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Unesa Journal of Chemistry

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Published by Universitas Negeri Surabaya

ISSN : - EISSN : 22528180 DOI : https://doi.org/10.26740/ujc.v11n2

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Materials Science & Nanotechnology

UNESA Journal of Chemistry is online Journal covering all aspects of Chemistry. The journal publishes original research paper and review articles.

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

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Search results for , issue "Vol 10 No 3 (2021)" : 16 Documents clear

PENGARUH SUHU PADA SINTESIS MOLECULARLY IMPRINTED POLYMER (MIP) TERHADAP KEMAMPUAN ADSORPSI KLORAMFENIKOL Excel Aida Fransiska; Maria Monica Sianita
Unesa Journal of Chemistry Vol 10 No 3 (2021)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

The purpose of this research was to determine the effect of temperature on the synthesis of Molecularly Imprinted Polymer (MIP) on the adsorption capability of cloramphenicol and for analyze the functional groups of the best polymers that were analyzed using Fourier Transform Infrared (FTIR) instrument. In this research, MIP has been made with variations in temperature of 60oC, 70oC, and 80oC using the precipitation method with chloramphenicol (CAP) as the template, ethyleneglycol dimethacrylate (EDGMA) as a crosslinker, methacrylic acid (MAA) as a monomer, acetonitrile as a porogen, and benzoyl peroxide (BPO) as a initiator. The ratio of CAP: MAA: EDGMA is 1: 3: 18 with 30 mL of porogen acetonitrile. The results showed that the temperature of 80oC resulted in the best Q adsorption of 4.286 mg/g with an Imprinting Factor (IF) value of 5.977 and percent of extraction of 96.66%. FTIR characterization showed that in Non-Imprinted Polymer (NIP) there was absorption of -NO2 functional groups at wave number 1521.77 cm-1, while in MIP and blank polymer (PB) there was no absorption of -NO2 groups. Key words: Molecularly Imprinted Polymer, chloramphenicol, precipitation method, temperature

KANDUNGAN SENYAWA BIOAKTIF DAN AKTIVITAS ANTIOKSIDAN BAWANG MERAH NGANJUK (Allium Cepa L.) Shela Insanul Hikmah; Mirwa Adiprahara Anggarani
Unesa Journal of Chemistry Vol 10 No 3 (2021)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

Nganjuk, East Java is a shallot producing area, but its potential as a medicinal and cosmetic plant has not been developed much, especially in the use of its bioactive compounds. The content of bioactive compounds is considered to be potential as antioxidants. This study aimed to determine bioactive compounds and antioxidant activity. Extraction of the samples used a multilevel maceration method with three types of solvents according to polarity, namely ethanol (polar), ethyl acetate (semi-polar), and dichloromethane (non-polar). The type of sample testing carried out is the measurement of bioactive compounds analysis and determination of antioxidant activity using the DPPH method. Flavonoid levels used the AlCl3 method and for the determination of phenolic levels using the Folin Ciocalteu method. The results showed that Nganjuk shallot extract contained bioactive compounds of alkaloids, flavonoids, phenolics, saponins, tannins, triterpenoids, and quinones. The total flavonoid and phenolic levels were weak, namely 0,881% respectively, and 0,966%. Antioxidant activity is shown at the IC50 values of in the ethanol, ethyl acetate, and dichloromethane extracts were 384,0341 ppm; 5336,7889 ppm; 884,2754 ppm. These results indicate that the antioxidant activity of Nganjuk activity is very weak because the value of IC50 > 200 ppm. Key words: nganjuk shallot, bioactive compounds, antioxidant activity

ANALISIS SENYAWA BIOAKTIF DAN AKTIVITAS ANTIOKSIDAN EKSTRAK BAWANG PUTIH (Allium Sativum L.) PROBOLINGGO Lailatul Wakhidah; Mirwa Adiprahara Anggarani
Unesa Journal of Chemistry Vol 10 No 3 (2021)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

Garlic is a plant from the Allium genus which is found in the mountainous area of Probolinggo. The potensial bioactive content of this local product has not been studied to be developed in the development of garlic product diversification. This study aims to see the bioactive components, phenol content, flavonoid levels, and antioxidant activity in Probolinggo garlic tubers. The method in this research is divided into two parts, namely the extraction process and sample testing. The extraction process uses a multilevel method with three kinds of solvents, namely dichloromethane (non polar), ethyl acetate (semi polar), and ethanol (polar). The sample tests carried out included analysis of bioactive compounds, phenol levels using the Folin Ciocalteu method, flavonoid levels using the AlCl3 method, and antioxidant activity using the DPPH method. The results of the research on Probolinggo garlic tuber extract with dichloromethane and ethyl acetate solvents containing bioactive steroids and triterpenoids, while ethanol solvent contains bioactive compounds of flavonoids, saponins, steroids, triterpenoids and phenolics. Garlic tuber extract with ethanol solvent has a total phenolic value of 28,756 mg GAE / g and total flavonoids of 21,601 mg QE / g. The IC50 values in the extracts of dichloromethane, ethyl acetate, and ethanol were 421.9643 µg / mL, 310.5998 µg / mL, 257.7503 µg / mL, respectively. In terms of the components of flavonoids, saponins, steroids, triterpenoids and phenolic, garlic tuber extract has a very weak antioxidant activity value. Keywords : garlic tubers, bioactive compounds, antioxidant activity.

PENGARUH SUHU TERHADAP KANDUNGAN FENOLIK TOTAL DAN AKTIVITAS ANTIOKSIDAN BAWANG PUTIH BUBUK DAN BAWANG HITAM BUBUK Ika Novianti Safitri; Nuniek Herdyastuti
Unesa Journal of Chemistry Vol 10 No 3 (2021)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

Black garlic is a fresh garlic product that has been heated for two weeks at a controlled temperature (65-90oC). Black garlic has a different color, smell, and taste than fresh garlic. High moisture content of garlic and black garlic make these foods spoil easily. Oven drying techniques can extend the shelf life of garlic. The purpose of this research is to determine the effect of drying temperature on total phenolic content and antioxidant activity of garlic powder and black garlic powder. Garlic and black garlic are to be dried at 60, 70, 80, and 90oC. Total phenolic content was determined by Folin-Ciocalteu reagent and antioxidant activity was measured by 2,2-diphenyl-1-picryhydrazyl (DPPH) method. The results of this reasearch showed that the best drying temperature for garlic was 60oC which had total phenolic content 0,178 mg gallic acid equivalent (GAE)/g and moderate antioxidant activity with IC50 value 105.01 ppm; while the best drying temperature for black garlic was 80oC which had total phenolic content 2.957 mg gallic acid equivalent (GAE)/g and strong antioxidant activity with IC50 value 67.32 ppm. Key words: black garlic, garlic, phenolic, antioxidant

PENGARUH VARIASI KOMPOSISI EKSTRAKTAN TERHADAP KEMAMPUAN ADSORPSI KLORAMFENIKOL MENGGUNAKAN MOLECULARLY IMPRINTED POLYMER (MIP) Eucharistia Oktavia Firda Listiadi; Maria Monica Sianita
Unesa Journal of Chemistry Vol 10 No 3 (2021)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

The aim of this study is optimazing the extractant composition of methanol:acetic acid was with variations of 90:10(v/v), 85:15(v/v), and 80:20(v/v) in the (Molecularly Imprinted Polymer- Chloramphenicol) MIP-CAP synthesis. MIP-CAP is obtained from (Non Imprinted Polymer)NIP through the template extraction process. The template was extracted using maceration method and analyzed using High Performance Liquid Chromatography (HPLC) to determine the extracted CAP. The best extractant composition variation was determined based on % extraction and adsorption capability. The characterization of the MIP-CAP polymer was carried out using Fourier Transform Infra Red (FTIR) to see the presence of the –NO2 group. In this study, the best composition of methanol:acetic acid extractant was 80:20 (v/v) (20% acetic acid) with extraction % gain of 89,5158% and adsorption capability of 4,0725 mg/g with the value of Imprinting Factor (IF) of 3.7369. The higher the addition of acetic acid, the higher the % extraction and adsorption capability. The FTIR characterization of MIP-CAP showed that there was no absorption of the –NO2 group. Key words: CAP, MIP-CAP, Composition of Extractant

PENENTUAN TOTAL FENOLIK, TOTAL FLAVONOID DAN AKTIVITAS ANTIOKSIDAN EKSTRAK DAUN BAWANG KUCAI (Allium tuberosum) Jihan Shofwatul Islam Dalilah Aziz; Mirwa Adiprahara Anggarani
Unesa Journal of Chemistry Vol 10 No 3 (2021)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

The purpose of this research was to determine total phenolic, total flavonoid and antioxidant activity of chinese leeks extract. The extraction process involves a method of leveling using three different types of solvents are dichloromethane, ethyl acetate and ethanol 96%. The samples tested included analysis of total phenolic using Folin-Ciocalteau method, total flavonoid using colorimetric aluminum chloride method and antioxidant activity using DPPH method. The results showed that dichloromethane extract was not found phenolic and flavonoid compounds that are potential as antioxidants. Total phenolic content in ethyl acetate and ethanol extract were 9.5975 mg GAE/g extract and 11.8015 mg GAE/g extract. Total flavonoid content were 4,3454 mg QE/g extract and 7,7165 mg QE/g extract. The value of IC50 on ethyl acetate extract were 563,1250 ppm and and ethanol extract 312,5532 ppm, which are categorized as weak antioxidant. Keywords: chinese leeks, total phenolic, total flavonoid, antioxidant activities

STUDI ELEKTROKIMIA EKSTRAK BETALAIN UMBI BIT SEBAGAI PEWARNA ALAMI DSSC (DYE SENSITIZED SOLAR CELL) Elma Alfianti Indri Lestari; Pirim Setiarso
Unesa Journal of Chemistry Vol 10 No 3 (2021)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

This research was conducted to explore and utilize fresh beetroot as raw material for natural dyes in DSSC. DSSC (Dye Sensitized Solar Cell) is a photovoltaic cell that can convert sunlight into electricity using environmentally friendly raw materials and low production costs. In this study, DSSC was made using the doctor blade method using natural dyes derived from betalain tuber extract. beet. Natural dyes were chosen because they are easy to obtain, as well as cheap and environmentally friendly. The betalain from the beetroot is macerated with ethanol as a solvent. Characterization of natural dyes was carried out using UV-Visible spectrophotometry to determine the wavelength absorption, electrochemical characterization of dyes was carried out using cyclic voltammetry, and to determine the efficiency of the DSSC was carried out by I – V characterization. In this study, an absorption wavelength of 534 nm was produced which showed the uptake of the pigment betasianin. The electrochemical characterization showed that the energy of the HOMO (Highest Occupied Molecular Orbital) in the dye was -5.00 eV. The LUMO (Lowest Unoccupied Molecular Orbital) energy in dye is -3.71 eV. Analysis of the energy bandgap (energy gap) of the dye yields 1.29 eV, meaning that the prepared dye can be used as a sensitizer on the DSSC. I-V characterization showed that the efficiency value of DSSC with natural dye for beetroot was 0.004%. These results indicate that the natural dye extract of beetroot betalain can be used as a natural dye in DSSC. Key words: betalain,DSSC,electrochemical

REVIEW: POTENSI EKSTRAK KAYU SECANG (Caesalpinia sappan L.) SEBAGAI ANTIDIABETES MELLITUS Ashari Kurniawan Sarjono; Tukiran Tukiran
Unesa Journal of Chemistry Vol 10 No 3 (2021)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

Diabetes mellitus is an acute metabolic disorder with several causes with symptoms such as high blood sugar volume accompanied by disorders of carbohydrate, lipid and protein metabolism as a result of insulin function insufficiency. The use of synthetic hypoglycemic chemical drugs can cause some side effects and require relatively expensive costs, so traditional herbal medicine is preferred because it has less side effects and lower costs. Plants that can be used as traditional medicine are secang wood plants (Caesalpinia sappan L). Based on literature studies, compounds contained in the stem or wood part of secang contain flavonoid, tannins, gallic acid, resins, brasilein, α-phellandrene, oscimene, essential oils, resorcinol, and brasilin. It is known that tannic acid (tannins) has antioxidant activity and has an antidiabetic mellitus effects and the brazilin content of secang wood plays a very important role in reducing blood sugar levels. brazilin has three mechanisms of action in reducing blood sugar levels, namely reducing oxidative stress, inhibiting intestinal mucosa GLUT 2, and inhibiting phosphodiesterase. The antihyperglycemic activity of brazilin helps insulin work in the absorption of glucose from the bloodstream into adipose cells by increasing the translocation of glucose transport especially GLUT4. This shows that the extract from the secang wood plant has the potential as an antidiabetic mellitus. Keywords: Antidiabetic mellitus; Antioxidant; Hyperglycemic; Secang wood

PENENTUAN FENOLIK TOTAL, FLAVONOID TOTAL, DAN AKTIVITAS ANTIOKSIDAN EKSTRAK BAWANG LANANG (Allium sativum L.) Dhini Tri Wilujeng; Mirwa Adiprahara Anggarani
Unesa Journal of Chemistry Vol 10 No 3 (2021)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

Free radicals are unstable molecules that can cause oxidative stress. Oxidative stress can lead to damage to cells, tissues, and organs, which can lead to degenerative diseases. Oxidative stress can be reduced by increasing the body's immunity through antioxidants, where these antioxidants can be found in one of the natural ingredients, namely single bulb garlic. The purpose of this study was to determine the potential of imported single bulb garlic with various solvents as a source of natural antioxidants based on total phenolic levels, flavonoids, and antioxidant activity. The Follin-ciocalteu method was used to determine total phenol, total flavonoids were determined colorimetrically with AlCl3, and antioxidant activity was determined by the DPPH (2,2-diphenyl-1-picryhydrazyl) method. The results showed that the total phenolic extract of ethanol 96%, ethyl acetate, and dichloromethane were 13.77 (medium); 26.60 (medium); and 6.36 (low) mg GAE/gr extract. The total flavonoids of ethanol 96% extract, ethyl acetate, and dichloromethane were 0.97; 2.88; and 0.47 mgQE / gr extract. Meanwhile, the antioxidant activity (IC50 value) for 96% ethanol extract was 339.69 ppm (weak), 174.03 ppm for ethyl acetate extract (medium), and 430.48 ppm for dichloromethane extract (weak). Based on the research results, it can be concluded that imported single bulb garlic with the three solvents have potential as a source of natural antioxidants, but the test results are no better than total phenolic, total flavonoids, and antioxidant activity of local single bulb garlic. Key words: Total Phenolic, flavonoid, antioxidant, single bulb garlic

PENGARUH SIRUP UMBI YAKON TERHADAP BIOAVAILABILITAS FE (ZAT BESI) RATTUS NORVEGICUS Alif Wildan Mohammad; Leny Yuanita
Unesa Journal of Chemistry Vol 10 No 3 (2021)
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

Yacon roots syrup is a processed product with high FOS content. FOS is a prebiotic compound that can increase the production of SCFA. SCFA can cause the pH in the colon to decrease which results in the bioavailability of Fe. The purpose of this research were to determine the effect of Yakon roots syrup supplementation on the bioavailability of Fe and the relationship between SCFA and Fe bioavailability. There were 43 R. norvegicus that divided into 3 treatment groups, namely the intake of yacon roots syrup supplements, commercial FOS, and water with a treatment duration of 48 days. The feces from each group were dry digested and then tested using SSA to determine the Fe content. Data were analyzed through the Aova one way, post hoc, and Pearson product moment correlation with a significance degree of 5%. The results showed that the significance value of Yakon roots syrup on Fe bioavailability was 0.034 and SCFA for Fe bioavailability had a coefficient correlation of 0.834. This can be interpreted yacon roots syrup supplementation could increase and significantly affect the bioavailability of Fe and there is a strong relationship between total SCFA levels and the average percentage of Fe bioavailability. The higher the SCFA levels in the colon, the higher the bioavailability of Fe. Key words : Fe bioavailability, FOS, yacon roots, SCFA

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Editorial Address Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia. 60231

Location Kota surabaya, Jawa timur INDONESIA

Abstract

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Abstract

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Abstract

Contact Name
Dina Kartika Maharani

Contact Email
dinakartika@unesa.ac.id

Phone
+628174140131

Journal Mail Official
dinakartika@unesa.ac.id

Editorial Address
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia. 60231

Location
Kota surabaya,

Jawa timur

INDONESIA