultures, Magnetic water.
The Effect of Ethanol on the Fetal Heart Muscle Galina Zhanaidarova
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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The survey goal was to study the effect of antenatal intoxication with ethanol on embryogenesis of the fetal cardiac muscle. The experiment was conducted on 48 female rats weighing 180-200 grams. To study the embryotoxic effect of ethanol, 2 groups were created. In group I, 18 rats throughout the pregnancy received a 15% ethanol solution daily instead of water. 18 animals of the control group were kept under normal vivarium conditions. On the 13th, 18th and 21st day of pregnancy, the females were killed, removed from the cauls of living fetuses, their length, body weight and heart weight were measured.Histological preparations stained with hematoxylin and eosin were prepared from the hearts of the fetuses. The nuclear cytoplasmic ratio, capillarydensity of the capillary network and cardiomyoblasts, procardiomyocytes and cardiomyocytes were measured. The data obtained were statistically processed. In group II, 6 animals during pregnancy (from 6 to 21 days) were injected daily with an endogastric solution of 30% ethanol at a dose of 5 g / kg of body weight, and 6 animals of the control group received physiological salt solution in equivalent amounts.On the 18th day of pregnancy, the females were killed, the material taken (cardiac muscle of the fetus) was studied by electron microscopy. Our study showed that antenatal intoxication with ethanol has a pronounced embryotoxic effect on the heart muscle, which manifests itself at the cellular and subcellular levels. The value of the obtained results lies in the fact that for the first time at the electron microscopic level, ultrastructural changes in the fetal cardiac muscle during prenatal intoxication with ethanol are shown. Keywords: Fetal alcohol spectrum disorder, Cardiac muscle, Electron microscopy.
Case History of Severe Toxicoallergic Dermatitis in Patient with Acute Leukemia Igor Y. Gadaev
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Adverse drug reactions are a serious problem in practical healthcare since they can have a significant impact on the patients’ quality of life while the global prevalence of morbidity and mortality caused by drug after-effects is increasing every year. Among the most common adverse drug reactions are skin reactions. They have described a case history of severe furosemide-induced toxicoallergic dermatitis in a 62-year-old man with acute myeloid leukemia taking saluretic due to comorbid cardiac pathology. Furosemide was withdrawn due to of severe toxicoallergic dermatitis onset while the glucocorticosteroids therapy with a 40 mg qd dose of prednisolone was prescribed. Secondary to furosemide withdrawal and due to glucocorticosteroid therapy, the following amelioration was registered: there were no new lesions, bullae and anabrosis disappeared, edema decreased and the patient’s general state of health improved. The described case of severe furosemide-induced toxicoallergic hemorrhagic vasculitis is associated not only with the direct allergenic action of the drug being the sensitization reaction trigger, but is also associated with the aberrant immunoreactive status of a particular patient due to his hematologic malignancies (acute myeloid leukemia). Such severe toxicoallergic reactions are rare enough, but it is extremely important to draw the clinicians’ attention to this problem, since these are the timely diagnosis of mentioned conditions, the identification and elimination of the trigger drug, timely and adequate treatment that guarantee a favorable prognosis for patients. That is why clinicians should not only aim for the verification and treatment of the underlying disease, but also consider the patient's comorbid conditions. Keywords: Drug-induced dermatitis, furosemide-induced severe toxicoallergic dermatitis, Delayed-onset allergy, Toxicoallergic dermatitis in acute leukemia.
Development of Extemporaneously Prepared Captopril Oral Dosage Forms - A Comprehensive Chronological Study Ayman M. Al-Qaaneh
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Captopril is an Angiotensin-converting enzyme inhibitor, its effectiveness as an antihypertensive agent and in the treatment of several cardiovascular conditions in neonates and children has been proved clinically. Unfortunately, in many countries, it is available as a solid dosage form only. As this does not satisfy the needs of these patients in terms of dosage and pharmaceutical formulations, extemporaneously prepared formulations represent the only available solution for this situation. Many attempts have been made to study the different factors that may affect the stability of captopril in oral liquid formulations, aiming to design a formula with maximum stability profile. Although there is still debate about the effect of some factors on captopril stability, other factors have a clear role. Low storage temperature, acidic media (up to pH 4), use captopril powder, absence of heavy metals, increase drug concentration, sugar-free vehicle, decrease oxygen contents in the formulation, and excipients such as chelating agents and antioxidants are well known to increase captopril stability. Varies type of extemporaneously prepared dosage forms (liquid, powder, or tablet) with different formulations have been prepared and studied. Unfortunately, the stability of captopril in these preparations has been highly variable and sometimes conflicting results obtained, reflecting the sensitivity of captopril to a variety of factors that have not yet been completely identified. This review discusses these factors and extemporaneously prepared formulations in a comprehensive chronological way. Keywords: Captopril, extemporaneous preparation, Drug stability, Pharmaceutical formulation, Drug compounding.

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