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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 17 Documents
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Search results for , issue "Volume 12 Issue 08" : 17 Documents clear
Sustained release of drugs from prepared polymeric systems for Alzheimer disease protection Doaa E El-Nashar
Journal of Global Pharma Technology Volume 12 Issue 08
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: Slow release technique is a trial for long-acting protection from Alzheimer. Drug delivery systems, polymer based, can be designed to improve the pharmacological and therapeutic properties. Slow release technique gave the availability of drugs to deliver the right location in the body. The main principle of this technique is holding and keeping the drug on the polymer carrier for a sustained release of medicine in the body for a long period of time. The present work aimed to prepare polymeric materials from starch cellulose acetate coacrylate (SCACA), containing sodium bentonite nano clay and tween 80 as a surfactant for improving drug loading. The objective of this formulated natural polymeric product is to obtain practical effective sustained release drug systems by evaluating its potency in vivo for protection from Alzheimer disease. SCACA biodegradable polymeric system formulations containing anti Alzheimer drugs (such as Curcumin, Rosemary or Donepezil) were investigated through oral administration in experimental animals (rats). Methods: The characterization of the prepared polymeric system was carried out by FTIR and SEM. The drug release was measured spectrophotometrically. The invivo evaluation of the released drug against Alzheimer disease was an assessment of the effect in rats through biochemical and histopathological studies. Results: The slow release of the drug according to the study time illustrated that Rosemary, Curcumin and Donepezil estimated values through the tested time gave promising results, especially for releasing Rosemary, Curcumin and Donepezil. In the present investigation, the biochemical findings were also confirmed by histopathological observations which showed improvements in most biochemical parameters accompanied with amelioration in histological architectures in rats treated. Conclusions: Slow release technique is a good means for long-acting protection from Alzheimer's disease. Starch cellulose acetate coacrylate (SCACOA) is a good carrier for drugs such as Donepezil as a conventional drug while Rosemary, Curcumin as bioactive natural products. The invivo study for Alzheimer's protection gave promising results.
Pharmacophore Screening and Molecular Docking of Andrographolide and Its Derivatives on Plasmepsin as Antimalarial Drug Sandra Megantara
Journal of Global Pharma Technology Volume 12 Issue 08
Publisher : Journal of Global Pharma Technology

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Abstract

The study was conducted to find out andrographolide and its derivatives which could interact with plasmepsin, an aspartic protease enzyme that usually used as target for antimalaria. The study began with pharmacophore modeling using LigandScout software. Pharmacophores were searched for plasmepsin I, II, and IV, with pdb codes were 3QS1, 1SME, and 1LS5 respectively. Pharmacophores were generated using structure-based and ligand-based pharmacophore methods and retrospective validation was used to validate them. Pharmacophore screening was carried out for andrographolide and its derivatives, then for the hit compounds, continued by molecular docking using AutoDock Vina module in LigandScout software. Pharmacophores for plasmepsin I, II, and IV consist of hydrogen bond donors, hydrogen bond acceptors and hydrophobic interactions, with the best validated AUC values for each model were 0.73, 1.00, and 1.00 respectively. Andrographolide derivatives (AND10 and AND15) had high fit scores for plasmepsin I, II, and IV pharmacophore. The results of molecular docking showed that andrographolide and its derivatives (AND10 and AND15) interacted well with the plasmepsin by binding to important aspartic amino acid residues in the active site. From the binding affinity, AND15 was the best compound interacted with plasmepsin I, II, and IV with ∆G values were 1, 2, and 3 kcal/mol respectively. Andrographolide derivative (AND15) was the best compound interacted with plasmepsin, so it was potential to be developed into new antimalarial drug.
Anti-Tuberculosis Therapy: International, State, and Regional Pharmaceutical Care Policy Egor Vadimovich Grebenev
Journal of Global Pharma Technology Volume 12 Issue 08
Publisher : Journal of Global Pharma Technology

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Abstract

Today, pulmonary tuberculosis is a disease, which potentially threatens the whole humanity. Therefore, prompt actions should be taken. Tuberculosis is still the main threat to the global community. In this article, we investigated anti-tuberculosis therapy in an international, state and regional perspective. We have studied the use of combined therapy in treating tuberculosis patients. Thus, combining several anti-tuberculosis drugs in chemotherapy is deemed effective nowadays. We evaluated the drug supply for tuberculosis patients in regions and found out that patients have to take medicines constantly at all stages of anti-tuberculosis therapy. When analyzing the outcomes of cases of treatment of patients with tuberculosis and methods of increasing its effectiveness, we showed that insufficient adherence to treatment, as well as its insufficient control, provide almost half (44.6%) of unfavorable outcomes. Thus, it is necessary to develop methods and methods to motivate patients to comply with the recommendations of doctors. Keywords: Tuberculosis, Tuberculosis infection, Tuberculosis morbidity, TB services, Primary course of chemotherapy.
The Development of Toddlers in Russia: Needs and Trends Mikhail Volchanskiy
Journal of Global Pharma Technology Volume 12 Issue 08
Publisher : Journal of Global Pharma Technology

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Abstract

The level of physical development of children reflects their health status. The goal is to evaluate the anthropometric indicators of toddlers aged 1-3 in Moscow as a sample model of Russia and to identify gender and age differences. The studies were conducted in 2017-2019 in Moscow (Russian Federation). On the basis of 10 pediatric clinics, 3000 children were selected, of which 1650 boys and 1350 girls of toddler age, 1-3 years old. 4 anthropometric parameters were regularly measured (body length, body weight, circumference of the chest and head). Significant differences in all anthropometric parameters were found to be large for boys compared to girls. In boys, there was a 9.0 cm difference in body length between 2 and 1 years (p ≤ 0.001), and 10.0 cm between 3 and 2 years (p ≤ 0.001). In girls, the results were identical (p ≤ 0.001). Boys aged 2 were 2.6 kg heavier than one-year-olds (p ≤ 0.001), and at the age of three they were 1.8 kg heavier than two-year-olds (p ≤ 0.001). Girls aged 2 had body weight 2 kg more than one-year-olds (p ≤ 0.001), and 3-years-olds were 1.3 kg (p ≤ 0.01) heavier compared with two-years-olds. The chest circumference in boys aged 2 is 2.5 cm larger than in one-year-olds, and 1.5 cm (p ≤ 0.001) smaller than in toddlers aged 3. In girls the differences were 2.5 cm and 1.2 cm, respectively (p ≤ 0.01). The head circumference for boys aged 2 was 2 cm more than the parameters of one-year-olds (p ≤ 0.001), and for boys aged 3 - 1 cm more than two-year-olds (p ≤ 0.001). For girls the differences were 2 cm between ages of 1 and 2, and 1 cm between ages of 2 and 3 (p ≤ 0.001). The research results can be adapted when creating a single database of world data to identify the processes of acceleration or deceleration and the factors that determine them. The processes of changing anthropometric indicators were identified for toddlers aged 1-3. Three anthropometric indicators (head and chest circumference, body length) in boys and girls change with the same growth rate over time. The fourth indicator, body weight, changes somewhat faster in boys (0.8 kg versus 0.7 kg in girls, p ≤ 0.05). The remaining three indicators significantly differ within groups of boys and girls between age groups (p ≤ 0.001). Thus, age differences prevail over gender differences. Keywords: Early childhood, Regional standards, Socio-economic factors, Anthropometry, Body weight, Body length, Chest circumference, Head circumference.
Role of PPAR-Α Signaling Pathway on the Protection of Antituberculosis-Induced Liver Damage by Purple Sweet Potato Extract i gusti ayu artini
Journal of Global Pharma Technology Volume 12 Issue 08
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Peroxisome proliferator activated receptor-α (PPAR-α) participates in protecting the liver from many cases of liver damage. It is involved in reducing lipid accumulation, oxidative stress and inflammation. Purple sweet potato extract is one of herbal extract that posses hepatoprotector activity related to its antioxidant and antiinflammatory action. Its hepatoprotective effect on isoniazid and rifampicin induced hepatic injury has not been established yet, as well as its effect on PPAR-α expression and activation in the liver. The aim of this research was to investigate the hepatoprotective effect of purple sweet potato extract on hepatic injury induced by isoniazid and rifampicin, as well as the effect of purple sweet potato on PPAR-α expression and activation in the liver. Methods: The study design was randomized post test only control group design. We included male Wistar rats, age 8-12 weeks, weight 180-220 gram (divided into 3 groups: control, intervention and normal group). The extraction was performed with masseration technique. PPAR-α expression was measured with ELISA; activated PPAR-α was detected using immunohistochemistry; ALT level was measured with spectrophotometry. Data were analyzed using One Way Anova test, continued with Post Hoc test. Results: The result represented that PPAR-α expression in intervention group was significantly higher than control (1.344±0.249 vs. 0.587±0.306; p
The Effect of Worried Doll Therapy on Pre-School Age Anxiety Levels With Hospitalization In Rumkital Dr. Ramelan Surabaya Dedi Irawandi
Journal of Global Pharma Technology Volume 12 Issue 08
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Play therapy is an effort to change problematic behavior by placing children in play situations. Anxiety is a pathological condition characterized by feelings of fear accompanied by somatic signs, a sign of a hyperactive autonomic nervous system. The aim of this study was to analyze the effectiveness of "Worried Doll" play therapy on the level of anxiety in preschool children with hospitalization in Navy Hospital Dr. Ramelan Surabaya. Materials and Methods: The study design was a quasi-experimental approach Non-equivalent Control Group with a total of 204 research respondents preschool children are cared for in Rumkital Dr. Ramelan Surabaya. The results showed that playing “worried doll” therapy was effective in reducing the level of anxiety in pre-school age children who experienced hospitalization. Results: Based on the results of the statistical test in the intervention group, the P value was 0.007
Walking Analysis Using the Angles around the Midpoint between Print Length and Toe Spread by Four Different Color Footprints and SFI in Sciatic Nerve-Injured Rat Model Treated With Curcumin Ria Margiana
Journal of Global Pharma Technology Volume 12 Issue 08
Publisher : Journal of Global Pharma Technology

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Abstract

SFI, the sciatic function index, has been applied as an evaluation method in walking analysis over a long period. It is a method that addresses the functionality of nerves using footprints during walking analysis. Other techniques developed previously make use of one-color ink. The method has difficulties in interpretation due to footprints mingled among the mice specimen's four legs. There exists a possibility of the rats not walking straight, and this leads to overlapping, and the result is complicated measurements. SFI, as a method, entails the application of a mathematical formula that is special. Researchers have questioned this method since it is affected by muscles' contraction, automatic mutilation, and rat motion speed. During this study, the idea is to use four different colors, allowing easier and faster interpretation of the footprints results. Moreover, the study will also modify tools based on the already existing available tools in pre-existing literature. The modified tool gives a measurement of print leg denoted as PL, toe spread TS, and inter- toe spread IT’S, all belonging to the SFI component. The tool's validity and reliability are essential when applied in the measurement of components used in the functional analysis of nerves. Confirmation from the study is that results from SFI and TOA (toe out of angle) all describe footprint. Toe out of angle is an essential measurement in the walking analysis as it has an impact on the alteration of abduction-adduction as well as the internal-external navigation of the hind legs. The study will help develop a method that assesses nerves' functional analysis using the sciatic functional analysis and total out of angle spread. The angle at the intersection point of the print length and the toe spread. Keywords: SFI, TOA and ITS.
Assessment of Dietary Intake among Patients with Metabolic Syndrome and Comparison with Healthy Patients in Accordance with the Questionnaire Ayaulym Nurgozhina
Journal of Global Pharma Technology Volume 12 Issue 08
Publisher : Journal of Global Pharma Technology

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Abstract

Metabolic syndrome is a cluster of conditions that occur together, increasing the risk of heart disease, stroke, hypertension, and glucose intolerance. Metabolic syndrome has a major impact on the development of diabetes and cardiovascular diseases. Insulin resistance and β-cell function are also related to metabolic syndrome function. It is crucial to manage correct balance of energy requirement of cells and bodily inflammation for insulin sensitivity and control of metabolic syndrome [1].
Analysis of Behavioral Factors on Medications in Gout Patients with Health belief Model Theory Ika Ratna Hidayati
Journal of Global Pharma Technology Volume 12 Issue 08
Publisher : Journal of Global Pharma Technology

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Abstract

Objective : To identify behavioral factor associated with medication adherence using the Health Belief Model theory. Methods : This study used a cross sectional approach with accidental sampling technique. The number of samples used 64 people. The instruments were used the adherence to refills medication scale and the Health Belief Model questionnaire which had been tested for validation and reliability on the questionnaire. Data were analysed using multiple linear regression analysis. Conclusions : Each Health Belief Model theory variables which are perceived susceptibility, perceived severity, perceived benefits, and perceived barriers had a significant effect on medication adherence in gout patients (p 0.05). The Health Belief Model Theory had coefficient determination (R2) 59.7%. This indicates that the Health Belief Model can predict the behavior of patients who adhere to treatment well. Keywords : Adherence, Health Belief Model, Gout, Community Health Center, Behavior
The Role of Growth-Associated Protein-43 (GAP-43) and Superior Cervical Ganglion-10 (SCG-10) mRNA and Protein Levels in Dorsal Root Ganglion Neurons of Lumbar Spinal Cord Segments (L4-L5) Associated with Sciatic Injured Nerve Ria Margiana
Journal of Global Pharma Technology Volume 12 Issue 08
Publisher : Journal of Global Pharma Technology

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Abstract

The analysis focuses on the role of growth-associated protein-43 (GAP-43) and superior cervical ganglion-10 (SCG-10) mRNA and protein levels not only in DRG neurons of lumbar spinal cord segments (L4-L5) associated with sciatic injured nerve. The objective of the research study is to unearth the role of growth-associated protein-43 (GAP-43) and superior cervical ganglion-10 (SCG-10) mRNA and protein level not only in DRG neurons of lumbar spinal cord segments (L4-L5) associated with sciatic injured nerve. The sources were past scientific papers that were published and obtained from google scholar and other sites with open source access. The research review is an original work. The analysis will be centered on a review article that focused on analysis on advantages and disadvantages GAP 43 as neuroregeneration marker examination in rat sciatic nerve injury. The study eligibility criteria was articles that are not older than fifteen years, are written in English and are published. Key words: Sciatic nerve injury, GAP-43, SCG-10 and DRG neurons of L4-L5.

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