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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 66 Documents
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Search results for , issue "Volume 9 Issue 10" : 66 Documents clear
Eco Friendly Synthesis, Characterization and Antibacterial Activity of ZnO Nan particles using Bacillus Subtilis against Multi-Drug Resistant Bacteria Ayad F. Alkaim
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Zinc oxide nanoparticles have received likely attention due to their immense uses. For such purpose, the improvement of innovative and biological methods is in significant request for raising these materials in industrial field. This document describes a unique way for the biosynthesis of ZnO nanoparticles using abacillus subtilis. The morphology structure and stability of the synthesized ZnO nanoparticles were studied using XRD, FTIR, FE-SEM and TEM. The results showed that the synthesized nanoparticles are stable, hexagonal phase, spherical with extreme particles in size range within 7–19 nm in diameter and has antibacterial activity against MDR bacteria from different sources.Keywords: Eco friendly Synthesis.
Nuclear Co-Localization of Expressional Products of CDK4&CDK6 and Human T Cell Lymphtropic Virus Type-1- Genes: An in Situ Hybridization and Immunohistochemical Study of Hodgkin’s Lymphoma Tissues from a Group of Iraqi Patients Noor Sami AL- Lebawy
Journal of Global Pharma Technology Volume 9 Issue 10
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Background Human T-cell leukemia/lymphoma virus type 1 (HTLV-1) infects 15-20 millions individuals worldwide. This on co retrovirus can be transmitted through 3 ways: horizontally, vertically (mother to child) and via blood transfusion. HTLV-1 causes 2 major diseases: Adult T-cell leukemia/lymphoma (ATLL) and tropical spastic par paresis/HTLV-1-associated myelopathy [1]. Although tumor cells exhibit rather infrequent mutations of cdk genes with the exception of G1 kinesis Cdk4 and Cdk6 amplification, over expression or hyper activation of basic cell cycle regulators is a general feature of human tumors [2]. Objective: To analyze the impact of concordant expression of cdk4, cdk6 and HTLV-1 infection on a group of tissues with Hodgkin’s lymphoma (HL). Patients and methods Eighty formalin-fixed, paraffin- embedded lymph node tissues were enrolled in this study; (40) biopsies from Hodgkin’s lymphoma (HL), and (40) lymph nodes with (unremarkable pathological changes) as apparently healthy controls. Detection of HTLV-1was done by ultra-sensitive version of in situ hybridization method whereas immunohisto chemistry detection system was used to demonstrate the expression of cdk4and cdk6 gene expression Results: The HBZ gene of HTLV-1positive – CISH reaction was detected in (22.5%: 9 out of 40 cases) of Hodgkin lymphoma tissues.NoHTLV-1 positive –CISH reaction was detected in healthy lymph nodes tissues of the control group. The differences between the percentages of HTLV-1 detection in HL tissues and control groups were statistically highly significant (P value = < 0.05). The positive cdk4&cdk6-IHC reactions were detected in 35% (14 out of 40 cases) and 57.5% (23 out of 40 cases) of Hodgkin lymphoma cases, respectively. A strong positive correlation was found between the detection, scores and intensity of cdk6 and cdk4markers. Conclusions: Significant expressions of both cdk6 and cdk4markersas well as HTLV-1 genes in Hodgkin’s lymphoma could indicate for their possible roles both in lymph node pathogenesis and carcinogenesis.Keywords: HTLV-1,Hodgkin’s lymphoma (HL), CDK6, CDK4, ISH, IHC.
Genotyping of Interleukin-1B SNPs in Correlation with Coronary Heart Disease associated Gingivitis Fatima Malik Abood
Journal of Global Pharma Technology Volume 9 Issue 10
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Objective: Designed to detect most important bacteria implicated gingivitis associated coronary heart disease and investigate interleukin-1 beta gene polymorphism (SNPs) and their possible role with CHD cases with and without chronic gingivitis at positions IL-1????-13 and IL-1????-511.Background:  Coronary heart disease is impaired blood flow in the arteries that supply blood to the heart. Methods: Study subjects consisted of 40 (22 males and 18 females with 45-76 year old, mean 63±6.18) and 30 control (18 males and 12 females) who were gingivitis free, from each subject 2 specimens (swab for bacterial isolation and 5mm of venous blood were taken in EDTA tubes for DNA extraction.IL-1B-31 and IL-1B-511SNPs were amplified by PCR and DNA products sequenced in Gen Bank (Gen Bank accession number NC-000009.11) and scanned for detecting IL-1B-31 and IL-1B-511SNPs. Results: bacteriological study was showed the dominant bacteria in patients were viridians streptococcus, staphylococcus aureus, black pigmented bacteria and candida. The numbers of theses bacteria in patients were higher than control. Genetic study showed three genotypes for -13IL-1B SNP among patients; CC, CT and TT were 29 (72%), 8 (20%) and 3 (7.5%) respectively, However, only two genotypes among control; CC: (27(90) and TT: (3(10), with no significance differences between patients and control (OR= 0.9 (0.87–1.07). While only two genotypes for -115IL-1B SNP among patients; CC: 31 (77.5%) and CT: 9 (22.5%). However, in both SNPs C allele frequency was (dominant) among patients and control. With significance differences p≤ 0.05) (OR=2.829, 95%CI), (OR=1.0(0.85–1.17) respectively, Conclusion: the presence of theses bacteria and SNPs at position -511and -13 of IL1B gene are associated with the severity of CHD with gingivitis and may affect the secretion of IL1B cytokine.
Teeth Samples in Forensic Evidence: A Literature Review Taif Mothhar Al-Khalidi
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Dental identification seem to be more powerful source in forensic evidence to identification disaster victim, mass graves and  fires victims .DNA evidence can eliminate suspect so it consider as tool  for innocence or condemnation. Use dental record as x-ray and dental cast can allow dental remains to be connected to victim. In brief, pulp and cement um are most appreciated sources of nuclear DNA in the tooth and both these tissues and dentine are   good   sources   of   mt DNA. Dentine   and   pulp are protected via enamel. Teeth are   not in save from contamination their lower porosity make them most resistant to contaminants than skeleton (bone).This research present a literature review refer to importance of forensic dentistry  and the main methods of extraction  DNA  from teeth samples and the role of DNA in  teeth  in forensic investigations.Keywords: DNA, PCR Inhibitors, Forensic Destiny, Human identification.
Biofilm Formation in Imipenem-Resistant Acinetobacter baumannii from the Intensive Care Unit Mohammed F. Al- Marjani
Journal of Global Pharma Technology Volume 9 Issue 10
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Acinetobacter baumannii is emerging as an important hospital pathogen, which can persist in the environment for extended periods of time. It is known to produce biofilms, a community of bacteria enclosed within a protective polymeric matrix. One hundred A. baumannii isolates were collected from patients from the intensive care unit (ICU). Antimicrobial susceptibility test was performed by disk diffusion method and MICs of imipenem were determined. Biofilm formation was assayed by micro titer plate and then PCR was performed for detection of ompA and bap genes. The results show that the imipenem-resistance was seen in 80% of A. baumannii isolates, and all these isolates were inferred to be (MBLs) producers. Among these isolates, 91.25% formed biofilms, 32.5% of isolates were categorized as moderately biofilm-producing isolates, 11.25% formed strong biofilms, and 8.75% of the isolates were non-biofilm producers. All isolates simultaneously carried the ompA gnes, whereas 70% of isolates harbored bap gene. Our results revealed a high prevalence of Metallo Beta-Lactamase and biofilm formation in Imipenem -resistant A. baumannii isolates from ICU.Keywords: Acinetobacter  baumannii, Imipenem -resistance, Biofilm, Iraq.
Removal of Malachite Green from Aqueous Solution by Iraqi Porcelanite Rocks Muneer. A . AL-Da&#039;amy
Journal of Global Pharma Technology Volume 9 Issue 10
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Removal of Malachite greendye has been carried out by using Iraqi Porcelanite rocks as an adsorbent. A series of experiments were undertaken in a batch adsorption technique to access the effect of the process variable i.e. namely initial dye concentration, contact time, adsorbent dose, initial pH, and temperature. Maximum adsorption of malachite green was achieved at the suggested optimum conditions: initial dye concentration (6mg.L-1), weight of adsorbent (0.05 g), pH solution (8.5) and contact time (30 min).Equilibrium data were well represented by the Freundlich model. Thermodynamic parameters were estimated. The negative values of the Gibbs energy indicated the spontaneous nature of the adsorption .The entropy was positive and the positive value of the enthalpy showed that the process is endothermic. The removal of Malachite green dye using Iraqi porcelanite rocks has been studied at different temperatures (298.15, 308.15, 318.15, and 328.15)K to determine the adsorption isotherms .The shapes of the isotherms obtained from the experimental data were found to be comparable in all cases to the (S- curve) type according to Giles classification.Keywords: Adsorption, Porcelanite rocks, Malachite green, Isotherms, Langmuir, Freundlich.
Study the Functional VNTR Polymorphism of Monoamine Oxidize a (maoa) Gene in Violent Criminal Behavior for Iraqi Prisoners Suhad Redah AL-Tayie
Journal of Global Pharma Technology Volume 9 Issue 10
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Monoamine oxidise A (MAOA) enzyme activity is changed in mood disorders and lower activity associated with criminal and aggressive behaviours. The monoamine oxidise-A (maoa) gene, which plays a vital role in degradation of neurotransmitters such as serotonin, nor epinephrine, and dopamine, contains a polymorphism in its promoter region that affects transcriptional efficiency. maoa -VNTR genotype has been related with both psychological and physical measures.   Blood samples were provided from 200 prisoners (case group) who convicted with terrorism (150 sample), murder (30 sample) and drug trading (20 sample) issues selected from Al –Hila prison reformist central for men and women / Babylon city and from position and deporting division /Karbala, this sample include (160 male and 40 female).Additionally, control subject (100) sample were provided included (54 male and 46 female). DNA was extracted and the mentioned polymorphism (VNTR) was genotyped by PCR. The results were confirmed by using sequencing technique.   The maoa VNTR polymorphism was analyzed in male and female separately due to the gene location on X-chromosome .The results demonstrated that there was non- significant  difference  observed  between all genotypes and alleles frequencies between case and control male (p> 0.05),whereas in female a significant association in 3.5/3.5 and 5.5/4.5 genotypes (p<0.01) ,additionally the 3.5 R alleles was associated with higher risk of violent criminal behavior in female (p= 0.004; OR=2.62; 95% CI=1.36-5.05). The maoa genotype 3.5/3.5 and the risk allele were a significantly associated   within female  and  they might be associated with increased risk of engaging in violent crimes.Keyword: Monoamine Oxidase- A, Maoa- VNTR, Genotype, Violent criminal behavior.
Molecular Characterization of AmpC Beta-Lactamase Gene Producing Carbapenem-Resistant Klebsiella Pneumoniae from Hilla River Waters-Iraq Fatima Moeen Abbas
Journal of Global Pharma Technology Volume 9 Issue 10
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This study was carried out to identify the prevalence of blaAmpC  producing Klebsiella pneumoniae isolated from surface waters of Hilla River. During the period from January to April 2015,one hundred and one water samples were collected from 10 various locations of Hilla river. Thirty five (34.6%) isolates were specified as K. pneumoniae. All K. pneumoniae isolates were subjected to antibiotic susceptibility testing using Kirby-Bauer disk diffusion method. The higher level of resistance was observed for penicillin antibiotics (ampicillin and piperacillin) with (57.14%) and (54.28%) resistance rate, respectively. Cefoxitin resistant isolates were checked for AmpC β- lactamase production phenotypically using modified three dimensional tests. Four (25%) isolates were screen-positive. Carbapenem resistance was identified in 2 isolates of K. pneumoniae, these were analyzed further by Polymerase Chain Reaction (PCR) assay for detection blaAmpC gene, 2 (100%) isolates gave positive result.Keywords: Klebsiella pneumoniae, AmpC β-lactamase, Carbapenem resistance, PCR, River water.
Molecular Detection of Par influenza Virus 1, 2, 3 and 4 Serotypes and Immunological Response in Otitis Media Patients in Babylon-Iraq Ayam M. Salih
Journal of Global Pharma Technology Volume 9 Issue 10
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(AOM) occur as a case of viral upper respiratory tract infections in young children. Respiratory viruses and AOM both exhibited seasonal discrepancy. Respiratory paramyxo viruses consist of human par influenza viruses are highly distribution, cause the common of childhood croup, bronchiolitis, and pneumonia.  The study was start from6March 2016 to 20May   2016 fifty  cases of otitis media infection were detect  inpatient’s admitted  to AL- Hilla teaching hospital in Babylon - Iraq. Ear swabs and nasopharynx secretion specimens were collected for studies the viral infection detection. The results display the percentage of parainfluenza virus in AMO 22(44%) was positive from fifty cases. The results also show percentage of parainfluenza virus one; two, three, and four types   were   27.2%, 22.7%, 31.8% and 18.1% respectively the study include measurement of IL-6 cytokine by using ELISA assay. Results show elevation level of IL-6 in sera of otitis media patients comparative with control group. The highest level of IL-6 in male occur in (>5-6 year) age group it was 218.39 Pg/ml .The result also shows elevation of IL-6 level in female The highest level of IL-6 in female occur in (>6-7 year) age group it was 209 Pg/ml. Result shows significant differences comparative with control group (P ≤ 0.05).Keywords: Otitis media, Ear swabs, Nasopharyngeal secretion, Parainfluenza virus, Cytokines. 
Biological Activity of Cefotaxime Sodium and their Complexes with Iron and Copper Metals Ayad M.J. Almamoori
Journal of Global Pharma Technology Volume 9 Issue 10
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This investigation was designed to compare between inhibitory effect of cefotaxime sodium and their complexes with heavy metals (iron and copper). In this study, five concentrations were used in range from 0.01 M to 0.005 M for cefotaxime sodium and 0.005 mL, 0.01mL from FeCl3 with 0.01mL cefotaxime sodium, and 0.005ml CuCl2 with 0.01mL cefotaxime. The statistical analysis results showed that cefotaxime sodium (0.01mL) have a highest inhibition effect on bacterial growth, and iron have a synergistic effect with cefotacime more than Copper. Also it was found that, E.coli species were recorded as most affected species by cefotaxime sodium, and their complexes relative to other species.Keywords: Biological activity, Cefotaxime sodium, Heavy metals, Cefotaxime sodium, biological activity, E.coli.

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