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Magna Neurologica
Published by Universitas Sebelas Maret
ISSN : 29636027     EISSN : 29853729     DOI : https://doi.org/10.20961/magnaneurologica.v1i2.647
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Magna Neurologica is a peer-reviewed and open access journal that focuses on promoting neurological sciences generated from basic neurosciences and clinical neurology. This journal publishes original articles, reviews, and also interesting case reports. Brief communications containing short features of medicine, latest developments in diagnostic procedures of neurology disease, treatment, or other health issues related to neurology that is important also acceptable. Letters and commentaries of our published articles are welcomed.
Arjuna Subject : Kedokteran - Neurologi Klinis
Articles 6 Documents
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Search results for , issue "Vol. 1 No. 2 (2023): July" : 6 Documents clear
Insomnia During The COVID-19 Pandemic and Its Relationship with Psychological Distress in Health Workers: A Literature Review Maryati, Yullytia Franika; Godwin, Ross James; Hidayat, Saiful
Magna Neurologica Vol. 1 No. 2 (2023): July
Publisher : Department of Neurology Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v1i2.630

Abstract

Background: The global COVID-19 pandemic has had a significant impact on all aspects of daily life. One area it has impacted is psychological stress experienced by health workers, particularly sleep disorders. Insomnia is frequently related to stressful situations, such as the current COVID-19 pandemic crisis and other mental health-related work. The development of sleep disorders such as insomnia may affect the well-being of healthcare workers. Objective: This literature review aims to summarize the evidence concerning insomnia during the COVID-19 pandemic and its relationship to psychological distress in healthcare workers and to detect associated stress symptoms with sleep quality in health workers. Methods: This literature review searched PubMed and ScienceDirect for articles (2020–2022) on insomnia during COVID-19 and its link to psychological stress. The review followed PRISMA guidelines. Results: A total of five articles were analyzed. Three studies indicated that insomnia was associated with stress symptoms even with low exposure to COVID-19 patient care. Two other articles showed that psychological distress has a negative impact on sleep quality to such a level that it interferes with daily activities. Conclusion: Sleep disorders, including insomnia, are related to psychological distress in health workers in the COVID-19 pandemic era. Providing social and psychological support to health workers is crucial because the emotional well-being of health workers affects the quality of patient care and, subsequently, the effective functioning of health services.
Attenuation of Neuronal Tissue Damage in Ischemic Stroke by Tat-NR2Bct-CTM and Tat-NR2B9c Benedictus, Benedictus; Tan, Kenneth; Pratama, Vincent Kurniawan Putra; Sulastyo, Jonathan Daniel
Magna Neurologica Vol. 1 No. 2 (2023): July
Publisher : Department of Neurology Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v1i2.647

Abstract

Background: Worldwide, stroke accounts for 15 million cases annually. Despite improved understanding of its pathophysiology, an effective treatment is yet to be available. Objective: This review aims to expound ischemic stroke pathophysiology from a bio-molecular perspective, and present two peptides, namely Tat-NR2B9c and Tat-NR2Bct-CTM, which has been proven to attenuate neuronal tissue damage in ischemic stroke. Methods: Scoping review of several electronic databases: PubMed, Medline, Researchgate, NCBI, SpringerLink, and Google scholar. Search query included: ischemic stroke, NR2B, DAPK1, nNOS, NOX, Tat-NR2Bct-CTM and Tat-NR2B9c. Results:  It is recognizable in a sense, that the pathophysiology pivots on the NR2B-DAPK1 and PSD-95-NR2B interactions. Tat-NR2Bct-CTM and Tat-NR2B9c thwarts NR2B-DAPK1 and PSD-95-NR2B interactions, respectively. These peptides show significant reliability, with the former capable of reducing free DAPK1 by 92,85%, and the latter, the first stroke treatment in two decades to reach Phase 3 clinical trials. Conclusion: These results strongly support Tat-NR2Bct-CTM and Tat-NR2B9c as effective means to reduce neuronal tissue damage in ischemic stroke.
Delayed Facial Palsy:Uncommon Complications ofMicrovascular Decompressionfor Hemifacial Spasm Syah, Faris Khairuddin; Hutabarat, Ervina
Magna Neurologica Vol. 1 No. 2 (2023): July
Publisher : Department of Neurology Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v1i2.652

Abstract

Background: Microvascular Decompression (MVD) is considered the most effective treatment for reducing hemifacial spasm (HFS) and achieving long-term resolution. However, in rare cases, this procedure can lead to delayed facial palsy, characterized by facial weakness occurring more than 24 hours after surgery. Case: A 50-year-old woman complaining of twitching in the right face, from the eye corner to the eyebrows and mouth, for 2 years. The Brain MRI-FIESTA revealed a neurovascular attachment between the right facial nerve and the right posterior inferior cerebellar artery. Despite medical treatment, the patient experienced dissatisfaction due to incomplete symptom remission and drowsiness from drug side effects. After undergoing MVD, the twitches disappeared. However, twelve days later, the patient developed right facial weakness, and after three months of rehabilitation, it was resolved. Discussion: HFS is a rare condition characterized by involuntary facial twitches that can significantly disrupt daily activities, despite being painless. Proper management can be provided according to the needs of the patient and the choices of HFS management include medications, botulinum toxin injection, and MVD. The potential side effects of each procedure should be carefully considered when making treatment decisions. It is crucial to thoroughly evaluate and monitor post-surgical conditions. Conclusion: Delayed facial weakness may be attributed to gradual edema occurring after surgery. The use of Teflon to separate nerve tissue and blood vessels, although beneficial, can sometimes be perceived as a foreign body leading to inflammation. Facial weakness can be managed with facial muscle exercises without requiring special treatment.
The Impact of 'Long COVID-19' Symptoms on Stroke Patients During The COVID-19 Pandemic Wahyu Dwihardi Raputra
Magna Neurologica Vol. 1 No. 2 (2023): July
Publisher : Department of Neurology Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v1i2.655

Abstract

Background: Coronavirus disease 2019 (COVID-19) has become a global pandemic, affecting millions of people. However, the relationship between COVID-19 and acute cerebrovascular diseases is unclear. Objective: This study aims to examine the potential effect of long COVID-19 on stroke patients. Methods: A descriptive approach was employed in this study to effectively portray and elucidate the facts, data, and information that were gathered from literature studies, including books, journals, and, and results related to the topic. Results: The results showed that stroke sufferers experienced several impacts due to their long COVID conditions. These perceived effects ranged from seizures to cognitive impairment or brain fog, encephalitis, as well as other symptoms that are likely to aggravate the condition of stroke sufferers. Conclusion: The presence of the pandemic has introduced further obstacles for stroke patients who are also dealing with long COVID-19 conditions. If left unattended, these challenges can result in heightened complications, severity, comorbidities, and eve death. Therefore, the government needs to prioritize the prevention and control of long COVID condition among patients to minimize its impacts and effects.
Cases of Meige’s Syndrome Controlled Following Administration of Low-Dose Botulinum Toxin Type-A: A Serial Case Series Ketaren, Retno Jayantri; Margono, Jacqueline Tasha; Stevano, Reza
Magna Neurologica Vol. 1 No. 2 (2023): July
Publisher : Department of Neurology Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v1i2.700

Abstract

Background: Meige syndrome is a form of cranial dystonia characterised by blepharospasm and oromandibular dystonia, with a twice-fold higher prevalence in women as compared to men. The definitive pathophysiology underlying Meige syndrome remains unknown, but some studies have postulated the role of striatal dopaminergic activity. Currently, no curative treatments are available for Meige syndrome, but non-specific modalities include oral agents such as anti-cholinergics, dopaminergics, and benzodiazepines. Botulinum toxin Type-A (BoNTA) constitutes an effective treatment option in cases of Meige syndrome refractory to oral management. Case: We report three cases of female patients, age 42, 57, and 61 years, presenting with complaints of blepharospasm and oromandibular dystonia. Discussion: Low-dose BoNTA injections were administered, 10 units total weekly divided into the orbicularis oculi, corrugator supercilii, frontalis, procerus, nasalis, zygomaticus, mentalis, dan risorius, and orbicularis oris areas. Following repeated administrations of BoNTA injections, the three patients no longer experience symptoms up till now. Conclusion: The authors report that low-dose BoNTA injections are effective in ameliorating dystonic symptoms associated with Meige syndrome, with low incidences of side effects.
Characteristics of Ocular Fundusin Brain Infections at Cipto Mangunkusumo Hospital Jakarta Purba, Maria Jheny Fulgensia; Pradita Sari; Septiana Andri Wardana; Ni Nengah Rida Ariarini; Kartika Maharani; Darma Imran; Riwanti Estiasari
Magna Neurologica Vol. 1 No. 2 (2023): July
Publisher : Department of Neurology Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v1i2.716

Abstract

Background: Brain infections (BI) may cause optic nerve abnormalities. Awareness on optic nerve abnormalities will be useful in assisting further management. The characteristics of the ocular fundus (fundus) in BI have not been widely studied in Indonesia. Objective: This study aimed to apprehend the depiction of the fundus in BI in Cipto Mangunkusumo Hospital Jakarta (RSCM). Methods: Cross-sectional study was conducted on October-December 2021 at RSCM. Inclusion criteria: BI patients who had fundas results. Exclusion criteria: fundas results cannot be interpreted. Images from 20D-lens fundoscopy were captured with a digital camera. Captured images were then interpreted by three examiners in disguise. Results are analyzed if there are similarities between at least two examiners. Results: Among 49 subjects, 25 had normal fundus. Abnormalities were found in 8 subjects: 4 (12.1%) papilledema, 3 (9.1%) papillatrophy, and 1 (3%) retinal hemorrhage. The highest mean aperture pressure was in the papillatrophy group (37 cmH2O), followed by papilledema (27 cmH2O). Cryptococcal meningitis caused papilledema in 60% of cases. Of BI cases with mortality, 80% were tuberculous meningitis with normal fundus. BI can increase ICP, but only 12.1% had papilledema. Papillatrophy indicated prolonged ICP elevation. The highest mortality was in the normal fundus group, suggesting papilledema alone is not a definitive predictor of poor prognosis due to confounding factors. Conclusion: Although BI causes an increase in ICP, papilledema is not always found. High aperture pressure was found in the papillatrophy group, but the highest mortality was found in the normal fundus group.

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