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Magna Neurologica
Published by Universitas Sebelas Maret
ISSN : 29636027     EISSN : 29853729     DOI : https://doi.org/10.20961/magnaneurologica.v1i2.647
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Magna Neurologica is a peer-reviewed and open access journal that focuses on promoting neurological sciences generated from basic neurosciences and clinical neurology. This journal publishes original articles, reviews, and also interesting case reports. Brief communications containing short features of medicine, latest developments in diagnostic procedures of neurology disease, treatment, or other health issues related to neurology that is important also acceptable. Letters and commentaries of our published articles are welcomed.
Arjuna Subject : Kedokteran - Neurologi Klinis
Articles 82 Documents
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SPINAL CORD INFARCTION AS A RARE NEUROLOGICAL COMPLICATION OF ANTERIOR STEMI FOLLOWING FIBRINOLYTIC THERAPY: A CASE REPORT Novia Heriza; Subandi
Magna Neurologica Vol. 4 No. 2 (2026): July
Publisher : Department of Neurology Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v4i2.3378

Abstract

Background: Spinal cord infarction (SCI) is a rare cause of acute neurological deficits and an exceedingly uncommon embolic complication of acute myocardial infarction (AMI). The primary mechanism involves cardioembolism originating from a left ventricular (LV) mural thrombus. We report a rare case of SCI presenting as acute paraplegia following fibrinolysis for anterior ST-elevation myocardial infarction (STEMI). Case: A 53-year-old man presented with typical chest pain. Electrocardiography demonstrated anterior STEMI, and fibrinolytic therapy with streptokinase was administered immediately. Six hours later, he developed sudden bilateral lower-limb weakness, sensory loss from the toes to the T10 level, and urinary retention. Neurological examination showed complete paraplegia (motor strength 0/0) with loss of pain and temperature sensation below T10, while vibration and proprioception were preserved, consistent with Anterior Spinal Artery Syndrome (ASAS). Spinal magnetic resonance imaging revealed T1-hypointense and T2-hyperintense lesions in the anterior horn at the T10 level, confirming anterior spinal artery infarction. Discussion: Acute paraplegia after fibrinolysis was strongly suspected to result from an embolic shower caused by destabilization of an LV mural thrombus, leading to occlusion of the radiculomedullary artery and subsequent ASAS. Because neurological recovery is often limited, prompt anticoagulation and early rehabilitation are essential to optimize outcomes. Conclusion: SCI is a rare but serious complication of anterior STEMI associated with LV thrombus formation, which may cause cardiogenic embolism through the artery of Adamkiewicz. Clinicians should maintain a high index of suspicion for spinal cord stroke in post-STEMI patients, particularly after fibrinolytic therapy, to facilitate timely diagnosis and management.
REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (rTMS) AS A NON-INVASIVE NEUROMODULATION FOR THE SPECTRUM OF NON-MOTOR SYMPTOMS IN PARKINSON’S DISEASE: A SYSTEMATIC REVIEW Izzati Paramadina; Ninda Pradani Futana; Sulistyani
Magna Neurologica Vol. 4 No. 2 (2026): July
Publisher : Department of Neurology Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v4i2.3441

Abstract

Background: Non-motor symptoms are an essential component of Parkinson’s disease (PD) and represent a major contributor to disability and quality of life. Repetitive transcranial magnetic stimulation (rTMS) has been explored as a non-invasive adjunctive therapy; however, evidence remains heterogeneous and limited to specific symptom domains. Objective: This systematic review aimed to synthesize randomized controlled trial (RCT) evidence on the efficacy and safety of rTMS for non-motor symptoms in PD. Methods: RCTs published between 2017 and 2026 were identified from PubMed, Nature Portfolio, and SpringerLink. Twelve studies with PD were included, comparing active rTMS with sham. Outcomes encompassed sleep disturbances, depression, anxiety, pain, apathy, constipation, and cognitive impairment. Risk of bias was evaluated using Cochrane RoB 2.0. Results: Twelve RCTs (566 patients) with PD were included. rTMS showed the most consistent benefits for sleep disturbances and depressive symptoms, particularly with low-frequency stimulation targeting the right dorsolateral prefrontal cortex (DLPFC). Evidence for anxiety, pain, apathy, and cognitive outcomes was moderate and variable, with effects dependent on stimulation parameters and cortical targets; cognitive benefits were largely confined to executive domains. Preliminary evidence suggested a potential emerging role for rTMS in improving constipation via prefrontal modulation of the gut–brain axis. Overall, rTMS was well tolerated, with only mild and transient adverse events reported and no serious safety concerns. Conclusion: rTMS is a safe and well-tolerated neuromodulation approach with potential domain-specific benefits for non-motor symptoms in PD, particularly sleep and depression. This review contributes to the current understanding of symptom-targeted rTMS applications in PD.

Page 9 of 9 | Total Record : 82

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