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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 66 Documents
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Search results for , issue "Volume 9 Issue 10" : 66 Documents clear
Estimation of Some Immunological and Physiological Parameters for Obese Human Amera Kamal Mohammed
Journal of Global Pharma Technology Volume 9 Issue 10
Publisher : Journal of Global Pharma Technology

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Abstract

Adipose tissue expansion during obesity is associated with inducing Proinflammatory and inflammatory cytokine responses, decreasing insulin sensitivity, type 2 diabetes mellitus and dyslipidemia. The objective of this study was to determine some humeral immune levels including, serum IL-1βand C-reactive protein (CRP) as well as blood glucose and lipid profile as physiological criteria. Blood samples were collected after  an overnight fast from a group of obese (n = 48)and none- obese (41) as a control group depending on BMI withwaist circumference with age ranged between (20-40 year).The results  revealed that significant increase (P≤ 0.05) in mean of BMI(Kg/M2) ,WC (cm), CRP (ng/mL), FBG (mmol/L), total cholesterol(mmol/L)and , low density lipoprotein (mmol/L), while there is no significant difference  in the levels of IL-1β (pg/mL), triglyceride(mmol/L), high-density lipoprotein (mmol/L) and very low density lipoprotein (mmol/L) among obese individuals  compared with control group , and depending  on the sex of the study groups the results showed that significant increase (P≤ 0.05) in means of BMI(Kg/M2) , WC (cm), IL-1β (pg/mL), FBG (mmol/L) ,while there is no significant difference  in means of CRP (ng/mL), TC(mmol/L) , LDL(mmol/L), TG(mmol/L), HDL(mmol/L) and VLDL(mmol/L). The data demonstrated that the three classes of obesity had higher significant differences (P≤ 0.05) in means of BMI (Kg/M2), WC (cm), and CRP (ng/mL), FBG (mmol/L), TC (mmol/L) and, LDL (mmol/L).Keywords: Obesity, Type 2 diabetes, Insulin resistance, Immunity, Inflammation.
Some Physiological and Immunological Response of Rats (Rattus rattus) to Purified Microcrystal-LR Moayed Jassim Yass Al-Amari
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

The results of present study showed purification of microcrystal-LR from Anabaena circinalis by preparative high performance liquid  chromatography  and observation of some physiological and immunological response of rats to purified microcrystal-LR , the rats was intraperitoneally inject by purified microcrystal-LR from A. circinalis with dose (3, 6, 9) µg/200 gb.w per day for 30 day, the result shown the physiological parameter such as Urea concentration, cholesterol and melatonin concentration in blood and liver tissue were significantly increased with dose elevation of microcrystal-LR as compared with control group, While the total protein concentration in blood and liver tissue was significantly decreased with increasing dose of toxin. The immunological parameter such as interleukin-6 and interleukin-7 in blood and liver tissue were significantly decreased with increasing dose of microcrystal-LR.Keywords: Purified microcrystal-LR, Physiological, Immunological parameter, Cyan toxins.
Evaluation of Surface Soils Contamination by Polycyclic Aromatic Hydrocarbons of Selected Samples in Al-Diwaniya City, Iraq Faiq F. Karam
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

The concentrations and spatial distribution of thirteen polycyclic aromatic hydrocarbons from٦ soil have been investigated in four regions locate in Al-Diwaniya city, Iraq. Sechelt extractions is used to extract PAHs compounds from all samples, gas chromatography was used to determine the PAHs concentration in all samples. The total concentrations of thirteen PAHs were ranged from 4.46ng.g-1 in site one to 17.24 ng.g-1 in site three of dry weight. The PAHs compounds those consist of four to six fused aromatic rings represent the majority among other PAHs in soil samples.Keywords: Al-Diwaniyah pollution, Contamination with PAHs, Extraction of PAHs from soil, Soil pollution, PAHs in Iraqi soil.
Epidemiology of Human Rabies Deaths in Babylon Province, Five Years Descriptive Epidemiologic Study Hasan Alwan Baiee
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Human rabies is a fatal zoon tic diseases, it was endemic in Iraq since 4000 BC, poor passive surveillance and lack of educational awareness of public in Iraq lead to the end emicity and outbreaks of the disease especially in the central governorates including Babylon province. The objective of this study was to evaluate the epidemiologic features and the incidence of deaths of human   rabies   in Babylon province during the years 2012 to 2016.Nine human rabies deaths were reported during this period. Diagnosis is majorly carried out by clinical presentation coupled with history of exposure to rabies infected dog. This number of human deaths due to rabies gotten from this review is a far cry to the number of human death due to the diseases. This study showed that this disease is endemic in Babylon governorate, an epidemic took place in the province during the year 2016, the victims were mainly males; male to female ratio was 8: 1, fatal human rabies affect mainly children and young age males, most of victims didn’t receive post exposure vaccine (88.9%).Human rabies in Babylon province still a public health problem, strategic plan for elimination of human rabies is strongly needed. Keywords: Epidemiology, Human rabies, deaths, Babylon, Iraq.
Excitation of Λ - type three Level System by Pulsed Radiation as a Model of Radiology Tissue Response Saddam Flayeh Haddawi
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

In several biomedical applications, it is desirable to transfer an electron in an atom from one energy level to another. This may be a direct transfer, involving only two atomic levels, or may involve some intermediate levels which the electron must pass through before coming to its final state. The model dealt with here incorporates one such intermediate level, and so we consider three atomic levels in all. Also, our model allows for the possible loss of the electron, via collisional excitation, spontaneous emission, or some other process. We have to de ne a parameter, in units of frequency, which is proportional to the loss rate. The purpose of the thesis is description of the interaction of a three level with pulsed radiation in the Λ scheme. And also we will consider the scheme of excitation whereas two neatly diverged long-term stayed ground states  and, are connected by two nearly resonant laser fields to a third distant short lived state b.
The Antimicrobial Activity of Silica Oxide Nanoparticles Against Some Bacteria and Fungi Isolates Ghaidaa J. Mohammed
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

The capability of some bacteria and fungi to resist common antibiotics has been a guide to discover new planning to treat the infections connected to antibiotic resistance in the patients. In this study, the antifungal and antibacterial activity of silica oxide nanoparticles was detected in vitro against some bacterial species (Klebsiella pneumonia, Staphylococcus aureus, Escherichia coli, Proteus mirabilis, and Pseudomonas aeroginosa) and some fungi (Aspergillus terrus, Aspergillus parasiticus, Aspergillus flavus, and Candida albicans) and contrasted with antibacterial antibiotics (Amikacin, Amoxillin, Augmastin, Cefotaxine, Ceftazidime, Ciprofloxacin, Gentamycin, Meropenum, and Tetracycline) and antifungal antibiotics (Amphotericin B and Ketoconazole). Silica oxide suspension was prepared by acetic acid solution. Results showed that concentrations of (10-40) µg/ml of silica oxide have antifungal and antibacterial activity against the tested microorganisms in this work more than antibiotics. In conclusion, Silica oxide relates superior antimicrobial characteristics.                       Keywords: Antimicrobial activity, Silica Oxide, Bacteria, Fungi.                                 
Synthesis, Characterization and Biological Evaluation of Some Novel Schiff’S Bases Derived from Vanillin Khudheyer J. Kadhim
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Many drugs contain primary amino group can be utilized for synthesizing Schiff’s basses with different uses. A series of Schiff’s bases ( Z1 - Z5 ) have been synthesized using  (vanillin) and3,4 diaminopyridine ,procaine , Met form in , 2-arsanilic acid and RhodamineZ1 and Z2 were synthesized using acidic catalyst while basic catalyst has been used in the synthesis of Z3- Z5 .The characterization was performed using elemental analysis , FT-IR and proton NMR spectroscopes . The prepared compounds were biologically evaluated against gram positive and gram negative bacteria. The results showed excellent to moderate anti-bacterial activity.Keywords: Vanillin, Schiff’s bases, Met form in, Condensation reaction, Anti-bacterial activity, Disk diffusion method.
Seminal Oxidative Stress Markers and Fertilization Rate in Sub fertile Male Undergo Assisted Reproductive Technique Ban J. Edan
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Objectives: The aim of this research is to examine effect oxidative stress in seminal plasma on fertilization rate in assisted reproductive technique (ART) Methods 70 men attended to fertility center in Al-sadder teaching hospital were rolled in this study .semen analysis was done according to the WHO 2010 guidelines. After analysis the results of SFA were classified as the nospermia, Oligospermia, Oligoasthenospermia and normospermia. Seminal free radicals and antioxidants were measured by spectrophotometric absorbance assay. Results MDA was insignificantly and negatively associated with sperm concentration and highly active motile sperm while CAT and GSH was insignificantly and positively associated with sperm concentration and highly active motile sperm (p>0.05). Oxidative stress parameters in different SFA abnormality shows MDA level insignificantly elevated in sub fertile men with abnormal SFA than normal one. Whereas CAT and GSH were in significantly lesser in sub fertile men with abnormal SFA than normal one. Patients with normal SFA had about five time more fertilization rate than patients with abnormal SFA (odds ratio= 5.585 (CI .529 -59.003)). Universal regression analysis was done to show the effect of measured factors on fertilization rate, count and percentage of active sperm was the most effective factor on FR. Conclusion Inadequate antioxidant protection and elevated oxidative stress destruction effect on semen quality and ultimately o fertilization rate and ART outcome.Keywords: Malondialdehyde (MDA), Antioxidant Enzymes, Reduced Glutathione (GSH), Catalase (CAT), Seminal fluid analysis (SFA), Fertilization rate (FR) and assisted reproductive technique (ART).
Used of Growth Charts among Children Age 1-5 Years Old and its Effects on Child Health in Al-Hillah City Amean A. Yasir
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Depending on the height, weight and head circumstances derived from 400 children (200 boys and 200 girls) ranged from one to five years of age. The data collected randomly from different health care centre of Hillah. The result showed that boys were significantly heavier and taller than girls in the first years of life. Height measurement revealed that boys head are bigger than the girls.  Objective this study aimed to suggested new technique of physical growth curve chart for children under five years old of age in non-probability sample.Keywords: Physical Growth charts, Child health, WHO, CDC, Weight, Height and head circumference.
Modification and Anticancer Activity Study of Polyvinyl Alcohol Containing 1, 3, 4-thiadiazole Ruwaidah S. Saeed
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Beginning from 2-amino-5-mercapto-1, 3, 4-thiadiazole a variety of new cyclic imides linked to 1, 3, 4-thiadiazole moiety. A  series of novel cyclic imides containing1,3,4- thiadiazole ring [1-6]through reaction of various cyclic anhydrides with 2-amino-5-mercapto-1,3,4-thiadiazole .Compounds [1-6]were reacted with anhydrous sodium carbonate  of distilled water as a solvent, then of chloroacetic acid was added to produce compounds [7-12].The compounds [7-12]reaction with SOCl2 in the presence of Benzene to producing the compounds [13-18].Chemical modification of Poly(vinyl alcohol) were obtained by reaction of PVA with compounds [13-18]using the Dimethyl formamide to produce compounds [19-24]. The structure of the synthesized compounds was identified by their analytical and spectral data such as, FTIR spectra, 1H-NMR. UV-Vis Spectroscopy, Thermal analysis [Differential Scanning Calorimetry (DSC), Thermo gravimetric analysis (TGA)], Scanning electron microscopy (SEM), Elemental analysis (CHNS) and Antibacterial activity screened via two types of bacteria. Anticancer activity also examined for all modified polyvinyl alcohol.Keywords: 1, 3, 4-thiadiazole, Polyvinyl alcohol, Antibacterial, Anticancer activities.

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