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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 17 Documents
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Search results for , issue "Volume 12 Issue 08" : 17 Documents clear
The Effect of Ajwa Dates Fruit Extract on Follicle Stimulating Hormone (FSH), Graafian Follicle and Endometrial Thickness in Female Rats Exposed to Arsenic Herdhika Ayu Retno Kusumasari
Journal of Global Pharma Technology Volume 12 Issue 08
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Abstract

Background: Arsenic exposure in humans can disrupt the reproductive system and reproductive organs in women, which can cause interference hormonal and fertility disorders. The pathogenesis of arsenic causes oxidative damage to the organs and reproductive system due to an imbalance between Reactive Oxygen Species (ROS) and antioxidants in the body. Ajwa dates contain powerful antioxidants that act as scavenger ROS as well as inhibit lipid peroxidase which stop reactions associated with oxidative stress. Objective: This study aims to determine the effect of Ajwa date extract on Follicle Stimulating Hormone (FSH) levels, Graafian follicle and endometrial thickness in female rats exposed to Arsenic Trioxide (As2O3) for 30 days. Methods : Experimental laboratory with 5 treatment groups, negative control group (without arsenic exposure), positive control (3 mg/kg BW arsenic), T1 (arsenic 3 mg/kg BW + date extract 2ml / kg BW), T2 (arsenic 3 mg / kg BW + date extract 4ml / kg BW), and T3 (arsenic 3 mg / kg BW + date extract 8ml / kg body weight). Results: Arsenic exposure significantly reduced FSH levels, Graafian follicle count and endometrial thickness. Conclusion: The administration of Ajwa date extract could significantly provide antioxidant protection in the treatment group with an increase in FSH levels, Graafian follicle count and endometrial thickness.
Gender inequalities in caries experience among primary school-children. A cross-sectional study in a rural area of Indonesia Sri Widiati; Al. Supartinah Santoso
Journal of Global Pharma Technology Volume 12 Issue 08
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OBJECTIVES Dental caries is known as one of the most prevalent chronic diseases among school-children, especially those with lower socioeconomic status and higher sugar consumption. The purpose of the study is to compare caries prevalence between female and male school-children aged 11-13 years, adjusting for socioeconomic status. METHODS A cross-sectional study was carried out in a rural area of Sleman, Indonesia, to estimate the effect of gender, parental education and family income. A sample of 1,144 children at fifth grade were selected from 45 elementary schools in Sleman, Indonesia. Information concerning paternal education, demographic data of the school-children and family income were obtained from parents or guardians of the children. Caries status (DMF-T) of the schoolchildren was examined according to WHO dental health survey guidelines. RESULTS The results of the study showed that female students had on average 0.39 higher DMF-T than male students (p=0.001) and 28% less odds for caries-free status (p=0.009) adjusting for paternal education and family income. University education of fathers was associated with 0.53 lower DMF-T compared to the lowest education category and 79% increase in odds for caries-free status. There is no difference in restorative index between male and female students reflecting similar experience in dental care. CONCLUSIONS Female school-children aged 11-13 years were consistently at a greater risk for dental caries adjusting for parental education, an issue for further research and school-based oral health promotion program.
The Study of Subjective Assessment of the Safety and Efficacy of Antihypertensive Drugs from the Group of Beta-Blockers and Calcium Antagonists Tetiana Nehoda
Journal of Global Pharma Technology Volume 12 Issue 08
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Introduction: In order to study in more detail the subjective assessment of the effectiveness of antihypertensive monotherapy, the questionnaires of patients were structured. They were divided into groups according to the drugs used by patients belonging to a particular clinical and pharmacological group: beta-blockers and calcium antagonists. The purpose of this study was to study of subjective factual and prognostic assessment of patients' effectiveness of treatment. Materials and methods: Methods such as: questionnaires of patients (content analysis of case histories) were used. Data processing was performed using statistical and mathematical methods and graphical analysis. Results and discussion: There were some patterns of lowering blood pressure in patients on the background of monotherapy of hypertension and patients following the doctor's instructions for treatment. Conclusions: As a result of the study, it was found that most patients follow the recommendations of doctors on the appointment of antihypertensive drugs.
Optimization and Validation of the Simultaneous Determination of Vildagliptin and Metformin, in Bulk and Formulation by A Reverse Phase HPLC Method Using D-Optimal Experimental Design K Balamurugan; Kirtimaya Mishra
Journal of Global Pharma Technology Volume 12 Issue 08 (2020) Aug. 2020
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This paper portrays a recently developed, optimized and validated isocratic RP-HPLC strategy for the separation of two anti-diabetic drugs Vildagliptin (VLD) and Metformin (MET).The optimization of the HPLC methodology included several variables, of which the impacts of each was studied. After a sequence of preliminary-screening experiments, the composition of the mobile phase and the pH of the added buffer solution were set as the examined variables, while the capacity factor (K1) of first peak i.e Metformin (MET), resolution (Rs) between Vildagliptin (VLD) and Metformin (MET), Separation (S) for both the drugs and the retention time (Rt2) of the second peak i.e Vildagliptin (VLD) were chosen as the dependent variables. Using the D-optimal design, the ideal chromatographic conditions for the separation were identified. The technique proved to show good harmony between the experimental data and predictive values throughout the studied parameter range. The optimum assay conditions were carried out with a Onyx C18 Monolithic column (100mm× i.d., 5µm) connected with an Onyx C18 guard cartridge (4mm×3mm i.d., 5µm) and a mixture of methanol (MeOH)/acetonitrile (ACN)/potassium dihydrogen orthophosphate (KH2PO4) (pH 4, 0.003 mol L−1) (31.362:10:58.638, v/v/v/v) as the mobile phase at a flow rate of 0.4 mL min−1 and detection wavelength of 220nm. The run time was under 8 min, which is a lot shorter than the prior optimized methods. The improved analytical method was validated as per FDA guidelines.
Protective Effect of Goat Kefir on Arsenic-Induced Ovarian Oxidative Stress in Female Rats Nur Aisyah Laily
Journal of Global Pharma Technology Volume 12 Issue 08
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Objective: To determine the role of goat kefir in ovarian protection from arsenic-induced ovarian oxidative stress. Methods: twenty female wistar rats were randomly divided into five groups; one group was treated as control, one group was treated with arsenic 2 mg/kg/day only, while three groups were treated with different doses (1.25, 2.5, 5 mL/kg/day) of goat kefir and arsenic for 35 days. After 35 days, the rats were terminated, then the ovaries were taken for analysis of MDA levels and SOD activity using spectrophotometry. Results: arsenic exposure significantly increased MDA levels but did not significantly decrease ovarian SOD activity compared to the control group. Kefir administration at doses of 1.25 and 2.5 mL/kg/day could reduce ovarian MDA levels although it was not statistically significant. However, MDA levels were greater in the 5 mL/kg/day group than the arsenic-only group. Kefir increased ovarian SOD activity at all three doses although it was not statistically significant. Conclusion: goat kefir was able to reduce MDA levels and increase ovarian SOD activity in rats that were exposed to arsenic although it was not statistically significant.
Legal Protection for Child Criminals at the Juvenile Detention Center: Study of Psychiatric Health Arief Budiono
Journal of Global Pharma Technology Volume 12 Issue 08
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Children are the young buds of the human beings. They are created by Allah as the best creature. But, they may be placed at a low degree as a human being if they are not obedient to Allah by doing evil things. To maintain their degree as a human being as intended by Allah in the creation of human beings, which is as the leaders of earth and as beloved servants, the human beings are obligated to have faith in Allah and carry out good deeds. But, not every person can grow and develop normally. Some cannot do so as they carried out criminal actions and have their liberties and their childhood taken away. This research is focused on the legal protection for criminal children at the Juvenile Detention Center through the legal-health analysis. The data obtained are then analyzed using the Capacities and Vulnerabilities Analysis (CVA).
Drug Use Evaluation in the Pediatrics Admitted with Severe Respiratory Tract Infections Vineela Chadalavada; Triveni P; Hameeda Begum Md; Pujitha S
Journal of Global Pharma Technology Volume 12 Issue 08 (2020) Aug. 2020
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The objective of the present study is to evaluate drug prescribing patterns in children admitted with respiratory tract infections into pediatric ward. This is a prospective cross-sectional study conducted for a period of one year at a tertiary hospital located in a city of Andhra Pradesh, South India. The study was done by using prescribing indicators from the World health organization (WHO) manual for the conduction of drug use evaluation studies. The prevalence of respiratory tract infections, particularly lower respiratory tract infection is high among children less than 5 years. 54.39% of drugs are prescribed with brand names, of which the majority of drugs are administered through parenteral route (58.26%). Antibiotics (34.7%) are highly prescribed in all the cases followed by other category drugs. A significant difference was found in the evaluation of prescribed daily dose and standard dose. The profile of drug use in the present study was similar to previous Indian studies. Most of the prescribing encounters are parental forms and band names that need exploration of the present treatment trends. The present baseline data can serve for the development of national Pediatric prescribing guidelines in the future.

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