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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 66 Documents
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Search results for , issue "Volume 9 Issue 10" : 66 Documents clear
Molecular Detection of Cytomegalo, CDK2 and P27 in Tissues from Patients with Thyroid Carcinoma Shakir H. Mohammed Al-Alwany
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Background: Thyroid cancers are related to many environmental and genetic predisposing factors. Cytomegalovirus infection may activate the protein kinase pathways, where in papillary thyroid cancer aberrant activation of these pathways is frequently associated with BRAF mutation. The bulk of thyroid cancers has maintained the expression of p27 which is the inhibitor of Cdk2.Objective: The study was designed to examine cellular dysregulation mediated by the concordant protein expressions of CDK2 and P27 tumor suppressor genes with CMV in tissues from thyroid goiter and thyroid cancers.Patients and Methods: A seventy thyroid tissues were examined for HCMV-DNA and CDK2 & P27 genes expression. Those samples belonged to ( 30) patients diagnosed with thyroid cancer and (25) thyroid goiter tissues blocks as well as (15) autopsies from apparently normal thyroid tissues. The detection of HCMV was by in situ hybridization (ISH) whereas CDK2 & P27 genes expression by immunohistochemistry (IHC). Results: HCMV DNA-ISH reaction in thyroid cancers was found in 14 / 30 (46.7%), whereas 32% (8 out of 25cases) HCMV- positivity was detected in thyroid goiter group. None of healthy thyroid tissues revealed ISH reaction. The difference of the HCMV in thyroid cancers and  control was highly significant. Detection of CDK2 in thyroid cancer was found in 13 out of 30 (43.3%) and benign thyroid goiters group was 28 % (7 out of 25). Detection of p27- expressions in thyroid cancers  in 18 out of 30 (60%) was noticed; In thyroid goiter was detected in 36% (9 out of 25) and none of the examined healthy thyroid in the control group revealed such IHC- reactions for both CDK2 &P27 IHC reactions. The difference between the percentages of CDK2- as well as P27 proteins detection in thyroid tissues & control group was statistically significant (<0.05).Conclusions: The significant detection of HCMV along with CDK2 & P27genes expression in thyroid cancer patients could support an etiologic role for that virus along with these genes in thyroid carcinogenesis.Keywords: Thyroid Cancer, HCMV, ISH, IHC, CDK2&P27.
The Short-Term follow up of Changes in Serum Leptin, Ghrelin, and HBA1c after Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) Operation Safauldeen Salim
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Introduction: Morbid obesity is connected with various health related problems, so treating obesity is an essential clinical concern. Swedish subject obesity study with 10 years follow up showed that surgical option is far better than conservative approach. Aim To assess changes in adipose hormones and HbA1c in obese patients after Laparoscopic Roux-en-Y Gastric Bypass (LRYGB). Materials and Methods the study was conducted on 25 subjects (14 females and 11 males), age 32±6, with BMI 52.01 ± 3.5 Kg/m² underwent LRYGB during the period from June 2015 to the end of February 2016. Fasting blood glucose (FBG), HbA1c, serum level of Lept in and Ghrel in were measured before the operation, 2, 4 and 6 months after LRYGB procedure. Results At 6 months point following LRYGB, a significant reduction in body weight and BMI (p< 0.001) was reported. The mean weight of the participants decreased to 82.7 Kg, mean BMI decreased to 31.1 Kg/m2 and mean fat % declined to 35.55%. The mean loss in the EBL percent was 77.3 % and %Excess Weight Loss (EWL) was 39.9%. There was significant reduction in FBG, HbA1c and serum Leptin level (p< 0.001) with significant increase in serum Ghrelin level (p<0.001).Conclusions LRYGB produced a rapid and significant weight loss and improvement in glucose homeostasis within six months after surgery. It had resulted in significant changes in the level of leptin and ghrel in. There were differences between males and females after 6 months of follow-up.Keywords: Obesity, Bariatric surgery, Ghrelin, Leptin, Follow-up. Fasting blood Sugar, Excess weight Loss.
Assessment the Effect of Different Genotypes of Sulfotransferase 1A1 Gene on the Response to Monoxide in Patients with Androgenic Alopecia Moaed E. Al-Gazally
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Objective is to assess the association between a specific genotype and the response to monoxide in patients with androgenic alopecia. Methods and materials: This study was conducted with the participation of thirty five androgenic alopecia patients. The presence of G<A single nucleotide polymorphism in the sulfotransferase 1A1 gene is detected by restricted fragment length polymorphism polymerase chain reaction technique. Result:  In this study, it was found that the levels of response to monoxide  are differ with different genotypes of the sulfotransferase 1A1 gene, and there is significant association between  the allele type and the response to monoxide. The G allele is significantly associated to the response in a p- value of 0.016 and also there is significant association to the GG genotype in a p- value of 0.0011, while it is insignificant to the GA genotype. Conclusion: The results of this study indicate that the monoxide is effective for those patients who are carrying the GG genotype of the sulfotransferase 1A1 gene, and that can be used as a genetic test to predict the response monoxide.
Bacteriological and Enzymatical Study on Rheumatoid Arthritis Patients Teeba Fares Hadi
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

The current study included the collection of 175 samples(blood-urea)of patients suffering from rheumatism, collected from Baghdad Teaching Hospital (Educational Laboratory), Al- Kindy Teaching Hospital, Al-Imamian Al-Kadhimya in Medical City in Baghdad at different duration between 2016/10/1 -2017/2/1. The bacterial growth results showed that 80% of urea samples positive for bacterial culture, while the rate of samples did not show any bacterial grow this 20%. The isolation subjugates to morphological, microscopically and biochemical tests, as also diagnosis by Api system. The most frequent bacterial pathogenic is E. coli which appeared highly rate(41.97)% followed by E. cloacae (21.25)%,P. aeruginosa (12.5)%, Salmonella (10)% and the proportion of K. pneumonia(7.5)%, while S. marcescens showed (6.25)%. When the measurement of the concentration of liver enzymes Glutamic Oxalate Transaminase (GOT), Glutamic Pyruvate Transaminase (GPT), Alkaline phosphates’ (ALP), the results showed a significant degreaseP≤0.05 in the level of enzyme GPT in patients serum which reachto16.94±0.84 mg/ml, while its level in the healthy serum was 0.68± 6.78 mg / ml.ALP enzyme results showed non-significant high atP≤0.05 in the level of patients serum with rheumatoid arthritis, as it reached the level in the serum 2.46±134.42 mg/ml, while the level in the healthy serum was 0.50±4.11 mg/ml. The enzyme GOT showed on-significant high at P≤0.05 in the level of patients serum as it reached the level in the serum 0.88±21.51 mg/ml, while the level in the healthy serum was 0.50±4.11 mg/ml.Keywords: Liver enzymes, Rheumatoid arthritis, Bacteria.
Nuclear in Situ Hybridization of High –Risk and Low-Risk Human Papilloma Virus DNA in Tissues from a Group of Iraqi Patients with Sino Nasal and Nasopharyngeal Benign and Malignant Tumors Saad Hasan Mohammed Ali
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Background: Human papilloma viruses (HPV) are well known viruses that can induce tumor genesis in proliferative epithelial tissues.  Many studies implicated HPV in progression of head and neck benign and malignant tumors by affecting cell cycle proteins expression. Objectives This study was designed to determine the rates of detection high- risk HPV16/18 and low -risk HPV6/11 genotypes in tissues from nasal cavity, par nasal sinuses and nasopharyngeal lesions that include apparently healthy tissue, nasal polyps (NP), sin nasal papillomas (SNP) , nasopharyngeal carcinomas(NPC) and sin nasal carcinomas (SNC).Methods: This study is a retrospective one. Total 125formalin -fixed paraffin embedded tissue blocks including: 35 nasal polyps, 35 sin nasal papilloma S, 29 nasopharyngeal carcinomas 6 sin nasal carcinomas and nasal apparently healthy tissues. After his to pathological confirmation Viral DNA localization performed using chromomeric in situ hybridization (CISH).  Results: In sin nasal papillomas and nasal polypsHPV6/11was detected in 54.3% and 22.9% respectively and in sin nasal and nasopharyngeal carcinomas (SNC+NPC) group was detected in 14.3% where the results have revealed highly significant differences (P<0.01).Percentage of HPV16/18 genotypes in SNC+NPC  group was 31.4 %, in sin nasal papilloma tissues was detected in 25.7% and in nasal polyps tissues was detected in 11.4 %where such results have revealed non-significant differences (P>0.05).Conclusions: The present results point for a possible association between  high on cogenic-risk HPV genotypes with sin nasal papillomas as well as SNC and NPC in the way of their pathogenesis and /or tumor genesis where as a low association was observed between high and low- risk HPV genotypes with nasal polyps lesions.Keywords:  Low- riskHPV-6/11, High- riskHPV-16/18, CISH, Sino nasal and Nasopharyngeal lesions.
Phenotypic and Molecular Identification of Trichophyton Rubrum and Microsporum gypseum of Dermatophytosis Jawad K. Abood Al-Janabi
Journal of Global Pharma Technology Volume 9 Issue 10
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Introduction: Dermatophytes fungi are the predominant source of skin, hair, and nails infection. The present study was carried out to identify and characterize the species of dermatophytes. Material and Methods: Predicated upon the convectional methods such as morphological and microscopic features, culture and biochemical techniques along with growth comparison on Sabouraud dextrose agar (SDA). Two species of fungi belonging to genera Trichophyton and Microsporum were culled to pursue ITS predicated PCR amplification of their genetic profile.  Results: The results of PCR amplification have shown that the ITS region, including 5.8S was successfully amplified by utilizing ITS1 and ITS4 as a primers. The amplicon size of dermatophytes species appeared in between 680-720bp, four isolates of T. rubrum and one isolate of M. gypseum were recorded in various regions of the patients bodies. Other fungi (non dermatophytes) such as Geotrichium candidaus, Candida albicans, Pencillium nutatum, Alternaria alternata, Aspergilus niger and Fusarium sp. were also observed on the infected human body with amplicon size in the range of 350-590 bp. Conclusion: These results have suggested not only a valuable baseline to identify pathogenic fungi but additionally emphasizes on future efforts toward the obviation of dermatophytic infections in our region.Keywords:  Identification, Trichophyton, Macrosporu   m, Dermatophyte mycosis.
Effect of Different Immobilizing Methods on L- Asparaginase Activity for Monitoring Leukemia Hadi Sajed Abd-Al-Abbas
Journal of Global Pharma Technology Volume 9 Issue 10
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Purified L-asparagines from Portulacaoleracea L. plant was immobilized by three immobilizing methods (agar , agarose and gelatin ) ,the  activity of immobilized enzyme was determined  and compared with free enzyme ,where immobilizing efficiency of agar , agarose and gelatin techniques was ( 72 %,78 % and 70 % ) respectively, all immobilizing technique proved an significant activity  increasing of enzyme in compaction of free enzyme, where agar and gelatin methods showed more stability of enzyme at alkaline PH (PH 9) , whereas only agarose method get the enzyme more heat stability than other immobilizing methods. there are significant elevation level of asparagine concentration in leukemic human blood samples than normal  human blood samples , where reached to 〖10〗^(-4)-〖10〗^(-7)M of asparagine in normal  human blood samples while it was  〖10〗^(-2)-〖10〗^(-3)  M of asparagine in leukemic human blood samples.
The Processing of Information According to the Linguistic Neural Programming and its Relation to the Level of Skills Performance of the Monument and Undermine the Scout Tent Aqeel Yahya Hashim Abdulaziz
Journal of Global Pharma Technology Volume 9 Issue 10
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Recently, the interest of trainers and teachers has increased to study the mental and physiological aspects of the player and the learner. The interest in the study of information processing and treatment levels has been highlighted as being one of the types of learning that has to do with the learner himself, directing and self-driving towards learning, and there is a close link between the representative systems owned by the learner whether (audio, visual, sensory) and the level of information processing on the one hand and between these systems and the level of learning skill on the other hand, the problem of this research is that there is a fluctuation among the students in the performance of the skills of erecting and undermining the scout tent. This may be due to the difference in their representation systems of the linguistic programming of the nervous system (auditory, visual and sensory) and related to the process of information processing within the brain.The researchers followed the following steps in the research procedures:The descriptive approach was used in the method of interconnectivity.The research was conducted on the students of the first stage in the Department of Physical Education College of Education for Girls - University of Kufa for the academic year 2016-2017 The sample (30)The sample was divided according to the Neural programming test into three groups representing the first group (the auditory system), the second group represented the visual system and the third group represented the sensory system.The research requires the use of several tests included the followingInformation processing test.Testing neural programming for representative systems (auditory, visual, and sensory).Skill tests of skill (erecting the tent, undermining the tent).The results of the researchThe level of information processing and accurate performance of the skill of setting the tent for those with the visual system is better than the audio and sensory system.The level of processing information undermines the tent for people with a visual system better than the system of audio and sensory.The processing of information is an important and essential role for the people of the visual system and the performance of the skills of the monument and undermines the tent.Keywords: Information Processing, Neural programming, Monument and undermine the scout tent.  
A Review on Manufacturing of Tablets by Using Various Granulation Techniques Girish Pai Kulyadi
Journal of Global Pharma Technology Volume 9 Issue 10
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Tablets are unit, compressed solid dosage form containing an Active Pharmaceutical Ingredient (API) with or without excipients. Tablets are manufactured by using different techniques such as wet granulation, dry granulation, and direct compression. Granulation is the procedure in which particles are held together with the help of linkages between the excipient and API. These links between the excipients and the API are developed both by compression and by employing various types of binding agents. Alternate approach includes using newer directly compressible (DC) grade excipients to prepare stable tablets. The present article mainly focuses on the different granulation techniques used for manufacturing of tablet and their advantages, disadvantages, and limitations and focuses on the technique to be selected for development of a good tablet.Keywords: Tablets, API, Direct compression, Dry granulation, Wet granulation, DC grade and Technique selection.
Molecular Identification of Two Species of Saprolegnia that Predominant in Diwaniyah River/Iraq and Studying Them Nutrition Preference Majid Kadhim Alshibly
Journal of Global Pharma Technology Volume 9 Issue 10
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This study including isolation and identification the Saprolegniaspp from Diwaniyah river waters via baiting method, waters samples were collected during September and November of 2016, the identification was confirmed by polymers chain reaction (PCR). The nutrition preference of isolated fungi was tested by using standard bites (seeds of millet) which compared with other nutrients such as yellow and red corn seeds, sesame seeds, mung bean seeds and alfalfa seeds, the nutrition preference test were experimented by baiting method and also on solid and liquid cultures. The results showed that two species of Saprolegnia were isolated from waters of Diwaniyah River S. ferax and S. parasitica the first one appeared in 14 isolates (61%) and the second appeared in 8 isolates (39%). The nutrition preference test showed that the red corn was the best in attraction and growing Saprolegnia spp., this results indicate that the ability to use it in preparation media to isolate this fungi.Keywords: S. ferax , S.prasitica , PCR, Nutrition preference, Seeds.

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