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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 66 Documents
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Search results for , issue "Volume 9 Issue 10" : 66 Documents clear
The Relationship of Emotional Arousal with the Level of Acetyl Cholinesterase and Lactic Acid in Young Basketball Players Hayder Naji Habash Alshawi
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

The study of the relationship between emotional arousal and the enzyme acetyl cholinesterase in terms of (acid lactic acid) in young basketball players is of great importance which has played a large role in the direction of the researchers towards such a study. The problem of research was that the basketball game of games of relatively small space The researchers should study the effect of the enzyme acetylcholine in the emotional excitation and lactic acid to achieve the best results. The objectives of the research were to identify the level of emotional arousal, the enzyme acetyl cholinesterase and the level of lactic acid and the level of some of the effectors Physiological studies of young basketball players, and to identify the correlation between the level of emotional arousal and the enzyme acetylcholine acetate and lactic acid for young basketball players, the researchers used the descriptive method in a method of surveying and correlative studies to suit the nature of the problem, the players of the Middle and South Euphrates basketball players participating in The Premier League for the sports season 2016-2017, the nine clubs (Basrah, Maysan, Muthanna, Wasit, Dhiqar, Rafidain, Solidarity, Babylon and Karbala). The sample was selected in a simple random way, (20) players (10) for the Sports Solidarity Club and (10) for the Rafidain Sports Club. The researchers used the following tests: First: to measure the level of emotional arousal, second: biochemical variables, The concentration of lactic acid, measured the concentration of acetylcholine enzyme, and the researchers concluded the high level of emotional arousal of players as a result of the impact of psychological factor. Decreased action of the enzyme acetyl cholinesterase due to the concentration of lactic acid in the muscle, which leads to slow work and sending instructions Increase the proportion of lactic acid in the muscles as a result of the high level of emotional arousal and recommended the adoption of the results of research and use by basketball coaches to know the psychological effects of physiological basketball players. Attention to the psychological preparation of the players in the course of the training along with the physical numbers and skills and plans because of its importance in its reflection on the physical and physiological aspect and therefore on performance. To establish a department for sports medicine in faculties of physical education and sports sciences and provide all specialized devices in order to facilitate the task of conducting research and studies. Conduct research and similar studies by researchers to standardize and determine standard levels of emotional arousal scores on individual and group games.Keywords: Emotional arousal, Acetyl cholinesterase, Lactic acid and basketball.
Estimation of TSH, T3, T4 and Testosterone Concentrations in Patients Suffering From Myocardial Infarction (MI) in Baghdad City-Iraq Noori Mohammed Luaibi
Journal of Global Pharma Technology Volume 9 Issue 10
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The most common cause of morbidity and mortality is cardiac disease, even minor alterations in thyroid hormone levels adversely effects on the cardiovascular system. In acute cardiac problems hypothyroidism occurs and it is associated with the increase of cardiac mortality. The purpose for this study is to investigate the alterations in hormone concentrations TSH , T3 , T4 , and testosterone  in patients suffering from myocardial infarction  in Baghdad city According to statistical analysis  revealed that the level of T3 , T4 and testosterone  were decreased in comparison with healthy control group and the decreasing value of these hormones were continuing to occur especially in 7 and 14 days after myocardial infarction occurs .While the levels of TSH illustrated increment in various periods of time used in this study after admission of myocardial infarction.Keywords: Myocardial infarction, TSH, T3, T4, Testosterone. 
Genotyping of Helicobacter Pylori Isolated From Iraqi Patient with Upper Gastrointestinal Disease Aseel H. Al-Sabary
Journal of Global Pharma Technology Volume 9 Issue 10
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H. pylori is one of the most frequent pathogen infected about half of the world population, despite that most infections are asymptomatic; some infections can develop chronic gastritis, peptic ulcer and gastric cancer. The aims of the study are the molecular detection of H. pylori and the main virulence factors association with clinical outcome of H. pylori infection. This study was start from February to September 2016, ninety two cases of H. pylori infections were detect in patients admitted to Medical Marjan City in Babylon -Iraq. The study display the high frequencies of H. pylori were observed for chronic gastritis, which h constituted 88% while low frequencies were 3.3% for gastric cancer whereas 8.7% for duodenal ulcer. Moreover, identification of H. pylori by PCR technique was performed on all gastric biopsy and ure C as well as ure genes were used as markers for confirmatory diagnosis of H. pylori through using specific primers of PCR technique. The result showed that, 84.8% and 73.9% of H. pylori were positive respectively for both genes. In additions, cag A gene was investigated in all H. pylori isolates. The result showed that65 (70.6%) was positive for PCR amplification of cag A gene whereas 56 (60.8%) was positive for PCR amplification of cag E gene. The frequency of the vac a gene found in the present study was 68.5% (63/92).It was concluded that the molecular detection of H. pylorigeno type is important tool to determine pathogen city of H. pylori.Keywords: Helicobacter pylori, Gastric biopsy, Gastric diseases, Ure A gene, Ure C gene, Virulence genes.
DNA-In Situ Hybridization for Molecular Localization of Human Cytomegalovirus in Cervical Tissues from Iraqi Patients with Cervical Adenocarcinoma Saad Hasan M.Ali
Journal of Global Pharma Technology Volume 9 Issue 10
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Cervical cancer pathogenesis is a multi-factorial process where cervical epithelium is exposed to several important carcinogenic influences. On epidemiological bases, cervical cancer has the characteristics of a venereal disease and among many genital infective agents; human cytomegalovirus (HCMV) might have a role in the etiology of this neoplasm. This study aimed to investigate rate of HCMV infections in cervical aden carcinoma using DNA -in situ hybridization (DISH) and to evaluate their impact on the expressed histopathological features of those cancers.  This study was designed as retrospective research. A total number of forty-nine (49) patients who had undergone hysterectomies or punch biopsies from their cervices were included. Among these, twenty-one (21) formalin-fixed paraffin-embedded tissue blocks were from cervical aden carcinoma while twenty-eight (28) cervical tissue blocks (either without any significant pathological changes or have chronic cervicitis) were included as a control groups for this study. Molecular detection of HCMV in those tissue blocks were performed by using ultra-sensitive versions of DISH technique. Human CMV DNA was found in 12 out of 21 (57.1 %) cervical adenocarcinoma tissues while no HCMV DNA was detected in any tissues from chronic cervicitis group or those in the histopathologically- healthy control group. Among those twelve positive results of Human CMV DNA –ISH reactions, eleven cases (91.7 %) of cervical adenocarcinoma have well or moderate differentiation while only one case (8.3%) was of poor grade.Keywords: Cervical adenocarcinoma, HCMV, DNA-ISH.
Aflatoxins and Aflatoxigenic Fungi Contamination of Dried Fruits in Iraqi Market Mohammad J. Al-Jassani
Journal of Global Pharma Technology Volume 9 Issue 10
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Objectives: Studying the incidence of Aspergillus sp. and Aflatoxins (AFs) contamination in dried fruits collected from local market of Hilla city and other origins. Methods: Intergenic fungi were isolated by direct plate method and were morphologically identified on specified media. AFs production by Aspergillus spp. were screened and determined by thin layer chromatography (TLC) and high performance liquid chromatography (HPLC). Results: Aspergillus spp. represented 93.33% of the total isolated mold species. A. niger was dominant (79.61%) and A. flavus was only 12.5%. Of the total Aspergillus spp., 54.4% found active aflatoxin B1 (AFB1) and aflatoxin B2 (AFB2) producers among 85.24% belong to A. niger and 14.75% belong to A. flavus. HPLC shows that 100% of dried fruit samples tested positive for AFs. Conclusion: Through our study the mold isolates showed different AFs production behavior that they are able to produce AFB1 and AFB2 at a pH range (3.1 to 4.5), optimum temperature at range (28-32ºC) and low aw for best AFs production and this needs much concern especially with dried fruit storage and treatment conditions.Keywords: Dried fruit, Aflatoxin, Aflatoxigenic fungi, TLC, HPLC.
The Effects of Purified Hepatotoxins, Microcystin-LR from Anabaena Circinalis on Some Biochemical Markers of Common Carp (Cyprinus carpio) Maher M. Khadairi
Journal of Global Pharma Technology Volume 9 Issue 10
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Determination the effects of purified microcrystal-LR from Anabaena sp on biochemical markers in liver of C. carpio, Microcrystal-LR was purification by using silica gel, and highly purified and collected by preparative high performance liquid chromatography and concentration of purified hepatotoxins reached to 74.832 µg/ml. fish was intraperitoneally injection with different concentration of microcrystal-LR (3, 6, 9) µg/ kg per day body weight for 30 days. The fish oxidative status was determined through measuring the lipid per oxidation levels MDA, reactive oxygen species ROS and antioxidants activities such as superoxide dismutase SOD, catalase CAT, and glutathione per oxidase GPx and glutathione GSH. The results of presents shown concentration of MDA as well as  ROS and activities of antioxidants such as SOD, CAT and GPx were significantly increased (P<0.05) with increased microcrystal-LR concentration but glutathione activities was significantly decreased with increasing concentration as compared with control groups.Keywords: Hepatotoxins, Microcystin-LR, Purification, Biochemical markers.
An Evaluation of Water Pollution in the Southern Iraqi Marshes by Using Bacterial Indicators and Other Related Parameters Mohammed Fadhil Abo-Ksour
Journal of Global Pharma Technology Volume 9 Issue 10
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Seven selected stations were chosen in Al-Hammer marshes in the south of Iraq. The stations were chosen to cover this big area on this natural lake starting from Mneba, Omria, Jzera, Tar, Sweha, as well as two stations were near to Chebaesh which namelyNC1 and NC2. The samples collection was done in the first day of three months; June, July, and August 2016.Water physical and chemical characteristics such as temperature, pH, salinity, and dissolved oxygen (DO) were analyzed. In addition, total bacterial concentration, total coli form, fecal coli form, streptococci and fecal streptococci were determined by the serial dilution technique using Most Probable Number method (MPN) and Total Bacterial Count (T.B.C). The results show that the averages of temperature, pH, salinity, and DO were 34.5°, 7.5, 1.28 ppm, 1.04 mg/respectively. The results bacterial detections showed that total bacterial count (T.B.C). We’re ranging from 1*105 /dl to 2*107 /dl with average equal to 2.4*106 /ml, while fecal coli form (FC) were ranging from 300 /dl to 5*104 /dl with average equal to 7*103 /dl, as well fecal streptococci (FS) average was 1000 /dl and the results were ranging from 100 /dl till it reaches to 5000 /dl, with average around1000 /dl. FC/FS ratio were ranging from 1to 40 and both of them were recorded in June with average of the whole stations equal to 10.9, The highest FC/FS average among all the selected stations was in Jzera (28.9), while the lowest one was in Sweha (1.8).However, FC/FS ratios in Jzera, Sweha and Mneba stations were <4, while they were >4 in the other stations. Keywords: Iraqi marches, Dissolved oxygen, Salinity, Fecal coli form, Fecal streptococci, FC/FS ratio.
Evaluation of Lactobacillus spp. as a Probiotic Agent against Pathogenic Bacteria Suhad Faisal Hatem Al-Mugdadi
Journal of Global Pharma Technology Volume 9 Issue 10
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Objective: The World Health Organization (WHO) and Agriculture Organization of the United Nations (FAO) defined the robotics in this manner: ‘live microorganisms which, when administered in enough amounts, give a health benefit on the host’. One of the significant features of robotic lactobacilli is to make aggressive activity against pathogenic bacteria because of their ability to produce lactic acid and other organic acids that reduce the pH in the human intestine, in addition to bacteria in and H2O2, which consider a unfriendly environment for the development and survival of various pathogenic bacteria. This study aimed to studying the effect of crude supernatant cell free component extracted from Lactobacillus sp. natural isolate from vagina and commercial sheet including Lactobacillus fermentum, Lactobacillus delbruekii as aprobiotic against various pathogenic bacteria isolates which is multidrug resistance. Materials and Methods: The lactic acid bacteria were isolated from two sources including Lactobacillus sp. from healthy vaginal swabs and commercial Lactobacillus fermentum and Lactobacillus delbruekii as a sachets on MRS selective media agar and broth. Cell free supernatant was extracted from Lactobacillus spp. by using autoclave and cooling centrifuge to evaluate it as Robotic in vitro using agar well diffusion method. Result Anti-bacterial activity of  lactobacillus sp. Isolate supernatant free cells  against pathogenic bacteria by using heat (autoclave) showed biological effect on K. pneumonia(28mm) E.coli in urine(20mm), S .aureus in ear(24mm) , S. aureus in vagina(28mm), Candida albiccans in vagaina (6mm), H. influence in sputum(10mm), K. pneumonia sputum(6mm) and Seriesin wound(16mm).No effect of supernatant was shown by using cooling centrifuge. Commercial mixture of Lactobacillus fermentum, Lactobacillus delbruekii supernatant cell free of these strains which obtained by Cooling centrifuge and Autoclave showed variation in diameter inhibition zones but it still less than  diameter of  zones of vaginal lactobacillus sp. Supernatant. Conclusion: The efficiency of fresh curd supernatant of lactobacilli from healthy vagina in addition to the commercially available lactobacilli strains consider, as a good robotic and therapeutics against pathogenic bacteria. In addition this results conclude that effect components (supernatant) obtained by the heating consider better method than cooling.Keywords: Lactobacillus spp, Probiotic, pathogenic bacteria, Antibacterial activity.
The Role of Some Hormone Levels and Histopathological Changes in Thyroid Gland and Testes in Experimentally Induced Myocardial Infraction in Male Rats Noori Mohammed Luaibi
Journal of Global Pharma Technology Volume 9 Issue 10
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Acute myocardial infarction is a common cardiac emergency, with the potential for substantial morbidity and mortality. Myocardial infarction occurs when myocardial ischemia, a diminished blood supply to the heart, exceeds a critical threshold and overwhelms myocardial cellular repair mechanisms designed to maintain normal operating function and homeostasis. The aim of the current study was to evaluate the alterations in hormone concentrations TSH, T3, T4, and testosterone in experimental rats has been induced for myocardial infarction. According to statistical analysis revealed that the levels of T3, T4 and testosterone were decreased in comparison with healthy control group and the decreasing value of these hormones were continuing to occur especially in 7 and 14 days after myocardial infarction occurs .While the levels of TSH illustrated increment in various periods of time used in this study after admission of myocardial infarction, in addition to histological changes that had occurred in thyroid and testes sections. Thyroid sections showed follicles empty from colloid and degenerative changes in thyroid follicular cells in long period of time after acute myocardial infarction, while testes showed immaturity of spermatogonial cells with deformed sperms inside the lumen.Keywords: Myocardial infarction, TSH, T3, T4, Testosterone. 
C-Reactive Protein a Suitable Marker for Heavy Metal Toxicity: A Comparative Study for Two Freshwater Fish Species Response to Cadmium Alaa J. Hassan
Journal of Global Pharma Technology Volume 9 Issue 10
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The present study estimate some blood parameters including, total and differential white blood cells (WBCs) count, red blood cells (RBCs) count, hemoglobin (Hb) level and packed cell volume percentage (PCV%), as well as the concentrations of serum total protein and C – reactive protein (CRP) in two species of Iraqi freshwater fishes (CyprinusCarpio and Hypophthalimchthyes molitrix) exposed to two concentration of cadmium (cd) (0.5 and 1) pep. Fishes exposed to cd in glass basins  for 7 and 14 days with five replicate for each treatment and control groups .Results: The results showed that there was a significant differences (p<0.05)  in the total WBCs count, monocytes (MON),granulocytes (GRA) and RBCs between individuals of both treated species in each period and treatment , but there was a significant decreases (p<0.05)  for this parameters in  treated silver carp group  compared with silver control group, furthermore , there was a significant decrease PCV% in silver fishes treated with cd , as well as there was a significant decrease in the level of Hb  for both  treated species  compared with healthy subject . The data revealed that there is a significant differences (p<0.05) in the concentration of total serum protein between individuals of both treated species in each period and treatment, but there was a significant decrease (p<0.05) in the level of this parameter in treated H. molitrix groups compared with control group, furthermore, the level of CRP revealed that significant increase in different periods and level of pollutant in both treated fishes groups compared with healthy subject. Conclusions:  The results displays that there is a significant differences (p<0.05) in the levels of blood parameters between treated species of fishes, and H. molitrix fish was more sensitive to cd in comparison with treated C. carpio and control group, also there was a significant difference in the levels of total serum protein and CRP in treated fishes compared with control groups.Keywords: Cyprinus Carpio, Hypophthalimchthyes molitrix, Cadmium, Hematology, Immunology

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