cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Patricia Wulandari
Contact Email
phloxinstitute@gmail.com
Phone
+6287788090173
Journal Mail Official
sriwijayajournalneurology@gmail.com
Editorial Address
Jl. Sirna Raga no 99, Delapan Ilir, Ilir Timur Tiga, Palembang, South Sumatera, Indonesia
Location
Kota palembang,
Sumatera selatan
INDONESIA
Sriwijaya Journal of Neurology
Published by Phlox Institute: Indonesian Medical Research Organization
ISSN : 29871425     EISSN : 29871425     DOI : https://doi.org/10.59345/sjn
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Neuroscience
Focus Sriwijaya Journal of Neurology (SJN) focused on the development of medical sciences especially neurology for human well-being. Scope Sriwijaya Journal of Neurology (SJN) publishes articles which encompass all aspects of basic research/clinical studies related to the field of neurology and allied science fields, especially all type of original articles, case report, review articles, narrative review, meta-analysis, systematic review, mini-reviews and book review.
Arjuna Subject : Ilmu Syaraf - Neorologi
Articles 29 Documents
 1   2   3 
The Relationship between Neutrophil Lymphocyte Ratio in Head Injured Patients and Patient Outcomes Hidayat, Ahmad; Sentosa, Alwi
Sriwijaya Journal of Neurology Vol. 1 No. 1 (2023): Sriwijaya Journal of Neurology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjn.v1i1.219

Abstract

Introduction: Head injury causes microglial activation and release of proinflammatory cytokines. One of the inflammatory markers that can be used is the neutrophils to lymphocytes ratio (NLR). Within 24 hours after brain injury, the number of circulating neutrophils was markedly increased compared to the uninjured control group. This study aimed to determine the relationship between ratios of neutrophil-lymphocyte head injury patients with patient outcomes at Dr. M Djamil General Hospital, Padang, Indonesia. Methods: This study was a cross-sectional analytic observational study. A total of 36 research subjects participated in this study. Observations on sociodemographic, clinical, and laboratory data were carried out in this study. Data analysis was carried out using SPSS using univariate and bivariate. Results: The majority of study subjects with a good Glasgow outcome scale had a neutrophil-lymphocyte ratio <7.35. Meanwhile, research subjects with Glasgow the poor outcome scale had a neutrophil-lymphocyte ratio ≥7.35, p<0.05. Conclusion: There is a relationship between the neutrophil-lymphocyte ratio and the outcome of head injury patients at Dr. M Djamil General Hospital, Padang, Indonesia.
The Relationship between Hba1c Levels and Body Mass Index with Severity of Diabetic Neuropathy Rauf, Muhammad; Sari, Masyita
Sriwijaya Journal of Neurology Vol. 1 No. 1 (2023): Sriwijaya Journal of Neurology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjn.v1i1.220

Abstract

Introduction: Diabetic neuropathy is the most common microvascular complication in diabetes mellitus patients. Diabetic neuropathy is known to be associated with conditions of hyperglycemia and obesity that occur in diabetic patients. Hyperglycemia in diabetic patients can be monitored through HbA1c levels. This study aimed to assess the relationship between HbA1C values and body mass index with the severity of diabetic neuropathy based on nerve conduction velocity examination. Methods: A study with a cross-sectional design with a total of 25 subjects with diabetes mellitus. The severity of diabetic neuropathy was determined based on Baba's diabetic neuropathy classification (BDC), degrees 0 to 4. In all study subjects, plasma HbA1c levels were examined, and body mass index was assessed. The relationship between categorical variables was tested with the chi-square test, and the relationship between numerical and categorical variables with a one-way ANOVA test, the value was considered statistically significant if the p-value <0.05. Results: The 25 subjects with diabetes found a mean age of 54.88 (±SD 8.918) years, with a gender distribution of 46.4% for women and 42.9% for men. The average HbA1c level was 8.9560 (± 2.21850), and the highest body mass index was obese (50%). There was a significant relationship between HbA1c levels and the severity of diabetic neuropathy based on electrophysiological examination (p<0.05), but there was no significant relationship between the value of body mass index and the severity of diabetic neuropathy. Conclusion: Increased HbA1c levels are associated with increased severity of peripheral neuropathy in patients with diabetes mellitus.
Pathophysiology of Primary Headache Syndrome: A Narrative Literature Review Asmedi, Ahmad
Sriwijaya Journal of Neurology Vol. 1 No. 1 (2023): Sriwijaya Journal of Neurology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjn.v1i1.221

Abstract

Primary headache syndrome is a chronic recurrent type not associated with structural abnormalities or systemic disease and includes migraine, cluster, paroxysmal hemicrania, and tension headaches. This literature review aimed to describe the types of primary headaches and their pathophysiology. Migraine is an episodic neurological disorder characterized by headaches that last 4 to 72 hours. This disorder is diagnosed when two of the following features occur: unilateral headache, throbbing pain, the pain worsening with activity, moderate or severe pain intensity, and at least one of the following: nausea and/or vomiting, or photophobia and phonophobia. Cluster headaches are one of a group of rare disorders known as trigeminal autonomic cephalgia. Tension-type headache (TTH) is the most common type of recurring headache. It's not a vascular headache or a migraine. The mean age of onset is during the second decade of life. Usually mild to moderate bilateral headaches with a feeling of tight bands or pressure around the head.
The Mechanism of Nerve Impulses: A Narrative Literature Review Asri, Jhoni; Rumantir, Christ
Sriwijaya Journal of Neurology Vol. 1 No. 1 (2023): Sriwijaya Journal of Neurology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjn.v1i1.222

Abstract

Neurons are not physically continuous with each other but form points of contact with adjacent neurons by special structures called synapses. The synapse consists of a small rounded end of the presynaptic neuron (synaptic knob) that is separated from the postsynaptic neuron by the synaptic cleft. This literature review aimed to describe the mechanism of nerve impulses in the human body. Neurons generate and conduct electrical impulses by selectively changing the conductance across their plasma membranes and influencing other nearby neurons by releasing chemical signals (neurotransmitters). Neurotransmitters are synthesized in neurons and in localization at the presynaptic terminal (synaptic boutons). The neurotransmitter is released into the synaptic cleft in response to the arrival of an electrical impulse and binds to receptor sites (binding sites) on the postsynaptic membrane of adjacent neurons or other effectors. In conclusion, an understanding of the impulse mechanism of nerves will assist in determining the treatment of neurological disorders.
Overview of Cellular Aspects of the Nervous System: A Narrative Literature Review Surbakti, Khairul
Sriwijaya Journal of Neurology Vol. 1 No. 1 (2023): Sriwijaya Journal of Neurology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjn.v1i1.223

Abstract

The structure of neurons varies so much that each neuron is adapted to perform a specific function. Although their functions may vary slightly, neurons have three common components, namely the cell body (soma), dendrites (thin branching fibers from the cell), and the axon. This literature review aimed to describe the cellular aspect of the system nerves in the human body. The cellular constituents of a typical neuron include microtubules (transporters within the cell), neurofibrils (thin supporting fibers extending throughout the neuron), microfilaments (proteins thought to be involved in the transport of cellular products), and Nissl bodies (endoplasmic reticulum and ribosomes). Involved in protein synthesis. Although most neurons are non-dividing cells, some continue to divide after birth; for example, the olfactory neurons in the nose continue to divide throughout life. In conclusion, there are two basic types of cells comprising nervous tissue: neurons and supporting neuroglia. Neurons are electrically excitable cells and transmit electrical or chemical information between other neurons or to effector organs. Neuroglial cells provide structural support, protection, and nutrition for neurons and facilitate neurotransmission.
Terminal Insomnia as a Phenotypic Biomarker of Geriatric Depression in a Balinese Cohort: A Cross-Sectional Analysis of Circadian Disruption and Sleep Continuity Made Citra Riesti Wulan; Wayan Saka Rahayu; Wayan Wiradana
Sriwijaya Journal of Neurology Vol. 3 No. 2 (2026): Sriwijaya Journal of Neurology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjn.v3i2.242

Abstract

Introduction: Sleep architecture undergoes significant fragmentation during aging, yet the specific phenotypic expression of insomnia in the context of geriatric depression remains under-characterized. While the bidirectional relationship between depression and sleep is established, few studies distinguish between initial, middle, and terminal insomnia subtypes in Southeast Asian geriatric populations. This study aims to characterize the predominant insomnia phenotypes among elderly patients with depression and investigate the association between sociodemographic determinants, chronic morbidity, and specific sleep continuity disturbances. Methods: A cross-sectional analytical study was conducted at the Geriatric Outpatient Clinic of Karangasem Regional General Hospital, Bali, Indonesia (N=58). Psychometric evaluation utilized the Geriatric Depression Scale (GDS-15) to screen for depressive symptoms and the Pittsburgh Sleep Quality Index (PSQI) to assess global sleep quality. Insomnia phenotypes were clinically adjudicated based on diagnostic interviews. To account for potential confounders, body mass index (BMI) and chronic pain scores were included in the analysis. Data were analyzed using Firth’s Penalized Likelihood Logistic Regression to stabilize estimates given the sample size. Results: The prevalence of depression in the cohort was 58.3%. Among depressed elderly patients, terminal (Late) Insomnia was the predominant phenotype, affecting 76.0% of the subgroup, followed by middle insomnia (66.7%) and initial insomnia (36.4%). Multivariate analysis adjusted for age, chronic disease status, BMI, and pain demonstrated that Terminal Insomnia was the strongest independent predictor of depression (Adjusted OR 6.42; 95% CI 2.15–14.8; p<0.001). Conclusion: Terminal insomnia represents a distinct and dominant clinical phenotype of depression in this geriatric cohort, potentially reflecting underlying circadian phase advances and HPA-axis hyperactivity characteristic of melancholic depression. Clinicians should prioritize sleep maintenance strategies over sleep induction pharmacotherapy in this population.
Tenecteplase versus Alteplase or Standard Care for Improving Functional Outcomes in Acute Ischaemic Stroke: A Systematic Review and Meta-Analysis Steffanny Regina Maria Andini; Praise Angelny Agnes Manoppo
Sriwijaya Journal of Neurology Vol. 3 No. 2 (2026): Sriwijaya Journal of Neurology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjn.v3i2.262

Abstract

Introduction: Intravenous alteplase is the standard fibrinolytic for acute ischaemic stroke, but tenecteplase offers practical advantages as a single-bolus alternative. This systematic review and meta-analysis aimed to consolidate recent randomised controlled trial (RCT) evidence on the effectiveness of tenecteplase for improving functional outcomes, with explicit attention to dose stratification. Methods: Following the PRISMA 2020 framework, we searched PubMed for RCTs published between January 2017 and May 2026 comparing tenecteplase with alteplase or standard care. The primary efficacy outcome was an excellent functional outcome at 90 days (modified Rankin Scale 0–1). Trial-level effects were harmonised on a standardised mean-difference scale (Hedges g) and pooled using a DerSimonian–Laird random-effects model. Pre-specified subgroup analyses examined dose (0.25 vs 0.40 mg/kg). Results: Ten RCTs (n=7,118) met eligibility, and eight contributed dichotomous data to the quantitative synthesis. The pooled Hedges g was 0.063 (95% CI –0.067 to 0.192; p=0.344) with substantial heterogeneity (I²=77.1%). Tenecteplase 0.25 mg/kg produced a small but statistically significant favourable effect (Hedges g 0.108; 95% CI 0.0001 to 0.215), whereas the 0.40 mg/kg dose was directionally inferior. Excluding the prematurely terminated NOR-TEST 2 Part A trial yielded a pooled Hedges g of 0.088 (p=0.029) and reduced heterogeneity (I²=39.7%). Conclusion: Intravenous tenecteplase performed at least as well as alteplase or standard medical care for 90-day functional recovery, with the most favourable signal confined to the 0.25 mg/kg dose. The findings supported the integration of tenecteplase 0.25 mg/kg into standard acute neurology pathways, particularly where bolus administration simplified workflow.
Efficacy and Safety of Melatonin on Pain Intensity and Sleep Quality in Adults with Neuropathic Pain: A Systematic Review and Meta-Analysis of Randomised Controlled Trials Maria Pamela Tiffani; Desak Ketut Indrasari Utami; I Putu Eka Widyadharma
Sriwijaya Journal of Neurology Vol. 3 No. 2 (2026): Sriwijaya Journal of Neurology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjn.v3i2.263

Abstract

Introduction: Neuropathic pain frequently coexists with sleep disturbance, and current pharmacotherapy is constrained by limited efficacy and adverse effects. Melatonin, a pleiotropic neurohormone with analgesic, antioxidant, anti-inflammatory and chronobiotic properties, has been proposed as an adjunctive treatment, but its magnitude of clinical benefit on pain and sleep across heterogeneous neuropathic-pain populations had not previously been quantitatively synthesised in a meta-analysis specific to neurology practice. Methods: PubMed, Embase, Web of Science and the Cochrane Central Register of Controlled Trials were searched for randomised controlled trials of oral melatonin versus placebo or active control in adults with neuropathic pain, in accordance with PRISMA 2020. Two reviewers independently screened, extracted and assessed risk of bias using Cochrane RoB 2.0 with the crossover extension where applicable. The primary outcome was change in pain intensity (NRS or VAS); secondary outcomes were sleep quality (PSQI, ESS, sleep-interference NRS), responder rate (≥ 50 % pain reduction) and adverse events. Standardised mean differences (Hedges’ g) were pooled under a random-effects model with restricted maximum likelihood and Knapp–Hartung adjustment, with parallel raw mean differences on the NRS where instruments matched. Heterogeneity was quantified with I² and τ². Pre-specified subgroups examined etiology, dose and duration; sensitivity analyses used leave-one-out resampling and exclusion of the open-label and the mechanism-only trials. Results: Ten randomised controlled trials enrolling 491 participants were included. The exploratory primary pooled SMD across the two trials with extractable continuous pain data was −0.43 (95 % CI −4.86 to 4.00; I² = 77.8 %; P = 0.436); the wide interval reflects the Knapp–Hartung correction with k = 2 and is a structural feature of the methodology. The corresponding raw mean difference on the NRS 0–10 scale was −0.70 (95 % CI −1.99 to 0.59). Substantial heterogeneity was driven by divergent results in painful diabetic neuropathy (SMD −0.76, 95 % CI −1.16 to −0.36; raw NRS difference 1.3 points; P < 0.001) and mixed neuropathic pain (SMD −0.06, 95 % CI −0.57 to 0.45; P = 0.8). Sleep favoured melatonin in painful diabetic neuropathy (sleep-interference SMD −0.81, 95 % CI −1.21 to −0.41) and in multiple-sclerosis-related neuropathic pain (PSQI ↓ 55.9 %, P < 0.001). The ≥ 50 % responder rate in painful diabetic neuropathy was higher with melatonin (RR 1.47, 95 % CI 1.01 to 2.14). Risk of bias was low for six trials, raised some concerns for three trials and was high for one open-label trial. Adverse events were infrequent and did not differ from placebo. Conclusion: Current evidence indicates that melatonin reduces pain and improves sleep in painful diabetic peripheral neuropathy with concomitant sleep disturbance and may benefit selected post-surgical neurosensory deficits and multiple-sclerosis-related neuropathic pain, but is unlikely to benefit unselected mixed neuropathic pain in tertiary chronic-pain settings. Substantial clinical heterogeneity and the small number of pooled trials preclude routine recommendation. Adequately powered, etiology-stratified trials with harmonised pain and sleep endpoints are required.
Inflammatory and Neuroendocrine Biomarkers of Insomnia in Acute Ischaemic Stroke: A Systematic Review and Meta-Analysis Alinda Weka Danastuti; Desak Ketut Indrasari Utami; Kumara Tini
Sriwijaya Journal of Neurology Vol. 3 No. 2 (2026): Sriwijaya Journal of Neurology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjn.v3i2.265

Abstract

Introduction: Insomnia complicates 40-75 % of acute ischaemic strokes (AIS) yet its biological determinants remain incompletely synthesised. We aimed to quantify the association between inflammatory and neuroendocrine biomarkers and post-stroke insomnia in AIS. Methods: PubMed/MEDLINE, Scopus, Web of Science and Cochrane Central were searched systematically. Observational studies reporting cortisol, the neutrophil-to-lymphocyte ratio (NLR), composite indices (PLR, SII, MHR) or cytokines (IL-6, IL-18, TNF-alpha, hs-CRP) alongside a validated sleep outcome (PSQI, ISI or HAMD insomnia items) in adult AIS were eligible. Risk of bias was appraised with the Newcastle-Ottawa Scale, JBI checklist and the ROBINS-I framework. Standardised mean differences (Hedges g) were pooled in a DerSimonian-Laird random-effects model, with Hartung-Knapp confirmation. Results:Thirteen studies entered qualitative synthesis; eight cohorts (n = 2 455) contributed 12 effects to the primary meta-analysis. The pooled g was 0.79 (95 % CI 0.52-1.05; p < 0.0001), with high heterogeneity (I2= 86.2 %). The composite-inflammation subgroup gave the most reproducible estimate (g = 0.53, 95 % CI 0.33-0.72, I² = 17.5 %). Leave-one-out g was 0.69-0.83 (all p < 1 × 10⁻⁷); Egger (p = 0.887) and Begg (p = 0.79) detected no small-study effect. Conclusion: Cortisol, NLR and composite inflammatory indices are robustly associated with insomnia in AIS, with composite indices the most reproducible biomarker class, supporting early biomarker-based identification of patients at risk for post-stroke insomnia.

Page 3 of 3 | Total Record : 29

 1   2   3 

Filter by Year

2023 2026


Reset
Filter By Issues
All Issue Vol. 3 No. 2 (2026): Sriwijaya Journal of Neurology Vol. 3 No. 1 (2025): Sriwijaya Journal of Neurology Vol. 2 No. 2 (2024): Sriwijaya Journal of Neurology Vol. 2 No. 1 (2024): Sriwijaya Journal of Neurology Vol. 1 No. 2 (2023): Sriwijaya Journal of Neurology Vol. 1 No. 1 (2023): Sriwijaya Journal of Neurology