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Mochamad Nashrullah
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JMGCB
Published by Antis Publisher
ISSN : -     EISSN : 30321085     DOI : https://doi.org/10.61796/jmgcb.v1i1
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
The European Journal of Medical Genetics and Clinical Biology is a peer-reviewed journal that publishes articles in English on various aspects of human and medical genetics, the genetics of experimental models, and developmental anomalies. Original clinical and experimental research articles, short clinical reports and review articles are welcome on topics such as: Clinical genetics and genomics, including neurodevelopmental disorders and single or multiple malformations syndromes and dysmorphology; Inherited predisposition to cancer: rare inherited cancer predisposition syndromes and biology and pathophysiology of inherited cancers; Fetal medicine and prenatal diagnosis, including prenatal diagnosis, prenatal screening, fetal therapies and teratology; Diagnostic methods including sequencing studies (gene level), transcriptome studies, methylome and other Omics technologies, variant interpretation and functional validation; Bioinformatics and statistical methods in genetics; Personalized Medicine and therapies, including gene therapy and gene editing, non-genetic treatment of genetic disease, pharmacogenetics and genomics, theranostics and clinical trials; Molecular biology and pathophysiology of genetic and genomic diseases: biology of cell, pathways and systems, epigenetics and gene regulation, biology and pathophysiology of specific genes and non-coding DNA; Genetics and variants in populations: carrier screening, population genetics, evolutionary genetics, genetic epidemiology of diseases, genome variation and architecture in normal population;
Arjuna Subject : Biokimia, Genetika dan Biologi Molekuler - Biokimia, Genetika dan Biologi Molekuler (Lain-Lain)
Articles 223 Documents
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EVALUATE THE EFFECT OF ORLISTAT, LIRAGLUTIDE, AND THE HERBAL SUPPLEMENT ON THE MOTHERS OF EXPERIMENTALLY FATTENED WHITE RATS Zainab Hasan Majeed; Ektifa Abdul Hamid Muhammad; Muna Salah Rasheed
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 6 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i6.583

Abstract

The current study aimed to evaluate the effect of orlistat, liraglutide, and the herbal supplement on the mothers of experimentally fattened white rats. The female rats were divided into two main groups, the first fed a standard ration, in which two groups were the first pregnant and the second non-pregnant, while the second main group was fed a special diet containing 35%. Fat for the purpose of fattening as a first stage and for a period of 6 weeks, then the second stage began, which is the pregnancy and treatment stage and included eight secondary groups. The first group was not treated with any drug, the second group was orlistat at a therapeutic dose, the third group was liraglutide at a therapeutic dose, the fourth group was an herbal supplement, and the fifth group was a supplement with a therapeutic dose. Of Orlistat, the sixth group is supplemented with a therapeutic dose of liraglutide, the seventh group is a high dose of orlistat, and the eighth group is a high dose of liraglutide. The current study showed that the obesity leads to changes in lipid profiles compared to control groups, as the effect of fattening is represented by an increase in the concentration of total cholesterol, triglycerides, low-density lipoproteins, very low-density lipoproteins, and a decrease in high-density lipoproteins, histological examinations. Pathological changes appeared in each of the liver tissues, represented by a large proliferation of fat droplets, steatosis, Müller bodies, collapse of the central vein wall, and lymphocytic infiltration. The two best groups were when the herbal supplement was used with both drugs, and the herbal supplement had a synergistic role. With the two drugs, it reduces the accumulation of fat in the cells.
A REVIEW OF THE DEVELOPMENT OF AN UNDERSTANDING OF ANTIBIOTIC INTERACTIONS, FROM MECHANISMS OF ACTION TO NOVEL RESISTANCE AND THE SEARCH FOR NATURAL ALTERNATIVES Mustafa Kareem AL-Azzawi; Nabaa Abbas Hasan; Mohammed M. Barrak
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 6 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i6.585

Abstract

Recent research has also highlighted the importance of interspecies signalling in terms of ecology, immunology, and evolution. Despite being frequently linked to the direct inhibition of microbial growth, signalling molecules can transmit data about complex, coordinated regulatory phenomena such as virulence island expression, periodic biosynthetic activity, stress responses, cell density, motility, and biofilm formation. Genetically encoded quorum sensing signals, at low concentrations, increase the spread of horizontally acquired antibiotic resistance genes, modify host immune response profiles, and control the expression of virulence determinants. Antibiotics suppress infectious diseases, facilitate health interventions such as surgery, and improve the treatment outcomes of human and animal diseases (e.g., by minimising morbidity, mortality, and hospital length of stay). However, the emergence of drug-resistant biofilms continues to undermine many therapeutic modalities. These intricate settings that provide antibiotics include the presence of individually resistant cells, non-linear nutrient transport and blockage effects, and limited yet subpopulation-biased genetic plasticity. For the longest time, the mainstay of contemporary medicine has been the use of antibiotics to treat bacterial infections 5. However, the creation and spread of antibiotic resistance, a serious worldwide health concern brought on by the abuse and misuse of antibiotics, constantly jeopardises their function. 2. The decrease in the number of novel, efficacious antibiotics being introduced to the market exacerbates these problems. Optimising the usage of already available antibiotics by learning more about how they behave in the intricate microbial and host ecosystems connected to bacterial illnesses is one way to address this. This involves, but is not limited to, looking into how combinations of antibiotics affect treatment outcomes and how these interactions alter in certain settings to either help or hinder the evolution of antibiotic resistance.
THE DISTRIBUTION OF HEPATITIS B VIRUS GENOTYPES AND SUBGENOTYPES IN ACUTE AND CHRONIC INFECTIONS. AND THE IDENTIFICATION OF AMINO ACIDS SUBSTITUTIONS IN ADDITION TO ALLELE FREQUENCY Mohammed Mhmood; Songül Şahin; Laith Najeeb; Pinar Arslan; Başak Karasu
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 6 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i6.589

Abstract

Infection with the hepatitis B virus (HBV) is a worldwide health concern, Genotyping HBV is important because it can help to guide treatment decisions, and the risk of developing severe liver disease can be predicted with the use of HBV genotyping, like hepatocellular carcinoma and cirrhosis. Our study aimed to determine HBV genotype and Allele frequencies in acute, and chronic HBV patients living in Al-Anbar governorate/Iraq. samples were analyzed by nested PCR for hepatitis B virus DNA. Round 1 PCR products revealed that all samples of hepatitis B patients showed a 1003 bp band, which confirmed that the current sample was infected with the virus, Second-run PCR demonstrated a pattern of nested PCR products with a 600 bp band. The amplicons from nested PCR were sequenced by the Sanger sequencing method and each viral genotype was investigated and ascertained by alignment with the reference sequence (GenBank acc. NC 003977.2) and blasted using the NCBI blastin database. The results showed the only type D genotype was found in all 80 HBV patients, with seven nucleic acid variants observed in the investigated samples in different positions, namely 348 T>C, 495 C>T, 501 A>C, 520 C>A, 522 G>A, 530 T>C, and 535 A>C. Additionally, ten variants of amino acids were found in different positions to exhibit effects on the S protein within the size of the amplified loci.
SPECIFIC FAUNISTIC AND TAXONOMIC CHARACTERISTICS OF HELMINTHS OF SMALL HORNED CATTLE OF KARAKALPAKSTAN Paluaniyazova D.A.; Dadayev S.D.; Beknayev U.A
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 6 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i6.600

Abstract

The article presents information on the species composition of small horned cattle helminths, their systematic status, distribution, seasonal dynamics, extent of invasion and intensity of invasion in the conditions of Karakalpakstan. As a result of the study of helminths of small horned cattle of Karakalpakstan and the analysis of published literature, it was noted that 37 types of helminths parasitize small horned cattle. Of these, 34 species were found in sheep and 31 species in goats. The listed helminths belong to 25 genera, 16 families, 9 suborders, 8 families, 3 classes and 2 types of fauna. 26 types (70.2%) of 37 types of helminths parasitizing small horned cattle belong to nematodes, 8 types (21.6%) to cestodes and 3 types (8.1%) to trematodes
RIFIZOSTREP – NEW DRUG AGAINST TUBERCULOSIS Mamadullaev G.Kh; Fayziev U.M
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 6 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i6.601

Abstract

The article presents the results of bacteriological studies of the internal organs of guinea pigs and rabbits experimentally infected with M. bovis and M. tuberculosis with the subsequent use of a new anti-tuberculosis drug “Rifisostrep”.
CURRENT ENVIRONMENTAL AND HYGIENIC PROBLEMS AND THE MAIN RISK FACTORS FOR WORKING CONDITIONS IN CARPET PRODUCTION A.A. Zhumaeva
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 6 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i6.602

Abstract

The aim of this present work became the ecology-hygienic characteristic of carpet manufacture by the example of “Vitebsk carpets” and development of recommendations on optimization of working conditions. decrease of case rate and maintenance of medicine-technological safety. In work the basics are considered professional the harm. Working on an organism of workers. It is established. that the dust allocated in air exceeds maximum concentration limit in 1.7-18.5 times at various stages of technological process of carpet manufacture.
SOIL BIOGENICITY OF WILT-INFECTED COTTON FIELDS DURING PLOWING OF VARIOUS PLANT RESIDUES Marupov Abboskhon; Turamuratova Gulshod
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 6 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i6.603

Abstract

The model experiment results reveal that easily mobilized organic matter introduced into the soil is absorbed much faster by bacteria than by fungi during the initial decomposition phase. This study examines the influence of composting duration of various plant residues on soil biogenicity, microbiological activity, and V. dahliae development. Findings indicate that the composition of organic matter affects the quantity and type of microorganisms in soil as well as its biological activity. Increased bacterial and fungal populations correlate with available organic resources. Addition of plant residues enhances soil microbiological activity while reducing its fungistatic potential. In conclusion, heightened activity of antagonistic bacteria and fungi through plant residue enrichment augments soil fungistatic activity, inhibiting the growth of Fusarium sp. and V. dahliae pathogens.
THE PROCESS OF SCREENING COMPLIANCE OF PATIENTS IN THE TREATMENT OF CHRONIC NON-COMMUNICABLE DISEASES Khodjieva Gulirano Sayfullaevna
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 6 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i6.604

Abstract

This article describes the results of a study on the adaptation, implementation and evaluation of the effectiveness of the MyTherapy mobile application in the practice of treating chronic non-infectious diseases in order to monitor treatment and patient compliance. Based on the more pronounced positive dynamics of the therapy itself, the improvement in the quality of life indicator and the indicator of adherence to treatment, it is shown that the use of this mobile application can be a highly effective method of monitoring the therapy of chronic non-infectious diseases when used correctly
A COMPARATIVE APPROACH TO UNDERSTANDING BACTERIAL PATHOGENICITY: THE ROLE OF ENZYMATIC AND HEMOLYTIC VIRULENCE FACTORS Raghad Z. Suleiman
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 6 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i6.605

Abstract

This comparison study has aimed to identify the impact of enzymatic and hematogenic virulence factors on the pathogenesis of bacteria using S. aureus (ATCC BAA-976) and E. coli (strain O157) as examples. Protease and lipase activity levels were measured using enzyme tests; the hemolytic activity was measured by examining the growth of the bacteria, with non-hemolytic colonies producing a zone around them. A two-tailed t-test was used to build this statistical relationship. The results showed that S. aureus and E. coli had significantly different levels of enzyme activity. Protease and lipase activity levels were higher in S. aureus than in E. coli. It also revealed significant differences in hemolysis zone widths between the two strains, with S. aureus having a greater hemolysis zone diameter than E. coli. Hemolytic virulence factors are crucial for bacterial pathogenic action, allowing them to thrive within host tissues, gain nutrition from red blood cells, and evade the host's defense mechanism. This study can help develop targeted strategies for fighting infections and improving patient outcomes during infection transmission
INFECTIOUS ENTEROTOXEMIA DISEASE OF SHEEP DIAGNOSTICS AND PREVENTION Klichov Odil Ilkhomovich; Salimov Ilkhom Khaitovich
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 6 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i6.606

Abstract

The article describes the diagnosis of infectious enterotoxemia of sheep, the epizootic state of the disease, the course and manifestation of clinical symptoms, and the identification of characteristic pathological changes. Isolation of the causative agent and diagnosis based on laboratory studies with bioassay results in susceptible laboratory animals. Information on the prevention of infectious enterotoxemia of sheep is provided

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