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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 106 Documents
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Search results for , issue "Volume 12 Issue 06 (2020) June 2020" : 106 Documents clear
Pharmacological Study of Schiff Base Derived from Amoxicillin Drug and Vanillin Huda K. Khassaf
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Objective: Our present investigation is based on development and synthesis for new derivatives of amoxicillin as the wide use of this antibiotic led to serious medical problem of drugs resistance. Methods: Condensation of amoxicillin trihydrate with 4-Hydroxy-3-methoxy benzaldehyde yielded a novel Schiff base derivative of amoxicillin in good yield. Characterization of synthesized compound detected by IR and 1HNMR spectroscopy. The antibacterial activity of new compound was screened against the selected bacteria species Staphylococcus aureus, Escherichia coli, Bacillus cereus, and Klebsella pneumonia. The LD50 value was determinate by using up and down method. Results: Our obtained results for this antibiotic modulation method are within high acceptance criteria in vivo study determination of the toxic effect (LD50) of synthesized compound which was 477.2 mg / kg of body weight give a moderate value. Furthermore, in vitro study included antibacterial activity against some bacteria species of new compound was higher than the respective standard drug at tested doses level. Conclusion: Modulating amoxicillin drug can be used in the management of bacterial resistant disorders. Key words: Amoxicillin, Micro-organism species, Antibacterial activity, Disorders. Schiff-base.
Determination of Diethyl Amine by Stop Flow Technique Dakhil Nassir Taha
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

The aim of this research is determination of diethyl amine by stop flow injection analysis technique. The method is based on the reaction between diethyl amine with NQS reagent. This method involves a homemade new valve, which is manufactured from a cheap available material. Optimization of the conditions of the reaction includes, flow rate, sample volume, reagent volume, reagent concentration and reaction coil length were done. Linearity was in the range of (1-10 v/v %), correlation coefficient (R2) was 0.9967. The method was applied successfully to the determination of diethyl amine in aqueous solution. Keywords: Diethyl amine, FIA, Stop flow technique, Dispersion.
Correlation Family Support on Independence of Patients Schizophrenic Activities Daily Living (ADL) Ronal Surya Aditya
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Family support for schizophrenics has proven to be very effective in supporting patients' healing and independence. And this program has been widely recommended by several minimum service standards published internationally. However, the reality is that the family is not yet fully supported, even though good family support can increase patient independence. Aims to find out the relationship between family support and ADL independence in schizophrenia patients. The research design used in this study was a correlation method that used a cross-sectional approach, with samples in this study were 70 family members with schizophrenia. The variables in this study are family supports (instrumental, informational, appreciation, assessment). Based on the results of statistical tests using the Spearman Rank shows ρ value for instrumental family support (0.020), informational family support (0.031), family support award (0.021), and family support assessment (0.021). Full family support is necessary and given to sufferers, especially schizophrenics. Comprehensive family support can be given if the caregiver is a member of the nuclear family who has a good psychological closeness with the sufferer. The results of this study can explain future approaches to dealing with the family support of schizophrenia patients Keywords: ADL Independence, Family Support, Schizophrenia.
Analysis of the study sample of patients and their use of antihypertensive drugs in monotherapy Tetiana Nehoda
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Introduction: Cardiovascular diseases are the primary socio-medical problem of the industrialized countries of the world. One of the most important in terms of increasing life expectancy and the preservation of the viability and quality of life is the solution to the question of the proper therapy of cardiovascular diseases and their timely prevention. The purpose of this study was to determining the structure of patients' use of antihypertensive drugs, as well as to study the subjective factual and prognostic assessment of patients' effectiveness of treatment. Materials and methods: Methods such as: questionnaires of patients (content analysis of case histories) were used. Data processing was performed using statistical and mathematical methods and graphical analysis. Results and discussion: There were some patterns of lowering blood pressure in patients on the background of monotherapy of hypertension and patients following the doctor's instructions for treatment. Conclusions: As a result of the study, it was found that most patients follow the recommendations of doctors on the appointment of antihypertensive drugs.
The Impact of Age and Parity in the Incident of Premature Rupture Membranes (PRM) Tinuk Esti Handayani
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Introduction: One of the most prominent problems due to pregnancy complications is the incidence of PRM. Premature rupture of membranes(PRM) is a complication in pregnancy and childbirth that plays a role in increasing meternal-perinatal morbidity and mortality which can be caused by infection. The purpose of this study was to determine the effect of age and parity on the incidence of PRM PRM at Widodo Ngawi Hospital. Methods: Case control analytical observation research design. The sample of cases of maternal PRM with a sample size of 30 respondents. The sample of maternal control was 30 respondents. Samples were taken using simple random sampling technique. The independent variables are age and parity, and the dependent variable is PRM. Data collection used a secondary data type checklist. Data analysis used Logistic Regression Test with a significant level of 0.05. Results: The results showed that most of the mothers aged 35 years (79.3%) and p value = 0.004. The OR value of the age variable is 7,020, the conclusion is that age has a 7 times greater risk of causing PRM. Multigravida parity (72.2%) and p value = 0.010. The OR value of the parity variable is 6.481, it can be concluded that parity has a 6 times greater risk of causing PRM. p-value
The Effects of Stress on the Levels of Some Biochemical Parameters in Patients Intended to Surgery Hayder Abbas Alwan
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Stress is actually an appreciation that’s most emanating during sole reacts ending with unusual doings. it’s tense body’s tone going from rising in order to a confront including formation as far as tournament a hard position for a focal point, energy, moxie, along with intensive attentiveness. Trauma has to want to be been displayed ending by allowing significant property resting on the metabolic action (for case remains value, entire chunky, as a consequence of insulin also leptin levels). Stress stimulates the discharge of assorted hormone, which may end up in uprising glucose levels. Keyword: Stress, Surgery, Serum Insulin, Glucose, Bilirubin, Uric acid.
Systemic Corticosteroids are Effective in about a Half of pemphigus Patients Anfisa Lepekhova
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Systemic corticosteroids (CS) can control flare-ups of the disease and remain the mainstay of treatment. However, even high doses of CS sometimes fail to produce adequate symptom control. We retrospectively analyzed the rate of CS efficacy in 123 pemphigus patients seen at our Department over 16-year period. Our research shows that half (54/123) of patients with pemphigus had lack of response to treatment. PNP was noted only in CS resistant patients (8/54). Also, higher mortality, at least one exacerbation a year and exacerbation during 2-5 year of the disease associated with reduction of CS dose were significantly more frequent in the group of CS resistant patients than in CS sensitive one.We showed that half of patients had a lack of response to CS. However, we found in pemphigus onlyclinical severity subdivision by frequency and clinical manifestations of steroid resistance useful in adjuvant therapy. Adjuvant therapy can beused to treatpemphigus vulgaris to reduce sideeffects of CS or when these therapies are ineffective to achieve a complete remission.Therefore, it is important to investigate a potential molecular biomarkers of CS resistance in patients with pemphigus and other bullous disorders. Keywords: Pemphigus, Steroid insensitivity, Potential biomarkers, Criteria of steroid insensitivity, Severity, Treatment.
Effect of Topical Laportea Decumana Leaves Extract on Labor Pain and Cortisol Level in the First Active Phase of Inpartu Condition Sisma HL
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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This research aims to obtain the effect of L. Decumana extract toward labor pain and cortisol level in the first active phase of inpartu condition. This research used True Experimental with pre post test control group on the first active phase in inpartu condition. This research was combining pharmacology and non-pharmacology method. In choosing the research’s subject, consecutive sampling and randomization were applied to divide the subject into four groups. To measure the pain level, Visual Analog Scale (VAS), and saliva liquid was applied to measure the level of cortisol. The smallest average of pain level before the treatment was KS+V group (6,40) and the highest was LD+KS group (7,70). After the treatment, the smallest level was in LD+KS (5,60) group and the highest is in the SP+V group (7,00). It meant that there was reduction in the pain level before and after treatment. L. Decumana as the medical medicine can be used as reducing the first active phase of labor pain in inpartu condition. However, the further research is needed to prove the effect of biomarker L. Decumana to initiate labor.
Clinical Assessment of the use of Sublimated Mare's Milk in Complex Therapy of Mild and Moderate Psoriasis Bakytgul Yermekbayeva
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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The article discusses the therapeutic effect of mare's milk in complex treatment in patients with psoriasis. Research objective: Clinical assessment of the use of sublimated mare's milk in complex therapy of mild and moderate psoriasis. Materials and methods: 20 patients in main group with mild and moderate psoriasis took part in the study - control, who during 12 weeks of standard therapy took sublimated mare’s milk and 20 comparison group patients on standard therapy. In the study participants in main group, the severity index of psoriasis course and spread (PASI) was calculated at 0 and 12 weeks.Results: A statistically significant decrease in the PASI index was found: after 6 weeks by 68%, with treatment within 12 weeks - by 88% (p = 0.0003) in the main group compared with the comparison group. Conclusions: in patients with psoriasis, it is necessary to include sublimated mare's milk in the complex treatment to increase the effectiveness of therapy and lengthen the period of remission. Keywords: Psoriasis, PASI index, Sublimated mare's milk.
Wharton’s Jelly Derived Mesenchymal Stem Cells: A Comparison Study in Preterm vs. Term Deliveries and in FBS vs. PRP vs Mesencult Culture Media Gita Pratama
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Background: Use of human mesenchymal stem cells (MSCs) for therapy in the field of degenerative medicine has been extensively studied. One of the potential sources of MSC which is easily available is from the human umbilical cords Wharton’s jelly of the newborn baby. Wharton's jelly derived MSCs (WJ-MSCs) from full-term labor has been isolated and differentiated, but very limited data came from preterm labor. This study aimed to compare the proliferation and differentiation characteristics between human WJ-MSCs from preterm and term labor using xeno-free culture media, particularly platelet rich plasma (PRP). Methods: WJ-MSCs from preterm and term deliveries was cultured using culture medium supplemented with 10% PRP or MSC or FBS culture media. Cells were cultured until the fifth passages. Cumulative cell numbers and differentiation capacity of the MSCs was tested according to International Society for Cellular Therapy (ISCT) criteria. Results: The preterm WJ-MSCs grown in culture media is not significant differences with WJ-MSCs derived from full-term labor, but have higher number of cell populations. WJ-MSCs are able to differentiate into osteocyte, chondrocyte and adipocyte., and xeno-free media can be used to replace FBS. WJ J-MSCs from preterm labor can be used as a source for mesenchymal stem cells. Conclusion: WJ-MSCs collected from preterm samples to have a better proliferation rate compared to term samples, while possessing equal differentiation capacity. In addition, PRP can replace FBS as it a xeno-free material for WJ-MSCs production that required for regenerative medicine. Keywords: Mesenchymal stem cells, Wharton’s jelly, Preterm labor, Proliferation, Differentiation.

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