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Giftania Wardani Sudjarwo
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Jl. Arief Rahman Hakim No.150, Keputih, Kec. Sukolilo, Kota SBY, Jawa Timur 60111 Gedung F7 Prodi Farmasi Fakultas Kedokteran
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Journal of Pharmacy Science and Technology
Published by Universitas Hang Tuah
ISSN : -     EISSN : 26140993     DOI : https://doi.org/10.30649/pst
Core Subject : Health,
Medicine & Pharmacology
The Journal of Pharmaceutical Science and Technology is a journal for scientific publications on all pharmaceutical aspects including pharmaceutical science (pharmaceutical technology, pharmaceutical chemistry, pharmaceutical biology, pharmacognosy, microbiology and pharmaceutical biotechnology), community pharmacy, clinical pharmacy until explore the potential of marine biota. This journal is published twice a year to provide a means for pharmacists and other health professionals to share research results to improve the science of pharmaceuticals. The Journal of Pharmaceutical Science and Technology is intended to present the best quality research articles in pharmaceutical science, community pharmacy and clinical pharmacy to become scientific guides in fields related to science and pharmaceutical technology. This journal is a peer-reviewed journal and publishes original research articles on all aspects of science and pharmaceutical technology. This journal accepts original articles as well as for other categories such as review articles and case reports for all aspects of pharmaceutical science, pharmacy clinics and community pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 6 Documents
 1 
Search results for , issue "Volume 3 No. 2: Desember 2022" : 6 Documents clear
Review Interaksi Obat-Obat Potensial Terapi Antibiotik Pada Infeksi Saluran Pernafasan Pasien Anak Rawat Inap Di Rumah Sakit Ainaya Rizqiah; Amitasari Damayanti
JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY Volume 3 No. 2: Desember 2022
Publisher : Prodi Farmasi Fakultas Kedokteran Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/pst.v3i2.41

Abstract

Drug interaction is a pharmacological or clinical response to the administration of drugs in combination or concurrently that can change the effectiveness of one drug with another drug. These effects can be dangerous if drug interactions lead to increased toxicity or decreased therapeutic effectiveness of a drug. Antibiotics are a treatment used for pediatric with respiratory infections. Overuse of antibiotics can lead to antimicrobial resistance. The purpose of the literature review study was to determine the types of antibiotic drug interactions and analyze the severity of antibiotic drug interactions in pediatric patients with respiratory tract infections who were hospitalized and carried out using the narrative review method. The results showed that there were interactions between antibiotics with antibiotics and antibiotics with other drugs with moderate and major severity, and there were types of pharmacokinetic and pharmacodynamic drug interactions in pediatric patients with respiratory tract infections.
AKTIVITAS ANTIDIABETES DARI BERBAGAI Genus Momordica SECARA IN VIVO Mella Afita; Nani Wijayanti Dyah Nurrahman; Giftania Wardani Sudjarwo
JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY Volume 3 No. 2: Desember 2022
Publisher : Prodi Farmasi Fakultas Kedokteran Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/pst.v3i2.43

Abstract

Diabetes mellitus (DM) is a chronic disease in the form of metabolic disorders where blood glucose levels are above normal limits. The example of the plants which can reduce blood glucose is Genus Momordica, there are 3 plants from the Genus Momordica, namely Momordica charantia, Momordica cymbalaria and Momordica dioica which contains the most common compounds found, namely saponins and charantin. This study aims to examine the presence of antidiabetic activity from various Momordica genus in vivo. The content of Saponins in the Genus Momordica works by inhibiting the work of the enzyme α-glucosidase, which is an enzyme in the intestine that functions to convert carbohydrates into glucose. The second content is charantin. Charantin works by stimulating the beta cells of the pancreatic gland to produce more insulin and increase glycogen reserves in the liver. From the literature review conducted, it can be concluded that plants from the momordica Genus, namely Momordica charantia, Momordica cymbalaria, and Momordica dioica contain saponin and charantin compounds that have the potential to be antidiabetics or reduce blood glucose levels in vivo.
KAJIAN EFEK INTERAKSI OBAT GOLONGAN STATIN DENGAN CALCIUM CHANNEL BLOCKER (CCB) TERHADAP RHABDOMIOLISIS Marathus Sholikhah Prihatini Sukma; Ana Khusnul Faizah; Amitasari Damayanti
JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY Volume 3 No. 2: Desember 2022
Publisher : Prodi Farmasi Fakultas Kedokteran Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/pst.v3i2.45

Abstract

Drug interaction is one of the factors that can affect drug activity in the body's response. Drugs can interact with chemicals, herbs, food, and other medications, thereby changing the drug's therapeutic effect. Drug interactions are common in hypertensive and hyperlipidemic patients receiving Calcium Channel Blocker (CCB) and statin therapy. This study uses a narrative review method to examine the effect of drug interactions between statins and calcium channel blockers from articles to analyze rhabdomyolysis. Secondary data is taken from the primary literature, namely journals or articles published in the database (Google Scholar, Pubmed). Drug interactions between statins and CCBs are known to have a severity level due to the administration of amlodipine and simvastatin. This severity can cause rhabdomyolysis and can be identified by pain, muscle weakness, urine color that looks like tea, and measuring CK levels that exceed expected levels (200 U/L). In this study, rhabdomyolysis was shown by increasing creatine kinase (CK) levels by ten times after simvastatin 20 mg and amlodipine 10 mg for one month; other studies also reported that CK levels increased up to 100,000 U/L given atorvastatin 80 mg and amlodipine 5 mg therapy. The effect of drug interactions between statins and CCBs that cause rhabdomyolysis can be detected as early as one month. Treatment of rhabdomyolysis due to drug interactions is replacing statin therapy (simvastatin instead of pravastatin or rosuvastatin).
Potensi Conotoxin dari Conus Spesies sebagai Analgesik Izzatiana Nabila Ramadhani; Nani Wijayanti Dyah Nurrahman; Giftania Wardani Sudjarwo
JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY Volume 3 No. 2: Desember 2022
Publisher : Prodi Farmasi Fakultas Kedokteran Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/pst.v3i2.46

Abstract

Pain is an unpleasant sensory and emotional experience resulting from actual or potential tissue damage or tends to damage tissue. Analgesic is one of the therapies commonly used to relieve pain. Analgesic itself is divided into two types, namely opioids and non-opioid, where each of these drugs has effectiveness and side effects. Researchers are trying to find other alternatives that have the potential as analgesics, with high effectiveness and fewer side effects. Conotoxin is a venom derived from Conus and it has potential as an analgesic. One form of Conotoxin that has been developed is Ziconotide. Ziconotide works by activating miu receptors that block N-type calcium channels through the G protein mechanism so that the transmission of pain signals to nerve cells can be inhibited at the spinal cord level. This review article aims to evaluate the use of Ziconotide as an analgesic. The evaluation was carried out by considering the effectiveness and the emergence of side effects from 10 article related to Ziconotide based on inclusion and exclusion criteria. The results obtained from this review article are that Ziconotide has a fairly high effectiveness as an analgesic, this can be proven by the number of patients experiencing pain reduction of more than 30% at least 40% of the population in each literature, as well as side effects that can be said to be quite mild.
KAJIAN PENGARUH PENGGUNAAN SURFAKTAN NON IONIK TERHADAP EFISIENSI PENJERAPAN SISTEM NIOSOM PADA SEDIAAN TOPIKAL Nur Musdalifah; Rakhma Rakhma; Yuli Ainun Najih
JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY Volume 3 No. 2: Desember 2022
Publisher : Prodi Farmasi Fakultas Kedokteran Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/pst.v3i2.47

Abstract

Some of active ingredients in formulation of topical preparations having problem at solubility. Therefore, an effort was made to overcome this problem, thats is a Novel Drug Delivery System (NDDS) for topical route that can increase solubility and stability active ingredients. Niosomes as a modern drug delivery system consist of a combination of non-ionic surfactant vesicles, cholesterol and other additives. In the formulation of niosomes, non-ionic surfactants have an important role because they do not have a charged nucleus in them, non-ionic surfactants have an amphiphilic molecular structure with hydrophilic heads and hydrophobic tails that are water soluble and organically soluble. Types of non-ionic surfactants that are often used in the formulation of niosomes are span and tween. Span 60 has the highest active ingredient entrapment efficiency compared to other types of surfactants. The purpose of this study was to determine the effect of non-ionic surfactants used in formulation of niosomes system on the entrapment efficiency active. This research was conducted using an iterative study method using 15 article about effect using non-ionic surfactants on entrapment efficiency niosome system on the active ingredients of topical formulations. The databases used are NCBI, MDPI, Elsevier, Google Scholar, and Science direct. The studies were screened according to the inclusion criteria that had been determined. Based on the results of this literature study, it can be concluded that the addition of variations type and concentration of non-ionic surfactants at niosome system has an influence on the quality of entrapment efficiency active ingredient.
KAJIAN EFEK SAMPING ANTIDEPRESAN TERHADAP FUNGSI SEKSUAL Vita Manda; Amitasari Damayanti
JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY Volume 3 No. 2: Desember 2022
Publisher : Prodi Farmasi Fakultas Kedokteran Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/pst.v3i2.49

Abstract

Depression is a mental health disorder that is a severe mood disorder characterized by the appearance of symptoms of a decrease in mood (mood), such as loss of interest, energy, concentration, and disturbances in appetite and sleep. One of the treatments for depression is the use of antidepressants. Still, sexual dysfunction has been reported as a side effect of using antidepressants, especially Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs), and other antidepressants, namely Tricyclic Antidepressants (TCAs) have also been reported. ). Research results on the side effects of using antidepressant drugs have been reported to have decreased sexual arousal and impaired orgasm (orgasm development). There are side effects that occur in the use of SSRI, SNRI, and TCA antidepressants on sexual function

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